Clinical trials: Transplantation, Liver
Chronic Liver Disease, Liver Transplantation
Comparison of Quantiferon-TB Gold Assay With Tuberculin Skin Testing in Patients With Chronic Liver Disease
The purpose of the study is to estimate the usefulness of the QuantiFERON®-TB Gold test for the diagnosis of latent tuberculosis infection in liver transplant candidates by correlating the test results with risk factors for LTBI
- Conditions
- Chronic Liver Disease, Liver Transplantation, Tuberculosis
- Trial name
- NCT00402402
- Testing
- Tuberculin skin test, Quantiferon-TB Gold assay
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- University Health Network, Toronto
Hepatic Transplantation
Clamp-crush Technique Versus Harmonic Scalpel in Living Donor Hepatectomy
The purpose of this study is to determine whether clamp-crush technique for liver parenchymal transection is as safe as Harmonic scalpel device.
- Trial name
- KK_HS (NCT02853981)
- Testing
- Harmonic scalpel, Kelly clamp crush technique
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Mansoura University
Liver Cirrhosis
Implications of Fecal Microbiota Transplantation in Modulating the Effects of Liver Cirrhosis
The study aims to investigate the beneficial effects of fecal transplantation in patients diagnosed with liver cirrhosis (regardless of etiology).
- Trial name
- NCT06478602
- Testing
- Fecal microbiota transplantation
- Where
- Romania
- Volunteers
- 19 people
- Sponsor
- Cristian Ichim
Liver Transplant; Complications, Cirrhosis, Liver
Prehabilitation and Posttransplant Training Program in Liver Transplantation
PreLiveR-T consists of a prospective randomized clinical trial conducted in an adult population that is a candidate for liver transplantation (LT) at the Hospital La Fe Valencia (Spain).
- Conditions
- Liver Transplant; Complications, Cirrhosis, Liver, Hepatic Carcinoma
- Trial name
- PreLiveR-T (NCT04246970)
- Testing
- Prehabilitation, Prehabilitation and posttransplant training program
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Maria dels Angels Cebria i Iranzo, PT, PhD
Transfusion Related Complication, Liver Transplant
Utilization of Donor Whole Blood for Blood Transfusion in Deceased Donor Liver Transplantation
We will study 40 matched patients. 20 patients will receive leukoreduced whole blood from the solid organ donor. These 20 patients will be compared to 20 historical matched controls with regards to allogenic blood product usage…
- Trial name
- NCT04383756
- Testing
- Donor Blood, Banked Blood
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Liver Transplantation, Reperfusion
A Study of Retrograde rEperfusion in Dbd Donor LIver Transplantation
To evaluate whether retrograde caval reperfusion of liver graft could be superior over antegrade portal reperfusion in regard of incidence and severity of early allograft liver dysfunction.
- Conditions
- Liver Transplantation, Reperfusion, Delayed Graft Function
- Trial name
- REDLIT (NCT02423941)
- Testing
- Retrogade reperfusion, Antegrade reperfusion
- Where
- Belarus
- Volunteers
- 90 people
- Sponsor
- Republican Scientific and Practical Center for Organ and Tissue Transplantation
MicroRNA Profile, Liver Transplant
MicroRNA Profile As a Biomarker of Liver Damage in Different Types of Liver Donors.
The goal of this observational study is to analyze the expression of liver-derived miRNAs in different types of liver donors to gain in depth knowledge about distinctive physiologic features within donors and find potential…
- Conditions
- MicroRNA Profile, Liver Transplant, Organ Donor
- Trial name
- NCT06611046
- Testing
- organ donor
- Where
- Spain
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Mar Dalmau
Liver Transplantation (LT)
Mental Health Outcomes and Psychological Evaluation After Liver Transplantation
Receiving a liver transplant is a major life event that can be physically and emotionally challenging. During the first five years after transplantation, more than one in two liver transplant recipients experience a mental health…
- Trial name
- mHOPE (NCT07734142)
- Testing
- questionnaires, Individual semi-structured interview
- Volunteers
- 250 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pediatric Liver Transplantation
Thromboelastometry as a Predictor of Thrombotic Complications During Pediatric Recipient Liver Transplantation
The study aims to correlate the perioperative results of a device called thromboelastogram, which is used to detect coagulation abnormalities, with thrombotic complications during pediatric recipient liver transplantation.
- Trial name
- NCT03494595
- Testing
- Pediatric Liver transplantation
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Acute Lung Injury
Risk Factors of Postoperative Acute Lung Injury Following Liver Transplantation
Postoperative acute lung injury (ALI) during the first 72 hours after liver transplantation is not uncommon. Injury may occur because liver transplantation is often associated with prolonged operative time, large volumes of fluid…
- Trial name
- NCT02412800
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- National Taiwan University Hospital
Transplantation, Liver
Removable Intraductal Stenting in Duct-to-duct Biliary Reconstruction in Liver Transplantation
Randomized controlled trial including 7 French transplantation centers. Pre-inclusion of the patients is made when enlisted for liver transplantation (LT).
- Trial name
- BILIDRAINT (NCT02356939)
- Testing
- intraductal removable stent custom-made segment (2 cm), stent extraction by ERCP
- Where
- France
- Volunteers
- 493 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Transplant, Liver Failure
Hypothermic Machine Perfusion for Liver Graft Preservation
The goal of this clinical trial is to evaluate whether hypothermic machine perfusion improves liver graft preservation and post-transplant outcomes compared to conventional static cold storage in adult patients undergoing liver…
- Trial name
- HOPE-Liver (NCT07595627)
- Testing
- Hypothermic Machine Perfusion, Static Cold Storage
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Hypoxemia
CPAP in Liver Transplant
The purpose of this study is to determine the effectiveness of continuous positive airway pressure compared to standard treatment in preventing the need for intubation and mechanical ventilation in patients who develop acute…
- Trial name
- NCT00510770
- Testing
- CPAP application
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Turin, Italy
Acute-On-Chronic Liver Failure, Chronic Liver Failure
Micro-encapsulated Hepatocyte Intraperitoneal Transplantation in Liver Failure Adults
This is a prospective single-center dose escalation study of the administration of the microencapsulated hepatocyte therapy in adult liver failure.
- Trial name
- NCT05727722
- Testing
- a single course of micro-encapsulated hepatocytes intraperitoneal transplantation therapy
- Where
- China
- Volunteers
- 10 people
- Sponsor
- RenJi Hospital
Liver Transplantation
Liver Spare the Nephron (STN) Study - A Study of CellCept (Mycophenolate Mofetil) and Sirolimus in Recipients of a Liver Transplant
This two-arm study will assess the efficacy and safety of a long-term calcineurin inhibitor-free maintenance regimen with CellCept and sirolimus in recipients of an orthotropic liver transplant.
- Trial name
- NCT00118742
- Testing
- mycophenolate mofetil [CellCept], Tacrolimus, Cyclosporine
- Where
- 46 sites in United States, Canada
- Volunteers
- 293 people
- Sponsor
- Hoffmann-La Roche
Liver Transplantation
Comparing Efficacy & Safety of Tacrolimus With/Without MMF or Monoclonal Anti-IL2R Antibody in Liver Transplantation.
To compare the efficacy and safety of two regimens containing tacrolimus and minimal steroids together with either monoclonal anti-IL2R antibodies (daclizumab) or mycophenolate mofetil.
- Trial name
- MARSILEA (NCT00295594)
- Testing
- tacrolimus
- Where
- 41 sites in Belgium, Denmark and 9 more
- Volunteers
- 627 people
- Sponsor
- Astellas Pharma Inc
Hepatitis C
Ribavirin Pre-treatment Followed by Combined Standard Therapy in Hepatitis C Virus (HCV) Recipients
The results of antiviral therapy in patients with recurrent hepatitis C after liver transplantation are lower than standard. Ribavirin has immune-modulating effects and seems to be crucial to optimize viral treatment.
- Trial name
- RBV (NCT00993122)
- Testing
- ribavirin pre-treatment
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Hemorrhage
TachoSil® Versus Surgicel® Original for the Secondary Treatment of Local Bleeding in Adult and Pediatric Patients Undergoing Hepatic Resection Surgery
The efficacy and safety of TachoSil® as secondary hemostatic treatment in hepatic resection surgery will be compared to the standard USA licensed hemostatic agent, Surgicel® Original.
- Trial name
- NCT01192022
- Testing
- TachoSil®, Surgicel® Original
- Where
- 17 sites in United States
- Volunteers
- 253 people
- Sponsor
- Takeda
Hepatic Transplantation, Rejection; Transplant, Liver
Tissue Analysis of Liver Grafts as a Predictor of Transplant Outcome.
Despite the good clinical results in terms of outcome with the application of HOPE prior to liver transplantation, very little is still known about the phenotypic and molecular changes that occur during perfusion/preservation…
- Trial name
- NCT06717542
- Testing
- histochemical and immunohistochemical analysis, RT-PCR
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Sepsis, Liver Transplant; Complications
Preoperative Sepsis Timeline, Profile and Its Association With Recipient Outcome Following Live Donor Liver Transplant
Preoperative sepsis timeline, profile and its association with recipient outcome following live donor liver transplant.
- Trial name
- NCT05109156
- Testing
- This is an observational study
- Where
- India
- Volunteers
- 500 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
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