Clinical trials: Transplantation, Liver
Liver Transplantation
Investigation of the Effects of Motor Cognitive Dual Task Exercises on Cognitive Function, Balance and Functional Capacity in Patients Who Have Undergone Liver Transplantation.
Liver transplantation is a life-saving treatment of choice for patients with acute or chronic liver failure. Liver transplantation is performed with a graft taken from a living donor or cadaver in patients with end-stage liver…
- Trial name
- NCT05909371
- Testing
- exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Hepatic Encephalopathy, Fecal Microbiota Transplantation
Fecal Microbiota Transplantation for the Treatment of Refractory Hepatic Encephalopathy After TIPS Surgery
This is a single-center, prospective, open-label, parallel-group exploratory clinical study designed to evaluate the safety and preliminary efficacy of fecal microbiota transplantation combined with standard medical therapy in…
- Conditions
- Hepatic Encephalopathy, Fecal Microbiota Transplantation, TIPS, Refractory Hepatic Encephalopathy
- Trial name
- NCT07683936
- Testing
- Fecal Microbiota Transplantation, Rifaximin、Lactulose, Dietary Fiber Prebiotic
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Liver Diseases
Fibrinogen Concentrates Versus Cryoprecipitate in Liver Transplant Surgery
We compared the time consumed for goal-directed management of hypofibrinogemia using two strategies during liver transplant (LT) surgery: a conventional cryoprecipitate-based strategy versus a lyophilized fibrinogen…
- Trial name
- NCT06144112
- Testing
- fresh frozen plasma, prothrombin complex concentrate
- Where
- South Korea
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Neuroendocrine Tumors
Liver Transplantation Versus Conventional Medical Therapy for Low-Grade GEP-NET With Liver Metastases
Liver Transplantation Versus Conventional Medical Therapy for Low-Grade GEP-NET With Liver Metastases
- Trial name
- TRANET-GEP (NCT07913113)
- Testing
- Liver Transplantation
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chiyi Chen
End-stage Liver Disease (ESLD), Liver Transplantation
View of Cerebral Perfusion in Liver Transplantation
Investigator's aim in this study is to compare the more accessible and low-cost Carotid Doppler USG measurements, which are relatively more difficult to access, costly, and have technical disadvantages, and to demonstrate their…
- Conditions
- End-stage Liver Disease (ESLD), Liver Transplantation, Cerebral Perfusion, Intraoperative Monitoring
- Trial name
- NIRS/Doppler (NCT07442214)
- Testing
- Carotid Doppler Ultrasonography and Near-Infrared Spectroscopy (NIRS)
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Inonu University
Liver Transplant Rejection, Liver Transplant; Complications
Safety of DNP007 in Healthy Subjects
This clinical trial evaluated the safety, tolerability, pharmacokinetic properties, and immunogenicity of DNP007 when administered as a single dose.
- Conditions
- Liver Transplant Rejection, Liver Transplant; Complications, Steatohepatitis, Nonalcoholic
- Trial name
- NCT06400771
- Testing
- DNP007
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Liver Transplantation
Intact Liver Innervation and Glucose and Glucagon-like Peptide-1 (GLP-1) Induced Insulin Secretion
The aim of the study is to investigate the significance of intact nerve supply to the liver for the glucagon-like peptide-1 (GLP-1) induced insulin secretion.
- Trial name
- NCT01176708
- Testing
- dipeptidyl peptidase 4 (DPP4) inhibitor, oral glucose, intravenous glucose
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Non-Alcoholic Fatty Liver Disease, Chronic Kidney Diseases
NAFLD Among Patients With Chronic Kidney Disease and the Effect of Kidney Transplantation
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in developed countries affecting approximately 30 % of the general adult population.
- Conditions
- Non-Alcoholic Fatty Liver Disease, Chronic Kidney Diseases, PreDiabetes, Kidney Transplant
- Trial name
- NCT03866421
- Testing
- MR spectroscopy of the liver, Fibroscan of the liver, Continuous glucose monitoring (CGM) for four days.
- Where
- Denmark
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Postoperative Pain
Intraoperative Magnesium Sulfate Administration During Orthotopic Liver Transplantation
The aim of study is to assess the effect of intraoperative use of magnesium sulfate in liver donating patients in reducing post-operative morphine requirements in early postoperative 24 hour in adult living liver donor.The…
- Trial name
- NCT03717467
- Testing
- isotonic saline, Magnesium Sulfate
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Liver Transplant; Complications, Infections
Inflammatory and Anti-Inflammatory Gene Expressions in Liver Transplant Patients
In our study, some inflammatory Interleukin-2 , Interleukin-6, Interferon-γ, Tumor Necrosis Factor-α and anti-inflammatory Interleukin-4 and Interleukin-10 cytokine genes expressions and Triggering Receptor Expressed On Myeloid…
- Conditions
- Liver Transplant; Complications, Infections, Gene Amplification, Immune Response
- Trial name
- NCT05852964
- Testing
- Molecular Immunology , gene expressions
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Inonu University
End Stage Renal Disease, End Stage Liver Disease
Dissemination of the Donor Application: Utilizing Social Media to Identify Potential Live Organ Donors
This study utilizes a web-based application to help patients on the organ transplant waitlist communicate patient's need for a living donor via social media and provide interested potential donors the opportunity to engage with…
- Trial name
- NCT03803423
- Testing
- The Donor App
- Where
- 6 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Liver Transplant Disorder
Kinesiophobia and Physical Fitness, and Related Factors in Liver Transplantation
Kinesiophobia and Physical Fitness, and Related Factors in Liver Transplantation
- Trial name
- NCT04031924
- Testing
- Assessment of: 1. Functional Capacity 2. Physical Fitness 3. Physical Activity Level 4. Balance 5. Kinesiophobia 6. Psychological Status 7. Fatigue Severity
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Diabetes Mellitus, Type 2, Glucose, High Blood
The Role of Hepatic Denervation in the Dysregulation of Glucose Metabolism in Liver Transplant Recipients
It is believed that important brain centers send signals through the vagus nerve to the liver to suppress the amount of glucose (sugar) that gets produced.
- Conditions
- Diabetes Mellitus, Type 2, Glucose, High Blood, Glucose Metabolism Disorders
- Trial name
- NCT03685773
- Testing
- Diazoxide, Nicotinic acid
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Liver Failure
Study to Evaluate if the Drug Vasopressin Protects the Kidneys for Patients Undergoing Liver Transplant
The purpose of this study is evaluate the medication vasopressin for its ability to preserve kidney function in patients undergoing liver transplantation.
- Trial name
- NCT00886262
- Testing
- Vasopressin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Influenza
Influenza Vaccine in Pediatric Transplant Subjects
The purpose of this study is to evaluate how well children responds to the recommended trivalent subviron influenza vaccine (flu shot).
- Trial name
- NCT00133510
- Testing
- Trivalent Subviron Influenza vaccine (Fluzone)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Alcohol Use Disorder, Alcohol; Liver
CM for Patients With ALD After Liver Transplant
Alcohol associated liver disease (ALD) refers to liver injury, such as cirrhosis, that is caused by alcohol use. It affects 2 million adults in the U.S.
- Conditions
- Alcohol Use Disorder, Alcohol; Liver, Post Liver Transplant, Contingency Management
- Trial name
- NCT06304467
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Arpan A. Patel, MD
Liver Failure
Fecal Microbiota Transplantation for Liver Failure
To investigate the safety, adverse reactions and therapeutic effects of fecal microbiota transplantation on patients with liver failure;to investigate the effect of fecal microbiota transplantation on the intestinal microecology…
- Trial name
- NCT05170971
- Testing
- fecal microbiota transplantation
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ningbo Medical Center Lihuili Hospital
Complete and Accurate Statistical Data of 60 Patients, CYP3A5*3 Genotypes of 60 Donors and Recipients Were Analyzed Accurately
Analysis of the Effect of Donor CYP3A5 Gene Polymorphism on Early Tacrolimus Concentration and Postoperative Acute Renal Injury After Liver Transplantation
Tacrolimus is the most commonly used immunosuppressant for preventing and treating rejection after liver transplantation. However, its treatment window is narrow, the pharmacokinetic individual differences are large, routine dose…
- Conditions
- Complete and Accurate Statistical Data of 60 Patients, CYP3A5*3 Genotypes of 60 Donors and Recipients Were Analyzed Accurately, Postoperative Tacrolimus Concentrations Were Accurately Recorded in 60 Patients, According to the Diagnosis and Grading Criteria of Acute Kidney Injury, the Cases and Grading of Postoperative Acute Kidney Injury in 60 Patients Were Counted
- Trial name
- NCT06319391
- Testing
- CYP3A5*1*、CYP3A5*1*3, CYP3A5*3*3
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ziqiang Li
Liver Transplantation, Comorbidities and Coexisting Conditions
The Danish Comorbidity in Liver Transplant Recipients Study
Background: Liver transplantation is the only curative treatment for patients with end-stage liver disease. Short-term survival has improved due to improved surgical techniques and greater efficacy of immunosuppressive drugs.
- Trial name
- DACOLT (NCT04777032)
- Where
- 4 sites in Denmark
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Diabetes Mellitus, Non-alcoholic Fatty Liver Disease
Transplantation of Microbes for Treatment of Metabolic Syndrome & NAFLD
Non-alcoholic fatty liver disease (NAFLD) occurs when excess fat is deposited in the liver. Almost all patients also have obesity and insulin resistance (the inability of the body to effectively use insulin).
- Trial name
- FMT (NCT02496390)
- Testing
- Autologous, Allogeneic
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's