Clinical trials: Transplantation, Liver
Cytomegalovirus Infections
An Observational Study of Valcyte (Valganciclovir) in D+/R- Liver Transplant Recipients
This retrospective review will evaluate the efficacy of Valcyte (valganciclovir) in preventing Cytomegalovirus (CMV) disease in D+/R- liver transplant recipients.
- Trial name
- NCT02062294
- Where
- 3 sites in Switzerland
- Volunteers
- 14 people
- Sponsor
- Hoffmann-La Roche
Hepatitis B Infection
Hepatitis B Virus Infection After Liver Transplantation in Children
China is a highly prevalent area of hepatitis B virus（HBV） infection, with at least 75 million hepatitis B virus carriers, and 80% of primary hepatocellular carcinoma (HCC) is associated with chronic hepatitis B virus infection.
- Trial name
- NCT03865966
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Qiu Li
Liver Transplant, Liver Cancer, Immunosuppressant
Analysis of Clinical Outcomes and Complications in Patients Received Liver Transplantation: A Retrospective Study
Liver transplantation is the last-line method for liver failure. Thomas Starzl completed the first liver transplant in 1967, liver transplantation is developing rapidly.
- Trial name
- NCT05587556
- Where
- Taiwan
- Volunteers
- 1,400 people
- Sponsor
- China Medical University Hospital
Liver Transplantation
Evaluation of Liver Disease With Elastography Measurements in Patients Undergoing Liver Transplant Surgery
The purpose of the study is to compare ultrasound measurements of the liver obtained prior to surgery on the skin to measurements obtained during surgery directly on the diseased liver.
- Trial name
- SupersonicOR (NCT01890460)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Baylor Research Institute
Liver Transplantation
Validity of Different Prognostic Models Assessing 1 Year Survival After Liver Transplantation
Validity of MELD vs MELD XI in assessing 1 year survival after living donor liver transplantation.
- Trial name
- ProgModels (NCT02412280)
- Testing
- retrospecive observational
- Volunteers
- 200 people
- Sponsor
- Mansoura University
Pediatric Liver Transplantation, Weaning From Mechanical Ventilation
NAVA vs PSV Ventilation During Weaning From Mechanical Ventilation in Children After Liver Transplantation
Liver transplantation is the treatment of choice for acute and chronic end-stage liver disease. Neurally Adjusted Ventilator Assist (NAVA) may be a feasible solution to guide the liberation from mechanical ventilation reducing…
- Trial name
- NAVIGATE (NCT04792788)
- Testing
- Weaning from mechanical ventilation
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Transplant-Related Disorder
Albumin, COP and Endothelial Damage in Patients With ESLD Undergoing OLT
To study the correlation between colloid osmotic pressure, albumin and the loss of vascular integrity in terms of endothelial dysfunction in patients with ESLD undergoing OLT and its impact on the perioperative course, as well as…
- Trial name
- NCT03448679
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
End Stage Liver Disease
Transoesophageal Echocardiography in Liver Transplantation
Severe hypotension during reperfusion in liver transplantation is a frequent adverse event. Rare data exist so far about pathophysiology of this phenomenon.
- Trial name
- NCT00547924
- Testing
- Transoesophageal echocardiography
- Where
- Switzerland
- Volunteers
- 17 people
- Sponsor
- University of Zurich
Liver Cirrhosis, Copeptin
Copeptin Serum Level in Liver Transplant Recipients
The study aim is to measure perioperative copeptin concentration in blood of liver transplant recipients and to assess whether there is a correlation between its level and hemodynamic derangement.
- Conditions
- Liver Cirrhosis, Copeptin, Liver Transplant
- Trial name
- NCT03587623
- Where
- Poland
- Volunteers
- 38 people
- Sponsor
- Medical University of Warsaw
Liver Cirrhosis
Human Umbilical Cord Mesenchymal Stem Cells Transplantation for Patients With Decompensated Liver Cirrhosis
Although liver transplantation provide a option to cure patients suffering with decompensated liver cirrhosis this condition, lack of donors, postoperative complications, especially rejection, and high cost limit its application.
- Trial name
- NCT01342250
- Testing
- conventional therapy plus low dose hUC-MSCs treatment, conventional therapy plus medium dose hUC-MSCs treatment, conventional therapy plus high dose hUC-MSCs treatment
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Beike Bio-Technology Co., Ltd.
Hepatitis C, Evidence of Liver Transplantation
Pilot Study of Hepatitis C Virus Entry Inhibitor (ITX 5061) in Liver Transplant Recipients
This is a phase I pilot study to determine the safety and preliminary efficacy of a novel hepatitis C virus (HCV) entry inhibitor (ITX 5061) in patients with HCV infection undergoing liver transplantation.
- Trial name
- ITX5061 (NCT01292824)
- Testing
- ITX 5061
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Birmingham
Newly Registered Patients for Primary Liver Transplantation
Effects of Preoperative Long-Term Immunonutrition in Patients Listed for Liver Transplantation
Patients with endstage liver disease characteristically are malnourished which is associated with poor outcome. Formulas enriched with arginine,ω3 fatty acids, and nucleotides potentially improve their nutritional status.
- Trial name
- PROUD (NCT00495859)
- Testing
- Immunonutrition, food for special medical purposes (FSMP)
- Where
- Germany
- Volunteers
- 156 people
- Sponsor
- Heidelberg University
Hepatocellular Carcinoma
Pre-Transplant INCBB099280 for Hepatocellular Carcinoma (HCC)
This is a pilot safety study of the oral PD-L1 inhibitor INCB099280 in patients with HCC awaiting liver transplant.
- Trial name
- HCC (NCT06337162)
- Testing
- INCB099280
- Where
- United States
- Sponsor
- Abramson Cancer Center at Penn Medicine
Diabetes, Liver Transplant; Complications
Optimal A1c Control in Post Liver or Combined Liver and Kidney Transplant Recipients Who Have Diabetes Mellitus
Major cardiovascular events are greatest in liver transplant recipients with sustained post-transplantation diabetes1. However, the optimal A1c target after transplantation has not been studied.
- Conditions
- Diabetes, Liver Transplant; Complications, Kidney Transplant Failure
- Trial name
- NCT04216303
- Testing
- hemoglobin A1c
- Where
- United States
- Sponsor
- Methodist Health System
Evidence of Liver Transplantation
Usefulness of Alpha-GST in Liver Transplantation
The primary objective of this study was to evaluate the ability of plasma alpha-GST measurements in liver donor (at the time of organ removal) to predict primary dysfunction in liver recipient.
- Trial name
- GST-LT (NCT02451046)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Beaujon Hospital
HIV Infections, Hepatitis C
Liver Transplantation in Patients With Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Coinfection
To show the feasibility of liver transplantation in HCV-HIV coinfected patients. To study the two-year survival after transplantation, the interaction between HCV and HIV after transplantation, the influence of HIV on HCV…
- Trial name
- NCT00158535
- Testing
- liver transplantation
- Where
- France
- Volunteers
- 15 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Liver Cirrhosis
Effect of Saccharomyces Boulardii in Patients in the Waiting List for Liver Transplant
The purpose of this study is to evaluate the effect of Saccharomyces boulardii in patients in the waiting list for liver transplant.
- Trial name
- NCT01762748
- Testing
- Saccharomyces boulardii
- Where
- Brazil
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Coagulation Defect; Bleeding
Quantra QStat Sample Type Comparison
This is a single center prospective observational study to compare QStat parameter measurements in arterial and venous blood samples collected in parallel from patients undergoing liver transplantation.
- Trial name
- NCT06025708
- Testing
- Diagnostic Test: Quantra QStat Cartridge
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- HemoSonics LLC
Liver Transplantation
Study of Sleep Quality and Its Specific Determinants During the Care Pathway of a Liver Transplant Patient
In the LIVERSLEEP study, investigators provide an overview of sleep disorders among patients in a liver transplantation (LT) pathway and a description of the criteria that can influence their sleep.
- Trial name
- LIVERSLEEP (NCT07674355)
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Hospices Civils de Lyon
Recurrent Hepatitis C
Efficacy of Everolimus as Inhibitor of Fibrosis Progression in Liver Transplant Patients With Recurrence of Hepatitis C Viral Infection
This study will assess the efficacy of everolimus as an inhibitor of fibrosis progression in liver transplant patients who have a recurrence of hepatitis C viral infection in the transplant
- Trial name
- REVERT (NCT00582738)
- Testing
- CsA-TAC (standard Treatment), Everolimus
- Where
- Argentina
- Volunteers
- 43 people
- Sponsor
- Novartis Pharmaceuticals
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