Clinical trials: Transplantation, Liver
Hepatocellular Carcinoma, Liver Transplant Disorder
Liver Transplant for Larger Hepatocellular Carcinoma in Malatya: The Role of GGT and AFP
Retrospective data on 50 prospectively-collected HCC patients with beyond-Milan criteria with >6cm tumors were analyzed. 5-year OS of 76.2% was found in patients with both AFP <200 ng/ml and GGT <104 IU/mL with tumors less than…
- Trial name
- NCT04412161
- Testing
- Liver transplantation
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Inonu University
Liver Transplantation, No-touch Technique
Impact of "No-touch" Technique on the Outcome of Liver Transplantation for Hepatocellular Carcinoma
The "no-touch" technique has been one of the most important principles of oncological surgery and aimed to prevent seeding and tumor cell dissemination.
- Conditions
- Liver Transplantation, No-touch Technique, Hepatocellular Carcinoma
- Trial name
- NCT06331273
- Testing
- Liver transplantation with "No-touch" technique
- Volunteers
- 800 people
- Sponsor
- Zhejiang University
Coagulopathy, Liver Transplantation
Clinical Evaluation of the Hemosonics Quantra® Coagulation Monitor in Liver and Multivisceral Transplantation
Severe coagulopathy and operative bleeding are common in liver and multivisceral transplant recipients. This is related to reduced synthesis and function of clotting proteins in end-stage liver disease, thrombocytopaenia…
- Trial name
- NCT04274699
- Testing
- Hemosonics Quantra coagulation monitor
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Non-Alcoholic Fatty Liver Disease, Renal Transplant Complication Pre-Existing Disease
Transient Elastograghy to Detect Non Alcoholic Fatty Liver Disease in Renal Transplantation Recipients.
a. Primary (main): The presence of non alcoholic fatty liver disease in post renal transplantation recipients by non invasive methods as transient elastograghy b-Secondary (subsidiary): to evaluate if transient elastograghy could…
- Trial name
- NCT05894993
- Testing
- transient elastograghy
- Volunteers
- 50 people
- Sponsor
- Amany Khaled Ali Ahmed
Liver Diseases
Autologous Bone Marrow Stem Cells Infusion for the Treatment of Liver Diseases.
This study evaluates the effect of autologous bone marrow stem cells infusion (ABMSCi) therapy for liver diseases.Treatment group will receive ABMSCi and drugs therapy ,while control group will only receive drugs therapy.
- Trial name
- ABMSCIFTLD (NCT02943707)
- Testing
- Autologous bone marrow stem cells infusion, drugs such as Ursodeoxycholic Acid tablets
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Wenzhou Medical University
Decompensated Cirrhosis, Liver Transplantation
New Prognostic Predictive Models of Mortality of Decompensated Cirrhotic Patients Waiting for Liver Transplantation
The MELD score is a predictive model of cirrhosis mortality used in France since 2007 to prioritize access to liver transplantation for patients enrolled in the national waiting list.
- Trial name
- SUPERMELD (NCT03820271)
- Testing
- SuperMELD
- Where
- France
- Volunteers
- 501 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Lung Injury
Thoracic Fluid Content and Acute Lung Injury
To study the association of the thoracic fluid content and acute lung injury during liver transplantation.
- Trial name
- NCT01922557
- Testing
- NICOM
- Where
- Taiwan
- Volunteers
- 22 people
- Sponsor
- National Taiwan University Hospital
Sinusoidal Obstruction Syndrome, Veno Occlusive Disease, Hepatic
Validating Ultrasound Biomarkers for Hepatic Sinusoidal Obstruction Syndrome in Pediatric Hematopoietic Cell Transplant Patients
Hepatic veno-occlusive disease/sinusoidal obstructive syndrome (VOD/SOS) is a potentially fatal complication of hematopoietic cell transplant (HCT).
- Conditions
- Sinusoidal Obstruction Syndrome, Veno Occlusive Disease, Hepatic, Bone Marrow Transplant Complications, Stem Cell Transplant Complications
- Trial name
- NCT03963999
- Testing
- Ultrasound Elastography, Contrast Enhanced Ultrasound (CEUS)
- Where
- United States
- Sponsor
- Children's Mercy Hospital Kansas City
Influenza
Influenza Vaccine in Pediatric Transplant Subjects
The purpose of this study is to evaluate how well children responds to the recommended trivalent subviron influenza vaccine (flu shot).
- Trial name
- NCT00133510
- Testing
- Trivalent Subviron Influenza vaccine (Fluzone)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Liver Transplantation, Carotid Intima-media Thickness
Effect of Preoperative CIMT on Hemodynamics During Liver Transplantation
Candidates for liver transplantation (CT) carry an increased risk of cardiovascular disease (CVD) due to underlying end-stage liver disease (ESHD) and immunosuppressive drugs used post-transplantation.
- Trial name
- CIMT-LIVER (NCT07660679)
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Dicle University
Hepatocellular Carcinoma Recurrent, Liver Transplant; Complications
Heterogeneity and Evolution of hepatoceLlular Carcinoma in Post-transplant HCC Recurrence
Objective of Study: This study will evaluate the heterogeneity and evolution pathway between primary HCC and tumor relapse after liver transplant.
- Trial name
- HELP-2020 (NCT04506398)
- Testing
- liver transplant, ctDNA, whole exome sequencing
- Where
- China
- Volunteers
- 40 people
- Sponsor
- RenJi Hospital
Liver Transplantation
Heart Rate Variability Change After Liver Transplantation
Cirrhotic cardiomyopathy describes a hyperdynamic state with the presentation of high cardiac output and low systemic vascular resistance. And the latent heart failure becomes obvious under physiologic and pharmacologic stress.
- Trial name
- NCT00778687
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Liver Fibrosis, Pediatric Disorder
Pediatric Liver Transplantation-Liver Fibrosis Evaluation by Using Fibrosis Panel
Liver transplantation in children is highly successful with >80% having 20 years survival. Most pediatric liver diseases are potentially curable with liver transplantation and it is important to establish whether children who…
- Conditions
- Liver Fibrosis, Pediatric Disorder, Liver Transplant; Complications
- Trial name
- PT-LiFE (NCT05308628)
- Testing
- Liver Allograft Fibrosis by Using Fibrosis Panel(PRO-C3, PIIINP, TIMP-1, HA etc.)
- Where
- 2 sites in China
- Volunteers
- 1,200 people
- Sponsor
- RenJi Hospital
Liver Transplant Rejection
Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Liver Transplant Recipients With Additional 12-month Follow-up and Long-term Extension
This was a multicenter, open-label, active-controlled study to evaluate the efficacy, safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of two CFZ533 maintenance doses in de novo liver transplant recipients.
- Trial name
- CONTRAIL I (NCT03781414)
- Testing
- CFZ533, Tacrolimus - MMF - corticosteroids
- Where
- 29 sites in United States, Argentina and 8 more
- Volunteers
- 129 people
- Sponsor
- Novartis Pharmaceuticals
Hcc
Salvage Living Donor Liver Transplantation for HCC Beyond All Criteria Yield Equivalent Results to Milan Criteria
The present study aims to evaluate the impact of expanding criteria beyond Milan on tumor recurrence and patient survival that will help identify the best selection criteria for HCC transplanted patients.
- Trial name
- NCT04069416
- Testing
- living donor liver transplantation
- Volunteers
- 241 people
- Sponsor
- Ain Shams University
Liver Transplantation
Propofol Versus Dexmedetomidine for Prevention of Sevoflurane Agitation in Recipients of Living Donor Liver Transplantation
The use of propofol or dexmedetomedine for prevention of sevofurane emergence agitation in LDLT recipients
- Trial name
- Agitation (NCT02544906)
- Testing
- Propofol, dexmedetomedine
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- AlRefaey Kandeel
Liver Transplant Infection, Fungal Infection
Rezafungin Prophylaxis in Liver Transplant
This is an interventional study to evaluate the efficacy of rezafungin, a new echinocandin, for the prevention of invasive fungal infections (IFIs) after liver transplantation.
- Trial name
- NCT06774144
- Testing
- Rezafungin, Standard of care antifungal prophylaxis
- Where
- United States
- Volunteers
- 385 people
- Sponsor
- Fernanda P Silveira, MD, MS
Biliary Atresia
Pentoxifylline Therapy in Biliary Atresia
The purpose of this study is to determine whether pentoxifylline reduces liver damage in infants with biliary atresia.
- Trial name
- NCT01774487
- Testing
- Pentoxifylline
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Baylor College of Medicine
Intrahepatic Cholangiocarcinoma
Liver Transplantation for Non-Resectable Intrahepatic Cholangiocarcinoma: a Prospective Exploratory Trial (TESLA Trial)
The study will investigate whether liver transplantation provides increased survival, low side effects and good quality of life in patients with bile duct cancer where the tumor cannot be removed by normal surgery.
- Trial name
- NCT04556214
- Testing
- Liver Transplant
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- Oslo University Hospital
Liver Transplant, Kidney Transplant
A 5 Year Follow-up of Patients Who Were Previously Enrolled Into an Advagraf Trial Following a Liver or Kidney Transplant
The purpose of this study is to evaluate the impact of Advagraf, prolonged-release, once daily tacrolimus formulation, on long-term graft survival in kidney and liver allograft recipients.
- Trial name
- ADDRESS (NCT02057484)
- Testing
- Tacrolimus
- Where
- 145 sites in Austria, Belarus and 22 more
- Volunteers
- 2,300 people
- Sponsor
- Astellas Pharma Europe Ltd.
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