Clinical trials: Treatment Levothyroxine
Hypothyroidism
Study of Dose Adjustment From Levothyroxine to a New Levothyroxine Sodium Test Formulation
The purpose of this study is to investigate the effect of switching participants taking levothyroxine to a new sodium formulation.
- Trial name
- NCT01916304
- Testing
- Levothyroxine sodium new formulation
- Where
- Belgium
- Volunteers
- 101 people
- Sponsor
- Takeda
Goiter, Nodular
LISA-study : Levothyroxin in Nodular Goiter
Primary objective: To evaluate change in total volume of all nodules. Secondary objectives: To evaluate change in goiter volume after a 12-months treatment, number of nodules and echogenicity of nodules.
- Trial name
- NCT00277589
- Testing
- Levothyroxin-Na, Levothyroxine-Na + iodide, Iodide
- Where
- Germany
- Volunteers
- 1,024 people
- Sponsor
- Sanofi
Hypothyroidism;Postablative
Levothyroxine Sodium in Thyroidectomized Patients Taking Proton Pump Inhibitors
This is an open-label therapeutic efficacy study of Tirosint (levothyroxine sodium) capsules in thyroidectomized patients taking proton pump inhibitors and levothyroxine, evaluating changes in serum levels of Thyroid Stimulating…
- Trial name
- NCT03094416
- Testing
- levothyroxine sodium capsule, Proton pump inhibitor (PPI), Levothyroxine Sodium (LT4) Tablets
- Where
- 9 sites in United States
- Volunteers
- 66 people
- Sponsor
- IBSA Institut Biochimique SA
Hashimoto Disease, Treatment Levothyroxine
Effect of Treatment for Vitamin D Deficiency on Thyroid Function and Autoimmunity in Hashimoto's Thyroiditis.
The objective of this study is to evaluate the effect of vitamin D supplementation on thyroid autoimmunity, thyroid function, and other metabolic and clinical variables associated with the thyroid axis in patients with…
- Conditions
- Hashimoto Disease, Treatment Levothyroxine, Vitamin D Deficiency
- Trial name
- NCT04778865
- Testing
- Vitamin D-correction, Vitamin D-RDA
- Where
- Chile
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad de Valparaiso
Intermediate-to-High Risk Differentiated Thyroid Cancer
Desiccated Thyroid Extract Combined With Levothyroxine for TSH Suppression Therapy in DTC
The global incidence of Differentiated Thyroid Cancer (DTC) is rising. While surgery followed by TSH suppression is the standard of care, achieving target TSH levels with levothyroxine (L-T4) monotherapy remains challenging, with…
- Trial name
- DELTA (NCT07239674)
- Testing
- desiccated thyroid extract (DTE)+levothyroxine (L-T4)
- Volunteers
- 646 people
- Sponsor
- West China Hospital
Cardiac Surgery Intensive Care Treatment, Delayed Recovery From Anaesthesia
Role of Levothyroxine Supplementation in Delayed Recovery Following Cardiac Surgery
Research indicates that hypothyroidism decreases heart contractility, reduces stroke volume and rate, affects the vascular endothelium, and increases the risk of atherosclerosis, systemic vascular resistance, hypertension…
- Conditions
- Cardiac Surgery Intensive Care Treatment, Delayed Recovery From Anaesthesia, Euthyroid Sick Syndrome, Cardiac Surgery Requiring Cardiopulmonary Bypass
- Trial name
- L-Thyroxine (NCT06660823)
- Testing
- L-thyroxine
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Hypothyroidism
Vitamin E Add-On Therapy, Thyroid Function & Oxidative Stress in Levothyroxine-Treated Hypothyroidism
The aim of this study is to learn if vitamin E supplementation as an adjunct to levothyroxine therapy help to reduce oxidative stress, improve antioxidant defence mechanisms, and favourably influence thyroid hormone status…
- Trial name
- NCT07781514
- Testing
- vitamin E
- Where
- Bangladesh
- Volunteers
- 74 people
- Sponsor
- Bangladesh Medical University
Hypothyroidism, Biomarkers
Identification of Non-responders to Levothyroxine Therapy
The purpose of this study is to assess differential effects of T4 and T3 on cell and tissue level
- Conditions
- Hypothyroidism, Biomarkers, Endocrine System Diseases
- Trial name
- NCT03627611
- Testing
- Levothyroxin, Liothyronine
- Where
- Norway
- Volunteers
- 69 people
- Sponsor
- Oslo University Hospital
Diabetes Mellitus
The Effect of Administration of Small Doses of Thyroxine on Glucose and Lipid Metabolism, in Type 2 Diabetes Mellitus.
We investigated the effect of the administration of small doses of thyroxine to healthy humans and patients with type 2 diabetes on postprandial forearm muscle glucose uptake, insulin sensitivity indices, lipid metabolism, in…
- Trial name
- NCT02509858
- Testing
- thyroxine, A meal (730kcal, 50%carbohydrate, of which 38% was starch, 40% fat, and 10% protein)
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Attikon Hospital
Graves' Disease
Early Levothyroxine Post Radioactive Iodine
The study will try to answer the question of whether early treatment with levothyroxine at 4 weeks after radioactive iodine for Graves'disease will prevent overt hypothyroidism (low thyroid hormone levels).
- Trial name
- NCT01950260
- Testing
- Levothyroxine
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Mayo Clinic
Recurrent Pregnancy Loss
Recurrent Pregnancy Loss and Thyroid Disease
The present study is divided into two groups ,one is the patients with subclinical hypothyroidism who has TPO antibody positive women with TSH concentrations > 2.5 mU/L and below the upper limit of the pregnancy specific…
- Trial name
- NCT03106935
- Testing
- Levothyroxine
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Soochow University
Toxic Nodular Goitre, Graves' Disease
Block-replacement Therapy During Radioiodine Therapy
Background: The use of radioactive iodine (131I) therapy as the definite cure of hyperthyroidism is widespread. According to a survey on the management of Graves' disease, thirty per cent of physicians prefer to render their…
- Trial name
- NCT00150124
- Testing
- MTZ+LT4, Methimazole
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Steen Bonnema
Hypothyroidism, Thyroid Disease
A Study of Armour® Thyroid Compared to Synthetic T4 (Levothyroxine) in Previously Hypothyroid Participants
This study will evaluate the safe and effective dose conversion from levothyroxine (synthetic T4) therapy to Armour Thyroid therapy in participants who are on a stable dose of levothyroxine and have thyroid stimulating hormone…
- Conditions
- Hypothyroidism, Thyroid Disease, Euthyroid, Thyroid Gland
- Trial name
- NCT04124705
- Testing
- Armour® Thyroid, Levothyroxine
- Where
- 28 sites in United States
- Volunteers
- 284 people
- Sponsor
- Allergan
Thyroid; Deficiency, Quality of Life
Quality of Life After Interventional Thyroid Treatment
In this study, patients are prospectively followed after radioiodine treatment to assess the relationship between thyroid status and their quality of life after thyroid ablative treatment.
- Trial name
- DSR (NCT03880578)
- Testing
- Levothyroxine Sodium
- Where
- Germany
- Volunteers
- 101 people
- Sponsor
- Klinikum Lüdenscheid
Hypothyroidism Primary, Lipid Disorder
Vitamin D & Levothyroxine Combination Versus Levothyroxine on Lipid Profile in Hypothyroidism
The goal of this clinical trial is to study the improvement of lipid levels in hypothyroid individuals after staring treatment. The main question it aims to answer is: whether adding Vitamin D to standard therapy has any…
- Conditions
- Hypothyroidism Primary, Lipid Disorder, Dyslipidemias
- Trial name
- ViDaLLiT (NCT06276205)
- Testing
- Vitamin D, Levothyroxin
- Where
- Pakistan
- Volunteers
- 62 people
- Sponsor
- King Edward Medical University
Hypothyroxinemia
Supplemental Thyroxine Treatment for Preterm Infants With Hypothyroxinemia
In order to determine the efficacy and safety of thyroxine replacement, a randomized clinical trial of thyroxine supplementation for VLBW infant with hypothyroxinemia during the first month of age is conducted.
- Trial name
- NCT00565890
- Testing
- thyroxine
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Tokyo Women's Medical University
Hypothyroidism
Hypothyroidism Treated With Calcitonin
Some people with hypothyroidism have persistent symptoms despite adequate treatment with thyroid hormones. We are testing whether giving calcitonin to such people will improve their quality of life.
- Trial name
- NCT03342001
- Testing
- Calcitonin
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Hypothyroidism
Monitoring and Evaluation of the Levothyroxin Replacement Therapy in Pregnant Women With Hypothyroidism
The aim of the study was to evaluate the clinical control program in patients with hypothyroidism during pregnancy (suggested in resent guidelines). Is it possible by monitoring the patients every 4.
- Trial name
- NCT02094079
- Testing
- biomedical outcomes
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Birte Nygaard
Obesity
Levothyroxine as Adjuvant to a Hypocaloric Diet for the Treatment of Obesity.
Obesity is a chronic disease with high relapse rates after initial weight loss. Thyroid hormones modulate energy expenditure, body composition, and thermogenesis; higher TSH within the reference range and subclinical…
- Trial name
- NCT07332273
- Testing
- Levothyroxine
- Where
- 5 sites in Spain
- Volunteers
- 286 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Hypothyroidism
Combined Replacement Therapy With Levothyroxine and Liothyronine in Thyroidectomized Patients
The aim of the study is to evaluate the peripheral tissue response to the combined administration of levothyroxine (LT4) and liothyronine (LT3) in hypothyroid patients with residual thyroid function virtually absent…
- Trial name
- LEVOLIO (NCT03053115)
- Testing
- Liothyronine, Levothyroxin
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Azienda USL Modena