Clinical trials: Treatment Response
Septic Shock
Midodrine Use in Septic Shock
The investigators aim to perform a randomized, double-blind, placebo-controlled trial to investigate the efficacy of midodrine in decreasing time to IV vasopressor liberation in patients with septic shock.
- Trial name
- NCT03706053
- Testing
- Midodrine Hydrochloride
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Respiratory Syncytial Virus Infections
A Study on the Immune Response, Safety and the Occurrence of Respiratory Syncytial Virus (RSV)-Associated Respiratory Tract Illness After Administration of RSV OA Vaccine in Adults 60 Years and Older
The purpose of the current study is to evaluate the immune response of the RSVPreF3 OA investigational vaccine in older adults (OA) at least (>=) 60 years of age (YOA) in China compared to OA in the same age range to be enrolled…
- Trial name
- NCT06551181
- Testing
- RSVPreF3 OA investigational vaccine
- Where
- 40 sites in China, Finland and 5 more
- Volunteers
- 2,620 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Age Related Macular Degeneration
Comparison of Treatment Response to Intravitreal Injection of Combined Propranolol and Bevacizumab Versus Bevacizumab Monotherapy in Patients With Wet Age Related Macular Degeneration :A Clinical Trial
This study is designed to compare the effect of combined intravitreal Bevacizumab and Propranolol injection versus Bevacizumab monotherapy in patients with Age Related Macular Degeneration.
- Trial name
- NCT03609307
- Testing
- Combined Intravitreal bevacizumab and propranolol, Intravitreal bevacizumab
- Where
- Iran
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Obesity, Overweight
Response Evolution Chart
This study evaluates patient response to a motivation evolution chart for a medical-nutrition intervention as a continuation of a previous study: adherence to an overweight and obesity treatment available at…
- Conditions
- Obesity, Overweight, Motivation, Adherence, Patient
- Trial name
- NCT03484637
- Testing
- Lifestyle-medicine intervention
- Where
- Colombia
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- BiomediKcal
Psoriasis Vulgaris
An Explorative Psoriasis Biomarker Study
Plaque psoriasis may be an ideal model disease to explore potential therapeutic effects of immunosuppressive agents, given the easy accessibility of inflammatory lesions.
- Trial name
- NCT04394936
- Testing
- Guselkumab
- Where
- Netherlands
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Centre for Human Drug Research, Netherlands
GERD
Physiology of GERD and Treatment Response
This study is designed to assess the physiologic and behavioral mechanisms associated with enhanced medication effects in adult patients with functional GERD-related symptoms.
- Trial name
- NCT04292470
- Testing
- Amitriptyline
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Multiple Sclerosis
Pharmacodynamic Study to Better Understand the Therapeutic Response and Immunomodulatory Effects of Avonex in Multiple Sclerosis (MS) Patients and Healthy Volunteers
This study will look at differences in bioanalytical measures among different groups of MS patients and Healthy Volunteers, when administered interferon beta-1a.
- Trial name
- NCT00913666
- Testing
- Interferon beta-1a (Avonex)
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Biogen
Colorectal Cancer
Anthocyanin-Rich Berry Supplementation in Patients With Colorectal Cancer
This prospective, open-label interventional study evaluated the effects of short-term supplementation with an anthocyanin-rich freeze-dried black raspberry and strawberry preparation in patients undergoing treatment for…
- Trial name
- NCT07819539
- Testing
- Anthocyanin-Rich Freeze-Dried Berry Supplement
- Where
- Poland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Bacteremia, Tooth Extraction Status Nos
Bacteraemia Secondary to Tooth Extraction: Chlorhexidine Prophylaxis Protocols
The first time the American Heart Association (AHA) suggested that disinfection of the gingival sulcus be performed as a complement to antibiotic prophylaxis in patients considered to be at risk of Infective endocarditis (IE) was…
- Trial name
- NCT02150031
- Testing
- 0.2% Chlorhexidine, 1% Chlorhexidine, Blood extraction
- Where
- 2 sites in Portugal, Spain
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
HER2 Positive Breast Carcinoma, Stage IIIA Breast Cancer
Cu64-DOTA-trastuzumab PET and Markers Predicting Response to Neoadjuvant Trastuzumab + Pertuzum in HER2+ Breast Cancer
This phase II trial studies how well copper Cu64-DOTA-trastuzumab positron emission tomography (PET) works in predicting response to treatment with trastuzumab and pertuzumab before surgery in patients with human epidermal growth…
- Conditions
- HER2 Positive Breast Carcinoma, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer, Stage IIIC Breast Cancer
- Trial name
- NCT02827877
- Testing
- Copper Cu 64-DOTA-Trastuzumab, Laboratory Biomarker Analysis, Pertuzumab
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Health Adult Subjects, Pressure Injury Prevention
A Trial to Investigate the New Caulis Pro® Low Air Loss (LAL) System
Investigation of biomechanical and physiological functions of laying on a new mattress in healthy volunteers.
- Trial name
- NCT07213739
- Testing
- CLP and pulsation
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Arjo AB
Seborrheic Dermatitis
Ruxolitinib in Seborrheic Dermatitis
This study is an open-label prospective interventional trial that will assess the efficacy of ruxolitinib in the treatment of seborrheic dermatitis.
- Trial name
- NCT05787860
- Testing
- Ruxolitinib 1.5% Cream
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pulp Inflammation
Analysis of the Influence of Desensitizing Treatments on the Pulp Inflammatory Response in Bleached Teeth
This randomized, controlled, blinded clinical trial evaluated the effectiveness of different desensitizing protocols in preventing pulp inflammation after bleaching treatment with 35% hydrogen peroxide (PH) (Whiteness PH 35%).
- Trial name
- NCT04548674
- Testing
- Whiteness HP 35%, Whiteness HP 35% + LASER, Whiteness HP 35% + CPP
- Where
- Brazil
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Para
Carcinoma, Glioblastoma
MRinRT: Swansea University and SWWCC Collaboration Study.
The aim of this study is to learn whether using MRI (magnetic resonance imaging) scans to plan radiotherapy is better than using CT (computed tomography) scans alone.
- Conditions
- Carcinoma, Glioblastoma, Radiotherapy, MRI
- Trial name
- MRinRT (NCT07365124)
- Testing
- MRI
- Where
- United Kingdom
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Swansea Bay University Health Board
Atrophic Acne Scars
Treatment of Atrophic Acne Scars With a Fractional CO2 Laser at 1 Versus 3 Months Intervals
To compare efficacy and adverse effects of fractional CO2 laser of acne scars treatment with 1 versus 3 months intervals
- Trial name
- NCT01773343
- Testing
- Laser
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Autism Spectrum Disorders, Mood Disorders
Multidimensional Measurement of Psychopharmacological Treatment Response
The study examines actigraphic, observational, psychometric and associated repeated measurements obtained prior to and during psychopharmacological treatment.
- Conditions
- Autism Spectrum Disorders, Mood Disorders, Sleep Disorders, Attention Deficit Disorders
- Trial name
- NCT01184235
- Testing
- Pharmacological Intervention
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Child Psychopharmacology Institute
Healthy, no Evidence of Disease
Cholecalciferol and Flu Vaccine in Treating Healthy Participants
This randomized clinical trial studies cholecalciferol and flu vaccine in treating healthy participants. Cholecalciferol may increase the immunologic response of flu vaccine in healthy participants.
- Trial name
- NCT01561989
- Testing
- cholecalciferol, questionnaire administration, trivalent influenza vaccine
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Diabetes Mellitus
Inflammatory Response to CSII Catheters in a Tummy Tuck Model
In insulin pump therapy, insulin is continuously infused into the subcutaneous adipose tissue via a continuous subcutaneous insulin infusion (CSII) catheter using a basal/bolus pattern.
- Trial name
- IRCATT (NCT03298295)
- Testing
- Continous Subcutaneous Insulin Infusion Catheter
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Breast Cancer
Assessing Treatment Response in Breast Cancer With Functional Imaging
Patients with large primary operable breast cancers are offered chemotherapy prior to surgery to shrink the tumour and enable breast conserving surgery.
- Trial name
- NCT02688257
- Testing
- MRI, Ultrasound
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Institute of Cancer Research, United Kingdom
Atopic Dermatitis
The Role of Confocal Microscopy in Estimating Dupilumab Treatment Response for Moderate/Severe Atopic Dermatitis
Atopic dermatitis (AD) is recognized as the most prevalent chronic inflammatory skin disease across all age groups. The introduction of reflectance confocal microscopy (RCM) signifies a substantial leap forward in the…
- Trial name
- NCT07098000
- Where
- Argentina
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital Italiano de Buenos Aires