Clinical trials: Transplantation, Liver
Liver Disease
Effect of Synbiotic on Postoperative Complications After Liver Transplantation
The purpose of this study is to evaluate the use of synbiotic in patients after liver transplantation and assess the effect of these agents on postoperative infections, antibiotic use, length of hospital stay, mortality and…
- Trial name
- NCT02938871
- Testing
- Synbiotic, Control
- Where
- Brazil
- Volunteers
- 76 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Hepatocellular Carcinoma
Blood Sample Collection for Experimental Blood Test to Track Liver Cancer
This study investigates if an experimental blood test can help predict how well cancer will remain under control with treatment. Ther experimental blood test involves measuring mircoRNAs.
- Trial name
- NCT04720430
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Thomas Jefferson University
Liver Transplants
Estimation of Steatosis on Liver Transplants by Intraoperative Spectrometry
The goal is to have a small spectrometer (pocket size) , reliable and rapid tool that can be used during liver harvesting, which enables macrosteatosis to be evaluated reproducibly and selectively, at any time.
- Trial name
- iGRAISSE (NCT05106322)
- Testing
- intraoperative spectrometer scan
- Where
- 3 sites in France
- Volunteers
- 240 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sinusoidal Obstruction Syndrome
Sinusoidal Obstruction Syndrome for Stem Cell Transplant Patients Biomarker Study
The goal of this is to learn more about stem cell transplant and complications that some people have after their transplants, in particular sinusoidal obstruction syndrome (SOS), also called veno-occlusive disease of the liver.
- Trial name
- SOSBiomarker (NCT03132337)
- Testing
- Serial Blood Draws
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Indiana University
Perihilar Cholangiocarcinoma
LIver TrAnspLantation for Non-resectable Peri-HIlar cholangioCArcinoma (LITALHICA)
LITALHICA is a prospective non-randomized study aimed at exploring the outcome of liver transplantation in selected patients with unresectable perihilar cholangiocarcinoma (pCCA) after treatment with standard of care…
- Trial name
- LITALHICA (NCT06125769)
- Testing
- Liver transplantation
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Sanitaria Ospedaliera
Cirrhosis
Use of Methacetin Breath Test to Predict Liver Failure in Patients With Cirrhosis
The methacetin breath test (MBT) is a non-invasive liver function test which measures the ability of the liver to metabolize a tracer dose of a compound to carbon dioxide, which is exhaled.
- Trial name
- NCT01157845
- Testing
- BreathID (Methacetin breath test)
- Where
- 4 sites in United States, Israel
- Volunteers
- 165 people
- Sponsor
- Virginia Commonwealth University
Cytomegalovirus, Organ Transplant
Strategic Help With Immunoglobulin to Enhance Protect Against Late Disease (CMV)
This study is being done to find out if administering CytoGam® after the end of standardly prescribed preventive antiviral treatment can help transplant recipients with a high risk for developing late CMV disease after a liver…
- Conditions
- Cytomegalovirus, Organ Transplant, Kidney Transplant; Complications, Liver Transplant Complications
- Trial name
- SHIELD (NCT06958796)
- Testing
- Cytomegalovirus Immune Globulin Intravenous (Human) monthly for three months
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Camille N. Kotton, MD
Hepatic Failure
Pyrophosphate Homeostasis and Hepatic Expression of ABCC6.Pyro-TH
In animals, normal hepatic expression of ABCC6 (ATP-binding transporter cassette, subfamily C, member 6) determines plasma pyrophosphate (PPi) concentration.
- Trial name
- Pyro-TH (NCT03576859)
- Testing
- blood sample
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Hepatocellular Carcinoma, Liver Cirrhosis
Comparison of the Incidence of Delirium Caused by Different Anesthetic Agents in Patients Undergoing Liver Transplantation
This study is a prospective observational study that analyzes the incidence of postoperative delirium in patients undergoing liver transplantation, based on the use of the inhalational anesthetic sevoflurane and the intravenous…
- Trial name
- NCT06767579
- Where
- South Korea
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Diabetes
Nitrite Infusion in Islet Cell Transplantation
This study seeks to investigate the effects of administering nitrite to pancreatic islet cells that have been removed from a patient for autotransplantation.
- Trial name
- NCT03544242
- Testing
- Control, Pre-Isolation Infusion, Post-Isolation Infusion
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Alabama at Birmingham
Encephalopathy, Hepatic, Cerebrovascular Disorders
Cerebrovascular Autoregulation During and After Liver Transplantation
The cerebrovascular autoregulation (AR) is impaired in patients with hepatic encephalopathy. Patients with the indication to liver transplantation mostly have mild to severe hepatic encephalopathy.
- Conditions
- Encephalopathy, Hepatic, Cerebrovascular Disorders, Liver Failure
- Trial name
- dARICULtx (NCT01597102)
- Testing
- No interventions
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Johannes Gutenberg University Mainz
Diabetes
Comparison of New-onset Diabetes After Transplantation Between Two Steroid Withdrawal Group With CellCept
With improvements in patient and graft survival, increasing attention has been placed on complications that contribute to long-term patient morbidity and mortality.
- Trial name
- NODAT (NCT02095418)
- Testing
- Mycophenolate mofetil, Corticosteroids, Corticosteroids, Mycophenolate mofetil
- Where
- 5 sites in South Korea
- Volunteers
- 152 people
- Sponsor
- Samsung Medical Center
Liver Transplant Disorder
Benefit of ESP Peri Operative Analgesia for Live Liver Donor Transplantation
Liver donors have a significant risk to develop persistent and chronic pain around 20 to 30% affecting social and professional life (17%) up to 1 year after the surgery.
- Trial name
- ESPLIVERDON (NCT04570969)
- Testing
- Erector spinae plane block
- Where
- Vietnam
- Volunteers
- 24 people
- Sponsor
- Vinmec Healthcare System
Blood Loss, Surgical
QStat in Liver Transplant
This study will assess the clinical performance of the Quantra System with the QStat Cartridge in the liver transplant population.
- Trial name
- NCT04114253
- Testing
- Quantra System
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- HemoSonics LLC
Liver Diseases, Liver Cirrhosis
Better Diagnostic Tools for Children and Adolescents With Acute Liver Failure and Chronic Liver Insufficiency
The aim of this study is to validate and develop a new diagnostic and prognostic approach for assessment of liver function in children and adolescents with acute liver failure and chronic liver insufficiency.
- Conditions
- Liver Diseases, Liver Cirrhosis, Pediatric Disorder
- Trial name
- DAKL (NCT03509194)
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Liver Cirrhosis
Late Evening Supplementation With Branched Chain Amino Acids in Liver Transplantation
Assess the impact in body composition and handgrip strength of the nocturne supplementation by a month with BCAA (Enterex hepatic in patients awaiting liver transplantation)
- Trial name
- NCT02407769
- Testing
- Late evening supplementation with branched chain amino acids
- Where
- Mexico
- Volunteers
- 38 people
- Sponsor
- Universidad de Guanajuato
Liver Transplant, Fungal Infection
An Assessment of Voriconazole Pharmacokinetics and Pharmacogenetics in Liver Transplant Recipients - Pilot Study
A fixed-dosing regimen of voriconazole is routinely used as prophylaxis against aspergillosis in liver transplant patients admitted to the transplant intensive care unit at UPMC.
- Trial name
- NCT00371605
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pittsburgh
Liver Transplant Rejection
TRU-IMMUNO: Optimizing Liver Immunosuppression
This is a prospective, multi-center, randomized study. The primary objective is to evaluate the feasibility and utility of TruGraf/TRAC Liver testing used in addition to standard of care measures of liver dysfunction to guide…
- Trial name
- NCT05335551
- Testing
- Patients monitored with TruGraf and TRAC Liver testing
- Volunteers
- 130 people
- Sponsor
- Transplant Genomics, Inc.
Liver Diseases
Biomarker-guided Reduction of Immunosuppression in Liver Transplant Recipients (BRITRE)
Researchers are interested in determining whether it is safe to reduce anti-rejection medication by approximately 50% after liver transplantation and whether special blood tests called biomarkers can identify early signs that the…
- Trial name
- BRITRE (NCT07862439)
- Testing
- miRNA Biomarker-Guided Immunosuppression Minimization, Conventional Biochemical Monitoring-Guided Immunosuppression Minimization
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Pennsylvania
Transplantation, Liver
A Trial to Assess Campath-1H and Tacrolimus Followed by Immunosuppression Withdrawal in Liver Transplantation
This is a prospective, multicenter open-label single arm trial in which recipients of liver allograft will receive uniform immunosuppressive induction and maintenance regimens.
- Trial name
- NCT00166556
- Testing
- Campath-1H and Tacrolimus
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
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