Clinical trials: Treatment Response
Hepatocellular Carcinoma (HCC), Treatment Response
Multimodalomics-based Construction of Spatiotemporal Characteristics of Dynamic Liver Cancer Microenvironment to Characterize the Clinical Application of Immune Mechanisms in Liver Cancer
This study aims to explore whether adding an additional MRI sequence to routine liver scans can better characterize the immune microenvironment of liver cancer.
- Trial name
- NCT07838415
- Testing
- time-dependent diffusion MRI and Cest sequence
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Tongji Hospital
Suicide Risk, Suicide Attempt
Study to Refine the Effectiveness of New Generation Therapies for Suicide
The purpose of this research study is to improve the effectiveness of a well-established therapy for suicidal thoughts and behaviors called Brief Cognitive Behavioral Therapy (BCBT) for Suicide Prevention.
- Conditions
- Suicide Risk, Suicide Attempt, Treatment Response
- Trial name
- STRENGTHENS (NCT07818889)
- Testing
- Brief Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ohio State University
Ovulation, Ovarian Function
Exogenous Progesterone as Ovulation Trigger
The goal of this clinical trial is to learn whether the sudden administration of vaginal micronized progesterone during the late follicular phase can trigger an LH surge and reactivation of oocyte meiosis in healthy oocyte donors…
- Conditions
- Ovulation, Ovarian Function, Assisted Reproductive Treatments, Oocyte Maturation
- Trial name
- PRO-TRIGGER (NCT07466199)
- Testing
- Vaginal micronized progesterone
- Where
- Portugal
- Volunteers
- 10 people
- Sponsor
- Instituto Valenciano de Infertilidade de Lisboa
High-risk Prostate Cancer, PSMA PET
Serial PSMA PET for Therapy Monitoring in Clinically Significant Prostate Cancer
This prospective, multicenter study aims to evaluate the clinical utility of serial PSMA PET for therapy monitoring in patients with newly diagnosed clinically significant prostate cancer.
- Conditions
- High-risk Prostate Cancer, PSMA PET, Treatment Response, Therapy Monitoring
- Trial name
- PSMA-TM (NCT07553780)
- Where
- 9 sites in China
- Volunteers
- 110 people
- Sponsor
- Xijing Hospital
Lymphoma Patients With Complete Response (CR) or Partial Response (PR) After Standard Treatment Had a Positive Minimal Residual Lesion (MRD)
RGL-305+ Lymphoma + Exploratory Clinical Study
This study is an open, prospective, dose-increasing exploratory clinical trial. To evaluate the safety, cytodynamics and initial efficacy of RGL-305 in patients with lymphoma.
- Trial name
- NCT07006012
- Testing
- RGL-305
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Fudan University
Classical Hodgkin Lymphoma, Child
Brentuximab Vedotin for Newly Diagnosed cHL in Chinese CAYA Based on PET/CT Assessment
Generally, pediatric patients tolerate acute toxicities but are vulnerable to late effects. Thus, increasing chemotherapy intensity to achieve more rapid complete early response to limit radiation therapy is worth testing.
- Conditions
- Classical Hodgkin Lymphoma, Child, Adolescent, Young Adult
- Trial name
- NCT06563245
- Testing
- Brentuximab Vedotin for Injection, response-adapted radiation, Doxorubicin
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Children's Cancer Group, China
ESCC, Total Neoadjuvant Treatment
Neoadjuvant Immunochemotherapy and Chemoradiotherapy Followed by Surgery for Advanced Esophageal Squamous Cell Carcinoma
Effective systemic therapy such as nivolumab as an adjuvant therapy has been demonstrated to improve the outcomes of patients receiving neoadjuvant chemoradiotherapy (CRT) for locoregional esophageal cancer.
- Conditions
- ESCC, Total Neoadjuvant Treatment, Pathological Complete Response
- Trial name
- NICE-ESCC (NCT06764355)
- Testing
- Tislelizumab, Paclitaxel, Cisplatin
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Immune Responses, Antibiotic Treatment
The Effects of Antibiotic Exposure in Early Infancy on Vaccine Responses
This prospective cohort study will include 200 term children born in Landspitali University Hospital in Iceland. The cohort will be divided into four groups according to antibiotic exposure of which one is the control group.
- Trial name
- NCT06079606
- Testing
- Antibiotic treatment
- Where
- Iceland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Landspitali University Hospital
Morbid Obesity Requiring Bariatric Surgery, Postoperative Pain
Effect of Lidocaine-Dexmedetomidine on Pain, Inflammation, and Oxidative Stress After Bariatric Surgery.
The goal of this randomized clinical trial is to find out whether giving an intravenous lidocaine + dexmedetomidine combination (LIDEX) during laparoscopic bariatric surgery can lower post-operative pain, inflammation, and…
- Conditions
- Morbid Obesity Requiring Bariatric Surgery, Postoperative Pain, Postoperative Pain Management, Postoperative Analgesia
- Trial name
- NCT07073846
- Testing
- Intravenous Lidocaine infusion + Standard Anesthesia, Intravenous Dexmedetomidine infusion + Standard Anesthesia, Lidocaine + Dexmedetomidine Combination (LIDEX) + Standard Anesthesia
- Where
- 2 sites in Mexico
- Volunteers
- 104 people
- Sponsor
- Instituto Mexicano del Seguro Social
Histologically Confirmed Metastatic or Locally Advanced Breast Cancer With no Radical Topical Treatment Available, If There is Liver Metastasis, Which the Researcher Believes Will be Difficult to Evaluate the Response Accurately With Bone Metastasis or CT
FDG PET-CT in Advanced Breast Cancer
This study is a prospective cohort study comparing metabolic response evaluation by F-18 FDG PET-CT versus conventional imaging for outcome stratification in patients with advanced breast cancer receiving first-line systemic…
- Trial name
- PET-000 (NCT07173868)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
Iron Deficiency Anemia, Vaccine Response Impaired
Iron and COVID-19 Vaccine Response
Vaccines often underperform in Africa compared to high-income countries. Why vaccines do not work as well in Africa remains uncertain. Malnutrition likely plays a role.
- Conditions
- Iron Deficiency Anemia, Vaccine Response Impaired, COVID-19 Vaccine, Iron Deficiency Anemia Treatment
- Trial name
- NCT04915820
- Testing
- Ferinject
- Where
- Kenya
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Jomo Kenyatta University of Agriculture and Technology
Evaluate Response to Treatment Both Biochemically and Virologically to Determine the Safety and Effectiveness of Bulevirtide Therapy in HDV Patients
Assessment of Response and Safety of Bulevirtide Treatment in Patients With Chronic Delta Virus Infection
1. The study is non-interventional, multicenter, non-profit 2. The primary objective of the study is to evaluate the safety and efficacy in clinical practice of the drug Bulevirtide in the treatment of patients with chronic HDV…
- Trial name
- ARISTOTLE (NCT07116044)
- Testing
- virological tests diagnostic tests
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- University of Molise
Depression - Major Depressive Disorder, Cognitive Flexibility
Cognitive Flexibility in Depression and TMS Response
The primary aim of this study is to determine the level of cognitive flexibility in patients with TRD before treatment and to explore whether there is a relationship with their response to TMS treatment.
- Conditions
- Depression - Major Depressive Disorder, Cognitive Flexibility, Treatment Response, Side Effects
- Trial name
- CogFelx_TMS (NCT06775054)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
Bacteriuria in Symptomatic Benign Prostate Hyperplasia, Antibiotic Susceptibility in Symptomatic Benign Prostate Hyperplasia
Prevalence of Bacteriuria, Antibiotic Susceptibility, and Treatment Response in Symptomatic Benign Prostatic Hyperplasia
The goal of this prospective observational study is to identify the common pathogens and antibiotic sensitivity pattern in urine samples of men with symptomatic BPH and to assess severity of LUTS in patients with symptomatic BPH…
- Conditions
- Bacteriuria in Symptomatic Benign Prostate Hyperplasia, Antibiotic Susceptibility in Symptomatic Benign Prostate Hyperplasia, Treatment Response to Antibiotics in Symptomatic Benign Prostate Hyperplasia
- Trial name
- BPH (NCT06520267)
- Testing
- Antibiotic therapy
- Where
- Nepal
- Volunteers
- 131 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Pleural Mesothelioma, Treatment Response
Evaluation of Response by FLT PET in Mesothelioma
Pleural mesothelioma (MPM) is an aggressive tumor that affects the pleura and originates from mesothelial cells. If untreated, median survival is 4-12 months following diagnosis.
- Conditions
- Pleural Mesothelioma, Treatment Response, Chemotherapy Effect
- Trial name
- FLT-MM (NCT06410625)
- Testing
- FLT PET imaging
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Ankara University
18F-FAPI, Pancreas Adenocarcinoma
A Study Using 18F-FAPI PET to Evaluate Treatment Response in Pancreatic Adenocarcinoma
To explore the potential utility of 18F-FAPI-04 PET/CT for pathologic response evaluation to systemic treatment in PDAC
- Conditions
- 18F-FAPI, Pancreas Adenocarcinoma, Systemic Treatment, Pathologic Response
- Trial name
- NCT06277206
- Testing
- 18F-FAPI PET/CT
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Zhejiang University
Solid Tumor, Hematologic Malignancy
COVID-19 Vaccine Efficacy in Patients With Malignant Pathologies
In the context of malignant disease, it is likely that vaccine efficacy and immunogenicity depends on the type of pathology, stage of the disease, immunosuppression induced by the treatments, in addition to more classic factors…
- Conditions
- Solid Tumor, Hematologic Malignancy, Thoracic Cancer, Cancer, Treatment-Related
- Trial name
- COVIDVAC OH (NCT04776005)
- Testing
- Data collection
- Where
- 2 sites in France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Characteristics That Modify the Response to Cholecalciferol Treatment
Individualized Response to Vitamin D Treatment Study
The goal of this clinical trial is to determine individual-level genetic and metabolic characteristics that modify the response to cholecalciferol treatment.
- Trial name
- INVITE (NCT02925195)
- Testing
- Vitamin D3
- Where
- 5 sites in United States
- Volunteers
- 666 people
- Sponsor
- University of Washington
Hemodynamic Response, Acute Appendicitis
Lidocaine VS Hemodynamic, Metabolic and Hormonal Response
Intravenous lidocaine - a potent local anesthetic with analgesic and anti- inflammatory properties has been shown to be an effective adjunct that reduces intra and postoperative opioid consumption and facilitates pain management…
- Conditions
- Hemodynamic Response, Acute Appendicitis, Complication of Treatment, Opioid Consumption
- Trial name
- NCT05238506
- Testing
- Intravenous lidocaine, Normal saline infusion
- Where
- Poland
- Volunteers
- 132 people
- Sponsor
- Medical University of Warsaw
Infective Endocarditis, Response, Acute Phase
Personalized Medicine in Patients With Infective Endocarditis
The hypothesis underlying this work is the identification of different sub phenotypes of patients with infective endocarditis through the study of the host's response to infection.
- Conditions
- Infective Endocarditis, Response, Acute Phase, Treatment
- Trial name
- NCT04838938
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Fundación para la Investigación Biosanitaria del Principado de Asturias