Clinical trials: Traumatic Injuries
Post Traumatic Stress Disorder, Major Depressive Disorder
Primary-Care Based Mindfulness Intervention
The purpose of this study is to pilot a primary-care based mindfulness intervention for chronically traumatized African Americans screening positive for posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) in…
- Trial name
- NCT03922581
- Testing
- Mindfulness-Based Cognitive Therapy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Emory University
Post-Traumatic Stress Disorder
Maximizing Treatment Outcome in Post-Traumatic Stress Disorder (PTSD)
The purpose of this study is to examine the efficacy of exercise + therapy to therapy alone to determine if they can improve the effects of prolonged exposure therapy (PE) in reducing symptoms of anxiety associated with…
- Trial name
- NCT01998100
- Testing
- Prolonged Exposure, Exercise
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Texas at Austin
Concussion, Mild
Reverse King-Devick Test and History of Multiple Concussions
The purpose of this study is to examine the effects of concussion history and reading direction on baseline King- Devick Test (KDT) performance, a common component of sideline concussion assessments.
- Trial name
- NCT04560400
- Testing
- Conventional King-Devick test, Reverse King-Devick test
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Indiana University
Head Injury Trauma, Traumatic Brain Injury, Mild
The PIONEER Comparative Effectiveness Study - Project 2
This is a pragmatic, open-label, multicenter, stepped-wedge, Type II hybrid effectiveness-implementation study. It is designed to evaluate both the comparative effectiveness and implementation feasibility of a…
- Trial name
- NCT07829107
- Testing
- Clinical pathway 1: Guidelines plus biomarkers, Clinical guidelines only
- Where
- 6 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- University of Michigan
Rib Fractures
Treatment of Adult Traumatic Rib Fractures With Percutaneous Cryoneurolysis
The purpose of this research study is to examine the effectiveness of using the Iovera Smart Time 190, for ultrasound-guided cryoneurolysis, in trauma patients 18-64 years old with rib fractures that are not candidates for…
- Trial name
- Trauma-PC2 (NCT05330611)
- Testing
- Cryoneurolysis of Intercostal Nerves, Standard of Care
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Stanford University
Stress Disorders, Post-Traumatic, Opioid Use Disorder
New Beginnings Following Trauma
Posttraumatic stress disorder (PTSD) is associated with increased rates of prescription opioid misuse, high-risk opioid use, illicit use of substances, and overdose (Meshberg-Cohen et al., 2021) Some research has demonstrated…
- Trial name
- NCT05817344
- Testing
- Written Exposure Therapy - Integrated
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Jesse McCann
Post Traumatic Stress Disorder, Smoking
Computerized Tailored Intervention for Behavioral Sequelae of PTSD in Veterans
This project assesses the usability and feasibility of a multi-behavioral computerized, tailored intervention (CTI) or expert system delivered via the Internet for veterans with Post-Traumatic Stress symptoms.
- Conditions
- Post Traumatic Stress Disorder, Smoking, Anxiety, Depression
- Trial name
- CTI-PTSD (NCT01510834)
- Testing
- Multibehavioral, Computerized Tailored Intervention STR2IVE
- Where
- 3 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- VA Pacific Islands Health Care System
Posttraumatic Stress Disorder, Substance Dependence
Trial of a Novel Cognitive-Behavioral Treatment for Posttraumatic Stress and Substance Dependence
The purpose of the study is to determine whether a novel integrated cognitive-behavioral treatment for posttraumatic stress disorder (PTSD) and substance dependence (i.e., Treatment for Integrated Posttraumatic Stress and…
- Trial name
- NCT02461732
- Testing
- Treatment for Integrated Posttraumatic Stress and Substance Use (TIPSS), Cognitive-Behavioral Therapy for Substance Dependence
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The University of Texas Health Science Center, Houston
Traumatic Brain Injury
The Relationship Between Obesity and Chronic Headache
The relationship between obesity and the development of chronic headache after traumatic brain injury will be investigated.
- Trial name
- NCT06445595
- Testing
- patients with traumatic brain injury
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Karaman Training and Research Hospital
Traumatic Injury
Prehospital Analgesia INtervention Trial (PAIN)
The Prehospital Analgesia INtervention trial (PAIN) is a proposed 4 year (3-year enrollment) multicenter, prehospital, randomized, double-blind, clinical trial that will enroll approximately 994 patients at select LITES Network…
- Trial name
- PAIN (NCT05437575)
- Testing
- Ketamine Hydrochloride, Fentanyl Citrate
- Where
- 11 sites in United States
- Volunteers
- 994 people
- Sponsor
- Jason Sperry
Traumatic Brain Injury, Subdural Hematoma
Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury
Cerebral edema is seen heterogenous group of neurological disease states that mainly fall under the categories of metabolic, infectious, neoplasia, cerebrovascular, and traumatic brain injury disease states.
- Conditions
- Traumatic Brain Injury, Subdural Hematoma, Cerebral Contusion, Head Injury
- Trial name
- NCT01605357
- Testing
- Induced, sustained hypernatremia using hypertonic saline, Standard of care (hypertonic saline and mannitol; serum sodium)
- Sponsor
- Massachusetts General Hospital
Sexual Violence, Posttraumatic Stress Disorder (PTSD)
Testing STAR and TextSTAR: A Randomized Controlled Trial
The goal of this clinical trial is to learn whether a video given for recent sexual assault survivors and/or a 3-week text messaging intervention with similar content is effective at reducing mental health problems and substance…
- Conditions
- Sexual Violence, Posttraumatic Stress Disorder (PTSD), Opioid Misuse
- Trial name
- NCT07630428
- Testing
- Skills Training in Active Recovery (STAR) Video, Text Skills Training in Active Recovery (TextSTAR) program
- Where
- 3 sites in United States
- Volunteers
- 394 people
- Sponsor
- University of Wisconsin, Madison
Mild Traumatic Brain Injury
Sub-symptom Threshold Aerobic Exercise After Mild Traumatic Brain Injury
This Randomized Controlled Trial (RCT) will explore the effect of sub-symptom threshold aerobic exercise on persistent post-concussion symptoms and exercise intolerance in patients with mild Traumatic Brain Injury (TBI).
- Trial name
- NCT05086419
- Testing
- Sub-symptom threshold aerobic exercise
- Where
- Norway
- Volunteers
- 105 people
- Sponsor
- Oslo University Hospital
Post Traumatic Stress Disorder
Exploring Nitrous Oxide Effects for Post Traumatic Stress Disorder (PTSD)
The purpose of this study is to understand nitrous oxide effects in post traumatic stress disorder (PTSD)
- Trial name
- tN2O (NCT03375294)
- Testing
- Nitrous Oxide
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Stanford University
Feedback, Psychological, Stress Disorders, Post-Traumatic
Neurofeedback Prevention For Early Stress Related Adversity
Exposure to life threatening, traumatic and stress inducing events in general is an inevitable part of military combat service .
- Trial name
- NFPES (NCT02477722)
- Testing
- EFP-NF
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Post-Concussion Syndrome
ATCell™ Expanded Autologous, Adipose-Derived Mesenchymal Stem Cells Deployed Via Intravenous Infusion
This is a Phase 1 Clinical Safety Study intended to provide preliminary assessments of the safety, tolerability, and clinical alleviation of symptoms associated with Post Concussion Syndrome (PCS), also known as Chronic…
- Trial name
- NCT04744051
- Testing
- 50 Adipose Derived Stem Cell Infusion, 150 Adipose Derived Stem Cell Infusion, 300 Adipose Derived Stem Cell Infusion
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- American CryoStem Corporation
Traumatic Stress Disorder
Exposing Narrative Exposure Therapy
The main purpose of the study is to further develop an existing measure of autobiographical memory integration (ABMI) to investigate and clarify the ABMI change process specific to narrative exposure therapy (NET).
- Trial name
- NCT05383846
- Testing
- Experimental Narrative Exposure Therapy
- Where
- United Kingdom
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
PTSD
Building Experience for Treating Trauma and Enhancing Resilience (BETTER)
Posttraumatic stress disorder (PTSD) is a significant problem among underserved populations who receive care in community health centers.
- Trial name
- BETTER (NCT05330442)
- Testing
- Written Exposure Therapy (WET)
- Where
- 10 sites in United States
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- RAND
Treatment Resistant Disorders, Post Traumatic Stress Disorder
Investigating the Therapeutic Effects of Psilocybin in Treatment-Resistant Post-Traumatic Stress Disorder
Post-traumatic stress disorder (PTSD) is a complex disorder expressed as a variety of neurobiological symptoms, including anxiety, re-experiencing, hyperarousal, and avoidance symptoms, along with comorbidities such as anxiety…
- Trial name
- NCT05243329
- Testing
- Psilocybin
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Halucenex Life Sciences Inc.
Chronic Subdural Hematoma
YL-1 Needle Puncture vs BHC With Postoperative Exhaustive Drainage for CSDH
A prospective multicenter cohort study was designed to compare the differences in complications with YL-1 Needle Puncture versus Bulr-hole Craniotomy (BHC) with postoperative Exhaustive Drainage strategy for patients with Chronic…
- Trial name
- NEBULA (NCT06072053)
- Testing
- Burr Hole Craniostomy and Postoperative Exhaustive Drainage Strategy, YL-1 puncture needle and Postoperative Exhaustive Drainage Strategy
- Where
- China
- Volunteers
- 460 people
- Sponsor
- Beijing Tiantan Hospital
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