Clinical trials: Traumatic Coma
Mild Traumatic Brain Injury
VIDAS® TBI Real Life Performance in Subjects With Mild Traumatic Brain Injury (mTBI)
Decision Rules for an initial CT-scan in patients arriving to Emergency Department (ED) and presenting a mild traumatic brain injury could be optimized by the use of an objective parameter easily and rapidly measured.
- Trial name
- NCT06449183
- Testing
- VIDAS® TBI Test [GFAP and UCH-L1 assays]
- Where
- 5 sites in United States
- Volunteers
- 903 people
- Sponsor
- BioMérieux
Mechanical Ventilator Weaning, Acute Brain Injury
Brain-injured Patients Extubation Readiness Study
The BIPER study is a stepped wedge cluster randomised clinical trial aiming to decrease extubation failure in critically-ill brain-injured patients with residual impaired consciousness using a simple clinical score.
- Conditions
- Mechanical Ventilator Weaning, Acute Brain Injury, Altered Level of Consciousness, Mechanical Ventilation
- Trial name
- Biper (NCT04080440)
- Testing
- Extubation readiness clinical score, Usual Care
- Where
- 21 sites in France
- Volunteers
- 660 people
- Sponsor
- University Hospital, Clermont-Ferrand
Consciousness Disorders
Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICU
Disorders of consciousness (DoC) caused by severe brain injury affect millions of people worldwide each year. A patient's level of consciousness in the intensive care unit (ICU) significantly impacts the recovery from disability…
- Trial name
- COMPASS (NCT06568536)
- Testing
- Repeated behavioral assessments, functional electroencephalography and brain imagery, TMS-EEG
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Brain Death
Organ Donation and Hydrocortisone Treatment
Brain death patients who are selected for organ donation very often suffer from haemodynamic instability. To treat this, high amounts of vasoactive drugs(norepinephrine) may be needed to raise blood pressure.
- Trial name
- HYDRO (NCT00675272)
- Testing
- hydrocortisone, sodium chloride
- Where
- 2 sites in Finland
- Volunteers
- 38 people
- Sponsor
- Kuopio University Hospital
Coma, Disorders of Consciousness
Recovery Trajectory for Coma and Disorders of Consciousness
This study aims to better understand recovery after coma caused by serious neurologic illness or injury. Patients who are unconscious (in a coma or disorder of consciousness) due to conditions such as stroke, cardiac arrest…
- Conditions
- Coma, Disorders of Consciousness, Cardiac Arrest (CA), Traumatic Brain Injuries
- Trial name
- Coma Cohort (NCT07614074)
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- University of California, San Francisco
Brain Injury
Efficacy Study of NH001 in Vegetative State & Minimally Conscious State Following a Traumatic Brain Injury
The purpose of this study is to test the drug apomorphine in subjects who are in a Vegetative State or a Minimally Conscious State.
- Trial name
- NH001-2 (NCT00761228)
- Testing
- Apomorphine
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- NeuroHealing Pharmaceuticals Inc.
Traumatic Brain Injury
Evidence Based Diagnostics and Treatment Planning Solution for Traumatic Brain Injuries
Adult patients, age ≥ 18 years, with clinically diagnosed mild, moderate or severe brain trauma will be asked to participate in the study.
- Trial name
- NCT02021877
- Where
- 2 sites in Finland, United Kingdom
- Volunteers
- 396 people
- Sponsor
- Turku University Hospital
Brain Injuries
Effectiveness of Sensory Stimulation for Person in a Coma or Persistent Vegetative State After Traumatic Brain Injury
Appraised the empirical evidence of effectiveness of sensory stimulation to improve arousal and alertness for persons in a coma or persistent vegetative state after traumatic brain injury (TBI).
- Trial name
- NCT02629588
- Testing
- Multimodal or Unimodal Sensory stimulation
- Volunteers
- 9 people
- Sponsor
- Creighton University
Coma, Brain Injuries, Traumatic
Evaluation of EEG Power Spectrum in Patients With Traumatic Coma
Development of objective, reliable, and convenient assessment methods of disorders of consciousness is crucial. We aim to conduct multicenter prospective observational study and non-invasively collect EEG from patients with…
- Trial name
- EPIC (NCT06321146)
- Where
- 5 sites in China
- Volunteers
- 210 people
- Sponsor
- RenJi Hospital
Traumatic Brain Injury
Deployment of a Novel National Institute of Neurological Disorders and Stroke Clinical, Biomarker, Imaging, and Modifiers (CBI-M) Classification Framework for Emergency Department Patients With Glasgow Coma Scale 15 Traumatic Brain Injury (PIONEER-Prognosis)
This study is being done to learn how information from blood tests, medical records, and wearable devices that track sleep, activity, and heart rate can help predict how people recover after a concussion.
- Trial name
- NCT07858266
- Where
- 5 sites in United States
- Volunteers
- 500 people
- Sponsor
- University of Michigan
Brain Injury Traumatic Severe (Diagnosis), Coma
Stimulant Therapy Targeted to Individualized Connectivity Maps to Promote ReACTivation of Consciousness
Phase 1 of the STIMPACT trial is an open label,dose-escalation,safety study of intravenous (IV) methylphenidate (MPH) therapy in patients with disorders of consciousness (DoC) caused by severe brain injuries.
- Conditions
- Brain Injury Traumatic Severe (Diagnosis), Coma, Consciousness, Level Altered, Anoxic Brain Injury
- Trial name
- STIMPACT (NCT03814356)
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Patients With Traumatic Brain Injury, Coma, Traumatic
Family-Centered Affective Stimulation for Patients With Traumatic Brain Injury: Its Effects on Coma Recovery
Family-centered affective stimulation involves creating an environment in which family members actively participate in the patient's recovery by providing emotional support, positive reinforcement, and a supportive presence.
- Trial name
- NCT07537023
- Testing
- Family-Centered Affective Stimulation (FCAS)
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cairo University
Trauma, Shock, Traumatic
Discriminant Ability of the Shock Index, Modified Shock Index, and Reverse Shock Index Multiplied by the Glasgow Coma Scale on Mortality in Adult Trauma Patients: A PATOS Study
We evaluated a cohort of adult trauma patients transported to emergency departments. The first vital signs were used to calculate the SI, MSI, and rSIG.
- Conditions
- Trauma, Shock, Traumatic, Morality
- Trial name
- NCT05549986
- Testing
- Observational
- Volunteers
- 105,641 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
Traumatic Brain Injury With Loss of Consciousness
Effect of Early Coma Arousal Therapy on Conscious Level Recovery and Cognition in Traumatic Brain Injury
PURPOSE: The aim of this study is to investigate the effect of early coma arousal therapy on conscious level and cognitive function in sever traumatic brain injury patients.
- Trial name
- NCT05521815
- Testing
- Coma arousal therapy, Selected physiotherapy program
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Cairo University
Neurocritical Conditions, Traumatic Brain Injury
Protein Intake Dosage on the Prognosis of Neurocritical Patients
This study investigates the effect of different early protein supplementation levels (1.0-2.0g/kg/d, divided into three groups) on the prognosis of neurocritical patients, focusing on the 28-day Glasgow Coma Scale (GCS) score…
- Conditions
- Neurocritical Conditions, Traumatic Brain Injury, Ischemic Stroke
- Trial name
- NCT07295301
- Testing
- Low-Dose Enteral Protein Supplementation (Enteral Nutrition Formulas + Whey Protein Powder), Moderate-Dose Enteral Protein Supplementation (Enteral Nutrition Formulas + Whey Protein Powder), High-Dose Enteral Protein Supplementation (Enteral Nutrition Formulas + Whey Protein Powder)
- Volunteers
- 216 people
- Sponsor
- Wenshan City People's Hospital
Stress Disorders, Post-Traumatic
Post Traumatic Stress Among Relatives of Brain-dead, Withdrawal of Life Support, and Sudden Death Patients
This study concerns the nearest relatives of patients who have passed away within 3 days of admission to an ICU due to: (1) brain death with multiple organ donation +/- tissues or (2) death via limitation and / or cessation of…
- Trial name
- NCT01412502
- Testing
- IES-R and HDAS scores
- Where
- 6 sites in France
- Volunteers
- 119 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Traumatic Brain Injury, Intracranial Injury
Usefulness of Biomarkers in the Management of Mild Traumatic Brain Injury in Adults (Biotraumap)
The indication of cranial computed tomography (CCT) is difficult to define for patients with mild traumatic brain injury (mTBI).
- Trial name
- Biotraumap (NCT04543162)
- Where
- France
- Volunteers
- 1,025 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acquired Brain Injury, Coma
Amantadine and Functional Improvement Following ABI Measured by MRI Tractography; A Pilot Study
This is a pilot study. The objective is to further understand the mechanism by which amantadine improves function in patients with persistent vegetative state and minimally conscious state.
- Conditions
- Acquired Brain Injury, Coma, Persistent Vegetative State, Minimally Conscious State
- Trial name
- NCT02566720
- Testing
- Amantadine, MRI Tractography Study
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Hamilton Health Sciences Corporation
Consciousness Disorder, Coma
REsting and Stimulus-based Paradigms to Detect Organized NetworkS and Predict Emergence of Consciousness
The aim of this study is to assess the utility of advanced magnetic resonance imaging (MRI) and electroencephalographic (EEG) technologies for predicting functional outcomes in patients with severe traumatic brain injury (TBI).
- Conditions
- Consciousness Disorder, Coma, Brain Injuries, Traumatic
- Trial name
- RESPONSE 2 (NCT03504709)
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Traumatic Brain Injury (TBI) Patients, Severe Traumatic Brain Injury
SeeMe: Using Automated Facial Tracking to Detect Voluntary Behavior in Brain Injury
Objective: This prospective interventional study introduces "SeeMe," an automated, high-resolution computer vision platform designed to objectively quantify microscopic, auditory command-evoked movements in patients with…
- Trial name
- NCT07560631
- Testing
- SeeMe Multimodal Auditory Command Protocol
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Stony Brook University