Clinical trials: Trauma Splenic
Quality of Life, Spleen Injury
Traumatic Splenic Injury and Management (SPLENIQ Study)
OBJECTIVE: To determine the quality of life (QOL) and clinical outcome after conservative therapy, embolization (proximal versus distal) or surgery in patients with traumatic splenic injury.
- Conditions
- Quality of Life, Spleen Injury, Trauma, Splenic Artery Embolization
- Trial name
- SPLENIQ (NCT03099798)
- Testing
- Questionnaires, MRI abdomen
- Where
- 10 sites in Netherlands
- Volunteers
- 106 people
- Sponsor
- Elisabeth-TweeSteden Ziekenhuis
End Stage Liver Disease, Jaundice
SSM Predicts Outcomes of CLD Inpatients With Acute Liver Injury
In this study, a single non-invasive tool, spleen stiffness measurement (SSM), was used to monitor the disease regression of inpatients with chronic liver disease (CLD) and acute liver injury.
- Conditions
- End Stage Liver Disease, Jaundice, Liver Dysfunction, Portal Hypertension
- Trial name
- NCT06173947
- Testing
- FibroScan® Expert 630
- Where
- China
- Volunteers
- 411 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Trauma
Prospective Evaluation of Spleen Injury Treatments in Languedoc Roussillon
Descriptive, prospective, multicenter evaluation of spleen injury treatment in the Languedoc Roussilon region according to trauma severity, morbi-mortality and length of hospitalization.
- Trial name
- NCT01103999
- Where
- 12 sites in France
- Volunteers
- 93 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Wounds and Injuries
Splenic Injury Embolization - the Question About NOM (SInE Qua NOM)
The primary objective is to compare the failure rate due to splenic bleeding between the patients undergoing pre-emptive splenic arterial embolization (SAE) as part of non-operative management (NOM) and the patients not…
- Trial name
- NCT03231202
- Testing
- Embolization
- Where
- 12 sites in United States, Australia and 7 more
- Volunteers
- 224 people
- Sponsor
- Oslo University Hospital
Drug/Agent Toxicity by Tissue/Organ, Leukemia
Growth Factor to Prevent Oral Mucositis in Patients With Hematologic Cancer
RATIONALE: Keratinocyte growth factor may prevent symptoms of mucositis in patients receiving radiation therapy and chemotherapy.
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00004132
- Testing
- filgrastim, palifermin, cyclophosphamide
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Radiofrequency Can be Used to Treat Splenic Trauma Because of Its Excellent Coagulation Hemostasis
RF-assisted Splenic Preservation VS Conventional Treatment of Blunt Splenic Injury.
Radiofrequency (RF) can be used to treat splenic trauma because of its excellent coagulation hemostasis. This study aimed to compare the efficacy of RF-assisted spleen-preserving surgery with that of conventional…
- Trial name
- NCT03890328
- Testing
- radiofrequency ablation
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Southwest Hospital, China
Spleen Injury, Machine Learning
Deep Learning Algorithm for Traumatic Splenic Injury Detection and Sequential Localization
Spleen laceration is a lethal abdominal trauma and usually be diagnosed by medical images such as computed tomography. Deep learning had been proved its usage in detect abnormalities in medical images.
- Trial name
- NCT05643612
- Testing
- Deep learning algorithm
- Where
- Taiwan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Spleen Injury
Observation vs Embolization in Severe Splenic Injury: A Randomized Controlled Trial
Nonoperative management (NOM) of blunt splenic injuries has been the standard of care for decades. While many splenic injuries can be successfully observed, studies have demonstrated increased failure rates for higher grade…
- Trial name
- NCT05008172
- Testing
- Splenic Artery Embolization
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Medical College of Wisconsin
Blunt Injuries
Nonoperative Management Protocol in Patients With Blunt Splenic Injuries
This study was designed to explore the adverse events and associated risk factors before and after protocol-based NOM of BSI over a 12-year period in our institution.
- Trial name
- NCT03943355
- Testing
- Patient before cohort (2005-2010), Patient after cohort (2011-2016)
- Volunteers
- 399 people
- Sponsor
- Chang Gung Memorial Hospital
Gut Microbiota, Spleen Injury
Microbiota is Related With Increasing Infection Rates After Splenectomy
Studies has shown an increasingly infection rate after splenectomy, and there is a potential correlation between microbiota and immune system.
- Conditions
- Gut Microbiota, Spleen Injury, Infection
- Trial name
- NCT03420599
- Testing
- splenectomy
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Intracerebral Hemorrhage (ICH), Hemorrhagic Stroke, Intracerebral
Spleen Volume Change Predicts 45-Day Mortality in Neurocritical Care: A Prospective Cohort Study
This study investigates whether changes in spleen size over 72 hours can help predict the risk of death within 45 days in patients who were admitted to the emergency department with a type of bleeding in the brain called…
- Conditions
- Intracerebral Hemorrhage (ICH), Hemorrhagic Stroke, Intracerebral, Neurocritical Care, Acute Brain Injury
- Trial name
- SCOPE (NCT07132996)
- Testing
- POCUS-based Splenic Volume Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Ankara City Hospital Bilkent
Trauma, Spleen Injury
Splenic Embolisation Decisions
The spleen is often injured when the body sustains trauma. This leads to bleeding. The bleeding can be stopped by a big operation cutting open the belly or a small hole in your groin where a blood vessel can be accessed and…
- Trial name
- SPEED (NCT06334263)
- Where
- United Kingdom
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University Hospital Plymouth NHS Trust
High-grade Splenic Injuries
Embolization of the Splenic Artery After Trauma
Our aim is to conduct a multi-center, Bayesian, randomized clinical trial to evaluate the primary technical success of coils and vascular plugs for proximal splenic artery embolization in the setting of high-grade splenic trauma.
- Trial name
- ELSA-2 (NCT05128955)
- Testing
- Splenic artery embolization with vascular embolic coils or plugs
- Where
- 5 sites in United States
- Volunteers
- 180 people
- Sponsor
- Andrew J. Gunn
Asplenia
Immunologic Response to Pneumococcal Polysaccharide Vaccine in Splenic Injury Patients
Persons without a spleen are susceptible to potentially lethal infections from certain bacteria, with pneumococcus being the most prevalent.
- Trial name
- NCT02232191
- Testing
- Pneumovax-23
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of California, Davis
Trauma to the Spleen
Embolization in Splenic Trauma
Randomized, prospective, feasibility study to begin evaluating the efficacy, safety, and cost of using either coils or vascular plugs (VPs) for proximal splenic artery embolization in the setting of traumatic splenic injury.
- Trial name
- ELSA (NCT03613454)
- Testing
- Splenic artery embolization with vascular embolic coils, Splenic artery embolization with vascular embolic plugs
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Alabama at Birmingham
Abdominal Injury, Pelvic Fracture
Developing a Decision Instrument to Guide Abdominal-pelvic CT Imaging of Blunt Trauma Patients
Unrecognized abdominal and pelvic injuries can result in catastrophic disability and death. Sporadic reports of "occult" injuries have generated concern, and physicians, fearing that they may miss such an injury, have adopted the…
- Conditions
- Abdominal Injury, Pelvic Fracture, Genital Hemorrhage, Lumbar Spine Injury
- Trial name
- NEXUS AP CT (NCT04937868)
- Testing
- There are no interventions associated with this study
- Where
- United States
- Volunteers
- 12,000 people
- Sponsor
- University of California, Los Angeles
Cardiac Toxicity, Chemotherapeutic Agent Toxicity
Cardiac Magnetic Resonance Imaging in Patients With Non-Hodgkin Lymphoma or Hodgkin Lymphoma Receiving Doxorubicin
RATIONALE: Diagnostic procedures, such as cardiac magnetic resonance imaging, may help doctors detect early changes in the heart caused by chemotherapy.
- Conditions
- Cardiac Toxicity, Chemotherapeutic Agent Toxicity, Lymphoma
- Trial name
- NCT00577798
- Testing
- contrast-enhanced magnetic resonance imaging
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Thrombosis of Portal Venous System.
Evaluation of Portal Venous System Thrombosis After Blunt Splenic Trauma Utilizing Doppler Ultrasound
The true incidence of thrombosis in the portal venous system after blunt splenic trauma is unknown and has not been elucidated in the medical literature.
- Trial name
- NCT01906983
- Testing
- Doppler Ultrasound
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Rambam Health Care Campus
Splenic Trauma
Benefit of Prophylactic Embolization of the Splenic Salvage
The main objective is to show that splenic embolization improves salvage rate at one month in a population of hemostatically stable closed splenic trauma patients with a high risk of splenectomy
- Trial name
- Splash (NCT02021396)
- Testing
- Embolization
- Where
- France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Grenoble
Splenic Injury
Treatment of Splenic Trauma: a Retrospective Cohort Study
In blunt trauma, the spleen is most frequent injured organ in the abdomen and the most frequent source of bleeding in the abdomen. Historically, splenectomy was the treatment of choice for splenic bleeding.
- Trial name
- NCT01965548
- Testing
- Treatment of splenic injury
- Where
- Norway
- Volunteers
- 109 people
- Sponsor
- University Hospital of North Norway