Clinical trials: Transplantation Lung
Congenital Heart Disease, Advanced Heart Failure
TORCH-LATAM-003: Regional Advanced-Therapy Pathways for Congenital Heart Disease
TORCH-LATAM-003 is a pragmatic stepped-wedge cluster randomized trial evaluating a regional pathway for children and adults with congenital heart disease and advanced cardiac and/or respiratory failure who may require heart…
- Conditions
- Congenital Heart Disease, Advanced Heart Failure, Respiratory Failure, Heart Transplantation
- Trial name
- TORCH-003 (NCT07837024)
- Testing
- TORCH Congenital Advanced Therapies Pathway (TORCH-CATP)
- Volunteers
- 360 people
- Sponsor
- CardioVision International Tech, S.A.S. de C.V.
Lung Transplant, Complications Surgical
Protest Trial: TXA vs Saline
To determine if endobronchial (topical) tranexamic acid used prophylactically prior to performing transbronchial biopsies in lung transplant recipients reduces bleeding risk.
- Trial name
- NCT06422273
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Corewell Health West
Bronchiolitis Obliterans Syndrome
A Retrospective Chart Review Study of Patients With CLAD-BOS Post Lung Transplantation
The Primary Objective of this study was to evaluate the FEV1 trajectory of patients diagnosed with CLAD-BOS. The Secondary Objectives of this study were: To describe demographics of patients diagnosed with CLAD-BOS To describe…
- Trial name
- NCT06503770
- Where
- 6 sites in United States, Belgium and 1 more
- Volunteers
- 284 people
- Sponsor
- Zambon SpA
Lung Transplant Failure, Lung Transplant; Complications
Cytokine Filtration in Lung Transplantation: A Swedish National Study (GLUSorb)
Lung transplantation (LTx) remains the gold standard for treating patients with irreversible end-stage pulmonary disease. Of the major organs transplanted, survival in LTx recipients remains the lowest (mean 5 years).
- Trial name
- NCT05526950
- Testing
- Device: CytoSorb
- Where
- Sweden
- Volunteers
- 116 people
- Sponsor
- Lund University Hospital
Allogeneic Hematopoietic Cell Transplant Recipients
Prospective Phase II Study for Assessment of Regulatory Immune Cell Populations After Allogeneic HSCT
Allogeneic hematopoietic cell transplantation offers high cure rates for patients with hematological and oncological diseases. Graft-versus-host disease (attack of donor's white blood cells on patient's tissues) is a serious…
- Trial name
- NCT00587574
- Where
- 2 sites in Austria, Czechia
- Volunteers
- 150 people
- Sponsor
- Medical University of Vienna
Extensive Stage Small Cell Lung Cancer
Auto-HSCT-Supported Dose-Dense Chemotherapy with Adebrelimab As First-Line Treatment for ES-SCLC
The goal of this clinical trial is to learn if hematopoietic stem cell transplantation-supported dose-dense chemotherepy with adebrelimb works to treat extensive-stage small-cell lung cancer in adults.
- Trial name
- NCT06597513
- Testing
- auto-HSCT-Supported Dose-Dense Chemotherapy With Adebrelimab
- Volunteers
- 10 people
- Sponsor
- Zhou Chengzhi
Pulmonary Surgical Procedures
Hyperpolarized Xenon MRI for Assessment of Pulmonary Function in Lung Transplant
This study compares the equivalence of hyperpolarized 129Xe MRI to 133Xe scintigraphy for the evaluation of pulmonary function in patients being evaluated for lung transplant.
- Trial name
- NCT03418090
- Testing
- 129Xe MRI, 133XE scintigraphy
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Polarean, Inc.
Lung Transplantation Rejection
Prospective Lung Transplant Database for Genetic Research
This study will create a database of clinical and biological research for use in future studies, with information obtained from lung transplant recipients.
- Trial name
- NCT00339209
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Infection
Voriconazole as Prophylactic Therapy in Lung Transplant Recipients
The purpose of this study is to compare the safety and efficacy of Voriconazole with Itraconazole following lung transplantation.
- Trial name
- VORI (NCT00455364)
- Testing
- Voriconazole
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Pulmonary Edema, Pneumonia
Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU
Dynamic digital radiography (DDR) is a new advanced version of chest radiography that captures dynamic images at a rate of 15 frames per second.
- Conditions
- Pulmonary Edema, Pneumonia, Atelectasis, Pleural Effusion
- Trial name
- NCT06538376
- Testing
- Portable Dynamic Digital Radiography (DDR)
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Brigham and Women's Hospital
Idiopathic Pulmonary Fibrosis, Lung Transplant; Complications
Continuation of Nintedanib After Single Lung Transplantation in IPF Subjects
The aim of this study is to assess the utility of nintedanib therapy in addition to usual transplant care in single lung transplant recipients with idiopathic pulmonary fibrosis (IPF).
- Trial name
- NCT03562416
- Testing
- Nintedanib
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Temple University
Disorder Related to Lung Transplantation
Morphofunctional Lung Analysis by PET and CT After Lung Transplantation
72 hours after lung transplantation, patients undergo a positron emission tomography (PET) scan and a computed tomography (CT) scan in order to analyse lung function and morphology.
- Trial name
- NCT01746914
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Policlinico Hospital
Non Small Cell Lung Cancer
Immune Checkpoint Blockade and Chemotherapy With or Without Fecal Microbiota Transplant in Advanced Non-Small Cell Lung Cancer
This study is being done to answer the following question: Can adding a treatment called Fecal Microbiota Transplant (FMT) to the usual treatment delay the growth or spread of cancer better than the usual treatment alone? FMT…
- Trial name
- LUNA-2 (NCT07890493)
- Testing
- LND101, Carboplatin, Pemetrexed
- Volunteers
- 160 people
- Sponsor
- Canadian Cancer Trials Group
Respiratory Tract Infections, Bronchiolitis Obliterans
Steroids, Azithromycin, Montelukast, and Symbicort (SAMS) for Viral Respiratory Tract Infection Post Allotransplant
For many patients with blood cancers, stem cell transplantation from a family member or from an unrelated donor remains the only potentially curative option.
- Conditions
- Respiratory Tract Infections, Bronchiolitis Obliterans, Cryptogenic Organizing Pneumonia, Lung Diseases, Interstitial
- Trial name
- NCT01432080
- Testing
- Prednisone, Azithromycin, Montelukast
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Pneumonia, Tetralogy of Fallot Correction
Bedside PEEP Selection in by Electrical Impedence Tomography During Mechanical Ventilation in Children
This prospective study evaluates the feasibility and safety of using Electrical Impedance Tomography (EIT) to guide PEEP selection in mechanically ventilated infants and toddlers under 3 years of age.
- Conditions
- Pneumonia, Tetralogy of Fallot Correction, Caustics Ingestion, Orthotopic Liver Transplantation
- Trial name
- BePeSEIT (NCT07319624)
- Testing
- Electrical Impedence Tomography
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Papa Giovanni XXIII Hospital
Idiopathic Pulmonary Fibrosis
Impact of Pre-transplant Anti-fibrotic Therapy for IPF Upon Lung Transplant Outcomes
Two oral medications, nintedanib and pirfenidone, were approved simultaneously by the FDA in October 2014 for the treatment of this disease.
- Trial name
- IPF-LTOS (NCT04316780)
- Testing
- Retrospective observational study- no intervention to occur.
- Where
- 8 sites in United States
- Volunteers
- 320 people
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Cystic Fibrosis
Needs in Education for Pulmonary or Cardiopulmonary Transplanted Cystic Fibrosis Patients
Main objective : This project aims to assess the educational needs of patients who received a lung transplantation or a simultaneous heart-lung transplantation for mucoviscidosis.
- Trial name
- NCT01285895
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Nantes University Hospital
Small Cell Lung Cancer
Autologous SCT Followed by Dendritic Cell p53 Vaccination in Patients With Limited Stage Small Cell Lung Cancer
The purpose of this study is to determine whether p53 vaccination followed by high dose chemotherapy and autologous HCT and T cell therapy significantly induces immune responses resulting in 1-year survival greater that the…
- Trial name
- NCT00776295
- Testing
- Combined adenovirus vectored p53 tranfected dedritic cell vaccine and ex vivo expanded T-lymphocytes
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Chronic Rejection of Lung Transplant
Advanced Immunoclinical Phenotyping of Rejection in Lung Transplant
Chronic allograft rejection of the transplanted lung (CLAD) is a major health issue in patients after lung transplant. This study is a registry-forming study with concurrent tissue banking from surveillance bronchoscopy in…
- Trial name
- NCT03697395
- Testing
- Lung transplant recipient without MRI imaging, Lung transplant recipient with MRI imaging
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- University of Virginia
Chronic Graft-versus-host-disease
Ibrutinib Plus Rituximab for cGVHD Following Allo-SCT
Allogeneic stem cell transplant is used to treat a variety of blood cancers. However, graft-versus-host disease (GVHD) is a common condition that may occur after transplant.
- Trial name
- NCT03689894
- Testing
- Ibrutinib, Rituximab
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Dartmouth-Hitchcock Medical Center