Clinical trials: Transmission Vertical
Hiv, Transmission Vertical
Enhanced Mentor Mother Strategy for Pregnant and Postpartum Women Living With HIV
Mentor Mothers (MMs) are peer supporters who help pregnant and postpartum women living with HIV (WLHIV) as they receive prevention of mother-to-child transmission of HIV (PMTCT) services in resource-limited settings like Kenya.
- Conditions
- Hiv, Transmission Vertical, Viremia, Adherence, Treatment
- Trial name
- PIE-eMMs (NCT06999928)
- Testing
- Enhanced Mentor Mother Strategy
- Where
- Kenya
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Indiana University
HIV Infections
HIV Vertical Transmission in Vietnam
Prevention of HIV-1 transmission from mother-to-child by non-breast-feeding is complicated by increased infant mortality in developing countries.
- Trial name
- NCT00669604
- Where
- Vietnam
- Volunteers
- 135 people
- Sponsor
- National Institute of Hygiene and Epidemiology, Vietnam
Human Immunodeficiency Virus
Evaluation of Problem Management Plus in Pregnant Women With HIV in Kenya
This study includes secondary quantitative analysis, qualitative methods, and hybrid type 2 implementation-effectiveness pilot trial.
- Trial name
- Tatua (NCT05841797)
- Testing
- In-Person Program Management Plus (PM+), Mobile Program Management Plus (mHealth PM+)
- Where
- Kenya
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
Chronic Hepatitis B, Late Pregnancy
Study of Telbivudine and Lamivudine to Prevent Vertical Transmission of Hepatitis B
The purpose of this study is to evaluate the efficacy and safety of telbivudine and lamivudine use during late pregnancy for the prevention of HBV perinatal transmission in highly viraemic mothers.
- Conditions
- Chronic Hepatitis B, Late Pregnancy, Transmission, Complication
- Trial name
- NCT01743079
- Testing
- Telbivudine, Lamivudine
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Beijing YouAn Hospital
Pregnancy, HBV
Prevention of Hepatitis B Virus Vertical Transmission by Serovaccination and Tenofovir During Pregnancy
The risk of vertical HBV transmission is related to HBV DNA level in pregnant women, around 30% in women with HBV DNA above 1, 000 000 I.U/mL despite serovaccination of newborns.
- Trial name
- NCT02039362
- Testing
- Tenofovir DF
- Where
- France
- Volunteers
- 37 people
- Sponsor
- Hopital Lariboisière
HIV Infections
The Safety of Nevirapine When Given to Breast-Feeding Babies From Birth to Age 6 Months
The purpose of this study is to see if it is safe to give nevirapine (NVP) to breast-feeding babies from birth to the age of 6 months and to determine what dose of NVP should be given.
- Trial name
- NCT00006279
- Testing
- Nevirapine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sars-CoV2
Study of Viral Load and Maternal-fetal Serology in the Interpretation of the Vertical Transmission of SARS Cov-2 (COVID-19) During Pregnancy
The study evaluates the distribution of immunological and virological profiles of newborns patients. Mothers of these children have a proven infection to SARS Cov-2 during pregnancy.
- Trial name
- TRANSCOVID (NCT04402918)
- Testing
- biological samples day of delivery
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Dengue, Pregnancy Preterm
Materno-fetal Consequences of Symptomatic Dengue in Pregnant Wowen in French Guiana
Symptomatic dengue virus infection in pregnant women could affect the mother, fetus and the newborn at birth. The risks of postpartum hemorrhage, prematurity and low birth weight are increased in dengue fever.
- Conditions
- Dengue, Pregnancy Preterm, Women, Fever
- Trial name
- CMFdeng (NCT04989673)
- Testing
- Biological sampling and collection (serum), Biological sampling and collection (placenta), Questionnaire
- Where
- French Guiana
- Volunteers
- 628 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Cayenne
HIV Infections, Disease Transmission, Vertical
Trial of Vitamins in HIV Progression and Transmission
This study tested the hypothesis that multivitamin supplementation given to HIV+ pregnant women in Tanzania would slow disease progression and enhance their overall health.
- Trial name
- NCT00197743
- Testing
- Vitamin A + Beta Carotene, Multivitamins
- Where
- United States
- Volunteers
- 1,085 people
- Sponsor
- Harvard School of Public Health (HSPH)
HIV Infections
Immune Function of Infants With HIV
This observational study will evaluate data from infants born to HIV infected mothers in order to better characterize disease progression in early HIV infection.
- Trial name
- NCT00073229
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Syphilis
Impact of COVID-19 on Provision and Uptake of Prevention of Mother-to-child Transmission of HIV Services in Zimbabwe
The COVID-19 pandemic and response are likely to lead to severe unintended consequences for the prevention of mother-to-child transmission (PMTCT) of HIV and syphilis.
- Trial name
- NCT04782739
- Testing
- None - Descriptive study
- Where
- 2 sites in Zimbabwe
- Volunteers
- 30 people
- Sponsor
- University of Zimbabwe
HIV
Clinical Study of an Aluvia-based HAART Regimen for Prevention of Mother-to-child HIV Transmission in Africa
Therapeutic options to prevent vertical transmission of HIV remain limited. Combination antiretroviral therapy in the form of HAART (Highly Active Anti Retroviral Therapy) is generally recommended in the developed world, both for…
- Trial name
- NCT01088516
- Testing
- Lopinavir/Ritonavir (200/50 mg) Tablets + Zidovudine + 3TC
- Where
- Zambia
- Volunteers
- 280 people
- Sponsor
- University of Zambia
Screening
Universal Screening Program for Cytomegalovirus Infection in the First Trimester of Pregnancy (CITEMB Study)
The aim of this study is to evaluate a universal cCMV screening programme in the first trimester of pregnancy in primary care in Catalonia (Spain).
- Trial name
- CITEMB (NCT05699421)
- Testing
- screening programme
- Where
- Spain
- Volunteers
- 3,357 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Acquired Immunodeficiency Syndrome, Disease Transmission, Vertical
Anti-HIV Immunoglobulin (HIVIG) in Prevention of Maternal-Fetal HIV Transmission (Pediatric ACTG Protocol 185)
To determine if HIV hyperimmune globulin (HIVIG) given to HIV-positive pregnant women during the second and third trimester of pregnancy reduced the likelihood of maternal-fetal HIV transmission.
- Conditions
- Acquired Immunodeficiency Syndrome, Disease Transmission, Vertical, HIV Infections
- Trial name
- NCT00000590
- Testing
- immunoglobulins
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hepatitis B
Prevalence of HBV in Pregnant Women Attending Antenatal Care in Tanzania
Chronic Hepatitis B virus (HBV) infection is a neglected disease with devastating consequences, particularly in countries with limited resources for the health sector.
- Trial name
- HBVPMTCT (NCT04325542)
- Testing
- HBSAg (sure screen test)
- Where
- Tanzania
- Volunteers
- 743 people
- Sponsor
- Medical Mission Institute, Germany
HIV Antiretroviral Therapy (ART) Adherence, PMTCT
Optimizing Prevention and Care for Pregnant and Postpartum Adolescent Girls and Young Women With HIV in Tanzania
The goal of this clinical trial is to find better ways to care for pregnant and postpartum adolescent girls and young women (AGYW) aged 15-24 years with HIV in Tanzania, and to prevent them from passing HIV to their babies.
- Conditions
- HIV Antiretroviral Therapy (ART) Adherence, PMTCT, Pregnancy, Retention in Care
- Trial name
- ENGAGE (NCT06605053)
- Testing
- Co-produced intervention to optimize PMTCT care engagement
- Where
- 2 sites in Tanzania
- Volunteers
- 222 people
- Sponsor
- Karolinska Institutet
HIV Infections, Pregnancy
Safety and Effectiveness of Ritonavir Plus Lamivudine Plus Zidovudine in HIV-Infected Pregnant Women and Their Babies
The purpose of this study is to see if it is safe and effective to give ritonavir (RTV) plus lamivudine (3TC) plus zidovudine (ZDV) to HIV-infected pregnant women during pregnancy and to their babies after birth.
- Trial name
- NCT00000888
- Testing
- Ritonavir, Lamivudine, Zidovudine
- Where
- 5 sites in United States
- Volunteers
- 14 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hepatitis C, Hepatitis C, Chronic
Vertical Transmission of Hepatitis C in Adult Children of Female Baby Boomers
The investigators aim to determine the prevalence of hepatitis C in the adult children of female baby boomers. During the years baby boomers were becoming pregnant, hepatitis C testing was either not available or was not standard…
- Trial name
- NCT03038763
- Testing
- Eligibility Screening, HCV test
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Pregnancy
Assessment of Obstetric, Fetal and Neonatal Risks and Vertical SARS-CoV-2 Transmission During COVID-19 Pandemic
A new coronavirus (COVID-19) highlighted at the end of 2019 in China is spreading across all continents. Most often at the origin of a mild infectious syndrome, associating benign symptoms (such as fever, cough, and headache) to…
- Trial name
- COroFet (NCT04360811)
- Testing
- COVID 19 diagnostic test by PCR
- Where
- France
- Volunteers
- 2,494 people
- Sponsor
- University Hospital, Toulouse
HIV Infections, Neutropenia
Study to Improve Survival Among HIV-Exposed Infants in Botswana
The purpose of this study is to find ways to improve infant health and survival among infants whose mothers are HIV-infected but who do not themselves have HIV.
- Conditions
- HIV Infections, Neutropenia, Anemia
- Trial name
- Mpepu (NCT01229761)
- Testing
- cotrimoxazole prophylaxis, exclusive breastfeeding until 6 months of age, breastfeeding for 12 months
- Where
- 3 sites in Botswana
- Volunteers
- 3,724 people
- Sponsor
- Harvard School of Public Health (HSPH)