Clinical trials: Trauma and Stress-related Disorders
Nightmares, Stress Disorders, Post-Traumatic
Understanding Trauma Nightmares Using In-Home Measurement
Trauma-related nightmares in Veterans are associated with poor clinical outcomes, greater substance use, and increased risk of suicide.
- Conditions
- Nightmares, Stress Disorders, Post-Traumatic, Actigraphy, Respiratory Sinus Arrhythmia
- Trial name
- NCT03974503
- Testing
- Exposure, Relaxation, and Rescripting Therapy, Sleep and Nightmare Management
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Combination Treatment for Posttraumatic Stress Disorder (PTSD) After the World Trade Center (WTC) Attack
This randomized controlled trial evaluates efficacy of combined prolonged exposure (PE) and the selective serotonin reuptake inhibitor (SSRI) paroxetine in the treatment of survivors of the World Trade Center (WTC) attacks.
- Trial name
- NCT01130103
- Testing
- Paroxetine, Prolonged Exposure Therapy
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Posttraumatic Stress Disorder, Anxiety Disorder
Pilot Study of Pharmaceutical and Behavioral Interventions to Treat Anxiety Disorders
The aim of this project is to create fear conditioning paradigm within which the relative strengths of various novel pharmacological and behavioral interventions can be tested.
- Trial name
- NCT01631682
- Testing
- Propranolol, Reactivation, Mifepristone
- Where
- United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Post-Traumatic Stress Disorder
Neurobiological Correlates of Post Traumatic Stress Disorder (PTSD) During Rapid Eye Movement (REM) Sleep
The overarching aim of this Exploratory/Developmental Research Grant Award (R21) is to explore the neurobiological correlates of PTSD during REM sleep by using state-of-the science positron emission tomography (PET) sleep…
- Trial name
- REM-P (NCT00871650)
- Testing
- Sleep data recording, PET scan - waking, PET scan - REM Sleep
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Post-Traumatic Stress Disorder
Biopsychosocial Effectiveness of Exercise Trainings in Earthquake Survivors With Post-Traumatic Stress Disorder
In study, the investigators aim to demonstrate the effectiveness of biopsychosocial-based exercise approach in post-traumatic stress disorder of physiotherapists in post-earthquake disaster management.
- Trial name
- NCT06390618
- Testing
- Aerobic Exercise (AE) Group, Combined Exercise (CE) Group
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Erkin Oğuz SARI
PTSD
Precise Transcranial Magnetic Stimulation for Post-traumatic Stress Disorder
The purpose of this study is to investigate the efficacy and safety of repetitive transcranial magnetic stimulation under precise localization for post-traumatic stress disorder
- Trial name
- NCT05544110
- Testing
- Active transcranial magnetic stimulation
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Xijing Hospital
PTSD, Cardiac Arrest
Stellate Ganglion Blockade to Reduce Cardiac Anxiety and PTSD Symptoms in Cardiac Arrest Survivors
This is a pilot randomized controlled trial (RCT) to gain preliminary evidence regarding the acceptability, tolerability, safety, and efficacy of a combined intervention of Stellate Ganglion Blockade (SGB) and psychoeducation on…
- Conditions
- PTSD, Cardiac Arrest, Anxiety and Fear, Sleep Disturbance
- Trial name
- SGB-PsychoED (NCT04582396)
- Testing
- stellate ganglion block injection, Normal saline injection, Psychoeducation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Columbia University
Posttraumatic Stress Disorder
Study of Safety and Effects of MDMA-assisted Therapy for Treatment of PTSD
The purpose of this clinical trial is to learn if MDMA-assisted therapy is safe and effective in people with PTSD. The main question it aims to answer is: Do two open-label sessions of MDMA-assisted therapy reduce PTSD symptoms?…
- Trial name
- NUMCAP1 (NCT04968938)
- Testing
- midomafetamine, Therapy
- Sponsor
- Resilient Pharmaceuticals
Cardiotoxicity, Anthracycline Related Cardiotoxicity in Breast Cancer
ANTthracycline-induced Inflammation and OXidative Stress: 10-year Follow-up
The goal of this observational study is to learn about the long-term effects of anthracycline chemotherapy on inflammation, oxidative stress, and heart function in adult women with breast cancer.
- Conditions
- Cardiotoxicity, Anthracycline Related Cardiotoxicity in Breast Cancer, Breast Cancer
- Trial name
- ANTIOX-10 (NCT07680855)
- Volunteers
- 17 people
- Sponsor
- University of Chile
Post Traumatic Stress Disorder
A Head-to-head Comparison of Virtual Reality Treatment for Post Traumatic Stress Disorder
Therapy that uses Virtual Reality (VR) has been shown to help in the treatment of Post Traumatic Stress Disorder (PTSD). It is unclear what role the VR simulator itself plays in recovery.
- Trial name
- NCT00978484
- Testing
- Virtual Reality Exposure Therapy - Dynamic, Augmented Exposure Therapy
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- United States Naval Medical Center, San Diego
Violence, Depression
A Pilot Evaluation of the Pregnant Moms' Empowerment Program
This project will use a longitudinal design with assessments at baseline (T1), post-treatment (T2), 3 month post-partum (T3), 1 year postpartum (T4) and 3.5-5 years postpartum to examine whether the PMEP improves participants'…
- Conditions
- Violence, Depression, Posttraumatic Stress Disorder, Parenting
- Trial name
- NCT05011825
- Testing
- Pregnant Moms' Empowerment Program
- Where
- 2 sites in United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- University of Notre Dame
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health in Tavua, Fiji
Ambient air temperatures in Fiji are increasing due to climate change. Solutions are needed to build heat resilience in communities and adapt.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- NCT07592117
- Testing
- Cool roof
- Where
- Fiji
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
PTSD, Depression
Online and Shared Decision-Making Interventions to Engage Service Men and Women in Post-Deployment Mental Health Care
OEF/OIF/OND war Veterans have unique post-deployment care needs that the VA is striving to understand and address. Unfortunately, there is a significant disparity in utilization of mental health (MH) care and VA access as most…
- Conditions
- PTSD, Depression, Substance Use Disorder, Traumatic Brain Injury
- Trial name
- eSDM (NCT03539068)
- Testing
- WEB-ED+ Treatment Arm
- Where
- United States
- Volunteers
- 1,312 people
- Sponsor
- VA Office of Research and Development
Post-traumatic Stress Disorder (PTSD), Post-traumatic Stress Symptoms
Developing and Testing Innovative Care Pathways for Screening and Treatment of OUD/PTSD in Jails
Opioid overdose is the leading cause of death among people recently released from incarceration. Recent evidence also shows a rise in stimulant use among justice-involved populations, as well as growing rates of concurrent opioid…
- Conditions
- Post-traumatic Stress Disorder (PTSD), Post-traumatic Stress Symptoms, Opioid Use Disorder (OUD), Stimulant Use Disorder
- Trial name
- HOPE (NCT07490717)
- Testing
- Cognitive Processing Therapy (CPT), Written Exposure Therapy (WET)
- Where
- 2 sites in United States
- Volunteers
- 338 people
- Sponsor
- University of Arkansas
Trauma, Posttraumatic Stress Disorder
Stress-induced Drinking in Emerging Adults: the Role of Trauma History
This project is the first to use a clinical laboratory method in emerging adults to test the hypothesis that a trauma history with or without concommitant posttraumatic stress disorder (PTSD) alters response to a stressor and…
- Trial name
- ARC5 (NCT01363180)
- Testing
- Trier Social Stress Test (TSST), No stress condition
- Where
- United States
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Obstructive Sleep Apnea, PTSD
Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD
Approximately 20 million Americans suffer from Obstructive Sleep Apnea (OSA) creating risks for major health problems, including dementia, heart attack, and stroke.
- Conditions
- Obstructive Sleep Apnea, PTSD, Posttraumatic Stress Disorder
- Trial name
- NCT02641496
- Testing
- CBT-OSA, Sleep Education
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder, Depressive Symptoms
Written Exposure Therapy for Nurses
Nurses often experience elevated levels of stress, overwork, and trauma in the workplace, leading to posttraumatic stress disorder (PTSD), depression, burnout, and even nurse turnover.
- Conditions
- Posttraumatic Stress Disorder, Depressive Symptoms, Burn Out, Anxiety
- Trial name
- NCT06432374
- Testing
- WET
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Texas at Austin
Post Traumatic Stress Disorder, Insomnia
Evaluation of Yoga for Sleep Disturbances in Post Traumatic Stress Disorder (PTSD)
The primary objective of this preliminary study is to estimate sleep outcome effect sizes and determine feasibility for a novel yoga treatment of insomnia in participants with post traumatic stress disorder (PTSD).
- Trial name
- NCT01556074
- Testing
- Yoga treatment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Post-traumatic Stress Disorder (PTSD)
Discontinuing Psychotropic Medication Before Psychotherapy for PTSD
Post-traumatic stress disorder (PTSD) is commonly treated with trauma-focused psychotherapy, including prolonged exposure therapy and eye movement desensitization and reprocessing (EMDR).
- Trial name
- NCT07802158
- Volunteers
- 100 people
- Sponsor
- Academic Centre for Dentistry in Amsterdam
Critical Illness, Sars-CoV2
Anxiety and Work Resilience Among Tertiary University Hospital Workers During the COVID-19 Outbreak: An Online Survey
For limiting COVID-19 spreading, the World Health Organisation (WHO) recommended worldwide confinement on 2010. In France, unessential institutions were closed on March 14th and population confinement was decided on March 17th.
- Conditions
- Critical Illness, Sars-CoV2, SARS Pneumonia, Coronavirus Infection
- Trial name
- PSY_CO_CHU (NCT04358640)
- Where
- France
- Volunteers
- 1,784 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
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