Clinical trials: Treatment Of Obesity
Surgery, Obesity
A Randomized Controlled Study Evaluating Bariatric Surgery as a Treatment for Severe NASH With Advanced Liver Fibrosis in Non-severe Obese Patients
The aim of the study is to demonstrate the superiority of bariatric surgery on the disappearance of NASH without worsening of fibrosis in comparison to medical standard treatment in obese patients (35 kg/m² > BMI ≥ 30 kg/m²) with…
- Conditions
- Surgery, Obesity, NASH - Nonalcoholic Steatohepatitis, Cirrhosis
- Trial name
- NASHSURG (NCT03472157)
- Testing
- Lifestyle therapy, Bariatric surgery
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Lille
Obesity, Diabetes
Gelesis Glycemic Index Study
A study to determine glucose and insulin responses to 50g and 100 g of carbohydrate with and without Gelesis200.
- Conditions
- Obesity, Diabetes, PreDiabetes
- Trial name
- GLIDE (NCT03124134)
- Testing
- Gelesis200
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gelesis, Inc.
Obesity
Lose Now North Carolina Community Weight Loss Program
The Lose Now NC research study aims to determine feasibility by delivering a community based weight loss program for 4 months in Kannapolis, NC in a large group format compared with smaller group format, (recruiting approximately…
- Trial name
- Lose Now NC (NCT01615471)
- Testing
- Group weight loss with companion internet
- Where
- United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Binge Eating Disorder, Cognitive Therapy/Methods
Psychological Treatment of Overweight Binge Eaters
Cognitive-behavioral therapy (CBT) has documented efficacy for the treatment of binge eating disorder (BED). Interpersonal psychotherapy (IPT) has been shown to reduce binge eating but its long-term impact and time course on…
- Conditions
- Binge Eating Disorder, Cognitive Therapy/Methods, Mental Disorders/Epidemiology, Obesity/Epidemiology
- Trial name
- NCT01208272
- Testing
- Cognitive Behavioral Therapy (CBT), Interpersonal Therapy (IPT)
- Where
- 2 sites in United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Bariatric Surgery Candidate, Obesity, Morbid
Korean OBEsity Surgical Treatment Study
This trial is a multi-center, single-arm, prospective, observational cohort study of patients undergoing primary bariatric surgical procedures in Korea.
- Trial name
- KOBESS (NCT03100292)
- Testing
- Sleeve gastrectomy or Roux-en-Y gastric bypass
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Bundang Hospital
Obesity
Quality of Life Following Gastric Bypass Surgery.
A central goal of health care is to maximize patient functioning and well-being. This has prompted measurement of health-related quality of life (HRQOL) that encompasses physical, psychological, and social functioning.
- Trial name
- NCT02032199
- Where
- Denmark
- Volunteers
- 121 people
- Sponsor
- René Klinkby Støving
Obesity
Impact of Employee Wellness Programme
The introduction of a wellness programme for workers employed in a clothing factory will improve quality of life, pain, attendance at work and levels of physical activity.
- Trial name
- NCT01625039
- Testing
- Employee wellness programme, Comparator (Once off educational session and educational materials)
- Where
- South Africa
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
Autosomal Dominant Polycystic Kidney, Obesity
Glucagon-Like Peptide-1 Receptor Agonist in ADPKD
The proposed clinical trial aims to assess if a year of treatment with a glucagon-like peptide 1 receptor agonist, a medication approved for weight management that also improves the body's response to glucose and insulin, can…
- Trial name
- NCT06582875
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- University of Colorado, Denver
Breast Cancer
Evaluation of a Physical Activity Program in Overweight Breast Cancer Patients
Patients diagnosed with breast cancer generally have a fairly well prognosis with estimated average survival rates of 73% and five year survival rates of 89% in developed countries.
- Trial name
- I-Move (NCT02424292)
- Testing
- Physical activity
- Where
- 4 sites in Netherlands
- Volunteers
- 141 people
- Sponsor
- University Medical Center Groningen
Asthma, Obesity
MitoQ for the Treatment of Metabolic Dysfunction in Asthma
A 14-week, randomized, placebo-controlled, double-masked clinical trial in 40 obese patients with poorly controlled asthma. The intervention is Mitoquinol (MitoQ) versus placebo.
- Trial name
- MIMDA (NCT04026711)
- Testing
- Mitoquinol
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- University of Vermont
Obesity, Atherosclerosis
Observational Study of Early Metabolic and Vascular Changes in Obesity
To work against the increasing burden of obesity, the STYJOBS / EDECTA (STYrian Juvenile OBesity Study / Early DetECtion of Atherosclerosis) project was started at the Medical University of Graz in 2003.
- Conditions
- Obesity, Atherosclerosis, Inflammation, Adiponectin Deficiency
- Trial name
- STYJOBS (NCT00482924)
- Testing
- Lifestyle intervention
- Where
- Austria
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Obesity
A Study to Assess the Compliance and Impact on Weight of Kurbo, a Pediatric Centered Weight Loss App
Kurbo is a health and fitness app that is targeted toward the pediatric population. It utilizes games and activities to educate children about healthy eating, portion control/size and exercise.
- Trial name
- Kurbo (NCT02880254)
- Testing
- Kurbo, Personal Health Coach
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Baystate Medical Center
Obesity, Weight Loss
Investigation of Acute Physiological Effects of Aspiration Therapy
In the present study, the investigators aim to investigate postprandial physiology in patients who have had the Aspire Assist® inserted.
- Trial name
- NCT03389269
- Testing
- Meal test
- Where
- Denmark
- Volunteers
- 14 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Overweight and Obesity, Pediatric Obesity
Evaluating the Feasibility of a Stepped-care Approach to Treating Adolescents With Binge and Loss of Control Eating
There are limited evidence-based treatments for adolescents with binge eating and fewer specifically targeting adolescents with both binge eating and overweight/obesity.
- Conditions
- Overweight and Obesity, Pediatric Obesity, Eating, Binge
- Trial name
- NCT03404713
- Testing
- Pathways to Health, Be4U
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Virginia Commonwealth University
Overweight and Obesity, Diabetes
EndoBarrier TM Gastrointestinal Liner Diabetes Trial
The management of obesity is challenging and obesity surgery is by far the most effective treatment currently available. Recent medical research indicates that it also improves the management of blood glucose levels in people…
- Trial name
- EndoBarrier (NCT02459561)
- Testing
- EndoBarrier TM Gastrointestinal Liner, Best Medical Care
- Where
- United Kingdom
- Volunteers
- 170 people
- Sponsor
- Imperial College London
Obesity, Surgery
Gastric Bypass, Gastric Band or Sleeve Gastrectomy to Treat Obesity
Obesity is an increasing health problem in the United Kingdom (UK) and is predicted to worsen. In the UK and worldwide the three most commonly performed operations are laparoscopic adjustable gastric banding ('BAND surgery')…
- Conditions
- Obesity, Surgery, Quality of Life, Weight Loss
- Trial name
- ByBandSleeve (NCT02841527)
- Testing
- Gastric Band, Gastric Bypass, Sleeve Gastrectomy
- Where
- 12 sites in United Kingdom
- Volunteers
- 1,351 people
- Sponsor
- University of Bristol
Hypertension With Overweight or Obesity
Phase III Study of HRS-7535 for Hypertension With Overweight or Obesity
The main objective of this study is to demonstrate the superior efficacy of HRS-7535 in controlling blood pressure compared to placebo in subjects with hypertension and overweight or obesity;
- Trial name
- NCT07528027
- Testing
- HRS-7535
- Where
- 2 sites in China
- Volunteers
- 648 people
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Morbid Obesity, Bariatric Surgery Candidate
Preoperative Condition in Giant Obese Patients
The frequency of super-super obese who need immediate weight loss surgery is risen continuously. For those patients a prior-to-surgery conditioning therapy is mandatory to gain technical and physical operability.
- Trial name
- NCT02616003
- Testing
- Liraglutide, Aminosteril hepa 8%, Caloric diet with 1000 kcal
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Sana Klinikum Offenbach
PCOS
A Treatment Legacy Effect of Metformin in Obese Women With PCOS
Metformin has multiple health promoting effects and it may serve as a preventive measure for individuals who are at high risk for metabolic complications.
- Trial name
- NCT04566718
- Testing
- Metformin
- Where
- Slovenia
- Volunteers
- 40 people
- Sponsor
- University Medical Centre Ljubljana
Obesity
Fecal Microbiota Transplantation for the Treatment of Obesity
This is a randomized controlled pilot study to assess the microbiological and clinical impacts of Fecal Microbiota Transplantation (FMT) in patients with obesity.
- Trial name
- FMT Obesity (NCT02741518)
- Testing
- Fecal Microbiota Transplantation
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Brigham and Women's Hospital
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