Clinical trials: Transplantation, Liver
Kidney Transplant; Complications, Liver Transplant; Complications
MR-proADM as a Early Biomarker for DGF and AR in Kidney and Liver Transplantation
To define the sensibility and the specificity of increased levels of MR-proADM for early, non-invasive, diagnosis of AR and DGF after kidney and liver transplantation creating a predictive model for related complications after…
- Trial name
- DARE (NCT06130046)
- Testing
- MR-proADM dosage
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Rome Tor Vergata
Liver Disease
Lifestyle Intervention For Liver Transplantation
(i) To develop a behavioural intervention that supports healthcare professionals to effectively deliver lifestyle behaviour change of patients undergoing liver transplantation (ii) To assess the acceptability and feasibility of…
- Trial name
- LIFT (NCT02696655)
- Testing
- Behavioural intervention
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Liver Transplant Failure and Rejection
Parenteral Ascorbic Acid Repletion in TransplantatIon
A single-center, randomized, double-blinded placebo-controlled trial is proposed to investigate administration of supraphysiologic doses of ascorbic acid (vitamin C, AA) to patients undergoing liver transplantation.
- Trial name
- PARTI (NCT04756063)
- Testing
- Ascorbic acid
- Where
- United States
- Sponsor
- University of Wisconsin, Madison
Acute Graft Rejection
Diagnosis of Graft Pathology by TruGraf
The goal of this observational study is to to identify different causes of liver diseases or damage in liver transplant patients and develop a machine learning algorithm as a non-invasive tool leveraging gene expression and…
- Trial name
- NCT06557564
- Testing
- TruGraf liver gene expression
- Where
- Canada
- Volunteers
- 471 people
- Sponsor
- University Health Network, Toronto
Postoperative Acute Kidney Injury, Pediatric Liver Transplantation
Acute Kidney Injury and Recovery Mode in Pediatric Liver Transplantation
Acute kidney injury (AKI) is a common complication after pediatric liver transplantation (PLT), and renal impairment after LT has proven to be related with increased graft failure and mortality.
- Trial name
- NCT06598228
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Tianjin First Central Hospital
Transplantation, Liver Diseases
Low-dose IL-2 for Treg Expansion and Tolerance (LITE)
Regulatory T cells (Tregs) suppress cytopathic immune responses and inhibit transplant rejection. Our goal is to exploit the Treg suppressive properties to induce transplantation tolerance.
- Trial name
- LITE (NCT02949492)
- Testing
- IL-2 (interleukin 2)
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- King's College London
Hepatocellular Carcinoma
FMT in IT-refractory HCC - FAB-HCC Pilot Study
This single-center, pilot study (phase IIa) will evaluate the safety, feasibility, and efficacy of FMT from patients with HCC who responded to PD-(L)1-based immunotherapy to patients with HCC who failed to respond to…
- Trial name
- NCT05750030
- Testing
- FMT combined with Atezolizumab plus Bevacizumab
- Where
- Austria
- Volunteers
- 12 people
- Sponsor
- Medical University of Vienna
Sexual Dysfunction in Patients With Cirrhosis Awaiting Liver Transplantation
Sexual Dysfunction in Cirrhosis
The prevalence of erectile dysfunction (ED) is about 10% in the general population, but increases with age, ranging from 9.1% in men 40-49 years to 55% in men >70.
- Trial name
- SEDYC (NCT05428267)
- Testing
- questionnaire, blood collection
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hepatocellular Injury, Liver Transplant Disorder
Hypothermic Oxygenated (HOPE) Versus Normothermic Machine Perfusion (NMP) in Human Liver Transplantation
The common practice of conventional cold storage (CCS) organ preservation has changed little since the initial introduction of the original University of Wisconsin (UW) organ preservation solution in the late 1980s.
- Trial name
- HOPE-NMP (NCT04644744)
- Testing
- Hypothermic oxygenated perfusion (HOPE), Normothermic machine perfusion (NMP)
- Where
- 4 sites in Germany
- Volunteers
- 213 people
- Sponsor
- Charite University, Berlin, Germany
Liver Transplant Rejection
MSC Therapy in Liver Transplantation
The general aim of the present study is to test a cell therapy with third-party allogeneic ex-vivo expanded MSCs as a strategy to induce tolerance in liver transplant recipients.
- Trial name
- NCT02260375
- Testing
- Mesenchymal Stromal Cells
- Where
- 6 sites in Italy
- Volunteers
- 20 people
- Sponsor
- Monia Lorini
Hepatocellular Carcinoma
Lenvatinib Following Liver Transplantation in Patients With High-Risk Hepatocellular Carcinoma
The aim of this study is to observe the efficacy and safety of lenvatinib in preventing high-risk recurrence of hepatocellular carcinoma patients after liver transplantation.The cases are from patients with hepatocellular…
- Trial name
- NCT04168944
- Testing
- Lenvatinib, Immunosuppressive regimen
- Volunteers
- 108 people
- Sponsor
- RenJi Hospital
Hepatocellular Carcinoma, HCC
Stereotactic Body Radiation Therapy (SBRT) Versus Trans-Arterial Chemoembolization (TACE) as Bridge to Liver Transplant
This study will compare stereotactic body radiation therapy (SBRT) to trans-arterial chemoembolization (TACE) as a bridging strategy for patients with HCC undergoing orthotopic liver transplantation.
- Trial name
- SBRTvsTACE (NCT02182687)
- Testing
- Stereotactic Body Radiation Therapy (SBRT), Trans-Arterial Chemoembolization (TACE), Doxorubin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Lahey Clinic
Non-Alcoholic Fatty Liver Disease, Chronic Kidney Diseases
NAFLD Among Patients With Chronic Kidney Disease and the Effect of Kidney Transplantation
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in developed countries affecting approximately 30 % of the general adult population.
- Conditions
- Non-Alcoholic Fatty Liver Disease, Chronic Kidney Diseases, PreDiabetes, Kidney Transplant
- Trial name
- NCT03866421
- Testing
- MR spectroscopy of the liver, Fibroscan of the liver, Continuous glucose monitoring (CGM) for four days.
- Where
- Denmark
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Liver Transplantation
Efficacy of Low Dose, SubQ Interleukin-2 (IL-2) to Expand Endogenous Regulatory T-Cells in Liver Transplant Recipients
The purpose of this investigation is to study if very low dose IL-2, given to liver transplant patients by subcutaneous (under the skin) injections, over a 4 week period of time, will cause an increase in the number of Treg cells…
- Trial name
- NCT02739412
- Testing
- Interleukin-2
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Beth Israel Deaconess Medical Center
Liver Transplant; Complications
Antithrombin III Concentrate After Liver Transplantation
This study was designed to demonstrate more effective administration method of AT-III in immediate post-liver transplantation period.
- Trial name
- NCT04219579
- Testing
- Antithrombin III, continuous infusion, Antithrombin III, Intermittent infusion
- Where
- South Korea
- Volunteers
- 130 people
- Sponsor
- Seoul National University Hospital
Acute Pain
Transversus Abdominis Plane Block for Postoperative Analgesia in Living Donor Hepatectomy
Living donor organ transplantation has increased in recent years due to an increased need for organs. The objective of this study was to investigate the effects of a TAP block on postoperative analgesia and opioid consumption in…
- Trial name
- NCT02645903
- Testing
- Transversus Abdominis Plane Block, standard general anesthesia
- Volunteers
- 50 people
- Sponsor
- Inonu University
Covid19, Kidney Transplant; Complications
Multicenter CTS Pre-and Post-Transplantation Covid-19 Serum Studies
The Covid-19 Serum Study is a prospective case-control study in 1. kidney or liver transplanted patients being hospitalized due to an infection with Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) after…
- Conditions
- Covid19, Kidney Transplant; Complications, Kidney Transplant Failure and Rejection, Liver Transplant; Complications
- Trial name
- NCT04694573
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- Heidelberg University
Colo-rectal Cancer
Liver Transplantation and Metastatic Colo-rectal Cancer.
Survival of colo-rectal cancer patients after liver transplantation.
- Trial name
- NCT00294827
- Testing
- Liver transplantation and colo-rectal cancer
- Where
- Norway
- Volunteers
- 25 people
- Sponsor
- Oslo University Hospital
Liver Disease, Immunosuppression
Immunity Against Varicella in Pediatric Orthotopic Liver Transplantation Recipients
Varicella is a vaccine-preventable disease, which can be severe in immunosuppressed children. Currently, the (live) vaccine is not recommended in pediatric orthotopic liver transplant recipients.
- Conditions
- Liver Disease, Immunosuppression, Varicella
- Trial name
- VZVinOLTx (NCT00492739)
- Testing
- Vaccination with VZV vaccine
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University Hospital, Geneva
Organ Transplantation
A Facilitated Access Program to Provide Everolimus (RAD) Maintenance for Patients Completing Therapy in RAD Trials in Solid Organ Transplantation
Facilitated access to everolimus until it is commercially available and reimbursable by appropriate parties
- Trial name
- NCT00149981
- Testing
- everolimus (RAD)
- Where
- 153 sites in United States, Australia and 17 more
- Sponsor
- Novartis Pharmaceuticals
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