Clinical trials: Treatment Resistant Obsessive Compulsive Disorder
Obsessive-Compulsive Disorder
Deep Brain Stimulation for Treatment-Resistant Obsessive Compulsive Disorder
This study will evaluate the use of Deep Brain Stimulation (DBS) to reduce symptom severity and enhance the quality of life for patients with treatment-resistant obsessive compulsive disorder (OCD).
- Trial name
- NCT00057603
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Florida
Obsessive Compulsive Disorder
Unilateral Deep Brain Stimulation (DBS) of the Nucleus (Nucl.) Accumbens (Acc.) in Patients With Treatment Resistant Obsessive Compulsive Disorder (OCD)
The purpose of the study was to evaluate whether a unilateral Deep Brain Stimulation of the right Nucleus Accumbens could lead to a more than 35% reduction of symptoms in patients with a treatment resistant Obsessive Compulsive…
- Trial name
- NCT00724490
- Testing
- Deep Brain Stimulation
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- University of Cologne
Obsessive-Compulsive Disorder
Patient-specific, Effective, and Rational Functional Connectivity Targeting for DBS in OCD
The study aims to improve patient-specific anatomical targeting of the Deep Brain Stimulation for the treatment of intractable OCD.
- Trial name
- PERFECT DBS (NCT03244852)
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Obsessive-Compulsive Disorder
Safety and Efficacy of Pramipexole Treatment in Resistant Obsessive-Compulsive Disorder (OCD)
The most common and effective treatment for OCD is pharmacological therapy that includes selective serotonin reuptake inhibitors (SSRIs) antidepressants and, in the case of patients resistant to this approach, a combination with…
- Trial name
- OCD-RT (NCT06611592)
- Testing
- Pramipexole 0.088mg/tid, Pramipexole 0.18 mg/tid, Pramipexole 0.35 mg/tid
- Where
- Portugal
- Volunteers
- 48 people
- Sponsor
- Clinical Academic Center (2CA-Braga)
Obsessive-Compulsive Disorder
rTMS in Treatment Refractory Obsessive-Compulsive Disorder
This study will evaluate the effectiveness of rTMS as a potential treatment for refractory OCD in a randomized, crossover design.
- Trial name
- NCT02450695
- Testing
- rTMS
- Where
- Canada
- Sponsor
- McMaster University
Obsessive-Compulsive Disorder (OCD)
Neurobehavioral Investigations of Approach Dynamics in the Ventral Striatum
Traditional strategies for diagnosing psychiatric disorders focus on definitions based on constellations of co-occurring symptoms.
- Trial name
- NCT05422469
- Testing
- Medtronic Percept RC neurostimulator
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Baylor College of Medicine
Obsessive-Compulsive Disorder
Phase II Adaptive Deep Brain Stimulation for Obsessive-Compulsive Disorder
This research study is for participants that have been diagnosed with intractable Obsessive -compulsive disorder (OCD). OCD is a persistent and oftentimes disabling disorder marked by unwanted and distressing thoughts…
- Trial name
- NCT04806516
- Testing
- Summit RC+S System with ECoG Paddles, One Month Blinded Discontinuation Period:
- Where
- 3 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Obsessive Compulsive Disorder
Combined Cortical/Subcortical Recording and Stimulation as a Circuit-Oriented Treatment for Obsessive-Compulsive Disorder
This study involves the use of the Medtronic PC+S deep brain stimulation for the treatment of intractable OCD.
- Trial name
- NCT03184454
- Testing
- Medtronic Percept Deep Brain Stimulation
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Massachusetts General Hospital
Obsessive-Compulsive Disorder
Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) as an add-on Treatment for Resistant OCD
OCD is a chronic condition with a high rate of poor responders to conventional treatments, such as antidepressants and psychotherapy.
- Trial name
- NCT01043900
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo General Hospital
Obsessive-compulsive Disorders and Symptoms, Obsessive-Compulsive Disorder
Inference-Based Cognitive Therapy Versus Exposure and Response Prevention for Obsessive-Compulsive Disorder
Obsessive-compulsive disorder (OCD) is a highly disabling psychiatric illness, characterized by obsessional thoughts that cause patients to perform time-consuming and distressing compulsive rituals.
- Trial name
- RCT_TOC_16 (NCT03677947)
- Testing
- Exposure and response prevention, Inference-based cognitive therapy
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal
Obsessive-compulsive Disorder
Electrophysiological Recording for Patients Receiving Deep Brain Stimulation Electrode for Treatment-resistant Obsessive-compulsive Disorder
The purpose of this project is to study live recordings from neuronal population of the human nucleus accumbens during the implantation of deep brain stimulation (DBS) electrodes for the treatment-resistant obsessive compulsive…
- Trial name
- NCT01429558
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Obsessive Compulsive Disorder
Ondansetron Augmentation in Treatment-resistant OCD
The aim of this study is to evaluate whether ondansetron augmentation to SSRI will improve and ondansetron discontinuation will result in worsening of obsessive compulsive symptoms among obsessive compulsive disorder resistant…
- Trial name
- NCT01303536
- Testing
- Ondansetron
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Institute of Neuroscience, Florence, Italy
Obsessive-Compulsive Disorder (OCD)
RNS for Treatment-resistant Obsessive-compulsive Disorder
The purpose of this study is to investigate the effect of personalized responsive neurostimulation (RNS) therapy guided by stereoelectroencephalography (SEEG) in patients with treatment-resistant obsessive-compulsive disorder…
- Trial name
- NCT06782867
- Testing
- Responsive Neurostimulation (RNS)
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xuanwu Hospital, Beijing
Obsessive Compulsive Disorder
Augmentation in Tx-resistant OCD: an Open Label Trial
This study examines the use of Acamprosate (Campral(R)) in the treatment of Obsessive Compulsive Disorder (OCD). The treatment of this condition is difficulty and a large percentage of patients fail to respond to medications and…
- Trial name
- NCT00590642
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Creighton University
Obsessive-Compulsive Disorder
Dextro-Amphetamine Versus Caffeine in Treatment-resistant OCD
The study hypothesis is that dextro-amphetamine (d-amphetamine) will be safe and effective when used to augment treatment for Obsessive-Compulsive Disorder (OCD), and that tolerance (loss of therapeutic effect) to the medication…
- Trial name
- NCT00363298
- Testing
- dextro-amphetamine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Stanford University
Obsessive-Compulsive Disorder
Transcranial Direct Current Stimulation (tDCS) for Treatment-Resistant Obsessive-Compulsive Disorder (FRONT)
Neuromodulation techniques for the treatment of Obsessive-Compulsive Disorder (OCD) have expanded with the greater understanding of the brain circuits involved in this disorder.
- Trial name
- FRONT (NCT02743715)
- Testing
- Active tDCS (transcranial direct current stimulation)
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- University of Sao Paulo
Schizophrenia, Treatment Resistant Depression (TRD)
Treatment Resistance in Psychiatric Disorders: the Search for Biological Markers Predictive of Response to Treatment
The disruption of immune system is a key candidate in the pathogenesis of psychiatric disorders, especially those resistant to traditional treatments.
- Conditions
- Schizophrenia, Treatment Resistant Depression (TRD), Bipolar Disorder (BD), Catatonia
- Trial name
- BIO-INM (NCT07741981)
- Testing
- Blood sampling, lumbar puncture, stool sampling, skin microbiopsy and psychometrics scales
- Where
- France
- Volunteers
- 700 people
- Sponsor
- Centre Hospitalier St Anne
Obsessive Compulsive Disorder (OCD), Treatment Resistant Obsessive Compulsive Disorder
Brain-Oscillation Synchronized Stimulation of the DMPFC
This trial aims to obtain initial evidence about the clinical efficacy and modulation of neurophysiological markers in obsessive compulsive disorder (OCD) using personalized (i.e., electroencephalography (EEG)-triggered)…
- Trial name
- BOSS-OCD (NCT06942559)
- Testing
- EEG-Triggered Repetitive Transcranial Magnetic Stimulation (rTMS), Non-EEG Triggered Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Centre for Addiction and Mental Health
Obsessive-Compulsive Disorder
Double Blinded, Placebo-Controlled Trial of Paliperidone Addition in SRI-Resistant Obsessive-Compulsive Disorder
Obsessive-compulsive disorder (OCD) is a common, chronic, and oftentimes disabling disorder. The only established treatments for OCD are a specific form of Cognitive Behavioral Therapy (CBT) and the Serotonin Reuptake Inhibitor…
- Trial name
- NCT00632229
- Testing
- Paliperidone
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of South Florida
Obsessive-Compulsive Disorder
Efficacy Study of add-on Therapy With N-Acetylcysteine in Resistant Obsessive-compulsive Disorder
The primary objective of this study is to determine if N-Acetylcysteine (NAC) has efficacy as an augmentation agent in the treatment of treatment-resistant obsessive-compulsive disorder (OCD).
- Trial name
- NACTOC (NCT01555970)
- Testing
- N-Acetylcysteine (NAC)
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo