Clinical trials: Transplant Recipients
Intestinal Microbiome, Febrile Neutropenia
Choosing the Best Antibiotic to Protect Friendly Gut Bacteria During the Course of Stem Cell Transplant
The purpose of this study is to see how different antibiotics affect the community of friendly bacteria existing in the intestinal tract (gut).
- Trial name
- NCT03078010
- Testing
- Piperacillin-tazobactam, cefepime
- Where
- 2 sites in United States
- Volunteers
- 347 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Kidney Diseases
A Trial of Tolerogenic Immunosuppression in Highly Sensitized Renal Transplant Recipients
Comparison between Campath induction and monotherapy with Tacrolimus vs Thymoglobulin induction and triple drug maintenance using Tacrolimus, mycophenolate, and steroids.
- Trial name
- NCT00407160
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- The University of Texas Medical Branch, Galveston
For Donors, Related Donors Giving Peripheral Blood Stem Cells (PBSC) to a Sibling
A Safety and Tolerability Study of CDX-301 With or Without Plerixafor for Stem Cell Mobilization in Matched Related Allogeneic Donor/Recipient Sibling Transplant Pairs
This is an open-label, multicenter, prospective pilot study of CDX-301 with or without plerixafor as a stem cell mobilizer for allogeneic transplantation (stem cells that come from another person).
- Conditions
- For Donors, Related Donors Giving Peripheral Blood Stem Cells (PBSC) to a Sibling, For Recipients, Acute Myelogenous Leukemia (AML)
- Trial name
- NCT02200380
- Testing
- CDX-301, CDX-301 and plerixafor
- Where
- 8 sites in United States
- Volunteers
- 36 people
- Sponsor
- Celldex Therapeutics
Kidney Transplant
Low Dose Sirolimus or CsA-Based Maintenance Immunosuppression After Induction With Campath-1 in Kidney Transplantation
During the past 15 years, however, the superior immunosuppressive efficacy of CsA and the well-known toxicity of long-term steroid therapy have prompted trials of steroid withdrawal from renal allograft recipients at various…
- Trial name
- NCT00309270
- Testing
- Campath-1H
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Organ Transplantation
Belatacept Post Depletional Repopulation to Facilitate Tolerance
Acute rejection is a common problem after a kidney transplant. Rejection can occur when the kidney recipient's immune system tries to attack (or reject) the new kidney.
- Trial name
- NCT00565773
- Testing
- Belatacept, Sirolimus, Alemtuzumab
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Allan D Kirk, MD, PhD
Lung Transplant; Complications, Disability Evaluation
Assessment of Lung Transplant Recipients Within The Scope of International Classification of Functioning, Disability and Health
This study was aimed to evaluate the patients undergoing lung transplantation under the International Classification of Functionality, Disability and Health (ICF) and to examine the relationships between the age at which lung…
- Trial name
- NCT05376605
- Testing
- assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Ankara City Hospital Bilkent
Rejection Chronic Renal
Belumosudil for Abrogation of Interstitial Fibrosis and Tubular Atrophy Following Kidney Transplantation
This is a randomized, double-blind, placebo-controlled trial in de novo kidney transplant patients to determine if the addition of belumosudil (brand name- REZUROCK®) on the background of standard immunosuppression will prevent…
- Trial name
- NCT06751602
- Testing
- Belumosudil 200 mg QD
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Methodist Hospital Research Institute
Stem Cell Transplantation
Physical Impairments in Allogeneic-HSCT
Pulmonary functions, exercise capacity and muscle strength deteriorate in survived hematopoietic stem cell transplantation (HSCT) recipients due to toxic effects of chemotherapy, radiotherapy, conditioning regimens and/or…
- Trial name
- NCT03448627
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Gazi University
Cytomegalovirus Infections
An Observational Study of Valcyte (Valganciclovir) in D+/R- Liver Transplant Recipients
This retrospective review will evaluate the efficacy of Valcyte (valganciclovir) in preventing Cytomegalovirus (CMV) disease in D+/R- liver transplant recipients.
- Trial name
- NCT02062294
- Where
- 3 sites in Switzerland
- Volunteers
- 14 people
- Sponsor
- Hoffmann-La Roche
Kidney Transplantation
Safety & Efficacy of Certican in Pediatric de Novo Renal Transplant Patients
The purpose of this study is to evaluate the safety and tolerability of RAD001 (Certican) administered to pediatric renal transplant recipients, and to provide additional safety data.
- Trial name
- NCT00098241
- Testing
- Certican
- Where
- 2 sites in United States, Belgium
- Volunteers
- 45 people
- Sponsor
- Novartis Pharmaceuticals
Allogeneic Hematopoietic Stem Cell Transplant Recipient, Hematopoietic and Lymphoid Cell Neoplasm
Gardasil 9 Vaccine in Preventing HPV Infection in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant
This phase IV trial studies how well Gardasil 9 vaccine works in preventing human papillomavirus (HPV) infection in patients with hematologic malignancies who are undergoing donor stem cell transplant.
- Trial name
- NCT03023631
- Testing
- Recombinant Human Papillomavirus Nonavalent Vaccine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- M.D. Anderson Cancer Center
Kidney Transplantation Recipients
MPA Pharmacokinetics in Renal Transplantation
Adequate exposure to mycophenolic acid (MPA) is associated with better outcomes in kidney transplantation. This study evaluated repeated, MPA pharmacokinetics (MPA-PK) according to post-transplant time-points and concomitant…
- Trial name
- NCT01892761
- Testing
- Renal transplant recipients were allocated to TCL/MMF or to CyA/MMF groups
- Where
- Brazil
- Volunteers
- 52 people
- Sponsor
- University of Sao Paulo General Hospital
Kidney Transplant
Study to Evaluate the Efficacy and Safety of Once-Daily Tacrolimus in Kidney Transplant Recipients
The purpose of this study is to evaluate the efficacy and safety and of Once-Daily Tacrolimus (TacroBell SR Cap.) in patients who received renal transplantation.
- Trial name
- OPIRUS (NCT03749356)
- Testing
- TacroBell SR cap.
- Where
- South Korea
- Volunteers
- 141 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Transplantation, Kidney
VEL-101 to Prevent Rejection After Kidney Transplantation
This study will evaluate the safety and efficacy of VEL-101 compared with tacrolimus in patients undergoing kidney transplantation.
- Trial name
- RENGEVITY-201 (NCT07290777)
- Testing
- Tacrolimus (TAC), VEL-101
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Veloxis Pharmaceuticals
Bronchiolitis Obliterans Syndrome (BOS)
Extracorporeal Photopheresis for Medicare Recipients of Lung Allografts
The primary aims of this study is to determine the efficacy and tolerability of Extracorporeal Photopheresis (ECP) for the treatment of either Refractory Bronchiolitis Obliterans Syndrome (BOS) patients (258 at cessation of…
- Trial name
- ECP (NCT02181257)
- Testing
- Extracorporeal Photopheresis (ECP), No intervention in the SOC / Retrospective Chart review.
- Where
- 22 sites in United States
- Volunteers
- 280 people
- Sponsor
- Washington University School of Medicine
Renal Transplant Recipients
Validation of a Novel Diagnostic Tool for the Evaluation of Post Renal Transplant Immunosuppression: The ImmuKnow Assay
Patients undergoing renal transplantation at London Health Sciences Centre, University Hospital and who are participating in the study "A Comparison of Effects of Standard Dose vs Low Dose Advagraf with IL-2 Receptor Antibody…
- Trial name
- NCT01859832
- Testing
- Cylex ImmuKnow Assay
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Kidney Transplant, Renal Transplant Recipients
Allogeneic Regulatory Dendritic Cell (DCreg) Renal Study
This study will evaluate the safety and feasibility of treatment involving a single infusion of donor-derived regulatory dendritic cells (DCreg) in first time, living donor renal transplant recipients.
- Trial name
- RTB-006 (NCT03726307)
- Testing
- DCreg: 0.5 million cells/kg+SOC, DCreg: 1.2 million cells/kg+SOC, DCreg:2.5 to 5.0 million cells/kg+SOC
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Angus W. Thomson PhD DSc
Cystinosis
Kidney Transplantation in Patients With Cystinosis
This study will test the effectiveness of a combination of anti-rejection medicines in preventing complications typically seen in cystinosis patients undergoing kidney transplants.
- Trial name
- NCT00074516
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Solid Organ Transplant
iParent2Parent Program for Parents of Pediatric Solid Organ Transplant Recipients
The iParent2Parent (iP2P) program is a new, innovative virtual mentorship program that will connect parents one-to-one with other parents of pediatric solid organ transplant (SOT) recipients who are trained to offer vital peer…
- Trial name
- NCT05968807
- Testing
- iParent2Parent Program
- Where
- Canada
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Kidney Transplant; Complications, Frailty
Effect of Home-based Training Program for Kidney Transplant Recipients (HOMETRAIN-KTR)
Does home-based training work in kidney transplant recipients with reduced physical function? The goal of this clinical trial is to learn if home-based training works to better physical function in adult kidney transplant…
- Conditions
- Kidney Transplant; Complications, Frailty, Physical Disability
- Trial name
- NCT06379009
- Testing
- Training
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital