Clinical trials: Traumatic Brain Damage
Head Injury, Sport Injury
Dynamic Vision Testing and Concussion Management Dream Team 65
The purpose of this study is to determine the value of including dynamic vision testing into California State University, Northridge (CSUN) Athletics' established concussion protocol.
- Conditions
- Head Injury, Sport Injury, Concussion, Brain
- Trial name
- NCT05326555
- Testing
- Dynamic Vision Testing (Bertec Vision Advantage System) and Balance Error Scoring System
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- California State University, Northridge
Traumatic Brain Injury
Effects of Moderate/Severe Traumatic Brain Injury in the Subacute or Chronic Phase on Locomotor Strategies Involved in Navigation in Complex Virtual Environments
While clinical assessment of locomotor function in this population is carried out using tasks involving walking in a straight line without any obstacles, it does not take into account ecological situations (i.e., situations…
- Trial name
- NAVIGO (NCT07230002)
- Testing
- Locomotion in a virtual reality setting
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pôle Saint Hélier
Mild Cognitive Impairment (MCI), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
Mindfulness for Cognition in Early-stage Alzheimer's Disease
The goal of this clinical trial is to learn if mindfulness meditation can improve outcomes in older adults with and without cognitive impairment. The main questions it aims to answer are: 1.
- Conditions
- Mild Cognitive Impairment (MCI), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, TBI (Traumatic Brain Injury), Aging
- Trial name
- NCT06792877
- Testing
- Mindfulness Intervention, Waitlist then mindfulness
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- VA Boston Healthcare System
Mild Traumatic Brain Injury, Suicide Prevention
Crisis Response Planning in Military Personnel With Mild Traumatic Brain Injury
The study purpose is to test the effect of Crisis Response Planning (CRP) when used as the second method of suicide prevention in military service members who are at risk for suicide due to mild traumatic brain injury (mTBI).
- Conditions
- Mild Traumatic Brain Injury, Suicide Prevention, Suicide Risk | Patient, Suicide Risk
- Trial name
- NCT07327567
- Testing
- Crisis Response Planning
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Coma, Traumatic
Dopaminergic Disruption Induced by Traumatic Coma: Dopaminergic Pathways Abnormalities and Biomarkers of Recovery Using MRI and 18F-LBT-999 PET
The neural correlates of consciousness have been studied at the macroscopic level. However, the neurochemical basis of these processes remains poorly understood.
- Trial name
- ComaDopa (NCT06930261)
- Testing
- LBT-999
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Brain Concussion, Traumatic Brain Injury
DANA Compared to MACE in Evaluation of Suspected Acute Concussion
The purpose of this study is to compare the sensitivity of the DANA Rapid exam with the MACE cognitive score. The primary hypothesis is that the DANA Rapid exam will be more sensitive for detecting impaired cognitive performance…
- Trial name
- NCT01728129
- Testing
- DANA Rapid, MACE
- Where
- Afghanistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Concussion (Diagnosis), MTBI - Mild Traumatic Brain Injury
BCAAs in Concussion 3.0
This study is a randomized, placebo-controlled, double-blinded, therapeutic exploratory clinical trial of branched chain amino acids (BCAAs) in the treatment of concussion.
- Conditions
- Concussion (Diagnosis), MTBI - Mild Traumatic Brain Injury, Concussion, Brain, Concussion
- Trial name
- NCT07670195
- Testing
- BCAA
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Akiva Cohen
Brain Concussion
Blood Biomarker Study to Diagnose Adolescent Sport Concussion
Concussions are one of the most complex conditions to manage in sport medicine due to the individualized clinical presentation, caused by a complex neurometabolic cascade, and the lack of a diagnostic standard.
- Trial name
- NCT05287997
- Testing
- Neurolytixs Index
- Where
- 2 sites in United States, Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Neurolytixs
Concussion, Brain, Motor Vehicle Accident
Research Evaluating Sports ConcUssion Events - Rapid Assessment of Concussion and Evidence for Return
RESCUE-RACER is jointly sponsored by the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust. The RESCUE-RACER programme evaluates motorsports competitors at baseline (CArBON) and post-injury (CARS).
- Trial name
- RESCUE-RACER (NCT03844282)
- Testing
- Clinical assessment (SCAT5), ImPACT, CANTAB
- Where
- United Kingdom
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Traumatic Brain Injury, Coagulation Disorder
The Relationship Between Lipid Peroxidation Products From Traumatic Brain Injury and Secondary Coagulation Disorders
The purpose of this study is to observe the relationship between the level of lipid peroxidation products in serum of patients with traumatic brain injury and secondary coagulation disorders.
- Trial name
- NCT04274777
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Traumatic Brain Injury
Traumatic Brain Injury and Yoga
This long-term goal of this project was to advance best practices in occupational therapy in conjunction with yoga. To address the long-term goal, this research team developed a pilot yoga intervention.
- Trial name
- NCT03008434
- Testing
- Assigned Interventions
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Concussion, Intermediate
Unblinded Data Collection Study of Concussion Using BrainPulse
This is a prospective, non-blinded, matched control study of young athletes (ages 10-28 years old) in collegiate sports. The cohorts are defined in accordance to the athlete's exposure of injury.
- Trial name
- NCT02992795
- Testing
- BrainPulse
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Jan Medical, Inc.
Traumatic Brain Injury
Amyloid Accumulation After Mild Traumatic Brain Injury
There will be 200 participants, who aged 30 years or older with TBI in 1,5,10,15 years ago and GCS=13-15 will be recruited. Another group of 200 participants with the same age and gender and without TBI will be recruited as the…
- Trial name
- NCT01871610
- Testing
- [18F]AV-45 PET amyloid binding imaging
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Acquired Brain Injury, Traumatic Brain Injury
Using Virtual Technologies to Prevent Injuries in Adolescents With Acquired Brain Injury
The objective of this study is to identify home safety hazards for adolescents with acquired brain injury and to identify adaptations to the home healthcare virtual simulation training system (HH-VSTS) to improve the user…
- Conditions
- Acquired Brain Injury, Traumatic Brain Injury, Stroke
- Trial name
- NCT04768946
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Mild Traumatic Brain Injury, Concussion, Mild
Neural Injury in Adolescents With Concussion
This study utilizes multimodal brain imaging to obtain quantitative biomarkers of brain injury and to improve understanding of the biological basis of brain pathology in adolescents with concussion.
- Conditions
- Mild Traumatic Brain Injury, Concussion, Mild, Acute Brain Injury
- Trial name
- NCT03011983
- Testing
- MEG, MRI, Neuropsychology assessment
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Head Injury, Sport Injury
Dynamic Vision Testing and Concussion Management
The purpose of this study is to determine the value of including dynamic vision testing into California State University, Northridge (CSUN) Athletics' established concussion protocol.
- Conditions
- Head Injury, Sport Injury, Concussion, Brain
- Trial name
- NCT04837066
- Testing
- Dynamic Vision Testing (Bertec Vision Advantage System) and Balance Error Scoring System
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- California State University, Northridge
Concussion, Brain
Objective Concussion Assessment Using MRI and Metabolomics
Mild traumatic brain injury (mTBI), also referred to as concussions, affect millions of people around the world and can cause harmful long term effects.
- Trial name
- NCT05993351
- Testing
- Magnetic resonance imaging (MRI), Urine and saliva samples, Questionnaires
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Brain Injury
Traumatic Brain Injury (TBI) Screening Instruments
Goal: The ultimate goal of this research program is to improve the health and quality of life for wounded warriors from Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) through screening, risk assessment, and outcome…
- Trial name
- NCT00875329
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Traumatic Brain Injury
18F-AV-1451 PET Imaging in TBI
This study will evaluate imaging characteristics of 18F-AV-1451 in subjects with subacute traumatic brain injury.
- Trial name
- NCT02512029
- Testing
- 18F-AV-1451
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Concussion, Mild, Concussion, Brain
Acute Concussion and Melatonin
In this study, the investigator plans a randomized trial of melatonin versus placebo post acute pediatric concussion. The investigator hypothesizes that patients with acute concussions managed with melatonin will have improved…
- Conditions
- Concussion, Mild, Concussion, Brain, Pediatric ALL
- Trial name
- NCT04731974
- Testing
- Melatonin 3 MG
- Where
- United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute