Clinical trials: Traumatic Injuries
Traumatic Brain Injury
Study to Assess the Safety of Amantadine Hydrochloride (HCl) Intravenous (IV) Solution (MR-301) in Patients With Severe Traumatic Brain Injury (TBI).
The main goal of this clinical trial is to check if the treatment is safe and well-tolerated. Researchers will compare the MR-301 active drug group with the placebo group to evaluate the safety and tolerability of the drug.
- Trial name
- NCT06253923
- Testing
- Amantadine Hydrochloride
- Where
- 13 sites in United States
- Volunteers
- 45 people
- Sponsor
- SHINKEI Therapeutics, Inc
Addiction, Depression/Anxiety
Healing Lodge First Face Training Evaluation Study
The purpose of this study is to evaluate a culturally grounded training program, xaʔtus (meaning First Face) for Mental Health. This program will train community members in how to recognize and respond to youth and adults…
- Conditions
- Addiction, Depression/Anxiety, Trauma, Psychological, Self-harm
- Trial name
- NCT06290180
- Testing
- First Face for Mental Heatlh
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
PTSD, Alcohol Abuse
Helping Families Help Veterans With PTSD and Alcohol Abuse: An RCT of VA-CRAFT
This project begins to evaluate the effectiveness of a web-based family outreach tool that is designed to promote treatment engagement among Veterans with posttraumatic stress disorder (PTSD) or alcohol use disorders (AUDs) but…
- Trial name
- NCT01678196
- Testing
- VA-CRAFT, Control
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- VA Office of Research and Development
Acute Stress Disorder Symptoms
Movement Sonification as an add-on to Immediate Post-event Psychotherapeutic Intervention in the Management of Acute Stress Disorder: a Feasibility and Acceptability Study
Natural disasters, conflicts, persecution, population displacement, often traumatic migration experiences, and terrorist attacks are all factors that currently expose a significant proportion of the world's population to…
- Trial name
- SONICUMP (NCT07307937)
- Testing
- The sonification of movement is an act studied in this research.
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Posttraumatic Stress Disorder
CBITS - Treat Trauma in Child Welfare
The goal of this randomized controlled trial is to evaluate the effectiveness of the trauma-focused group intervention CBITS compared with enhanced treatment as usual (TAU+) in child welfare programs in Germany.
- Trial name
- CBITS (NCT06038357)
- Testing
- CBITS, TAU+
- Volunteers
- 90 people
- Sponsor
- University Hospital Ulm
Children, Only, Traumatic Brain Injury
Neurophysiological Measurements Using the NeuroCatch™ Platform in Pediatric Concussion
EEG signals have been collected and studied since the early 1990's as a way of assessing brain function at a gross level. As early as the 1930's a derivative of the raw EEG signal - event-related potentials (ERPs) - have been…
- Conditions
- Children, Only, Traumatic Brain Injury, Concussion, Mild, Pediatric ALL
- Trial name
- NCT03889483
- Testing
- NeuroCatch™ Platform
- Where
- Canada
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Dr. Michael Esser
Human Immunodeficiency Virus, Substance Related Disorder
Trauma Intervention for Affect Regulation, AIDS, and Substances
The Purpose of this study is to see if it is possible to deliver an intervention that targets trauma, substance use, and engagement in HIV care with HIV-positive women.
- Conditions
- Human Immunodeficiency Virus, Substance Related Disorder, Post Traumatic Stress Disorder
- Trial name
- TIARAS (NCT02923141)
- Testing
- Neutral Writing, Expressive Writing, Contingency Management
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Miami
Sleep, Phototherapy
Light Therapy to Improve Sleep in TBI: Sleep-active Biomarkers and Glymphatic Function
This is a clinical trial designed to examine how improved sleep through morning bright light therapy is improving downstream key physiologic processes related to brain health, i.e., mitochondrial function, systemic inflammation…
- Conditions
- Sleep, Phototherapy, Glymphatic System, Mitochondrial Dynamics
- Trial name
- GLIMPSE-LION (NCT07601841)
- Testing
- Morning Bright Light Therapy, Negative Ion Generator Therapy
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Oregon Health and Science University
Major Depressive Disorder, Post-Traumatic Stress Disorder
Examination of Glutamate and mGluR5 in Psychiatric Disorders
This research study is designed to look at the involvement of the glutamate system in depression. Each subject will undergo a screening appointment to determine study eligibility.
- Conditions
- Major Depressive Disorder, Post-Traumatic Stress Disorder, Bipolar Disorder
- Trial name
- NCT02727972
- Testing
- Cognitive Testing, MRI, PET
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Yale University
Mild Traumatic Brain Injury
Cognitive and Psychosocial Outcome After Mild Traumatic Brain Injury
Patients with traumatic brain injury are likely to present with cognitive, psychological, emotional and behavioral problems during different periods, all of which affect patients' life quality seriously.
- Trial name
- NCT02161172
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Shanghai 6th People's Hospital
Brain Injuries, Traumatic, Sleep Initiation and Maintenance Disorders
The Feasibility of Home-Based Measurement of Circadian Timing for Veterans With TBI and Insomnia
Veterans with traumatic brain injury (TBI) frequently experience insomnia, which is linked with delayed TBI recovery, more severe functional impairment, and exacerbation of disabling TBI after-effects such as depression, chronic…
- Trial name
- Home DLMO (NCT05665764)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- VA Office of Research and Development
Amyotrophic Lateral Sclerosis, Brain Stem Stroke
Real World Testing of a Brain-Computer Interface
The goal of this project is to test a new AAC-BCI device comparing gel and dry electrode headgear used for communication while providing clinical care.
- Conditions
- Amyotrophic Lateral Sclerosis, Brain Stem Stroke, Cerebral Palsy, Traumatic Brain Injury
- Trial name
- NCT04026581
- Testing
- Speech generating device (SGD) evaluation including BCI access, Training and treatment
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- University of Pittsburgh
PTSD
Attention Control Treatment for Post Traumatic Stress Disorder ׂ(PTSD)
The purpose of this study is to explore the efficacy of Attention Control Training for Post Traumatic Stress Disorder (PTSD). ACT was found to be effective in decreasing attention bias variability and PTSD symptoms in combat…
- Trial name
- NCT02945709
- Testing
- Personalized Attention control training (ACT), Non-personalized Attention control training (ACT), Control training.
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Tel Aviv University
Eye-tracking
EYE-TRAC Advance: Technology Verification (ETA-TV) Cohort 2
This is a prospective multi-center cohort feasibility and exploratory study.
- Trial name
- ETA-TV (NCT02877732)
- Testing
- EYE-SYNC eye-tracking, SCAT-3 subtests, DEM
- Where
- 4 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Stanford University
Sexual Abuse, Posttraumatic Stress Symptom
Voices of Transformation: A Deep Dive Into the Struggles and Successes of Reclaiming Sexuality After Sexual Trauma
This study aims to gain insight into the experiences of participants in the "Take Your Sexuality Back" intervention groups, evaluate the intervention's acceptability, and identify necessary modifications.
- Conditions
- Sexual Abuse, Posttraumatic Stress Symptom, Sexual Trauma
- Trial name
- NCT07165834
- Testing
- Treatment group. "Take your sexuality back"
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Sykehuset Telemark
Traumatic Brain Injury, Degeneration
Offsetting Hippocampal Degeneration in m-sTBI
The goal of this study is to establish the feasibility of an intervention designed to improve memory in patients who have experienced a moderate or severe traumatic brain injury (m-sTBI) and to examine its effect on brain…
- Conditions
- Traumatic Brain Injury, Degeneration, Memory; Loss, Mild, Following Organic Brain Damage
- Trial name
- m-sTBI (NCT03727334)
- Testing
- Online Spatial Navigation Training
- Where
- 2 sites in Canada
- Volunteers
- 25 people
- Sponsor
- University of British Columbia
Traumatic Brain Injury
Mild Hypothermia and Supplemental Magnesium Sulfate Infusion in Severe Traumatic Brain Injury (TBI) Subjects
The investigators hypothesize that hypothermia (body cooling) and additional magnesium sulfate will improve the outcome of severe Traumatic Brain Injury (TBI) patients.
- Trial name
- NCT01333488
- Testing
- Arctic Sun, Magnesium Sulfate
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- United States Department of Defense
Concussion, Traumatic Brain Injury
Concussion Device Audiological Measures
Significant morbidity, mortality, and related costs are caused by traumatic brain injury (TBI). A simple, effective, and lightweight device worn by athletes or war fighters in the field, designed to mitigate TBI resulting from…
- Trial name
- NCT02262507
- Testing
- Device Wearing
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Posttraumatic Stress Disorder
Using Wearable Technology to Detect Symptoms of Posttraumatic Stress Disorder
The aim of the project is to advance our understanding of how individuals with Posttraumatic Stress Disorder (PTSD) experience symptoms in their every-day lives when they are in their home environment.
- Trial name
- NCT05534100
- Testing
- Biostrap EVO Wristband
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Brain Injury
Remotely Deployed TBI Study
Injury to the brain can change the core of a person's being, affecting brain functions necessary to accomplish important goals in a complex world.
- Trial name
- RD (NCT01882244)
- Testing
- Neural Pathfinder Training, Brain Health Education
- Where
- 2 sites in United States
- Volunteers
- 85 people
- Sponsor
- VA Northern California Health Care System
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