Clinical trials: Transplantation Lung
Lung Transplantation, Respiratory Failure
Prognosis of Lung Transplant Candidates
The purposes of the study are (1) to analyze the baseline patient characteristics cross-sectionally, (2) to analyze the prognosis and its predictive factors and (3) to examine the longitudinal clinical course in the lung…
- Trial name
- NCT00905463
- Testing
- Lung transplantation
- Where
- 4 sites in Japan
- Volunteers
- 272 people
- Sponsor
- Kyoto University, Graduate School of Medicine
Lung Transplant, Bronchiolitis Obliterans
Viral Triggers in Pediatric Lung Transplantation
The purpose of this study is to determine whether respiratory viral infections increase the risk of bronchiolitis obliterans syndrome (BOS), obliterative bronchiolitis (OB), death, or retransplantation in children who have…
- Conditions
- Lung Transplant, Bronchiolitis Obliterans, Obliterative Bronchiolitis
- Trial name
- NCT00891865
- Where
- 6 sites in United States
- Volunteers
- 61 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cell Transplantation
An Exploratory Study on the Treatment of Chronic Obstructive Pulmonary Disease With Autologous Bronchial Basal Cell Transplantation
Chronic obstructive pulmonary disease(COPD)is characterized by recurrent cough, expectoration and asthma, and eventually develop chronic pulmonary heart disease ,chronic respiratory failure and even death.
- Trial name
- NCT03021681
- Testing
- autologous bronchial basal cell transplantation
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Huai'an No.1 People's Hospital
Cancer
Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain
This is a phase III, randomized, double-blind, placebo-controlled, multicenter study of the clinical response to fentanyl sublingual spray as a treatment for breakthrough cancer pain.
- Trial name
- NCT00538850
- Testing
- Fentanyl sublingual spray
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- INSYS Therapeutics Inc
Lung Transplant, Diaphragmatic Function
Evaluation of Diaphragmatic Function After Bi-pulmonary Transplantation
A current complication after lung transplantation is diaphragmatic dysfunction. These dysfunction result to several factors: duration of mechanical ventilation, chest tube, atelectasis, denutrition, phrenic nerve injury during…
- Trial name
- DIATRIB (NCT03977597)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Lung Transplant
Study to Evaluate Adenosine 2A Receptor Agonist (Regadenoson) in Patients Undergoing Lung Transplantation
This study will evaluate the maximum safe dose and duration of regadenoson (Lexiscan) that can be given to people who are having a lung transplant. Regadenoson will be given as a continuous IV infusion.
- Trial name
- NCT03072589
- Testing
- Regadenoson infusion
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Christine Lau, MD
Cancer
Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation
RATIONALE: Antivirals such as ribavirin are used to treat infections caused by viruses. It is not yet known if ribavirin is more effective with or without monoclonal antibody therapy in treating patients who develop RSV pneumonia…
- Trial name
- NCT00014391
- Testing
- palivizumab, ribavirin
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Bone Marrow Transplantation
Early Versus Late Bronchoscopy in Bone Marrow Transplantation (BMT) Patients
This study will evaluate the outcomes of bronchoscopy in Bome Marrow Transplant (BMT) patients who develop lung infiltrates suspicious for infections of the lungs.
- Trial name
- NCT00846352
- Testing
- Variation in the time for performing bronchoscopy
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Wake Forest University Health Sciences
Lung Transplant; Pain
Impact of a Multidisciplinary Protocol of Respiratory Kinesitherapy and Active Music Therapy on Anxiety, Depression and Pain in Lung Transplant Patients
Transplantation remains the last resort to prolong life when the patient reaches the stage of terminal respiratory failure. Lung transplantation improves survival and quality of life compared to medical treatment, at acceptable…
- Trial name
- PPKRMA (NCT05219292)
- Testing
- Active music therapy, Questionnaires
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Hospices Civils de Lyon
Lung Cancer, Lymphoma
AMG 706 and Gemcitabine in Treating Patients With Advanced Solid Tumors or Lymphoma
RATIONALE: AMG 706 may stop the growth of cancer cells by blocking blood flow to the cancer or by blocking some of the enzymes needed for cell growth.
- Conditions
- Lung Cancer, Lymphoma, Lymphoproliferative Disorder, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00324597
- Testing
- gemcitabine hydrochloride, motesanib diphosphate, pharmacological study
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Antibody Mediated Rejection of Lung Transplant
A Phase 1 Clinical Trial of Siltuximab for the Treatment of Antibody-Mediated Rejection After Lung Transplantation
Antibody-mediated rejection after lung transplantation commonly results in allograft failure and death in spite of current therapeutic regimens.
- Trial name
- Siltux-AMR (NCT06990711)
- Testing
- Siltuximab
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Childhood Cancer
Cardiopulmonary Fitness and Its Clinical Determinants of a Population of Childhood Cancer Survivor
Medical progress have made it possible to considerably improve the survival of children with an oncological disease. Currently, the survival rate increased to above 90 % in the most developed countries .
- Trial name
- ONCO-SPORT (NCT04815447)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Lung Transplantation
Effect of Early Pulmonary Rehabilitation After Lung Transplantation
The purpose of this observation study is to evaluate the effects of an early, 3 week lasting rehabilitation program, that starts roundabout 4 weeks after lung or combined lung transplantation, on physical activity, functional and…
- Trial name
- NCT00759538
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Hannover Medical School
Infections, Coronavirus, Kidney Transplantation
COVID-19 in Immunosuppressed Children
Viral respiratory infections are common infectious complications after kidney transplantation, especially in the pediatric age group, and immunosuppressed patients may develop more severe disease.
- Conditions
- Infections, Coronavirus, Kidney Transplantation, Liver Transplantation, Cancer
- Trial name
- NCT04511429
- Where
- 2 sites in Brazil
- Volunteers
- 200 people
- Sponsor
- D'Or Institute for Research and Education
Lung Transplant Reject, Bronchiolitis Obliterans
Mesenchymal Stem Cell Therapy for Lung Rejection
To assess the safety and feasibility of mesenchymal stem cells therapy in patients with transplant related bronchiolitis obliteran syndrome (BOS)
- Trial name
- NCT02181712
- Testing
- Mesenchymal stem cell 0.5, Mesenchymal stem cell 1.0
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mayo Clinic
Bronchiolitis Obliterans Syndrome, Graft Rejection
Azithromycin in Bronchiolitis Obliterans Syndrome
Preventive treatment with azithromycin reduces the prevalence fo Bronchiolitis Obliterans Syndrome after lung transplantation.
- Conditions
- Bronchiolitis Obliterans Syndrome, Graft Rejection, Lymphocytic Bronchiolitis, Respiratory Infection
- Trial name
- AZI001 (NCT01009619)
- Testing
- Azithromycin
- Where
- Belgium
- Volunteers
- 83 people
- Sponsor
- KU Leuven
COVID-19, Vaccine Adverse Reaction
COVID19 Vaccine in SOT Adult Recipients
Background: ISHLT and AASLD guidelines recommend SARS-CoV2 vaccination in all individuals undergoing lung and liver transplantation, but there are currently scarce data on the safety and efficacy of these vaccines in this…
- Conditions
- COVID-19, Vaccine Adverse Reaction, Vaccine Response Impaired, Vaccine Reaction
- Trial name
- COVID19_VaxSOT (NCT05116748)
- Testing
- COVID19 mRNA vaccine
- Where
- Italy
- Volunteers
- 364 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Lung Transplant Rejection, Antibody-mediated Rejection
Lung Transplant Plasmapheresis/Belatacept/Carfilzomib for Antibody Mediated Rejection and Desensitization
Antibody mediated rejection (AMR) post transplant contributes to poor long term outcomes after lung transplantation. Additionally, high antibodies detected pre transplant in candidates limit donor availability for lung…
- Trial name
- NCT03805178
- Testing
- Belatacept, Carfilzomib
- Sponsor
- Duke University
Graft Versus Host Disease
Ultra-Low Dose Interleukin-2 for Refractory Chronic Graft Versus Host Disease
The purpose of this research study is to determine the safety of IL-2 and the highest dose of this drug that can be given safely to people with chronic graft versus host disease (GVHD).
- Trial name
- NCT00529035
- Testing
- Interleukin-2
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Dana-Farber Cancer Institute
COPD, Pre-Lung-Transplantation
Pulmonary Rehabilitation in Patients Before Lung Transplantation (LTx)
The purpose of this study is to study the effects of a complex pulmonary rehabilitation program on mobility measured by 6 minute walking distance (6MWD) and physical activity, measured via Dynaport and Actibelt Aktivitätsmonitor…
- Conditions
- COPD, Pre-Lung-Transplantation, Hypercapnia, Respiratory Insufficiency
- Trial name
- NCT00962078
- Testing
- continuous endurance training, interval training
- Where
- Germany
- Volunteers
- 71 people
- Sponsor
- Schön Klinik Berchtesgadener Land