Clinical trials: Traumatic Injuries
Posttraumatic Stress Disorder, Depression
Narrative Exposure Therapy Versus Group Interpersonal Psychotherapy
The present study is a pragmatic trial that investigates the efficacy and usefulness of two treatment modules in a sample of Rwandan genocide orphans: Narrative Exposure Therapy (NET) versus group-Interpersonal Psychotherapy…
- Conditions
- Posttraumatic Stress Disorder, Depression, Narrative Exposure Therapy, Interpersonal Psychotherapy
- Trial name
- NCT00623298
- Testing
- Narrative Exposure Therapy, group IPT, 6 months-baseline
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Konstanz
Cardiac Arrest, Cognitive Function
Brain Function After Cardiac Arrest (Measured With FMRI and Cognitive Tests)
The aim of this longitudinal study is to determine whether brain function is affected after a cardiac arrest. The primary question is whether cognitive function is affected after cardiac arrest and whether it changes over time…
- Trial name
- BRAINnHEART (NCT03579498)
- Where
- 2 sites in Norway, Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Uppsala University
mTBI - Mild Traumatic Brain Injury
MindRhythm Detection of Concussion and Recovery Study
This study is designed to observe HeadPulse data in concussed subjects that may have experienced a concussion via an injury down to the age of 4.
- Trial name
- DISCOVERY (NCT07190963)
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- MindRhythm, Inc.
Acute Myocardial Infarction, Heart Attack
Acute Coronary Syndrome and Care-Seeking Delay: A Web Based Behavioral Study
The primary aim of this study is to increase our understanding of care-seeking behavior surrounding heart attacks or acute coronary syndromes [ACS].
- Conditions
- Acute Myocardial Infarction, Heart Attack, Acute Coronary Syndrome, Unstable Angina
- Trial name
- NCT01407146
- Where
- United States
- Volunteers
- 2,381 people, healthy volunteers welcome
- Sponsor
- Yale University
Moral Injury
Assessing the Implementation and Feasibility of the SMART-MR
The objective of the proposed pilot study is to assess the feasibility and implementation of the SMART-MR program, an integration of stress management, general resilience, and moral resilience skills, with frontline staff who…
- Trial name
- NCT05122910
- Testing
- Stress Management and Resilience Training - Moral Resilience (SMART-MR) program
- Where
- Canada
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Combat Disorders
Prospective Study of Veteran Health in Previously Deployed Soldiers
Background: Previous deployments like that to the Persian Gulf in 1991 produced veterans with post-deployment symptom-based health problems with no medical explanation.
- Trial name
- NCT00285246
- Where
- 2 sites in United States
- Volunteers
- 838 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Trauma, Sepsis
Prediction Study of Complications After Severe Trauma
The purpose of this study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of post-traumatic complications in a multicenter sample of severe trauma patients.
- Conditions
- Trauma, Sepsis, Multiple Organ Dysfunction Syndrome
- Trial name
- PSCAT (NCT01713205)
- Where
- 6 sites in China
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Jiang Jianxin
Depression, Anxiety
Whole Body Hyperthermia Registry Study
This protocol will allow for the implementation of a research registry pertaining to Whole Body Hyperthermia (WBH) use in various subject populations.
- Conditions
- Depression, Anxiety, PTSD, Fibromyalgia
- Trial name
- NCT02174003
- Testing
- High intensity whole-body infrared heating
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Post-Traumatic Stress Disorder
Resilience and Modification of Brain Control Network Following November 13
This is a multiwave longitudinal neuroimaging study in a cohort of direct survivors of 11/13 Paris terrorist attacks. Both structural and functional brain imaging data will be collected at 8-12 months, 3 years, and 6 years after…
- Trial name
- REMEMBER (NCT02810197)
- Testing
- Psychopathological assessment, Neuropsychological assessment, Functional magnetic resonance imaging (fMRI)
- Where
- France
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Brain Injuries, Traumatic, Demyelinating Disorder
Exploring the Utility of [18F]3F4AP for Demyelination Imaging in Controls, Neurodegeneration and Traumatic Brian Injury
The overall objective is to obtain an initial assessment of the value of using [18F]3F4AP for imaging demyelinating diseases such as traumatic brain injury (TBI), neurodegenerative diseases such as mild cognitive impairment (MCI)…
- Conditions
- Brain Injuries, Traumatic, Demyelinating Disorder, Alzheimer Disease
- Trial name
- NCT04710550
- Testing
- F18-3F4AP
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Work Related Stress
Somatic Psychoeducational Intervention
The goal of this clinical trial is to explore possible benefits and mechanisms through which the Somatic Psychoeducational Intervention can improve health and wellness.
- Trial name
- NCT06580119
- Testing
- Somatic Psychoeducational Intervention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
MDD, Bipolar Disorder
Evaluation of Generalization Paradigm Patterns Among Different Psychiatric Disorders
Learning includes the ability to generalize to new situations and respond to similar, yet not identical stimuli. In previous work, focused on stimulus generalization in healthy volunteers, tones that were negatively reinforced…
- Conditions
- MDD, Bipolar Disorder, Schizophrenia Disorder, Anxiety Disorder (Panic Disorder or GAD)
- Trial name
- NCT01501812
- Testing
- Generalization pattern
- Where
- Israel
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Shalvata Mental Health Center
Post-traumatic Stress Disorder, Traumatic Brain Injury
Multisite RCT of STEP-Home: A Transdiagnostic Skill-based Community Reintegration Workshop
In this proposal, the investigators extend their previous SPiRE feasibility and preliminary effectiveness study to examine STEP-Home efficacy in a RCT design.
- Conditions
- Post-traumatic Stress Disorder, Traumatic Brain Injury, Substance Related Disorders, Depression
- Trial name
- STEP-Home (NCT03868930)
- Testing
- STEP-Home, PCGT
- Where
- 2 sites in United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Brain Injuries
Multimodal Monitoring of Cerebral Autoregulation After Pediatric Brain Injury
Various methods have been studied to evaluate autoregulation. However, there is currently no universally accepted technique to assess integrity of the cerebral autoregulation neurovascular system.
- Conditions
- Traumatic Brain Injury, Brain Injuries, Brain Injury, Vascular
- Trial name
- NCT04242602
- Testing
- Transcranial Doppler
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Trauma, Psychological
Flash Open Trial With Therapists In Training
This study will test the eye movement desensitization and reprocessing (EMDR) based Flash technique and a progressive counting (PC) based variant.
- Trial name
- NCT03271437
- Testing
- PC-based Flash, EMDR-based Flash
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Trauma Institute & Child Trauma Institute
Spleen Injury, Machine Learning
Deep Learning Algorithm for Traumatic Splenic Injury Detection and Sequential Localization
Spleen laceration is a lethal abdominal trauma and usually be diagnosed by medical images such as computed tomography. Deep learning had been proved its usage in detect abnormalities in medical images.
- Trial name
- NCT05643612
- Testing
- Deep learning algorithm
- Where
- Taiwan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Brain Death
Non-randomized, Open-labeled, Interventional, Single Group, Proof of Concept Study With Multi-modality Approach in Cases of Brain Death Due to Traumatic Brain Injury Having Diffuse Axonal Injury
This is the proof of concept study with multi-modality approach (using intra-thecal bioactive peptides, stem cells, laser and transcranial IV laser and Median Nerve stimulation as adjuvants) in cases of brain death due to…
- Trial name
- NCT02742857
- Testing
- BQ-A Peptide Extract, Mesenchymal Stem Cells, Transcranial Laser Therapy
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bioquark Inc.
Borderline Personality Disorder
NEUROIMAGING OF ADOLESCENT BORDERLINE PERSONALITY DISORDER WITH AND WITHOUT POST-TRAUMATIC STRESS DISORDER
Borderline personality disorder (BPD) is a common mental disorder in adolescents with significant individual and societal repercussions, characterized over the long term by emotional hyperresponsiveness, relational instability…
- Trial name
- BorderStress (NCT04852744)
- Testing
- Brain MRI
- Where
- France
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Covid-19, Mental Health Disorder
The Covid-19 HEalth caRe wOrkErS (HEROES) Study
Since December 2019 the world has been shaken with an enormous global threat: the Covid-19 pandemic. This new kind of coronavirus is generating an unprecedented impact both on the general population and on the healthcare systems…
- Conditions
- Covid-19, Mental Health Disorder, Stress Disorder, Anxiety
- Trial name
- HEROES (NCT04352634)
- Testing
- Exposure to the SARS-CoV-2 and its consequences
- Where
- 22 sites in United States, Argentina and 19 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Chile
PTSD
Novel EEG Coherence Biomarkers for PTSD Assessment
Current practice for diagnosing and managing PTSD relies primarily on subjective clinical assessments by clinicians as well as patient self-report.
- Trial name
- NCT04209387
- Testing
- Acceptance and Commitment Therapy to Improve Social Support for Veterans with PTSD ( ACT-SS)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
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