Clinical trials: Treatment Of Obesity
Type 2 Diabetes
Roux-en-Y-Gastric Bypass vs. Lifestyle Modification and Medical Therapy in the Treatment of Type 2 Diabetes
The study is aimed to compare: Laparoscopic Roux-en-Y-Gastric Bypass (RYGB) + optimal medical therapy versus Intensive lifestyle modification and optimal medical therapy in the treatment of type 2 diabetes in…
- Trial name
- NCT01231308
- Testing
- Roux-en-Y-Gastric Bypass, Intensive lifestyle modification and Optimal medical Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Weill Medical College of Cornell University
Obesity, COVID-19 Infection
Efficiency and Security of NIVOLUMAB Therapy in Obese Individuals With COVID-19(COrona VIrus Disease) Infection
Although SARS-CoV-2 (Severe Acute Respiratory Syndrome-associated coronavirus) due to COVID-19 evolves poorly towards ARDS (Acute Respiratory Distress Syndrome) and death, there is to date no validated drug available for severe…
- Trial name
- NIVISCO (NCT04413838)
- Testing
- NIVOLUMAB, Routine standard of care
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hospices Civils de Lyon
Non-Alcoholic Fatty Liver Disease
Gemcabene for the Treatment of Pediatric NAFLD
This is a multicenter, prospective, open-label, Phase 2, proof of concept study to test preliminary efficacy and safety of gemcabene in children with established nonalcoholic fatty liver disease (NAFLD) incompletely treated by…
- Trial name
- NCT03436420
- Testing
- Gemcabene
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Emory University
Obesity
A Research Study Looking at How NNC0487-0111 Affects Food Intake, Appetite and Metabolism After Meals in People With Obesity
The purpose of this clinical study is to look at if/how much NNC0487-0111 affects food intake, appetite and metabolism in participants with obesity when compared to placebo. There are 2 study treatments in this study.
- Trial name
- NCT07508020
- Testing
- NNC0487-0111
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Novo Nordisk A/S
Obesity, Physical Activity
Treatment of Pediatric Obesity (TOP) - A Multidisciplinary Approach Involving Adolescents and Their Peers
The purpose of this study is to analyse if a multidisciplinary approach including peers is effective in the treatment of obesity in adolescence.
- Conditions
- Obesity, Physical Activity, Sedentary Lifestyle
- Trial name
- TOP (NCT02024061)
- Testing
- Peer support, Regular treatment
- Where
- 2 sites in Portugal
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Grupo Lusófona
Obesity, Hypoglycemia
Etiology, Assessment and Treatment of Post-gastric Bypass Severe Hypoglycemia
With increasing rates of obesity the number of anti-obesity operations performed is increasing; one of the most common is gastric bypass.
- Conditions
- Obesity, Hypoglycemia, Surgery
- Trial name
- NCT01865760
- Testing
- Oral Glucose tolerance test (OGGT), Liquid mixed meal, Octreotide
- Where
- Denmark
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obesity
Effect of Different Weight Vests on Body Weight in Obese Individuals
Obesity related ailments, such as cardiovascular diseases (CVD) and metabolic disorders are major causes of death in the Western World.
- Trial name
- EVO (NCT03672903)
- Testing
- Weight Vest
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Obesity
Pregnancy-Related Obesity Prevention Through Education & Communication Technology in AFRICA:The PROTECT-AFRICA STUDY
The purpose of this study is to investigate whether overweight but not obese pregnant African women having unlimited access to a health education-information technology (IT) based intervention package gain weight within the…
- Trial name
- PROTECT-AFRI (NCT01948323)
- Testing
- HEDUAfrica IT package+ standard care
- Where
- 2 sites in South Africa
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
Obesity
Considering Patient Diet Preferences to Optimize Weight Loss
Obesity is increasingly common and can lead to decreased quality of life, increased medical and psychiatric illness, high health care costs, and early mortality.
- Trial name
- DietChoice (NCT01152359)
- Testing
- Choice, Control
- Where
- United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Childhood Obesity
Development and Pilot Testing of a Childhood Obesity Treatment Program
The primary aims were to assess community capacity to develop, implement, and sustain a childhood obesity reduction initiative in the health-disparate Dan River Region as well as to pilot test iChoose to determine the potential…
- Trial name
- NCT03513510
- Testing
- iChoose
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Obesity
Spirulina Supplementation and Cardiovascular Risk in Obese Caucasians With Treated Hypertension
Potential protective cardiovascular effect of Spirulina maxima supplementation was studied in a double-blind placebo-controlled trial of obese subjects with treated hypertension, each randomized to receive spirulina or a placebo.
- Trial name
- NCT02575690
- Testing
- Spirulina
- Volunteers
- 50 people
- Sponsor
- Poznan University of Medical Sciences
Hepatitis
Treating Nonalcoholic Steatohepatitis (NASH) With Metformin
Nonalcoholic Steatohepatitis (NASH) is associated with progressive liver disease, fibrosis, and cirrhosis. Although the cause of NASH is unknown, it is often associated with obesity, type 2 diabetes, and insulin resistance.
- Trial name
- NCT00063232
- Testing
- Metformin
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Psoriatic Arthritis
Changes in Body Composition Under Ustekinumab in PsA
There is not much body composition and bone mineral density data available for patients with psoriatic arthritis (rheumatoid arthritis) compared to control subjects.
- Trial name
- STELARA-CC (NCT03823924)
- Testing
- Bone mineral density (BMD)
- Where
- France
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Philadelphia Chromosome Negative, B Cell Acute Lymphoblastic Leukemia (B-ALL)
Study of Nutrition and Exercise in Adults Hospitalized for Treatment of Acute Lymphoblastic Leukemia (ALL)
This clinical trial aims to assess the effect of nutrition and exercise on muscle and adiposity in adults with Philadelphia Chromosome (Ph) Negative B-ALL undergoing inpatient induction therapy.
- Conditions
- Philadelphia Chromosome Negative, B Cell Acute Lymphoblastic Leukemia (B-ALL), B-ALL
- Trial name
- NEOMA ALL (NCT06785324)
- Testing
- Nutrition Intervention, Exercise intervention
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Obesity, HIV Infections
A Study to Evaluate CJC 1295 in HIV Patients With Visceral Obesity
This is a multicenter, randomized, placebo-controlled, double-blind, Phase 2 study. Patients will be treated for a total of 12 weeks. There will be a 6 week follow-up period after the treatment period ends.
- Trial name
- NCT00267527
- Testing
- CJC 1295
- Volunteers
- 120 people
- Sponsor
- ConjuChem
Obesity, Weight Loss
Investigation of Acute Physiological Effects of Aspiration Therapy
In the present study, the investigators aim to investigate postprandial physiology in patients who have had the Aspire Assist® inserted.
- Trial name
- NCT03389269
- Testing
- Meal test
- Where
- Denmark
- Volunteers
- 14 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Obesity
A Safety and Efficacy Study of VI-0521 to Evaluate the Long Term Treatment of Obesity in Adults With Obesity-Related Co-Morbid Conditions. An Extension Study of Protocol OB-303 (NCT00553787)
The purpose of this study is to evaluate the long-term safety and efficacy of VI-0521 compared to placebo for the treatment of overweight and obesity in adults who have completed study OB-303 (NCT00553787) at selected study…
- Trial name
- NCT00796367
- Testing
- VI-0521
- Volunteers
- 676 people
- Sponsor
- VIVUS LLC
Obesity, Hypertension
A Study of Efficacy and Safety of Topiramate in the Treatment of Obese Patients With Mild to Moderate Essential Hypertension
The purpose of this study is to compare the efficacy and safety of daily topiramate (96mg or 192mg) versus placebo in obese patients with mild to moderate high blood pressure.
- Trial name
- NCT00236665
- Testing
- topiramate
- Volunteers
- 531 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Obesity, Fibromyalgia
Impact of WBC on Patients With Metabolic or Neurological Diseases or Fibromyalgia (WBC-MeNeFi)
The purpose of this clinical trial is to investigate on different types of patients the effects of 10 sessions of whole-body cryostimulation (WBC): 1) in patients with obesity (BMI > 30), we want to investigate whether WBC…
- Conditions
- Obesity, Fibromyalgia, Neurological Conditions
- Trial name
- WBC-MeNeFi (NCT05443100)
- Testing
- Whole-body cryostimulation (WBC), Rehabilitation program
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Istituto Auxologico Italiano
Hypogonadism, Male, Diabetes Mellitus, Type 2
Study on Effects of Testosterone Replacement Therapy in Hypogonadal Type 2 Diabetic Patients" (SETH2)
Aim of the study was to investigate the effects of testosterone replacement therapy on components of metabolic syndrome, vascular function and morphology, grade of non-alcoholic fatty liver disease (NAFLD), bone mineral density…
- Conditions
- Hypogonadism, Male, Diabetes Mellitus, Type 2, Obesity
- Trial name
- SETH2 (NCT03792321)
- Testing
- Testosterone Undecanoate
- Volunteers
- 55 people
- Sponsor
- University Medical Centre Ljubljana
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