Clinical trials: Treatment Response
Depression
p11 Protein Levels in Patients With Major Depressive Disorder Treated With Citalopram
This study will compare levels of p11 protein in people with and without major depressive disorder (MDD) and examine if p11 levels in patients are affected by treatment with citalopram (Celexa).
- Trial name
- NCT00697268
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Seborrheic Dermatitis
Ruxolitinib in Seborrheic Dermatitis
This study is an open-label prospective interventional trial that will assess the efficacy of ruxolitinib in the treatment of seborrheic dermatitis.
- Trial name
- NCT05787860
- Testing
- Ruxolitinib 1.5% Cream
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Periodontal Disease, Chronic Periodontitis (Disorder)
Salivary Mitofusin-1 Levels in Periodontitis: Associations With Disease Severity, Smoking, and Treatment Response
Periodontitis (gum inflammation) is a common disease worldwide. This study aims to investigate a novel biomarker, a protein called Mitofusin-1 (Mfn1), in saliva that may be associated with the severity of periodontitis and…
- Trial name
- NCT07262606
- Testing
- Non-surgical Periodontal Therapy (Scaling and Root Planing), Saliva Collection
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Ömer Faruk Okumuş
Efficacy of DHEA, Pregnancy Rate
Administration of DHEA in Patients With Poor Response to Ovarian Stimulation for IVF
Poor responders to ovarian stimulation represents one of the most frustrating problems in reproductive medicine. The investigators hypothesize that ovarian response of those patients could improve by treating these patients with…
- Conditions
- Efficacy of DHEA, Pregnancy Rate, Diminished Ovarian Reserve, Changes in AMH
- Trial name
- DHEA (NCT02099916)
- Testing
- gonadotropins plus DHEA, Gonadotropins
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Athens
Major Depressive Disorder (MDD), Neuroimaging
Efficacy of Bright Light Therapy on Cognitive Impairment in Major Depressive Disorder and Its Neuroimaging Mechanisms: Protocol for a Randomised Controlled Trial
This study aims to validate the therapeutic efficacy and safety of bright light therapy (BLT) in ameliorating cognitive impairment (CI) in major depressive disorder (MDD), characterize the functional and structural features of…
- Conditions
- Major Depressive Disorder (MDD), Neuroimaging, Bright Light Treatment, Cognitive Impairment
- Trial name
- NCT07508215
- Testing
- BLT, DRL
- Where
- 2 sites in China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University Sixth Hospital
Smallpox
MVA Post-Event: Administration Timing and Boost Study
The purpose of this study is to evaluate an investigational smallpox vaccine, called IMVAMUNE®, with respect to safety and immune (body's defense system) response.
- Trial name
- NCT00437021
- Testing
- Live vaccinia virus vaccine, MVA Smallpox Vaccine
- Where
- 7 sites in United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Obesity
Learning Theory to Improve Obesity Treatment
The purpose of this study is to optimize an obesity treatment program targeting overweight 8-12 year old children using "Cue Exposure Training".
- Trial name
- iROC (NCT01708785)
- Testing
- Single food Cue Exposure Treatment, Multiple food Cue Exposure Treatment, Partial Reinforcement - Enhanced Cue Exposure Treatment
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Rh Disease
Circulating microRNAs as Novel Prognosis Biomarkers for Rheumatoid Arthritis
The correlation of circulating serum miR-125ba and miR-146a expression and clinical response to green tea therapy were analysed in RA patients.Clinical response to green tea therapy for 24 weeks was calculated from DAS28 scores.
- Trial name
- NCT03719469
- Testing
- Green tea group
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- King Saud University
Bipolar Disorder
FMRI Study of Brain Response Before and After Lithium Treatment in People With Bipolar Disorder
This study will assess the effects of bipolar disorder on brain activity and will determine if medication changes the brain activity in people with bipolar disorder.
- Trial name
- NCT00596622
- Testing
- Lithium
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Indiana University
Migraine
Human Electrophysiological Model to Quantify the CGRP-related Axon Reflex of Trigeminal Afferents
The proposed project aims at establishing Calcitonin gene-related peptide (CGRP)-Related Axon Reflex of Trigeminal Afferents as a neurophysiological biomarker for migraine.
- Trial name
- MiPro-CGRP (NCT04796766)
- Testing
- High frequency stimulation (HFS), Low-frequency sinusoidal transcutaneous stimulation (sLFS)
- Where
- Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Invasive Candidiasis, Candidemia
Risk Of Severe Hepatic Injury In Patients With Invasive Candidiasis Treated With Echinocandins
The purpose of this study is to estimate the relative risk of severe hepatic injury in hospitalized patients with invasive candidiasis and candidemia who received anidulafungin, compared to patients who received caspofungin…
- Trial name
- NCT01213823
- Testing
- Does not apply
- Volunteers
- 536 people, healthy volunteers welcome
- Sponsor
- Pfizer
Nocturnal Enuresis
A New Check-list Method for Nocturnal Enuresis
The study is aimed to demonstrate the benefits of newly formed written check-list of behavioral instructions and investigate its effects on parent's awareness, consciousness and motivation toward MNE.
- Trial name
- NCT03510975
- Testing
- desmopressin melt form 120 μg, Verbal behavioral therapy, Behavioral therapy with written check-list
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ankara Training and Research Hospital
Depression, Healthy
Quetiapine in Melancholic Depression
In summary, the investigators propose to integrate fMRI assessments within a clinical trial of quetiapine XR in patients with melancholic depression in order to test the predictions that: 1.
- Trial name
- NCT01200901
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Atopic Dermatitis
The Role of Confocal Microscopy in Estimating Dupilumab Treatment Response for Moderate/Severe Atopic Dermatitis
Atopic dermatitis (AD) is recognized as the most prevalent chronic inflammatory skin disease across all age groups. The introduction of reflectance confocal microscopy (RCM) signifies a substantial leap forward in the…
- Trial name
- NCT07098000
- Where
- Argentina
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital Italiano de Buenos Aires
BCG Infection, Reaction - Vaccine
A Study of the Interaction Between BCG And MenC Immunisation: BAM
The Bacille Calmette-Guérin (BCG) vaccine is the only vaccine licenced to prevent tuberculosis (TB). The stimulus it gives to the immune system allows it to respond more effectively to a subsequent infection with TB.
- Conditions
- BCG Infection, Reaction - Vaccine, Immune Response
- Trial name
- BAM (NCT02002156)
- Testing
- BCG, NeisVac-C®, Pediacel®, Infanrix™, Prevenar-13®, Menitorix®, Priorix®, Rotarix®, NeisVac-C®, Pediacel®, Infanrix™, Prevenar-13®, Menitorix®, Priorix®, Rotarix®
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Oxford
COVID-19 Acute Respiratory Distress Syndrome, Cytokine Release Syndrome
Tazemetostat for the Treatment of Moderate to Severe COVID-19 Infection
The purpose of this study is to assess the safety and efficacy of repurposing tazemetostat for the treatment of Acute Respiratory Distress Syndrome (ARDS) or Systemic Cytokine Release Syndrome (SCRS) in COVID-19 patients.
- Trial name
- IST (NCT05018975)
- Testing
- Tazemetostat
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Vision Disorders, Eye; Movement Disorder (Binocular)
Characteristics of the Vergence Responses of Binocularly Normal Subjects After a Vision Therapy Protocol
A vision therapy protocol for vergence ability is mentioned. The purpose of this study is to evaluate objectively the change in the vergence responses of binocular and accommodative normal subjects after performing a classic…
- Conditions
- Vision Disorders, Eye; Movement Disorder (Binocular), Vision Therapy, Binocular Vision Disorder
- Trial name
- NCT05208658
- Testing
- Experimental: Classical Vision Therapy Treatment, Control: Eye Movement Therapy Treatment
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universitat Politècnica de Catalunya
Systemic Lupus Erythematosus, BAFF Polymorphism
BAFF and APRIL and RESPONSE TO BELIMUMAB in SLE
This project is intended to identify the routes on which BAFF and APRIL act in order to detect possible future candidates to Belimumab treatment among patients diagnosed of SLE.
- Trial name
- BAFF (NCT03919643)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Motor Response Time
Influence of Spinal Manipulative Therapy Upon Stroop Task Performance
The purpose of this study is to determine if spinal manipulative therapy can affect cognitive processing as determined by performance on a Stroop task.
- Trial name
- NCT00335426
- Testing
- Spinal manipulative therapy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Logan College of Chiropractic
Panic Disorder
Investigations of Factors Associated With Treatment Response and Prognosis in Anxiety Disorders
The purpose of this study is to build a comprehensive brain and behavioral dataset on anxiety disorders and identify clinical factors related to treatment response and prognosis in patients with anxiety disorders.
- Trial name
- IRPA (NCT06773585)
- Testing
- Psychiatric scale assessments, VR-Based Behavioral Assessment, Brain MRI
- Where
- South Korea
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Kangbuk Samsung Hospital