Clinical trials: Transplantation, Liver
Recurrence of HCC After LDLT
Single Center Experience Over a Decade in Living Donor Liver Transplantation for Egyptian Patients With Hepatocellular Carcinoma: Stretching the Limits
Within community with high incidence of HCC, stretching the limits could be justified based on tumor characters and its biological behavior
- Trial name
- NCT01937286
- Where
- Egypt
- Volunteers
- 590 people
- Sponsor
- Ain Shams University
Liver Transplantation, Ischemia/Reperfusion Injury
Effect of Nitric Oxide (NO) on Ischemic/Reperfusion Injury During Extended Donor Criteria (EDC) Liver Transplantation
In this study, the researchers propose to investigate the efficacy of inhaled nitric oxide to prevent ischemia-reperfusion (I/R) hepatocyte injury in patients who receive extended donor criteria(EDC)liver grafts based on changes…
- Conditions
- Liver Transplantation, Ischemia/Reperfusion Injury, Oxidative Injury
- Trial name
- NCT00948194
- Testing
- Nitric Oxide
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Colorado, Denver
Blood Transfusion Complication
To Establish a Blood Transfusion Prediction Model for Liver Transplantation Patients Based on PBM
Based on the principle of patient blood management, this study aims to reduce the risk of blood transfusion in allogeneic liver transplantation patients, to ensure the safety of blood transfusion, and to provide new methods and…
- Trial name
- NCT03814772
- Testing
- Liver transplant
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Antibiotic Prophylaxis, Postoperative Infection
Comparison of 9 Doses vs 3 Doses of Post Operative Antibiotics in Live Liver Donors
Antibiotic resistance is a very serious and dangerous situation in modern world. Judicious use of antibiotics is therefore of extreme importance not just in preventing antibiotic resistance but also it decreases cost of the…
- Trial name
- NCT03765645
- Testing
- Piperacillin + Tazobactam
- Where
- India
- Volunteers
- 126 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Transplant Recipients
The Effects of Angiotensin II Receptor Blockade on Kidney Function and Scarring After Liver Transplant
This research study is being done to study the effects, both good and bad, of calcineurin inhibitors and the drug Cozaar (losartan), on kidney function and kidney scarring following a liver transplant.
- Trial name
- NCT00275639
- Testing
- Cozaar
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Mayo Clinic
Acute-On-Chronic Liver Failure, Hepatitis B
Efficacy of Addition of Fecal Microbiota Transplant (FMT) and Plasma Exchange to Tenofovir in Comparison to Monotherapy With Tenofovir in ACLF-HBV
A randomized controlled trial to study the efficacy of addition of FMT \& plasma exchange to tenofovir compared to monotherapy with tenofovir in patients with HBV reactivation who develops Acute on chronic liver failure.
- Trial name
- NCT04431375
- Testing
- Plasma Exchange, Tenofovir, Fecal Mircobiota Transplantation
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Cirrhosis
Faecal Microbiota Transplantation for Liver Cirrhosis
The purpose is to investigate the effect of faecal microbiota transplantation (FMT) on complications, progression, and mortality of patients with liver cirrhosis.
- Trial name
- CHiFT (NCT04932577)
- Testing
- Faecal microbiota transplantation
- Where
- Denmark
- Volunteers
- 220 people
- Sponsor
- University of Aarhus
Liver Cirrhosis
Umbilical Cord Mesenchymal Stem Cell Transplantation for Decompensated Hepatitis B Cirrhosis
This study aims to evaluate the safety and clinical efficacy of umbilical cord mesenchymal stem cell transplantation for decompensated hepatitis B cirrhosis.
- Trial name
- NCT05106972
- Testing
- UC-MSC infusion
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Asia Stem Cell Regenerative Pharmaceutical Co., Ltd.
Liver Failure, Liver Diseases
Biliary Anastomosis Using Surgical Loupe Versus Microscope in Living Donor Liver Transplantation
Comparison of biliary complications in right lobe living donor liver transplantation patients undergoing biliary reconstructions using microscope versus surgical loupes .
- Conditions
- Liver Failure, Liver Diseases, Liver Cancer, Liver Neoplasms
- Trial name
- NCT04618692
- Testing
- Surgical Loupes, Microscope
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Istanbul Medipol University Hospital
Living Donor Liver Transplantation
Population Pharmacokinetics of Fentanyl in Patients Undergoing Living Donor Liver Transplantation
The aim of this study was to characterize pharmacokinetics of fentanyl during and after Living Donor Liver Transplantation (LDLT), using population pharmacokinetic analysis with non linear mixed effects modeling.
- Trial name
- NCT01144312
- Testing
- Fentanyl
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Asan Medical Center
Occult Hepatitis B, Liver Transplant; Complications
Detecting Occult HBV Infection in Liver Donors Positive for Antibody to Hepatitis B Core Antigen (Anti-HBc)
After LT, long-term immunosuppressive therapy is required to prevent organ rejection. Therefore, for organs which may harbour OBI, there is a risk of reactivation which may result in liver graft failure.
- Trial name
- OBI (NCT04199819)
- Testing
- entecavir
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Hepatocellular Carcinoma
Registry 17-009: Multi-Institutional Study Examining Patients With HCC Undergoing Liver Transplantation
This is a registry study examining patients with HCC undergoing liver transplantation including outcomes and predictors of recurrence
- Trial name
- NCT06018857
- Where
- 2 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Federico Aucejo
Hepatitis B, Liver Transplantation
Entecavir Combined Short-term Intravenous Hepatitis B Immune Globulin (HBIG) to Prevent Hepatitis B Recurrence After Liver Transplantation
The purpose of this study is to observe a new scheme can achieve is the same as the traditional scheme of the effect of preventing hepatitis B recurrence.
- Trial name
- NCT02417207
- Testing
- Entecavir combined long-term low-dose HBIG group intramuscular, Entecavir combined HBIG group short-term high-dose intravenous
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Cirrhosis
Breath Test to Assess Hepatic Metabolic Reserve and to Predict Hepatic Decompensation in Cirrhotics
The three objectives of this trial are: 1. To demonstrate that a decline in hepatic metabolic function as measured by BreathID will correlate with changes in CTP and MELD scores in patients with cirrhosis. 2.
- Trial name
- NCT00375011
- Where
- 3 sites in United States, Israel
- Volunteers
- 200 people
- Sponsor
- Meridian Bioscience, Inc.
Renal Function, Liver Transplant
Efficacy, Safety and Tolerability of Everolimus in Combination With Reduced Exposure Cyclosporine or Tacrolimus in Paediatric Liver Transplant Recipients.
This study was designed to assess the evolution of renal function and to collect efficacy, safety, and tolerability data of everolimus in co-exposure with reduced CNI in paediatric liver transplant recipients.
- Trial name
- NCT01598987
- Testing
- Introduction of everolimus with reduced cyclosporine or tacrolimus dose, the earliest 1 month and the latest 6 months after liver transplantation.
- Where
- 32 sites in United States, Australia and 10 more
- Volunteers
- 56 people
- Sponsor
- Novartis Pharmaceuticals
Liver Transplant; Complications
Response of Cardiovascular Parameters to Physical Therapy Post Liver Transplantation
Liver transplantation (LT) is the only life-saving treatment option in patients with advanced liver disease. Deceased-donor LT is not frequent but is increasing in Asian countries.
- Trial name
- NCT05514743
- Testing
- 6 minute walk test , Blood pressure monitoring
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Liver Cirrhosis
Dynamic Preload Parameters During Liver Transplantation
The arterial system compliance is compromised in liver cirrhotic patients. Dynamic preload variables are either pressure-based (e.g.pulse pressure variation; PPV), flow-based (e.g.
- Trial name
- NCT01971333
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Liver Transplant Recipients
Liver Transplant Recipients and 30-Second Lie-to-Sit Test
The aim of this study is to assess functional capacity in liver transplant recipients using the 30-second lie-to-sit test and to examine the relationships between functional capacity and variables such as muscle strength, upper…
- Trial name
- NCT07365098
- Testing
- 30-second lie-to-sit test, Modified Borg Scale, waist circumference
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Inonu University
Liver Transplant; Complications, Quality of Life
Starzl Network Patient Reported Outcomes
This study uses a smartphone application/web interface (RealTime Clinic; RTC) to collect patient and parent reports of a pediatric liver transplant recipient's quality of life (QOL), and examines the extent to which QOL…
- Conditions
- Liver Transplant; Complications, Quality of Life, Child Behavior, Adolescent Behavior
- Trial name
- SPaRO (NCT05241847)
- Testing
- PeLTQL delivery via electronic means
- Where
- 7 sites in United States, Canada
- Volunteers
- 200 people
- Sponsor
- University of Pittsburgh
Bile Leak
White Test in Intra-operative Detection of Donor Biliary Leak in LDLTx.
Biliary leak is a common complication after partial liver resection in living donor liver transplant. It debases the quality of the postoperative course and affects morbidity and mortality.
- Trial name
- LDLTx (NCT04451447)
- Testing
- The White test uses fat emulsion (SMOFLIPID), for localization of bile leakage., Saline test (routine test)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Amr Abdelaal
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