Clinical trials: Transposition of Great Vessels
Transposition of Great Vessels
Influence of Timing of Switch Operation in Transposition of Great Arteries
Transposition of great vessels are usually corrected by an arterial switch operation. This operation is often done during the first week of life as surgical delays lead to deconditioned left ventricle.
- Trial name
- NCT05160116
- Where
- Belgium
- Volunteers
- 151 people
- Sponsor
- Brugmann University Hospital
Transposition of Great Vessels, Outcome, Fatal
Outcomes of Transposition of the Great Arteries After Arterial Switch Operation
Transposition of the great arteries (TGA) is a complex cyanotic congenital heart disease and patients suffer from a high mortality rate within one year of age without appropriate management.
- Trial name
- NCT05089773
- Testing
- The arterial switch operation
- Where
- 2 sites in China
- Volunteers
- 1,281 people
- Sponsor
- Children's Hospital of Fudan University
Congenital Heart Disease, Congenital Heart Defect
Characterization of the Cardiac Reinnervation of Patients With Transposition of the Great Arteries Long After Repair With the Arterial Switch Operation. Correlation With Electrocardiographic and Exercise Test Parameters
Cardiac denervation is inherent to the arterial switch (ASO) technique for the repair of transposition of the great arteries (TGA) and the long term reinnervation process has not been studied.
- Conditions
- Congenital Heart Disease, Congenital Heart Defect, Transposition of the Great Arteries
- Trial name
- NCT03469843
- Testing
- Non intervention
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Heart Defects, Congenital, Transposition of Great Vessels With Ventricular Inversion
Effect of Phosphodiesterase-5 Inhibition With Tadalafil on SystEmic Right VEntricular Size and Function
This study assesses in a double-blind, randomized, placebo-controlled multi-center pilot trial the effect of PDE-5 inhibition with Tadalafil on right ventricle size and function, exercise capacity and neurohumoral activation in…
- Trial name
- SERVE (NCT03049540)
- Testing
- Tadalafil 20 MG
- Where
- 7 sites in Austria, Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Transposition of the Great Arteries, Artery Switch Operation
Cardiovascular MRI and Cardiopulmonary Exercise Capacity After Neonatal ASO) in Young Adults
Magnetic Resonance Imaging of the heart at rest and stress conditions relative to the cardiopulmonary exercise capacity in young adults after neonatal surgery for transposition of the great arteries.
- Trial name
- ASO (NCT02415491)
- Testing
- Correlation Heart Magnetic Resonance Imaging at rest and stress with Cardiopulmonary stress test
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- RWTH Aachen University
Coarctation of the Aorta, Tetralogy of Fallot
Haemodynamics and Function of the Atria in Congenital Heart Disease by Cardiovascular Magnetic Resonance
The purpose of this study is to determine whether patients with repaired congenital heart disease show differences in size or function of their heart atria compared to normal controls and depending on the nature of their heart…
- Conditions
- Coarctation of the Aorta, Tetralogy of Fallot, Transposition of the Great Arteries
- Trial name
- NCT02161471
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Congenital Heart Disease, Cyanotic Congenital Heart Disease
Prenatal Maternal Mental Health and Neurodevelopment in Congenital Heart Disease
Congenital heart disease (CHD) is the leading cause of congenital malformations, representing 1% of live births. Progress in surgical care have led to the dramatic increase in the population of children and adults living with…
- Conditions
- Congenital Heart Disease, Cyanotic Congenital Heart Disease, d-Transposition of the Great Arteries, Hypoplastic Left Heart Syndrome
- Trial name
- Neuro-Moms (NCT06711666)
- Where
- 5 sites in France
- Volunteers
- 174 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Tetralogy of Fallot (TOF), Pulmonary Stenosis
Investigation of Tetralogy of Fallot in Neonates
Child health serves as the foundation for overall public health, with neonatal mortality recognized globally as a comprehensive indicator of national health standards and societal advancement.
- Conditions
- Tetralogy of Fallot (TOF), Pulmonary Stenosis, Ventricular Septal Defects (VSD), Double Outlet Right Ventricle
- Trial name
- RIFAN (NCT06822400)
- Testing
- corrective surgery within 28 days of birth, corrective surgery between 3-6 months of age
- Where
- 5 sites in China
- Volunteers
- 160 people
- Sponsor
- Beijing Anzhen Hospital
Right Ventricular Hypertrophy, d-TGA
Right Ventricular Hypertrophy After Atrial Switch and Cardiovascular Magnetic Resonance (CMR) Findings
Systemic RV hypertrophy and impaired systolic function occur after atrial switch (AS) in d-transposition of the great arteries (d-TGA). Echocardiography has limitation in the assessment of the right ventricle (RV).
- Trial name
- NCT01430897
- Where
- Germany
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Heart Septal Defects, Ventricular, Double Outlet Right Ventricle, Noncommitted VSD
A Randomized Controlled Trial:Treatments on Infundibular Ventricular Septal Defect
The purpose of this study is to investigate the security and validity of transesophageal echocardiography(TEE)-guided perventricular device closure(TPDC) through minithoracotomy in treatment of infundibular ventricular septal…
- Conditions
- Heart Septal Defects, Ventricular, Double Outlet Right Ventricle, Noncommitted VSD, Double Outlet Right Ventricle, Subaortic VSD, Double Outlet Right Ventricle, Subpulmonary VSD
- Trial name
- NCT02361008
- Testing
- TEE-guided perventricular device closure without CBP, Surgery repair with CBP
- Where
- China
- Volunteers
- 20,121,212 people
- Sponsor
- Bentong Yu
Transposition of the Great Vessels, Hypoplastic Left Heart Syndrome
Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study)
The purpose of the Oxy-CAHN study is to improve the monitoring capabilities of newborn infants recovering from congenital heart surgery.
- Conditions
- Transposition of the Great Vessels, Hypoplastic Left Heart Syndrome, Oxygen Consumption Based Assessment of Hemodynamics
- Trial name
- Oxy-CAHN (NCT02184169)
- Testing
- General Electric Healthcare E-COVX Gas Monitoring Module for VO2 Measurments, Edwards Continuous SVO2 Catheter and Monitoring System - 4.5 fr
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Boston Children's Hospital
Heart Defects, Congenital, Transposition of Great Vessels
Hypertonic Saline Dextran in Pediatric Cardiac Surgery
The purpose of this study is to determine whether infusion of hypertonic saline dextran attenuates the inflammatory response and the water overload, during and after major cardiac surgery in small children.
- Conditions
- Heart Defects, Congenital, Transposition of Great Vessels, Heart Septal Defects, Ventricular, Endocardial Cushion Defects
- Trial name
- NCT00199771
- Testing
- 7.5% NaCl in 6% dextran 70 solution
- Volunteers
- 14 people
- Sponsor
- Oslo University Hospital
Transposition of Great Vessels
Late Function After Surgery for Transposition of the Great Arteries
The investigators proposed to review the exercise tolerance, cardiac function, and quality of life in patients born with transposition of the great arteries that have undergone surgery with either the Mustard or Senning…
- Trial name
- NCT03078413
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Indiana University
Congenital Heart Defect, Single-ventricle
NIRS in Congenital Heart Defects - Correlation With Echocardiography
Neonatal patients with congenital heart defects (CHD) have changing physiology in the context of transitional period. Patients with CHD are at risk of low perfusion status or abnormal pulmonary blood flow.
- Conditions
- Congenital Heart Defect, Single-ventricle, Coarctation of Aorta, Atrioventricular Canal
- Trial name
- NCT04106479
- Testing
- NIRS evaluation
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Transposition of Great Vessels
A Retrospective Comparison of the Efficacy and Safety of Celsior® in Pediatric Cardiac Surgery for Transposition of the Great Vessels
Celsior® is an organ preservation solution used for the harvesting and the preservation of solid organs. Its use as a crystalloid cardioplegia solution has been established recently.
- Trial name
- CELSIOR-TGV (NCT04616222)
- Testing
- CELSIOR® group, Saint-Thomas group
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
Transposition of Great Vessels
Physical Training in Transposition of the Great Arteries
In transposition patients after atrial switch operation, the morphological right ventricle serves as the systemic ventricle. These patients often develop signs of heart failure.
- Trial name
- TrainingTGA (NCT00837603)
- Testing
- Training
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Hannover Medical School
Transposition of the Great Arteries, Tetralogy of Fallot
A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and Pharmacokinetics
The purpose of this Phase I study is to determine the safety of a drug called dexmedetomidine (DEX) as part of a balanced general anesthetic and sedative strategy for neonates and infants undergoing corrective cardiac surgery…
- Conditions
- Transposition of the Great Arteries, Tetralogy of Fallot, Ventricular Septal Defect
- Trial name
- NCT01915277
- Testing
- Dexmedetomidine
- Where
- 4 sites in United States
- Volunteers
- 119 people
- Sponsor
- Carelon Research
Double Outlet Right Ventricle
Surgical Planning for Reconstruction of Complex Heart Defects
The purpose of this study is to utilize cardiac imaging data acquired as part of the standard of care for these patients, such as MRI, 3D echo, and CT, and existing 3D reconstruction protocols to assess the feasibility of using…
- Trial name
- NCT00972608
- Testing
- Anatomic Reconstruction and Surgical Planning
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- Emory University
Congenital Heart Disease, Hypoplastic Left Heart Syndrome
Genetic Determinants of Congenital Heart Disease Outcomes
The purpose of this study is to examine the role of genetic variation in the oxidative stress response on critical perioperative and short-term outcomes after neonatal heart surgery.
- Conditions
- Congenital Heart Disease, Hypoplastic Left Heart Syndrome, Hypoplastic Right Heart Syndrome, d-Transposition of the Great Arteries
- Trial name
- GECHO (NCT01656941)
- Where
- 5 sites in United States, Australia
- Volunteers
- 250 people
- Sponsor
- University of Michigan
Great Vessels Transposition Surgery
Measurement of the Prevalence of Sensory Integration Disorders in Babies Having Heart Disease Surgery for Transposition of the Great Vessels Before 6 Months of Age
The purpose of this study is to mesure the prevalence of severe sensory integration disorders in babies after one week of their heart surgery.
- Trial name
- SENSOCOEUR (NCT05137873)
- Testing
- Dunn-2 infant Sensory Profile (PS2-N)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris