Clinical trials: Transplantation, Liver
Kidney Transplant Recipients, Liver Transplant Recipients
Pharmacokinetic Studies of Tacrolimus in Transplant Patients
The study is designed to compare the steady-state pharmacokinetics of Prograf (Brand) and the two most disparate generic formulations (Generic Hi and Generic Lo) in a fully replicated, 3-way cross-over study in stable kidney…
- Trial name
- PK (NCT01889758)
- Testing
- Prograf, Tacrolimus
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- University of Cincinnati
Liver Transplantation
Safety and Feasibility of Normothermic Machine Perfusion to Preserve and Evaluate Orphan Livers
Orphan livers are organs that have been declined for clinical use by all centers due to their marginality. The current standard of care of liver preservation before transplant is cold storage.
- Trial name
- NCT03456284
- Testing
- Normothermic Liver perfusion
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
Liver and Biliary Tract Disorders in Duration of Pregnancy, Other End-stage Liver Diseases in Children
Prediction of Early Recovery of Liver Function After LDLT in Children: An Ambispective Cohort Study
The investigators included children with living donor liver transplantation (LDLT) from January 1, 2018 to July 31, 2022 as a retrospective cohort, and the group from August 1, 2022 to June 30, 2023 as a prospective cohort.
- Trial name
- NCT06045949
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Huiwu Xing
Transfusion Related Complication
Effects of Packed Red Blood Cell Storage Duration on Pediatric Living Donor Liver Transplantation
The patients assigned to either short-storage leukoreduced RBCs group (stored for ≤ 14 days) or longer-term storage leukoreduced RBCs group(stored for ≥21 days).When the hemoglobin concentration fell below 7.0 g per deciliter…
- Trial name
- NCT04413721
- Testing
- RBC transfustion
- Volunteers
- 360 people
- Sponsor
- RenJi Hospital
Hepatocellular Carcinoma
Efficacy of Sirolimus In Liver Transplantation for Hepatocellular Carcinoma (HCC)
The purpose of this study is to evaluate the anti-tumor effect of sirolimus-based immunosuppressive regimen in patients following living donor liver transplantation for hepatocellular carcinoma exceeding Milan criteria with…
- Trial name
- Sirolimus (NCT01374750)
- Testing
- Sirolimus, m-TOR inhibitor free
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Seoul National University Hospital
Cardiac Output, Low, Liver Transplant; Complications
Hemodynamic Monitoring in Liver Transplant With VEnaRt Cardiac Output Versus Swan-Ganz Catheter (VERO Study)
The Swan-Ganz catheter is the gold standard to measure cardiac output during liver transplantation surgery. This is an invasive hemodynamic monitoring system.
- Trial name
- VERO (NCT04825015)
- Testing
- VEnaRt Cardiac Output
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Artificial Intelligence (AI), Hepatocellular Carcinoma (HCC)
Use of Machine-learning Algorithms, Biomarkers and Measures of Quality of Life to Personalize Medical Management of Liver and Heart Transplant Recipients
This is an observational, low risk tissue based, non-pharmacological, retrospective-prospective study for adults heart and liver transplant patients, related to IRCCS Azienda Ospedaliero-Universitaria di Bologna (IRCCS AOUBO).
- Conditions
- Artificial Intelligence (AI), Hepatocellular Carcinoma (HCC), Heart Transplantation, Liver Transplantation
- Trial name
- DARE (NCT06774768)
- Where
- 2 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Liver Transplant; Complications
Right Ventricular Function During Liver Transplantation as Assessed by Transesophageal Echocardiography.
Cirrhotic patients undergoing liver transplantation might develop acute transient right ventricular dysfunction, ranging from mild to severe form.
- Trial name
- NCT03459924
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Liver Transplantation
co2 Gap and co2/o2 Ratio in Liver Transplant Patients
finding surrogate to co to trace the effect of preload challenge would make the test more applicable without the need of advanced hemodynamic monitors,suggested that co2 gap can be used to detect FR after mini fluid challenge and…
- Trial name
- co2gap (NCT03374579)
- Testing
- Fluid challenge
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Kasr El Aini Hospital
Liver Transplantation, Ischaemia Reperfusion Injury
Effect of Discarding Initial Reperfusion Blood on Hemodynamics, Liver Function, and 30-Day Outcomes in Liver Transplantation
Hepatic reperfusion during liver transplantation remains a critical phase associated with significant hemodynamic and systemic disturbances, despite advances in surgical and anesthetic management.
- Conditions
- Liver Transplantation, Ischaemia Reperfusion Injury, Perioperative Complications
- Trial name
- NCT07631689
- Testing
- Reperfusion Blood Discard, Standard Liver Transplantation
- Volunteers
- 132 people
- Sponsor
- University of Sao Paulo General Hospital
End-stage Liver Disease (ESLD), Acute Liver Failure
Establishing a Reference Framework for Outcomes After Machine-Preserved Liver Transplantation in Europe
Machine perfusion (MP) has become routine clinical practice in liver transplantation. However, as the field has matured, direct randomized comparisons between distinct MP modalities have become increasingly impractical, given…
- Conditions
- End-stage Liver Disease (ESLD), Acute Liver Failure, Liver Cirrhosis, Liver Transplantation
- Trial name
- REFRAME-MP (NCT07585890)
- Testing
- Endischemic hypothermic oxygenated machine perfusion (any device), Endischemic (back-to-base) normothermic machine perfusion (any device), Continuous (device-to-donor) normothermic machine perfusion (any device)
- Where
- 38 sites in Austria, Belgium and 8 more
- Volunteers
- 10,000 people
- Sponsor
- University Medical Center Groningen
Liver Transplant; Complications
Left Lobe Versus Right Lobe in Adult Living Donor Liver Transplantation in Borderline GRWR
a prospective cohort study comparing outcomes of left lobe and right lobe adult living donor liver transplantation
- Trial name
- LDLT (NCT06542913)
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Liver Transplant Disorder
Effect of Mannitol on Postreperfusion Syndrome During Living Donor Liver Transplant
Postreperfusion syndrome during living liver transplants remains a serious concern for transplant anesthesiologists. This syndrome is responsible for decreases in systemic blood pressure, systemic vascular resistance, and cardiac…
- Trial name
- NCT05277623
- Testing
- Mannitol, 0.9% normal saline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Liver Transplantation, Immunosuppression
Extracorporeal Photopheresis in Liver Transplantation. Phase II Clinical Trial in Safety and Efficacy in Patients With Gradual Decrease of Immunosuppression.
The purpose of this study is to evaluate the safety of extracorporeal photopheresis in patients with long-standing liver transplantation subjected to a progressive reduction of immunosuppression by complications arising from its…
- Trial name
- FEC-TH (NCT01824368)
- Testing
- Extracorporeal Photopheresis Procedure (FEC)
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Red de Terapia Celular
HIV, Awaiting Organ Transplant
HIV-to-HIV Transplant at MGH
HIV-infected (HIV+) individuals who agree to accept and receive a solid organ transplant from an HIV+ deceased donor will be followed to determine the safety and efficacy of this practice.
- Trial name
- NCT02750397
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Massachusetts General Hospital
Liver Cirrhosis
Trial of Mesenchymal Stem Cell Transplantation in Decompensated Liver Cirrhosis
There has been great interest in recent years to take advantage of stem cells to treat liver cirrhosis. Mesenchymal stem cells (MSC) has been shown to be safe and effective for liver diseases in some studies.
- Trial name
- NCT03209986
- Testing
- mesenchymal stem cell transplantation via peripheral vein, mesenchymal stem cell
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Neuroendocrine Tumors
Liver Transplantation Versus Conventional Medical Therapy for Low-Grade GEP-NET With Liver Metastases
Liver Transplantation Versus Conventional Medical Therapy for Low-Grade GEP-NET With Liver Metastases
- Trial name
- TRANET-GEP (NCT07913113)
- Testing
- Liver Transplantation
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chiyi Chen
Liver Diseases
APHP Plateform of Normothermic Perfusion for Rehabilitation of Hepatic Grafts
This study aimed to evaluate fatty liver grafts, considered as unsuitable for upfront liver transplantation, by using normothermic perfusion. Grafts have to be allocated to one of 3 liver transplantation centres of Paris.
- Trial name
- PENOFOR (NCT04154696)
- Testing
- Liver transplantation of a graft after assessment by normothermic perfusion
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus Risk
Hyperglycemia and (Pre)Diabetes in Pediatric Renal and Liver Transplantation.
Background: Diabetes is a common complication of transplantation and is associated with unfavorable medical outcome and increased cardiovascular disease at long term.
- Trial name
- DIAB-GRAFT (NCT05464043)
- Testing
- evaluation of second line glucose homeostasis
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Université Catholique de Louvain
Hepatocellular Carcinoma
Relationship Between 18FDG PET/MRI Patterns and ctDNA to Predict HCC Recurrence After Liver Transplantation
Liver transplantation is the standard treatment for patients with early-stage Hepatocellular Carcinoma (HCC). Currently, important treatment decisions, like the selection of patients for transplantation, are made on crude, static…
- Trial name
- PETMRIinHCC (NCT03839706)
- Testing
- PET MRI
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.