Clinical trials: Transplantation Lung
Lung Transplant, Ex Vivo Lung Perfusion
TorEx Lung Perfusion System
Lung transplantation is a life-saving and life-prolonging therapy for patients with end-stage lung disease. However, the number of patients listed for lung transplantation exceeds the number of available donor lungs, leading to…
- Trial name
- NCT05656404
- Testing
- TorEx Lung Perfusion System
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Lung Transplantation, Bronchiolitis Obliterable Syndrome
Safety and Efficacy of Inhaled Alpha-1 Antitrypsin in Preventing Bronchiolitis Obliterable Syndrome in Lung Transplant Recipients
Bronchiolitis obliterable syndrome (BOS) is the most common cause of death in long-term survivors after lung transplantation and refractory to most interventions.
- Trial name
- NCT01394835
- Testing
- Alpha -1 Antitrypsin, Alpha-1 Antitrypsin, AAT
- Volunteers
- 40 people
- Sponsor
- Rabin Medical Center
COVID-19 Pandemic, Transplant-Related Disorder
EVALUATION OF DIFFERENT PROPHYLACTIC INTERVENTIONS TOWARD COVID-19 IN SOLID ORGAN TRANSPLANT PATIENTS
The goal of this observational study is to evaluate the immune response after COVID-19 vaccination in Liver(LT) and Kidney(KT) transplant recipient.
- Trial name
- NCT05629923
- Testing
- tixagevimab-cilgavimab(AZD7442, AstraZeneca)
- Where
- Italy
- Volunteers
- 306 people
- Sponsor
- University of Rome Tor Vergata
Immune Mediated Anemia, Immune Mediated Thrombocytopenia
Using Fostamatinib to Treat Post-Hematopoietic Stem Cell Transplant Immune-mediated Cytopenias
Background: People who have a blood stem cell transplant can sometimes develop cytopenia. This means that their levels of one or more types of blood cell, such as the red cells or platelets, are lower than they should be.
- Conditions
- Immune Mediated Anemia, Immune Mediated Thrombocytopenia, Chronic GVHD
- Trial name
- NCT05502783
- Testing
- fostamatinib
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Congenital Heart Disease, Heart Failure
The PAtients pResenTing With COngenital HeaRt DIseAse Register (ARTORIA-R)
Advances in surgical and medical care have led to improved outcomes in patients with congenital heart disease (CHD). As a consequence, the majority of patients nowadays survives to adulthood (adults with CHD, that is, adult CHD…
- Conditions
- Congenital Heart Disease, Heart Failure, Transplant; Complication, Failure, Arrythmia
- Trial name
- ARTORIA-R (NCT04848844)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Sickle Cell Disease, Chronic Kidney Diseases
Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic Conditions
The purpose of this study is to test the efficacy of a peer support coaching intervention to improve activated chronic illness self-management versus an attention control group in 225 adolescents and young adults with childhood…
- Conditions
- Sickle Cell Disease, Chronic Kidney Diseases, Systemic Lupus Erythematosus, Childhood Cancer
- Trial name
- PiCASO (NCT03938324)
- Testing
- PiCASO Intervention Group
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- Duke University
Lung Transplantation, Extracorporeal Membrane Oxygenation (ECMO)
Prospective Observational Pilot Study of LMWH Versus UFH as ECMO Anticoagulation in Lung Transplantation
The aim of this observational pilot study is to evaluate the effectiveness and safety of low-molecular-weight heparin (LMWH) compared to unfractionated heparin (UFH) as anticoagulation in perioperative ECMO during bilateral lung…
- Conditions
- Lung Transplantation, Extracorporeal Membrane Oxygenation (ECMO), Anticoagulants and Bleeding Disorders
- Trial name
- LUX-ET-LT (NCT06868823)
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital, Motol
Lung Cancer
Microbiota Transplant in Advanced Lung Cancer Treated With Immunotherapy
The gut microbiota can modulate the effectiveness of cancer therapies, especially immunotherapy. Manipulating the microbial populations in patients with advanced lung cancer through fecal microbiota transplantation from healthy…
- Trial name
- NCT04924374
- Testing
- Microbiota Transplant plus anti PD1 therapy, anti PD1 therapy
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Post-Lung Transplantation Bronchiectasis
Lung Ultrasound Artefact Analysis for Exclusion of Acute Rejection in Lung Transplant Recipients
This study is being done to study a safe and non-invasive way to diagnose lung rejection and infection.
- Trial name
- NCT04582279
- Testing
- Lung ultrasound
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Transplantation
Vaccines Immunogenicity in Renal, Hepatic, Cardiac or Pulmonary Transplanted Children
Thanks to improved surgical techniques, postoperative management and immunosuppressive therapies, an increasing number of children benefit from renal, hepatic, cardiac and pulmonary transplantation.
- Trial name
- COVAGREF (NCT03180359)
- Testing
- Recommended vaccine scheme according to French Vaccine Schedule 2015
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Hospices Civils de Lyon
Interstitial Fibrosis/Tubular Atrophy of Transplanted Kidneys
Magnetic Resonance Elastography of Transplanted Kidney (GREFFE_ELASTO IRM)
: GREFFE_ELASTO IRM will evaluate Magnetic Resonance Elastography (MRE) in renal transplant patients with suspected interstitial fibrosis/tubular atrophy lesions requiring biopsy graft sampling under ultrasound control.
- Trial name
- NCT03918161
- Testing
- MRE exam
- Where
- France
- Volunteers
- 73 people
- Sponsor
- University Hospital, Bordeaux
Hematopoietic Stem Cell Transplantation, Aerobic Exercise
Effects of Upper Extremity Aerobic Exercise Training in Hematopoietic Stem Cell Transplantation Recipients
Hematologic malignancy is a tumor of myeloid or lymphatic cells that affects lymph nodes with the involvement of blood, bone marrow or other organs.There are various treatment options for hematological malignancies ranging from…
- Trial name
- NCT03007602
- Testing
- Upper Extremity Aerobic Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gazi University
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia
Umbilical Cord Blood Transplant With Added Sugar and Chemotherapy and Radiation Therapy in Treating Patients With Leukemia or Lymphoma
This phase II trial studies how well an umbilical cord blood transplant with added sugar works with chemotherapy and radiation therapy in treating patients with leukemia or lymphoma.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia, Acute Leukemia, Acute Lymphoblastic Leukemia
- Trial name
- NCT03096782
- Testing
- Anti-Thymocyte Globulin, Busulfan, Clofarabine
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- M.D. Anderson Cancer Center
Kidney Transplantation, Transplantation
Pre-transplant Assessment of Tacrolimus Blood Level Concentration, as a Predictor of Tacrolimus Dose Requirements After Kidney Transplantation
The purpose of this study is to evaluate two groups of kidney transplant recipients, to determine the proportion of patients that achieve therapeutic blood concentrations of tacrolimus by Day 3 after transplantation.
- Trial name
- NCT00297310
- Testing
- tacrolimus
- Volunteers
- 89 people
- Sponsor
- Janssen-Cilag Pty Ltd
Lung Diseases, Transplant-Related Disorder
Quantra® System With the QPlus® Cartridge in Double-lung Transplantation
Transfusion in lung transplantation is common, and despite improved techniques and limitations in the use of mechanical circulatory support (MCS), the incidence of massive transfusion has remained stable over the years.
- Trial name
- QUANTRANS (NCT05798286)
- Testing
- Quantra, Control
- Where
- France
- Volunteers
- 128 people
- Sponsor
- Hopital Foch
Lung Transplant; Complications
Trial Comparing Immediate Versus Extended Release Tacrolimus; Reducing Calcineurin Inhibitor Related Toxicity in Lung Transplantation Patients
Lung transplantation is a life-saving option in patients with end-stage lung disease. The introduction of calcineurin inhibitors has significantly improved long-term outcome in lung transplantation.
- Trial name
- REVOLUTION (NCT05001074)
- Testing
- Extended release tacrolimus, Immediate release tacrolimus
- Where
- Netherlands
- Volunteers
- 145 people
- Sponsor
- Heleen Grootjans
Lung Transplant, Chronic Allograft Rejection
Mechanisms of Lung Allograft Rejection
This study will explore the ways in which lung transplants are rejected. A series of experiments will evaluate the differences in airway gene expression.
- Trial name
- NCT00340418
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Lung Transplantation, Inspiratory Muscle Training
The Effects of IMT on Physical Activity and Quality of Life in LTx Candidates
Inspiratory Muscle Training (IMT), which is used to strengthen the respiratory muscles, is one of the techniques used in PR. It is mostly used in patients with chronic obstructive pulmonary disease, and has been shown to be…
- Trial name
- NCT03584620
- Testing
- Inspiratory muscle training, Pulmonary rehabilitation
- Volunteers
- 34 people
- Sponsor
- Istanbul Medipol University Hospital
Chronic Graft Versus Host Disease
Multiple Donor Treg DLI for Severe Refractory Chronic GVHD
This is a INTERVENTIONAL TRANSPLANTATION STUDY WITHOUT DRUGS. The INTERVENTION is represented by the INFUSION of DONOR T REGULATORY CELL-ENRICHED LYMPHOCYTES to PATIENTS suffering from REFRACTORY CHRONIC GVHD after ALLOGENEIC…
- Trial name
- TREG2015001 (NCT02749084)
- Testing
- T reg DLI
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Mario Arpinati
Post-operative Pain Management
Intercostal Cryoanalgesia in Double Lung Transplant Recipients
This study is testing a new way to help manage pain after a double lung transplant. Instead of relying only on strong pain medicines like opioids, doctors will use a cold-therapy probe during surgery to help numb the nerves near…
- Trial name
- NCT07281118
- Testing
- Atricure CryoSPHERE MAX Probe
- Where
- 3 sites in United States
- Volunteers
- 148 people
- Sponsor
- University of California, Los Angeles