Clinical trials: Transgender Persons, active
Substance Abuse, Substance Addiction
The Trans-Led Care Study
This study is testing a new mutual-help group called "the TLC program" for transgender adults who use substances or are recently in recovery.
- Conditions
- Substance Abuse, Substance Addiction, Substance Use Disorder (SUD), Substance Use (Drugs, Alcohol)
- Trial name
- TLC (NCT06880705)
- Testing
- The TLC Program
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Illinois Institute of Technology
HIV Prevention, Substance Use
Integrating Sexual Pleasure Into Harm Reduction Services for Men Who Have Sex With Men and Transgender Persons Who Engage in Chemsex or Substance Use in Thailand
The study evaluates the integration of a sexual pleasure-based approach into harm reduction services for MSM and transgender persons engaging in chemsex or substance use in Thailand, using the "Pleasuremeter" tool to improve…
- Conditions
- HIV Prevention, Substance Use, Mental Health, Sexually Transmitted Infections (STIs)
- Trial name
- PLEASURE (NCT07509853)
- Testing
- Pleasuremeter-guided qualitative interview, Pleasuremeter-based sexual pleasure discussion integrated with harm reduction services
- Where
- Thailand
- Volunteers
- 300 people
- Sponsor
- Institute of HIV Research and Innovation Foundation, Thailand
Surgery, Larynx
Voice Outcome of Glottoplasty, Cricothyroid Approximation, Thyroplasty, and Chondrolaryngoplasty
The purpose of this study is to measure the short- and long-term voice outcome and outcome predictors of glottoplasty, cricothyroid approximation, thyroplasty, and chondrolaryngoplasty using a prospective non-randomized…
- Conditions
- Surgery, Larynx, Transgenderism, Gender Dysphoria
- Trial name
- NCT06439290
- Testing
- Phonosurgery, Mastectomy/breast augmentation
- Where
- 2 sites in Belgium
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University Ghent
Transgenderism
Prospective Imaging Assessment of Perineo-pelvic Static's Evolution After Sexual Reassignment Surgery in MtF Transgender Patient, by Peno-scrotal Inversion Vaginoplasty Technique (TRANSPELV)
The research consists of adding to the usual MtF transgender patient undergoing vaginoplasty care course, static and dynamic perineo-pelvic MRI before, and at 6 and 24 months.
- Trial name
- TRANSPELV (NCT06093724)
- Testing
- Static and dynamic perineo-pelvic MRI
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Limoges
Suicide
Implementing Evidence Informed Practices in Schools to Address LGBTQ Adolescent Suicide
Reducing youth suicide in the U.S. is a national public health priority. Sexual and gender minority adolescents are at elevated risk for suicide. Safer school environments, however, can decrease this risk.
- Trial name
- RLAS (NCT02875535)
- Testing
- RLAS
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Pacific Institute for Research and Evaluation
Pregnancy (Unwanted), Sexually Transmitted Disease (STD)
#TranscendentHealth: A Text Messaging Pregnancy Prevention Program for Transgender Boys
Transgender and gender-diverse young people who were assigned female at birth (AFAB), including transgender boys, nonbinary youth, and others, face real sexual health disparities.
- Conditions
- Pregnancy (Unwanted), Sexually Transmitted Disease (STD), HIV Infection, Sexual Behavior
- Trial name
- THPP (NCT07681908)
- Testing
- #TranscendentHealth, Universal Sexual Health Program
- Where
- United States
- Volunteers
- 467 people, healthy volunteers welcome
- Sponsor
- Center for Innovative Public Health Research
Gender Incongruence, Cardiovascular (CV) Risk
Cardiovascular Health of Transgender Individuals During the Gender-affirming Pathway
Gender incongruence, now classified in ICD-11 as a "marked and persistent incongruence between an individual's experienced gender and the gender assigned at birth," is managed in dedicated, multidisciplinary centres that…
- Conditions
- Gender Incongruence, Cardiovascular (CV) Risk, Cardiovascular Disease Risk Factor, Cardiovascular Disease Acute
- Trial name
- CV-TGD (NCT07187947)
- Testing
- Feminizing GAHT, Masculinizing GAHT
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
HIV Prevention
Digital Limited Interaction Efficacy Trial of LifeSkills Mobile to Reduce HIV Incidence in YTW
The LifeSkills Mobile app will be evaluated in a randomized controlled trial (RCT) among 5,000 young transgender women (YTW), ages 16-29 in the United States (U.S.).
- Trial name
- LifeSkills (NCT05018611)
- Testing
- LifeSkills Mobile
- Where
- United States
- Volunteers
- 5,100 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Transgender Persons
Cohort Study on Factors Associated with the Evolution of Quality of Life Among Transgender Individuals in the French Population
This research focuses on identifying medical, social, and healthcare journey determinants associated with the evolution of quality of life in the transgender population at 12 months.
- Trial name
- TRANSPOSE (NCT06854965)
- Where
- France
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- CNGE Conseil
HIV Prevention
WePrEP: Developing a PrEP Shared Decision-making Tool for Transgender Women
HIV prevalence among transgender women (TW) in the United States is high (~14%). The best way to reduce HIV incidence in this population is to link TW to HIV pre-exposure prophylaxis (PrEP), which can reduce HIV transmission by…
- Trial name
- NCT06656676
- Testing
- WePrEP: A shared decision-making tool, Active comparator: CDC recommendations for discussing PrEP
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Colorado, Denver
Pain, Postoperative
Saddle Block With IT Morphine for Penile Inversion Vaginoplasty
Penile Inversion Vaginoplasty (PIV) is a transition-related surgery (TRS) that is associated with severe postoperative pain. The optimal pain management strategies for this surgery remain unknown.
- Trial name
- NCT06556121
- Testing
- Saddle block, pudendal nerve block
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Women's College Hospital
Drug Interaction
Assessment of Drug-drug Interactions Between Feminizing Hormone Therapy and Emtricitabine/Tenofovir Alafenamide Concomitantly for Pre-exposure Prophylaxis Among Transgender Women
Recent studies have showed that there were significant drug-drug interactions (DDI) from feminizing hormone therapy (FHT) towards emtricitabine/tenofovir disoproxil fumarate (F/TDF)-based pre-exposure prophylaxis (PrEP) among…
- Trial name
- NCT04590417
- Testing
- Estradiol valerate 2 mg, cyproterone acetate 25 mg
- Where
- Thailand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thai Red Cross AIDS Research Centre
HIV
A Clinical Study of Alimatravir (MK-8527) in Transgender (Trans) and Gender Diverse Individuals on Gender-affirming Hormone Therapy and at Low Likelihood of Human Immunodeficiency Virus (HIV)-1 Exposure (MK-8527-018)
The goal of this study is to learn about the safety of alimatravir (MK-8527) in transgender and gender-diverse people and if they tolerate it.
- Trial name
- EXPrESSIVE-18 (NCT07850609)
- Testing
- Alimatravir
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Sexual Functioning, Transgender Men
Evaluating Sexual Functioning in Trans Men During the Gender Affirmation Process: A Mixed Methods Study
Both sexual experiences and the process of gender transition initiated to reduce gender dysphoria carry cultural characteristics.
- Conditions
- Sexual Functioning, Transgender Men, Gender Affirmation Surgery
- Trial name
- ESFTMGAP (NCT07131267)
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Transgender Women
Progesterone in Gender Affirming Hormone Therapy Study
This study aims to study the effects of Oral Progesterone in Transgender Women. The primary goal is to study the effect of progesterone on psychological distress and secondarily on sleep quality, breast size, quality of life and…
- Trial name
- NCT06807580
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emory University
Transgenderism
Transgender Men, Non-binary Persons and Testosterone Treatment BODY IDENTITY CLINIC
The aim of this study is to investigate transgender men and non-binary persons before and during testosterone treatment. The study will focus on: Cardiovascular status Muscle strenght and power Aggression and quality of life…
- Trial name
- NCT04254354
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Marianne Andersen
Substance Use, HIV Prevention
Pre-implementation Study to Develop Trans-tailored Services for Transgender Persons in Relation to chemsEX
The study is a pre-implementation cross-sectional study exploring chemsex behaviors among transgender persons and gathering perspectives from multiple stakeholders to inform the development of transgender-tailored harm reduction…
- Conditions
- Substance Use, HIV Prevention, Sexually Transmitted Infections (STIs)
- Trial name
- T-REX (NCT07505875)
- Testing
- Understanding of chemsex patterns, impacts, and service needs among transgender persons
- Where
- Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institute of HIV Research and Innovation Foundation, Thailand
Sensation Disorders, Sensation, Phantom
Prospective Study of Sensation and Satisfaction in Cancer and Transgender Mastectomy Patients
During breast surgery, sensory nerves are cut which may lead to reduced sensation and pain. Surgical reinnervation techniques have been developed with the aim of improving postoperative sensation by preserving the nerves and…
- Conditions
- Sensation Disorders, Sensation, Phantom, Pain, Postoperative, Pain, Chronic
- Trial name
- NCT06094257
- Testing
- Sensory testing
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
HIV Prevention, Substance Use
The Implementation of a Trans-tailored Harm Reduction Service for Transgender Persons in Relation to chemsEX and Substance Use (iT-REX)
This study evaluates a comprehensive transgender-tailored harm reduction service for transgender women, transgender men, and non-binary individuals engaging in chemsex or substance use in Thailand, focusing on PrEP uptake…
- Conditions
- HIV Prevention, Substance Use, Mental Health Disorders, Sexually Transmitted Infections (STIs)
- Trial name
- NCT07512856
- Testing
- Transgender-tailored Harm Reduction Service
- Where
- Thailand
- Volunteers
- 140 people
- Sponsor
- Institute of HIV Research and Innovation Foundation, Thailand
Gender Dysphoria, Gender Identity
Early Mental Response - The EMRE Study
Primary question: Does transgender men's experience of gender incongruence improve within 6 weeks of hormonal treatment compared to placebo? Long before any bodily changes occur.
- Conditions
- Gender Dysphoria, Gender Identity, Gender Issues
- Trial name
- EMRE (NCT05649605)
- Testing
- Testosterone treatment
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Karolinska University Hospital