Clinical trials: Transplantation Lung
Work of Breathing, Lung Transplant; Complications
Physiological Response in Lung Transplant Recipients Undergoing Neurally Adjusted Ventilatory Assist
Primary Graft Dysfunction (PGD) respresents the leading cause of mortality in early post-operative period of Lung Tranplantation (LTx). Protective ventilatory strategy could potentially reduce the risk of PGD in these patients.
- Conditions
- Work of Breathing, Lung Transplant; Complications, Neurally Adjusted Ventilatory Assist, Ventilator-Induced Lung Injury
- Trial name
- TRANS-NAVA (NCT03367221)
- Testing
- NAVA ventilation
- Where
- 2 sites in Italy, Switzerland
- Volunteers
- 20 people
- Sponsor
- Policlinico Hospital
Lung Transplant, Organ Preservation
10°C vs 4°C Lung Preservation RCT
Despite lung transplantation (LTx) being the most effective treatment for end-stage lung disease, its success rate is lower than that of other solid organ transplantations.
- Trial name
- NCT05898776
- Testing
- Lung transplantation after 10°C donor lung preservation, Lung transplantation after standard ice cooler donor lung preservation
- Where
- 17 sites in United States, Australia and 6 more
- Volunteers
- 317 people
- Sponsor
- University Health Network, Toronto
Lung Transplant Recipient
Safety and Efficacy Study of Inhaled AmBisome for Prevention of Aspergillus Colonization in Lung Transplant Recipients
Lung transplant recipients have the highest rate of Invasive Aspergillus (IA)infection among solid organ transplant recipients. The most important risk factor for the development of IA (which is associated with disease and death)…
- Trial name
- NCT01254708
- Testing
- Ambisome ®, Regular standard of care medication
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University Health Network, Toronto
Mechanical Ventilation
Protective Ventilatory Strategy in Potential Organ Donors
The aim of the study is to verify if a "PROTECTIVE" ventilatory strategy (low tidal volume and high PEEP, application of CPAP during the apnea test and recruitment maneuvers), improves lung function and increases the number of…
- Trial name
- NCT00260676
- Testing
- change ventilation
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Turin, Italy
Lung Transplantation
Film Array Pneumonia Plus Panel® Multiplex PCR for Early Adaptation of Antibiotic Prophylaxis During Lung Transplantation
Postoperative pneumonia significantly worsens the prognosis for patients undergoing lung transplantation (LT). It is therefore recommended to use antibiotic prophylaxis after LT, although the specific types of antibiotics or the…
- Trial name
- FilmArray-TP (NCT07792018)
- Testing
- Early adapation of antibiotic prophylaxis according to FAPP results.
- Volunteers
- 98 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
COVID-19, Renal Transplant Infection
COVID-19 Infection
Post-transplant patients with COVID-19 infection who attended Shenzhen No. 3 Hospital from December 2022 to February 2023, and enrolled the general population with COVID-19 infection who were hospitalized during the same period…
- Trial name
- NCT05926076
- Testing
- Treatment plan
- Where
- China
- Volunteers
- 610 people, healthy volunteers welcome
- Sponsor
- Tianjin First Central Hospital
Lung Transplantation, Heart-Lung Transplantation
Empowerment of Lung and Heart-lung Transplant Patients
Lung or combined heart-lung transplantation represents an established treatment strategy for patients with end-stage lung disease.
- Conditions
- Lung Transplantation, Heart-Lung Transplantation, "Rehabilitation", Psychotherapy
- Trial name
- NCT00808600
- Testing
- resource-activating behavioural training programme, Relaxation training, Intensified anaerobic exercise training
- Where
- Germany
- Volunteers
- 132 people
- Sponsor
- Hannover Medical School
Pain
Acute and Chronic Pain in Lung Transplantation: Prevalence, Associated Factors, Taken Care
The objective of this project is to estimate the frequency and the characters of the chronic pains by a follow-up which begins during the registration on the waiting list of transplant and which ends at the end of the third year…
- Trial name
- MUCODOULEUR (NCT02897882)
- Testing
- Lung transplant
- Where
- France
- Volunteers
- 94 people
- Sponsor
- Hopital Foch
Covid19
Comorbidities and Risk Score in COVID-19 Patients
Retrospective multi-center cohort study. Consecutive patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) up to October 2020 will be included.
- Trial name
- Comorbidities (NCT04670094)
- Where
- 5 sites in Italy
- Volunteers
- 4,555 people
- Sponsor
- University of Milano Bicocca
Lung Transplant Infection, Molecular Diagnostic
Molecular vs Conventional Microbiologic Diagnosis for Infections in Lung Transplantation
The goal of this prospective study is to compare rapid molecular technique BioFire Pneumonia Panel Filmarray and conventional culture-based methods in the microbiologic diagnosis on bronchoalveolar lavage of lung transplant…
- Conditions
- Lung Transplant Infection, Molecular Diagnostic, Bacterial Infections, Pneumonia
- Trial name
- PNEUMOARRAY (NCT05960383)
- Testing
- BioFire Pneumonia Panel Plus
- Where
- Italy
- Volunteers
- 53 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Cardiac Transplant Rejection, Lung Transplant Rejection
Genome Transplant Dynamics: Non-invasive Sequencing-based Diagnosis of Rejection
The purpose of this study is to determine whether shotgun sequencing technology, which can be used to detect donor DNA in recipient plasma, can be used as a rapid, accurate, non-invasive method to detect Acute Cellular Rejection…
- Trial name
- GTD (NCT01985412)
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Stanford University
Lung Transplant Rejection
Adipose Derived Mesenchymal Cell Treatment in Lungtransplantation
To investigate safety of treatment with allogeneic adipose tissue-derived mesenchymal stromal cells (ASCs) in patients undergoing lung transplantation, to evaluate whether the treatment can reduce host immunological reaction…
- Trial name
- NCT04714801
- Testing
- adipose derived mesenchymal stromal cells, Saline
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Lung Transplant Failure
Intraoperative Echocardiographic Evaluation of Pulmonary Vein Velocities and Outcomes in Lung Transplantation
This study will evaluate if an association exists between levels of blood flow through the pulmonary veins and the incidence of graft dysfunction post operatively.
- Trial name
- NCT03052153
- Testing
- No investigational intervention performed for this study
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ohio State University
Lung Transplant
Envarsus XR in Lung Transplant
Patients undergoing a lung transplant will be enrolled. All patients will undergo lung transplantation with standard post-operative management, including triple immunosuppression.
- Trial name
- NCT04420195
- Testing
- Extended-Release Tacrolimus, Immediate-Release Tacrolimus
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- NYU Langone Health
Lung Transplantation
Twice Daily Versus Once Daily Administration of the Tacrolimus in Lung Transplantation
This study is a prospective randomized trial to compare twice daily to once daily administration of the basic immunosuppressive regimen in lung transplanted patients.
- Trial name
- NCT00930241
- Testing
- Advagraf®, Prograf®
- Where
- 3 sites in Germany
- Volunteers
- 25 people
- Sponsor
- Hannover Medical School
Chronic Graft-versus-host Disease, Chronic GVHD
Tele-Palliative Care Intervention for Patients With Chronic Graft-Versus-Host Disease
This research study is evaluating the feasibility and acceptability of implementing a telehealth palliative care intervention in patients with moderate to severe chronic graft-versus-host disease.
- Conditions
- Chronic Graft-versus-host Disease, Chronic GVHD, cGVHD
- Trial name
- cGVHDTele-PC (NCT06458127)
- Testing
- Tele-palliative care visit
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Kidney Failure, Chronic, Transplantation
Fibrosis in Renal Allografts
This prospective, randomized study, comparing sirolimus to cyclosporine in renal transplant recipients, has two major objectives: 1.
- Conditions
- Kidney Failure, Chronic, Transplantation, Immunosuppression, Interstitial Fibrosis
- Trial name
- NCT00493194
- Testing
- sirolimus, cyclosporine, daclizumab
- Where
- 3 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Antwerp
Respiratory Tract Diseases
Evaluation and Reconditioning of Marginal Lung Donors to Transplantation by ex Vivo Lung Perfusion
Only about 15% of the potential candidates for lung donation are considered suitable for transplantation. A new method for ex vivo lung perfusion (EVLP) has been developed and can be used for evaluation and reconditioning of…
- Trial name
- NCT01353105
- Testing
- Ex vivo lung transplantation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- InCor Heart Institute
Parenthood Status, Transplant Lung
Access to Parenthood and Gynecological Follow-up After Organ Transplantation
Solid organ transplants affect subjects of all ages, including young women of childbearing age. The improvement in the management of young female transplant patients makes it possible to consider pregnancies, about which the…
- Conditions
- Parenthood Status, Transplant Lung, Transplant Kidney
- Trial name
- FerGyTransplan (NCT05610670)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Hopital Foch
Lung Transplant; Complications, Extracorporeal Circulation; Complications
Routine Versus Selective Intraoperative ECMO in Lung Transplant
Intraoperative hemodynamic management is vital in the success of lung transplantation. Significant intraoperative hemodynamic compromise and hypoxic episodes may contribute to an increase in severe postoperative complications…
- Conditions
- Lung Transplant; Complications, Extracorporeal Circulation; Complications, Postoperative Complications
- Trial name
- NCT05505422
- Testing
- Routine ECMO, On demand ECMO
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)