Clinical trials: Traumatic Bleeding
Traumatic Brain Injury, Subarachnoid Hemorrhage
Normothermia in Patients With Acute Cerebral Damage
The purpose of our study is to verify wherever normothermia (achieved with diclofenac administration) may improve intracranial pressure control and may limit secondary cerebral damage thus positively influencing outcome in…
- Trial name
- NCT00491192
- Testing
- Diclofenac
- Where
- Italy
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Coagulopathy, Hemorrhage
REPlaCE- Randomized Trial Evaluating the Use of Prothrombin Complex concEntrate to Improve Survival in Patients With Traumatic Coagulopathy
Uncontrolled hemorrhage continues to be a significant source of mortality for trauma patients. Their condition is further complicated by Trauma Induced Coagulopathy (TIC), which makes it more difficult to control bleeding due to…
- Trial name
- REPLaCE (NCT03981484)
- Testing
- Prothrombin Complex Concentrate, Whole Blood, Plasma, Packed Red Blood Cells
- Volunteers
- 280 people
- Sponsor
- Bellal A. Joseph, MD, FACS
Neurologic Disorders, Nervous System Diseases
Neurologic Stem Cell Treatment Study
This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will…
- Conditions
- Neurologic Disorders, Nervous System Diseases, Neurodegenerative Diseases, Neurological Disorders
- Trial name
- NEST (NCT02795052)
- Testing
- Intravenous and Intranasal BMSC
- Where
- 3 sites in United States, United Arab Emirates
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Severe Traumatic Brain Injury, Severe Brain Injury
The Örebro Severe Traumatic Brain Injury Registry
Traumatic brain injury and other severe brain injuries requiring neurointensive care are associated with high mortality, long-term disability and substantial societal burden.
- Conditions
- Severe Traumatic Brain Injury, Severe Brain Injury, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- ÖrSBID (NCT07398274)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- András Zoltán Buki
Chronic Subdural Hematoma
Chronic Subdural Hematoma Treatment With Intra-Arterial Bevacizumab Injection
The goal of this clinical trial is to test whether infusing bevacizumab into the middle meningeal arteries can be used to treat chronic subdural hematomas (cSDH).
- Trial name
- CHAI (NCT06510582)
- Testing
- Bevacizumab 2 mg/kg, Bevacizumab 4 mg/kg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The Cooper Health System
Intracranial Hemorrhages, Intracranial Hemorrhage, Hypertensive
Start or STop Anticoagulants Randomised Trial (SoSTART)
Primary research question: For adults surviving spontaneous (non-traumatic) symptomatic intracranial haemorrhage with persistent/paroxysmal atrial fibrillation/flutter (AF), does starting full treatment dose oral anticoagulation…
- Conditions
- Intracranial Hemorrhages, Intracranial Hemorrhage, Hypertensive, Subarachnoid Hemorrhage, Subdural Hematoma
- Trial name
- SoSTART (NCT03153150)
- Testing
- Apixaban, Rivaroxaban, Edoxaban
- Where
- 67 sites in United Kingdom
- Volunteers
- 203 people
- Sponsor
- University of Edinburgh
Blood Donors, Traumatic Blood Loss
Comparison of the Accuracy of Non-invasive Hemoglobin Measurement (SpHb) and Vena Cava Inferior Ultrasound
The aim of this work is determine the more successful noninvasive method by comparison of two noninvasive methods ( IVC ultrasound - noninvasive hemoglobin measurement (SpHb)) that used in the detection of patients with blood…
- Trial name
- NCT02944851
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Haseki Training and Research Hospital
Shock, Hemorrhagic
Early Administration of Prothrombin Concentrate Complex in Patients With Acute Hemorrhage Following Severe Trauma
Acute traumatic coagulopathy (ATC) is common in severe trauma patients (around 25 to 30% of patients with severe trauma) and is associated with increased mortality.
- Trial name
- PROCOAG (NCT03218722)
- Testing
- Pro-Thrombin Concentrate Complex, NaCl 0.9%
- Where
- 12 sites in France
- Volunteers
- 350 people
- Sponsor
- University Hospital, Grenoble
Chronic Subdural Hematoma, Recurrence
The Effectiveness and Safety of Body Posture in Preventing Postoperative Recurrence for Chronic Subdural Hematoma
This study aims to investigate the effectiveness and safety of body posture to improve intracranial pressure in preventing postoperative recurrence for chronic subdural hematoma
- Trial name
- NCT06401772
- Testing
- Intracranial Hypotension Targeted(IHT) Body Posture
- Where
- China
- Volunteers
- 830 people
- Sponsor
- Huashan Hospital
Subdural Hematoma, Chronic
The SQUID Trial for the Embolization of the Middle Meningeal Artery for Treatment of Chronic Subdural Hematoma (STEM)
STEM Study is a pivotal, international, multi-center, prospective, randomized (1:1) controlled trial designed to provide an assessment of the safety and effectiveness of Middle Meningeal Artery (MMA) embolization with SQUID for…
- Trial name
- STEM (NCT04410146)
- Testing
- SQUID Embolization, SQUID Embolization and Surgical Evacuation, Surgical Evacuation
- Where
- 32 sites in United States, France and 2 more
- Volunteers
- 319 people
- Sponsor
- Balt USA
Anticoagulants; Increased
Restart TICrH Alpha Pilot Protocol, Restarting DOACs After Traumatic Intracranial Hemorrhage
Randomized pilot trial of restarting DOACs at 1 week versus 4 weeks after traumatic intracranial hemorrhage
- Trial name
- NCT04891861
- Testing
- Apixaban
- Volunteers
- 100 people
- Sponsor
- University of Texas at Austin
Shock, Hypovolemia
Vasopressin in Traumatic Hemorrhagic Shock Study
The purpose of the present trial is therefore to assess effects of arginine vasopressin vs. saline placebo on hospital admission rate (primary end point), as well as hemodynamic variables, fluid resuscitation requirements and…
- Conditions
- Shock, Hypovolemia, Hemorrhagic Shock
- Trial name
- NCT00379522
- Testing
- Vasopressin
- Where
- 14 sites in Austria, Germany
- Volunteers
- 64 people
- Sponsor
- Volker Wenzel
Shock Hemorrhagic
Pre-hospital Administration of Lyophilized Plasma for Post-traumatic Coagulopathy Treatment (PREHO-PLYO)
In severe bleeding due to trauma, a decrease in coagulation factors maintains and promotes bleeding. The plasma allows, through its contribution of coagulation factors, early prevention or correction of this post-trauma induced…
- Trial name
- PREHO-PLYO (NCT02736812)
- Testing
- French Lyophilized Plasma, Normale Saline Solution
- Where
- 22 sites in France
- Volunteers
- 140 people
- Sponsor
- French Defence Health Service
Hemorrhagic Shock
Resuscitative Endocrinology: Single-dose Clinical Uses for Estrogen-Traumatic Hemorrhagic Shock (RESCUE - Shock)
Based on encouraging results from animal studies, the investigators hypothesize that early administration of IV Premarin® in patients with hemorrhagic shock will safely reduce secondary injury, and improve survival.
- Trial name
- RESCUE-Shock (NCT00973102)
- Testing
- Premarin IV
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Texas Southwestern Medical Center
Decompressive Craniectomy, Brain Injuries
Good Prognosis Factors After Decompressive Craniectomy : a Ten-year Retrospective Study
Decompressive craniectomy is a treatment of refractory intracranial hypertension after various etiologies : malignant ischemic stroke, traumatic brain injury, intraparenchymal hemorrhage, aneurysmal subarachnoid hemorrhage…
- Conditions
- Decompressive Craniectomy, Brain Injuries, Treatment Outcome
- Trial name
- NCT04682951
- Testing
- Decompressive Craniectomy
- Where
- France
- Volunteers
- 544 people
- Sponsor
- Central Hospital, Nancy, France
Partial Corticotrope Insufficiency
Neuropsychological Effects of Hydrocortisone in Patients With Partial Adrenal Insufficiency
The purpose of this study is to evaluate the efficacy of hydrocortisone replacement therapy in patients with partial cortisol deficiency after traumatic brain injury or subarachnoid hemorrhage on cognitive function.
- Trial name
- CSMünchen01 (NCT01089075)
- Testing
- Hydrocortisone
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Seizures, Subdural Hematoma
Diagnostic Subdural EEG-electrode And Subdural hEmatoma (DISEASE)
Epileptic seizures are one of the frequent complications in patients with traumatic brain injury; the incidence lies approximately at 20%.
- Trial name
- NCT04211233
- Testing
- invasive subdural grid electrode, Control arm
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- University Clinic Frankfurt
Traumatic Brain Injury, Subarachnoid Hemorrhage
NOninVasive Intracranial prEssure From Transcranial doppLer Ultrasound Development of a Comprehensive Database of Multimodality Monitoring Signals for Brain-Injured Patients
This is an observational study in neurocritical care units at University of California San Francisco Medical Center (UCSFMC), Zuckerberg San Francisco General Hospital (ZSFGH), UC Davis, and Emory University.
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracerebral Hemorrhage, Liver Failure
- Trial name
- NOVEL ICP (NCT04548596)
- Testing
- Transcranial Doppler
- Where
- 3 sites in United States
- Volunteers
- 162 people
- Sponsor
- Emory University
Brain Edema, TBI (Traumatic Brain Injury)
Dynamic Decompressive Craniotomy
Prospective observational study on patients undergoing decompressive craniotomy
- Conditions
- Brain Edema, TBI (Traumatic Brain Injury), Stroke, Acute, Cerebral Hemorrhage
- Trial name
- NCT05051488
- Testing
- Dynamic craniotomy
- Volunteers
- 20 people
- Sponsor
- Rohit Khanna, MD
Subdural Hematoma, Chronic
Comparing Simultaneous and Consecutive Drainage of Bilateral Chronic Subdural Hematoma
Surgical evacuation CSDH via burr hole craniostomy appears to be the most widely practiced treatment technique worldwide and outcomes are generally favorable.
- Trial name
- NCT06337851
- Testing
- Simultaneous burr hole craniostomy, Consecutive burr hole craniostomy
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Ataturk Training and Research Hospital