Clinical trials: Transplantation Lung
Idiopathic Pulmonary Fibrosis and Progressive Fibrotic Interstitial Lung Disease
Human Autologous Lung Stem Cell Transplant for Idiopathic Pulmonary Fibrosis
Purpose: To demonstrate the safety and efficacy of autologous Lung Spheroid Stem Cells (LSCs) administered by intravenous infusion in patients with idiopathic pulmonary fibrosis Progressive Fibrotic Interstitial Lung Disease.
- Trial name
- HALT-IPF (NCT04262167)
- Testing
- Lung Spheroid Stem Cells 100 million, Lung Spheroid Stem Cells 200 million
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Liver Transplant Infection, Covid19
Humoral Immunity Against SARS-CoV-2 in Liver Transplanted Patients After COVID-19 in Comparison With Immunocompetent Patients
This is a prospective study analyzing the development of humoral immune response against SARS-Cov-2 in patients with previous Covid19: the aim is to compare the incidence, titration and evolution of IgG an IgM in a prospective…
- Conditions
- Liver Transplant Infection, Covid19, Mortality, Immune Response
- Trial name
- NCT04410471
- Testing
- CLIA of IgG and IgM against SARS-Cov-2
- Where
- 2 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Magdalena Salcedo
Acute Kidney Injury
Cell Cycle Arrest Proteins for Early Diagnosis of Acute Kidney Injury After Solid Organ Transplant
Renal failure is a common complication of lung transplant (LUTX) and orthotopic liver transplantation (OLTX). Early diagnosis of acute kidney injury (AKI) in this cohort is of utmost importance, since AKI after solid organ…
- Trial name
- LUTX/OLTX_AKI (NCT05907434)
- Testing
- Nephrocheck (AKI score)
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Policlinico Hospital
Transplant Failure
T-lymphocytes CD8+/HLA-DR+ and Acute Rejection After Lung Transplantation
The objectives of the study is to identify associations between acute rejection and the increase of T (CD4/CD8) and B circulating lymphocytes expressing specific markers of activation and differentiation (HLA-DR, CD25, CD38…
- Trial name
- NCT03587493
- Testing
- BLOOD SAMPLE ANALYSIS
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Heart Failure
Inhaled Nitric Oxide and Inhaled Prostacyclin After Cardiac Surgery for Heart Transplant or LVAD Placement
Research study evaluating the individual and combined effects of inhaled nitric oxide (iNO) and inhaled prostacyclin (iPGI2), on the function of the right heart after surgery for either heart transplant or for left ventricular…
- Trial name
- NCT01717209
- Testing
- Nitric Oxide, Prostacyclin
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Stanford University
Hematopoietic Stem Cell Transplantation (HSCT), Pulmonary Rehabilitation
Effects of Different Inspiratory Muscle Training Protocols in Hematopoietic Stem Cell Transplant Recipients
Introduction: After haematopoietic stem cell transplantation (HSCT), patients often experience complications such as respiratory difficulties, fatigue and decreased quality of life.
- Conditions
- Hematopoietic Stem Cell Transplantation (HSCT), Pulmonary Rehabilitation, Inspiratory Muscle Training
- Trial name
- NCT07061444
- Testing
- Inspiratory Muscle Training, Functional Inspiratory Muscle Training
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ceren Derya Gültekin
Pulmonary Hypertension
Natrecor for Pulmonary Hypertension in Lung Transplants
This study seeks to demonstrate that Natrecor® (nesiritide) is safe and effective and has a favorable hemodynamic profile in lung transplant recipients that will allow for the avoidance of inhaled nitric oxide (iNO) use.
- Trial name
- NCT00205426
- Testing
- Natrecor
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Wisconsin, Madison
Acute Lung Injury, Acute Respiratory Distress Syndrome
Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Acute Lung Injury
Phase I-II Clinical Trial - Safety and efficacy of umbilical-cord-derived mesenchymal stem cell (UC-MSC) in patients with Acute Lung Injury ,open label, controlled prospective study.
- Trial name
- UCMSC-ALI (NCT02444455)
- Testing
- UCMSC group
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Childhood Cancer
Cardiopulmonary Fitness and Its Clinical Determinants of a Population of Childhood Cancer Survivor
Medical progress have made it possible to considerably improve the survival of children with an oncological disease. Currently, the survival rate increased to above 90 % in the most developed countries .
- Trial name
- ONCO-SPORT (NCT04815447)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Restrictive Chronic Lung Allograft Dysfunction, Lung Transplant Rejection
Pirfenidone for Restrictive Chronic Lung Allograft Dysfunction
Despite advances in lung transplantation, the median survival remains only 55% at 5 years. The main limitation to long term survival is the development of chronic lung allograft dysfunction.
- Trial name
- PIRCLAD (NCT03359863)
- Testing
- Pirfenidone
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, San Francisco
Transplant
Cell Mediated Immunity and the Prediction of CMV Infection In Solid Organ Transplant Recipients
Cytomegalovirus (CMV) is a common cause of illness in patients who have undergone a transplant. Serious infections due to CMV can affect many parts of the body including the lungs, the gut, and the liver.
- Trial name
- NCT00436384
- Testing
- Monitoring-blood samples drawn for CMV testing
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University Health Network, Toronto
Bronchiolitis Obliterans Syndrome, Graft Rejection
Azithromycin in Bronchiolitis Obliterans Syndrome
Preventive treatment with azithromycin reduces the prevalence fo Bronchiolitis Obliterans Syndrome after lung transplantation.
- Conditions
- Bronchiolitis Obliterans Syndrome, Graft Rejection, Lymphocytic Bronchiolitis, Respiratory Infection
- Trial name
- AZI001 (NCT01009619)
- Testing
- Azithromycin
- Where
- Belgium
- Volunteers
- 83 people
- Sponsor
- KU Leuven
Stem Cell Transplantation
Physical Functions in Allogeneic-HSCT Candidates
Physical inactivity and impairments in physical functions have been observed in patients due to hematological malignancy itself and treatments of chemotherapy, radiotherapy, corticosteroids.
- Trial name
- NCT03915249
- Volunteers
- 49 people
- Sponsor
- Gazi University
Graft vs Host Disease, Bronchiolitis Obliterans
Efficacy Study of Azithromycin-based Therapy for Bronchiolitis Obliterans
[Study Objectives] To evaluate the efficacy of azithromycin, N-acetylcystein, and inhaled corticosteroid combination therapy in patients with bronchiolitis obliterans as a complication of allogeneic hematopoietic cell…
- Trial name
- NCT01327625
- Testing
- azithromycin + N-acetylcystein + inhaled corticosteroid
- Where
- South Korea
- Volunteers
- 6 people
- Sponsor
- Asan Medical Center
Lung Transplant; Complications
Readmissions of Lung Transplant Patients in ICU.
A multi-centre, prospective and observational study was carried out from August 2012 to June 2016 in five Spanish tertiary-care university hospitals with well-established lung transplant programs: Vall d'Hebron (Barcelona)…
- Trial name
- NCT03767049
- Testing
- Colection of clinical data
- Volunteers
- 153 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Lung Transplant Rejection
Study of Transbronchial Cryobiopsy in Monitoring Complications of Lung Transplantation
The goal of this randomized controlled trial is to compare the diagnostic efficacy and safety of transbronchial cryobiopsy (TBCB) and traditional transbronchial lung biopsy for diagnosing the lung transplantation rejection , so…
- Trial name
- NCT05792384
- Testing
- transbronchial lung cryobiopsy with a 1.1 mm flexible cryoprobe, transbronchial lung biopsy with biopsy forceps
- Volunteers
- 120 people
- Sponsor
- China-Japan Friendship Hospital
Invasive Fungal Disease, Lung Transplant Recipients
Assessing Diagnostic Methods for Invasive Fungal Disease in Lung Transplant Recipients
This study aims to assess the diagnostic performance of different tests, including metagenomic next-generation sequencing (mNGS), real-time PCR, galactomannan assay, and lateral-flow device tests, in detecting invasive fungal…
- Conditions
- Invasive Fungal Disease, Lung Transplant Recipients, Invasive Pulmonary Aspergillosis, Pneumocystis Jirovecii Pneumonia
- Trial name
- NCT06654076
- Volunteers
- 109 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Lung Transplantation
Patient Reported Outcomes in Living Donor Lung Transplantation
The purpose of the present study is to investigate how the health of donors in living donor lung transplantation will change after transplant operations.
- Trial name
- NCT00905697
- Testing
- Living donor lung transplantation
- Where
- Japan
- Volunteers
- 40 people
- Sponsor
- Kyoto University, Graduate School of Medicine
Pulmonary Arterial Hypertension
Microbiota Transplant Therapy for Pulmonary Arterial Hypertension: Early Safety and Feasibility Study
This pilot clinical trial will evaluate the initial safety and feasibility of intestinal microbiota transplantation (IMT) in patients with pulmonary arterial hypertension (PAH).
- Trial name
- NCT04884971
- Testing
- Intestinal microbiota transplant (IMT)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Minnesota
Lung Diseases
Study to Evaluate the Value of the Follow-up of CALCIneurin Activity to MOdulate Calcineurin Inhibitors-induced Immunosuppression in Lung Transplantation
The study is an interventional, multicentre, prospective, randomized, controlled, single-blind, comparative trial of two processes for adjusting the inhibitor of calcineurin (CNI) dosage in lung transplant recipients.
- Trial name
- CalciMo-TP (NCT02897895)
- Testing
- levels of CNI in whole blood, Calcineurin activity (CN-a) in peripheral blood mononuclear cells (PBMCs)
- Where
- France
- Volunteers
- 134 people
- Sponsor
- Assistance Publique Hopitaux De Marseille