Clinical trials: Treatment Resistant Anxiety Disorders
Obsessive-Compulsive Disorder
A Study of Pregabalin (Lyrica) Augmentation in Serotonin Reuptake Inhibitor-Refractory Obsessive Compulsive Disorder
This study will examine the efficacy of pregabalin (Lyrica) added to SRI treatment in OCD for individuals who have not responded or only partially responded to an adequate trial of SRI.
- Trial name
- NCT00994786
- Testing
- pregabalin
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- McMaster University
Obsessive-Compulsive Disorder
Deep Brain Stimulation and Obsessive-compulsive Disorder
Obsessive-compulsive disorder (OCD) is a relatively common psychiatric condition, which is classically treated by antidepressant medications in combination with psychotherapies.
- Trial name
- STOC2 (NCT01329133)
- Testing
- Deep Brain Stimulation (DBS)
- Where
- 14 sites in France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Bordeaux
Cardiovascular Risk Factor, Diabetes Mellitus, Type 2
Evaluation of a Physical Activity Referral Scheme
The study will evaluate the effectiveness of a co-developed exercise referral scheme. Participants will be recruited to one of three groups 1. Co-developed exercise referral scheme, 2. Usual care exercise referral scheme, 3.
- Conditions
- Cardiovascular Risk Factor, Diabetes Mellitus, Type 2, Anxiety, Depression
- Trial name
- NCT03490747
- Testing
- Physical activity referral scheme, Usual care exercise referral scheme
- Where
- United Kingdom
- Volunteers
- 68 people
- Sponsor
- Paula Watson
Obsessive-Compulsive Disorder
European Study of Quality of Life in Resistant OCD Patients Treated by STN DBS
Obsessive-Compulsive Disorder (OCD) is among the most disabling psychiatric disorders as more than 40% of patients are resistant to the standard pharmacological and psychotherapy approaches and about 10% show severe disability…
- Trial name
- EQOLOC (NCT02844049)
- Testing
- Deep Brain Stimulation
- Where
- 8 sites in France, Germany and 2 more
- Volunteers
- 60 people
- Sponsor
- University Hospital, Grenoble
Panic Disorder
Guided and Traditional Cognitive Behavioral Therapy Protocol for Resistant Panic
Self-guided therapy for anxiety disorders has focused on various cognitive-behavioral treatments mediated by technologies such as web applications.
- Trial name
- NCT07247955
- Testing
- The group intervention used the sessions described in traditional form, The group intervention used the sessions described in a self-guided format using an application
- Where
- Brazil
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Major Depressive Disorder, Depression
Using Neuroimaging to Investigate Major Depressive Disorder
The purpose of this neuroimaging study is to investigate the brain correlates of Major Depressive Disorder with anxiety symptoms as well as potentially identify predictors of treatment outcome.
- Conditions
- Major Depressive Disorder, Depression, Anxiety
- Trial name
- NCT00781677
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Texas Southwestern Medical Center
Treatment Resistant Disorders
rTMS Effect on Cognitive and Psychiatric Dysfunction in Patients With Fibromyalgia
the aim of this work was to evaluate the effect of low frequency rTMS over the right dorsolateral prefrontal area (DLPFC) on Fibromyalgia patients.
- Trial name
- rTMS (NCT06356805)
- Testing
- repetitive transcranial magnetic stimulation
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Assiut University
Obsessive-Compulsive Disorder
tDCS as an add-on Treatment in SSRI-resistant OCD
The purpose of this study is to determine whether tDCS is effective as an add-on treatment in SSRI-resistant patients with obsessive and compulsive disorder
- Trial name
- TDCSTOC (NCT02407288)
- Testing
- transcranial dirrect current stimulation
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Hôpital le Vinatier
Panic Disorder
Therapies for Treatment-Resistant Panic Disorder Symptoms
This study will determine the effectiveness of different treatments for panic disorder symptoms in individuals who still have symptoms after initial treatment with medication.
- Trial name
- NCT00118417
- Testing
- Clonazepam, Sertraline, Cognitive behavioral therapy
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Massachusetts General Hospital
Obesity, Morbid, Insulin Resistance
Stool Transplantation for Treatment of Insulin Resistance in Morbidly Obese Patients
More and more people in Canada and around the world are severely (morbidly) obese, and this is associated with a high risk for poor blood sugar control (insulin resistance, IR) and diabetes.
- Trial name
- NCT02970877
- Testing
- Fecal filtrate from 150 g stool from healthy lean donors, Fecal filtrate from 150 g of the recipient's own stool
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Johane Allard
Obsessive-Compulsive Disorder (OCD)
DBS for Treatment-resistant Obsessive-compulsive Disorder
The primary purpose of this study is to investigate the effect of deep brain stimulation (DBS) implantation targeting the anteromedial region of subthalamic nucleus (amSTN), or nucleus accumbens (NAc), or bed nucleus of the stria…
- Trial name
- NCT06360991
- Testing
- Deep brain stimulation (DBS)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xuanwu Hospital, Beijing
Generalized Anxiety Disorder, Social Anxiety Disorder
Attention Retraining for Anxiety Disorder Patients Resistent to Antidepressants
The objective of this project is to test the combination of active or placebo Attentional Bias Modification Treatment (ABMT) to usual treatment for anxiety disorder patients resistant to antidepressants.
- Conditions
- Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder
- Trial name
- NCT01906268
- Testing
- Attentional Bias Modification Treatment (ABMT) - Active
- Where
- 2 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Obsessive-Compulsive Disorder (OCD)
DBS for Obsessive-Compulsive Disorder
There are two primary approaches to the treatment of OCD, pharmacotherapy and cognitive behavior therapy (CBT). Lack of therapeutic success with one approach leads to trials of the alternative approach or a combination of the…
- Trial name
- DBS (NCT02773082)
- Testing
- Reclaim™ DBS Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Obsessive-Compulsive Disorder
Feasibility, Clinical Effects, and Safety of Psilocybin-assisted Psychotherapy for Treatment-resistant OCD
Psilocybin, the chemical component of "magic mushrooms", has been administered with psychotherapy in several randomized clinical trials (RCTs) showing large and sustained antidepressant effects.
- Trial name
- PAP-OCD (NCT06299319)
- Testing
- Psilocybin
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Centre for Addiction and Mental Health
Obsessive-Compulsive Disorder, OCD
pBFS Guided High-dose rTMS Therapy for Treatment-Resistant Obsessive-Compulsive Disorder
The research aims to evaluate the safety and efficacy of pBFS-guided High-dose rTMS therapy targeting preSMA for patients with treatment-resistant Obsessive-Compulsive Disorder.
- Trial name
- NCT05964062
- Testing
- active rTMS treatment
- Volunteers
- 30 people
- Sponsor
- Changping Laboratory
Anxiety Disorders
Schema Therapy for Treatment-resistant Anxiety Disorders
The aim of this study is to assess the cost-effectiveness of schema therapy compared to treatment as usual (TAU) in patients with treatment-resistant anxiety disorders.
- Trial name
- PaDoLA (NCT06298695)
- Testing
- Individual Schema Therapy, TAU
- Volunteers
- 172 people
- Sponsor
- Amsterdam UMC, location VUmc
Obsessive-Compulsive Disorder
Development of Adaptive Deep Brain Stimulation for OCD
This research study is for participants that have been diagnosed with intractable Obsessive -compulsive disorder (OCD). OCD is a persistent and oftentimes disabling disorder marked by unwanted and distressing thoughts…
- Trial name
- Phase Ib (NCT04281134)
- Testing
- Summit RC+S System, One Month Blinded Discontinuation Period:
- Where
- 3 sites in United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Social Phobia
Efficacy of Adding Topiramate to Current Treatment in Treatment-Resistant Generalized Social Phobia (GSP)
SSRI's are considered first-line treatments for GSP, however many patients continue to have significant symptoms despite an adequate trial of an SSRI.
- Trial name
- NCT00182455
- Testing
- Topiramate
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- McMaster University
Depressive Disorder, Treatment-Resistant, Stress Disorders, Post-Traumatic
Ketamine Infusions for PTSD and Treatment-Resistant Depression
The relationship between depression and trauma is well established. Co-occuring depression and post-traumatic stress disorder (PTSD) are associated with more severe symptoms and lower levels of functioning.
- Trial name
- NCT02577250
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Obsessive Compulsive Disorder (OCD)
Examining the Feasibility and Acceptability of Good Quality Intensive CBT for OCD and Good Quality Weekly CBT for OCD
The purpose of this study is to examine how feasible and acceptable it is to deliver a talking treatment called Cognitive Behavioural Therapy (CBT) in two different formats for people who have had treatment for OCD in the past…
- Trial name
- NCT02216981
- Testing
- Cognitive Behavioural Therapy (CBT)
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Bath