Clinical trials: Transplantation Lung
Lung Cancer
High-Dose Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Trial name
- NCT00003284
- Testing
- filgrastim, carboplatin, etoposide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Herbert Irving Comprehensive Cancer Center
Lung Transplant; Complications
Vasoactive-inotropic Support and Levosimendan Use After Lung Transplantation
Bilateral Lung transplantation (LUTX) is performed in selected patients with end-stage respiratory failure. During surgery, pulmonary arteries are sequentially cross-clamped.
- Trial name
- VASO_LUTX (NCT05702333)
- Testing
- Epinephrine Norepinephrine Dobutamine Dopamine Levosimendan
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Policlinico Hospital
Disorder Related to Lung Transplantation, Chronic Rejection of Lung Transplant
Standard Therapy Using Tacrolimus, Mycophenolate Mofetil and Prednisone For Chronic Lung Transplant Rejection (BOS)
This is a prospective single-center, open-label, randomized, controlled pilot study in the treatment of chronic rejection (CR), defined as grade 1 and 2 BOS, in adult recipients of a pulmonary allograft (single or double…
- Conditions
- Disorder Related to Lung Transplantation, Chronic Rejection of Lung Transplant, Decreased Immunologic Activity
- Trial name
- NCT04415476
- Testing
- Assigned Interventions
- Sponsor
- University of Maryland, Baltimore
Heart and Lung Transplants
The Experience, Perceptions and Unexpressed Needs of Heart and Lung Transplant Patients Admitted to Intensive Care
Qualitative descriptive phenomenological study aimed to investigate the experience, perceptions and unexpressed needs of patients undergoing heart and lung transplantation admitted to intensive care unit through semi-structured…
- Trial name
- ReF2201 (NCT06773052)
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Lung Transplant; Complications
Management of Cytomegalovirus (CMV) Infection in Lung Transplant Recipients (LTR)
Background: Lung transplant recipients (LTR) have the highest risk of CMV infection. CMV pneumonitis, lymphocytic bronchitis, and detection of CMV DNA in bronchoalveolar lavage fluid are independent risk factors for the…
- Trial name
- NCT04377139
- Testing
- Prophylaxis, Preemptive
- Volunteers
- 1,500 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Cystic Fibrosis, Lung Transplant; Complications
Implementation of a Clinical Tool to Improve Waitlist Mortality in Patients With Cystic Fibrosis
Implementation of a Clinical Tool to Improve Waitlist Mortality in Patients With Cystic Fibrosis
- Trial name
- NCT04687475
- Testing
- Clinical Tool (Mobile Spirometry and Survey)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The Cleveland Clinic
Pulmonary Complications
Pulmonary Complications of Allografts
This is a prognostic study of the late lung complications arising at the patient's having received an allograft of hematopoetic stem cells.
- Trial name
- ALLOPULM (NCT01219972)
- Where
- France
- Volunteers
- 245 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lung Transplantation
SI-EVLP Study: STRESS INDEX in Lung Reconditioning
In order to minimize mechanical stress the investigators propose to implement EVLP procedure with a ventilation monitoring guided by the analysis of the Paw-t shape.
- Trial name
- NCT01729637
- Where
- Italy
- Volunteers
- 11 people
- Sponsor
- University of Turin, Italy
Coronary Artery Disease
Comparison of Coronary CT Angiography With Conventional Coronary Angiography in Liver and Lung Transplant Candidates
The overall goal of this study is to determine if non-invasive imaging with state of the art CT coronary angiography can be used to screen for coronary artery disease in high risk patients prior to liver and lung transplantation.
- Trial name
- NCT00727051
- Where
- United States
- Sponsor
- University of California, San Francisco
Heart Transplantation, Kidney Transplantation
Effects of Donor and Recipient Genetic Expression on Heart, Lung, Liver, or Kidney Transplant Survival
Activity of genes in donor tissues that are involved in inflammation are thought to be involved with early organ dysfunction, increased immune responses in transplant recipients, and organ rejection.
- Conditions
- Heart Transplantation, Kidney Transplantation, Liver Transplantation, Lung Transplantation
- Trial name
- NCT00531921
- Where
- 5 sites in United States
- Volunteers
- 313 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pneumonia, Hematologic Malignancy
Ceftolozane-Tazobactam for Directed Treatment of Pseudomonas Aeruginosa Bacteremia and Pneumonia in Patients With Hematological Malignancies and Hematopoietic Stem Cell Transplantation
The goal of this clinical trial is to learn whether the antibiotic ceftolozane-tazobactam works to treat serious Pseudomonas aeruginosa infections in people with blood cancers or who received a stem cell transplant.
- Conditions
- Pneumonia, Hematologic Malignancy, Pseudomonas Aeruginosa Infection, Bacteremia
- Trial name
- NCT04673175
- Testing
- Ceftolozane / Tazobactam Injection
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Weill Medical College of Cornell University
Inspiratory Muscle Training
Inspiratory Muscle Training in Lung Transplant Candidates
Recovery after lung transplantation (LTx) may be complicated by prolonged mechanical ventilation (MV) and protracted intensive care unit (ICU) stay leading to immobilization and impaired health-related quality of life (HRQoL).
- Trial name
- NCT06370832
- Testing
- IMT and exercise training group
- Where
- 4 sites in Canada
- Volunteers
- 90 people
- Sponsor
- University Health Network, Toronto
Acute Graft Versus Host Disease
Tocilizumab for Treatment of Steroid Refractory Acute Graft-versus-Host Disease
This trial designed to evaluate the toxicity and efficacy of tocilizumab in the treatment of steroid refractory acute graft versus host disease (GVHD).
- Trial name
- NCT01475162
- Testing
- Tocilizumab
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Medical College of Wisconsin
Chronic Graft-Versus-Host Disease
Treatment of Refractory Acute Graft-Versus-Host Disease by Sequential Infusion of Allogenic Mesenchymal Stem Cell.
The purpose of this study is to determine the safety and efficacy of sequential infusion of allogenic mesenchymal stem cells (MSC) expanded "in vitro" in treating patients with acute graft-versus-host disease refractory to…
- Trial name
- CSM/EICH2010 (NCT01956903)
- Testing
- Allogenic Mesenchymal Stem Cell
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Grupo Espanol de trasplantes hematopoyeticos y terapia celular
Lung Transplantation, Bronchiolitis Obliterans Syndrome
Characterization of Bronchiolitis-obliterans Syndrome (BOS) Following Lung Transplantation
Chronic organ dysfunction after lung transplantation (BOS) is the most common cause of death in long-term survivors after lung transplantation and refractory to most interventions.
- Trial name
- NCT00774449
- Where
- Germany
- Volunteers
- 261 people
- Sponsor
- Hannover Medical School
Pulmonary Hypertension
Natrecor for Pulmonary Hypertension in Lung Transplants
This study seeks to demonstrate that Natrecor® (nesiritide) is safe and effective and has a favorable hemodynamic profile in lung transplant recipients that will allow for the avoidance of inhaled nitric oxide (iNO) use.
- Trial name
- NCT00205426
- Testing
- Natrecor
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Wisconsin, Madison
Cognitive Impairment, Pulmonary Rehabilitation
The Effect of Pulmonary Rehabilitation on Cognitive Status in Lung Transplantation Candidates
Pulmonary rehabilitation program with aerobic and strengthening for 3 months will be applied to the candidates for lung transplantation. The program will be designed to be 2 days supervised weekly and 3 day home program.
- Trial name
- NCT03528447
- Testing
- Pulmonary Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people
- Sponsor
- Istanbul Medipol University Hospital
Idiopathic Pulmonary Fibrosis, Lung Transplant; Complications
Continuation of Nintedanib After Single Lung Transplantation in IPF Subjects
The aim of this study is to assess the utility of nintedanib therapy in addition to usual transplant care in single lung transplant recipients with idiopathic pulmonary fibrosis (IPF).
- Trial name
- NCT03562416
- Testing
- Nintedanib
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Temple University
Interstitial Fibrosis, Kidney Transplant; Complications
Fingolimod for the Abrogation of Interstitial Fibrosis and Tubular Atrophy Following Kidney Transplantation
This is a randomized, double-blind, placebo-controlled trial in de novo kidney transplant patients to determine if the addition of fingolimod (brand name Gilenya®, candidate name- FTY720) on the background of standard…
- Conditions
- Interstitial Fibrosis, Kidney Transplant; Complications, Kidney Transplant Rejection, Kidney Transplant Failure and Rejection
- Trial name
- NCT05285878
- Testing
- Fingolimod
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Methodist Hospital Research Institute
Lung Injury, Acute, Respiratory Distress Syndrome, Adult
Study of Enbrel (Etanercept) for the Treatment Sub-Acute Pulmonary Dysfunction After Allogeneic Stem Cell Transplant
The purpose of this study is to determine the effectiveness of etanercept in the treatment of patients with sub-acute lung injury following a bone marrow transplant.
- Conditions
- Lung Injury, Acute, Respiratory Distress Syndrome, Adult, Bronchiolitis Obliterans
- Trial name
- NCT00141726
- Testing
- Etanercept
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Michigan Rogel Cancer Center