Clinical trials: Trauma Induced Coagulopathy
Trauma
Pragmatic, Randomized Optimal Platelet and Plasma Ratios
Pragmatic, Randomized, Optimal Platelet and Plasma Ratios (PROPPR)is a Phase III trial designed to evaluate the difference in 24-hour and 30-day mortality among subjects predicted to receive massive transfusion ([MT] (defined as…
- Trial name
- PROPPR (NCT01545232)
- Testing
- 1:1:1 Blood Transfusion Ratio, 1:1:2 Blood Transfusion Ratio
- Where
- 12 sites in United States, Canada
- Volunteers
- 680 people
- Sponsor
- The University of Texas Health Science Center, Houston
Wounds and Injuries, Acute Coagulopathy
Rapid Administration of Blood by HEMS in Trauma
Trauma is a leading cause of death among people younger than 44 years. Five million people worldwide die from trauma annually. Uncontrolled haemorrhage causing traumatic-haemorrhagic shock (THS) is the leading cause of…
- Conditions
- Wounds and Injuries, Acute Coagulopathy, Trauma
- Trial name
- RABBIT (NCT03522636)
- Where
- 2 sites in Czechia
- Volunteers
- 100 people
- Sponsor
- Zdravotnicka Zachranna Sluzba Kralovehradeckeho Kraje
Multiple Trauma, Massive Bleeding
Evaluation of the TICCS Capacity to Identify Trauma Patients With Acute Coagulopathy and Massive Bleeding
A prospective single-centre non-comparative non-interventional open study has been designed to validate, in a target number of 100 trauma patients, the correlation between TICCS evaluated on the site of injury and…
- Conditions
- Multiple Trauma, Massive Bleeding, Early Complication of Trauma
- Trial name
- NCT02132208
- Where
- Belgium
- Volunteers
- 82 people
- Sponsor
- Centre Hospitalier Régional de la Citadelle
Trauma Injury, Trauma
Trauma Induced Coagulopathy and Inflammation
While a number of factors are known to be associated with the development of trauma induced coagulopathy (TIC), inflammation, and multi-organ failure, we currently cannot predict which patients are at risk for developing these…
- Conditions
- Trauma Injury, Trauma, Coagulopathy
- Trial name
- TrICI (NCT03128658)
- Testing
- Thromboelastography, Computational model
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Pennsylvania
Scoliosis, Spinal Deformity
Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations
Improving the anesthesiology management for surgical correction of spinal deformations with introducing the diagnostic methods and treatment strategy of acute pain, preventing the evolution of chronic pain.
- Conditions
- Scoliosis, Spinal Deformity, Acute Pain, Chronic Pain
- Trial name
- BBESPB (NCT04697498)
- Testing
- Bilateral bi-level Erector spine plane block, General anaesthesia
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Lviv National Medical University
Snakebite, Coagulopathy, Consumption
Waveform Analysis In Snakebite Victims With Hematotoxicity
In hematotoxic snakebites, due to the lack of a better alternative, 20 minute whole blood clotting test (20'WBCT) or Clotting time remains the standard test in developing countries even though its reliability and sensitivity has…
- Trial name
- WISH (NCT03859154)
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Trauma Induced Coagulopathy, Trauma Coagulopathy
Point of Care Fibrinogen Measurement in Trauma Patients in the Emergency Department
Background: Why This Study Matters When someone suffers a severe injury (like from a car crash), they can bleed heavily. One complication doctors often face is something called Trauma-Induced Coagulopathy (TIC).
- Conditions
- Trauma Induced Coagulopathy, Trauma Coagulopathy, Fibrinogen Deficiency, Fibrinogen; Deficiency, Acquired
- Trial name
- POCFIB (NCT07097337)
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Erasmus Medical Center
Sepsis - to Reduce Mortality in the Intensive Care Unit, Trauma Coagulopathy
ROTEM in Sepsis Trauma Outcome in Intensive Care
This prospective observational study aims to investigate the ability of advanced ROTEM analysis using Principal Component Analysis (PCA) to detect early signs of disseminated intravascular coagulation (DIC) and trauma-induced…
- Trial name
- ROSTIC (NCT06891599)
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Region Stockholm
Trauma Induced Coagulopathy
Mitochondrial Dysfunction in Trauma-related Coagulopathy
Bleeding control often poses a great challenge for clinicians due to trauma-induced blood clotting disorder (TIC), a condition that is present in one-third of bleeding trauma patients.
- Trial name
- NCT05004844
- Testing
- Viscoelastic assays and aggregometry tests
- Where
- Hungary
- Volunteers
- 40 people
- Sponsor
- Petra Hartmann MD Ph.D.
Peripheral Venous Catheter Complications, Occlusion
Heparin 100U/L for Prevention of PVC Complications
Flushes with saline solution are used for maintaining patency of peripheral intermittent intravenous catheters in many institution based on the results of previous studies showing that 10 U heparin/mL is not better than saline in…
- Conditions
- Peripheral Venous Catheter Complications, Occlusion, Phlebitis, Ecchymosis
- Trial name
- NCT01131754
- Testing
- heparin 100U/L flushes
- Where
- Italy
- Volunteers
- 214 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Snake Envenomation, Thrombi
Effects of Bothrops Spp. Snake Envenomation on Willebrand Factor Activity in Martinique and French Guiana
In 2017, the World Health Organization placed snakebites at the top of its list of neglected tropical diseases in an effort to facilitate funding for prevention programs, improve access to anti-venom, and stimulate new research…
- Conditions
- Snake Envenomation, Thrombi, Coagulopathy, Hemorrhage
- Trial name
- WBOTHROPS (NCT06304714)
- Testing
- Patients suffering from envenomation by Bothrops
- Where
- Martinique
- Volunteers
- 30 people
- Sponsor
- University Hospital Center of Martinique
Trauma Coagulopathy
Viscoelastic Tests (VET) Versus Conventional Coagulation Tests (CCT) for Management of Trauma-Induced Coagulopathy
Traumatic coagulopathy is a complex, multifactorial event that occurs in 20-30% of patients on admission. It increases mortality, and its treatment is one of the main priorities in the early management of severely injured…
- Trial name
- VISCOTAC (NCT06820879)
- Testing
- Viscoelastic Tests (ROTEM)
- Where
- 7 sites in France
- Volunteers
- 316 people
- Sponsor
- Hospices Civils de Lyon
Major Trauma
RETIC Trial: Reversal of Trauma Induced Coagulopathy Using Coagulation Factor Concentrates or Fresh Frozen Plasma
Severe traumatized patients (ISS > 15) admitted to emergency department (ED) University Hospital Innsbruck with obvious bleeding and/or who are at risk for significant hemorrhage will be screened by rotational thrombelastometry…
- Trial name
- NCT01545635
- Testing
- Fibrinogen concentrate, Prothrombin complex concentrate and FXIII concentrate, Fresh Frozen Plasma blood type 0, A, B and AB
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University Innsbruck
Trauma-induced Coagulopathy
An Observational Study of Early Coagulopathy, or Clotting Disorder, in Injured Patients
Trauma continues to be the major killer of young Americans, mainly due to hemorrhage or brain injury. In trauma centers, up to a quarter of these severely injured patients arrive with a coagulopathy and thereby experience an…
- Trial name
- NCT00744003
- Where
- United States
- Sponsor
- Emory University
Early Trauma Induced Coagulopathy, Tic
The Incidence of Early Trauma Induced Coagulopathy and Hyperfibrinolysis in Severely Injured Trauma Patients in the Emergency Room: a Retrospective Cohort Study
The aim of this study is to quantify the incidence of eTIC (defined as an elevated appt) and hyperfibrinolysis (defined as Ly30>7) in early trauma patients.
- Trial name
- eTIC (NCT07186712)
- Where
- Austria
- Volunteers
- 263 people
- Sponsor
- Medical University of Graz
Trauma Induced Coagulopathy
Pre-hospital Administration of Fibrinogen in Trauma-Induced Coagulopathy
A prospective, randomized controlled trial of fibrinogen concentrate (FC) plus standard of care versus standard of care alone in adult trauma patients with major bleeding or presumed major bleeding is developed to evaluate the…
- Trial name
- PAF-TIC (NCT06582420)
- Testing
- Fibrinogen concentrate, Standard trauma care
- Volunteers
- 52 people
- Sponsor
- Unidade Local de Saude do Arco Ribeirinho
Abdominal Injuries, Wounds and Injuries
Predictors of In-Hospital Mortality in Severe Abdominal Trauma
Severe abdominal trauma is a leading cause of early death from bleeding and of later death from sepsis and organ failure. Clinicians use scoring systems to estimate the risk of dying, but most of these scores were developed and…
- Conditions
- Abdominal Injuries, Wounds and Injuries, Wounds, Nonpenetrating, Wounds, Penetrating
- Trial name
- NCT07843628
- Where
- Egypt
- Volunteers
- 430 people
- Sponsor
- Minia University
Snake Bites, Coagulopathy, Consumption
Hemostatic Variables In Snakebite Study
Background Novelty The global assays of coagulation, namely the viscoelastometric tests and clot waveform has never been studied in detail before in snakebite victims.
- Trial name
- HISS (NCT04520282)
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Major Trauma, Traumatic Brain Injury
Severe Trauma Registry in Tarragona
Severe trauma is one of the leading causes of morbidity, mortality, and disability worldwide. Currently, it is the primary cause of death among individuals under 45 years of age.
- Trial name
- IcuTrauma (NCT06007807)
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Hospital Universitari Joan XXIII de Tarragona.
Trauma, Multiple, Coagulopathy
Use of Viscoelastic Tests in the Treatment of Traumatic Induced Coagulopathy: a Pragmatic Randomized Clinical Trial.
Trauma is the leading cause of death in young people. Trauma-induced coagulopathy (TIC) encompasses several aspects of traumatic bleeding.
- Conditions
- Trauma, Multiple, Coagulopathy, Massive Hemorrhage
- Trial name
- VISCOTRAUMA (NCT03380767)
- Testing
- Trauma-induced coagulopathy treatment
- Where
- Italy
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII