Clinical trials: Treatment Response
PTCL Patients Who Achieved Complete Response From Frontline Treatment
An Open, Single Center, Non-randomized, Single Arm Clinical Study of Evaluating the Efficacy of Selinexor in the Maintenance Treatment of PTCL
To evaluate the efficacy and safety of Selinexor maintenance therapy in PTCL patients who achieved complete response from frontline treatment, and to analyze the relationship between gene mutation in PTCL and disease prognosis…
- Trial name
- NCT05822050
- Testing
- Selinexor
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The First Hospital of Jilin University
Cancer, Treatment-Related, Tumor of Breast
To Detect Cryoimmunologic Response Induced by Early Breast Cancer Ultrasound-guided Cryoablation (ICE-study)
The aim of our study is to examine the cryoimmunologic response and its mechanisms induced by US-guided cryoablation of small breast tumors (<2 cm) not eligible to neoadjuvant therapy.
- Conditions
- Cancer, Treatment-Related, Tumor of Breast, Systemic Inflammatory Response, Stage I Breast Cancer
- Trial name
- NCT05727813
- Testing
- cryoablation
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Roma La Sapienza
To Evaluate PSQ as Clinical Tool in the Decision Between Medical and Surgical Treatment for Adenotonsillar Hypertrophy, To Determine Clinical Response to Montelukast or Nasal Steroids Based on PSQ Results
Medical vs Surgical Treatment in OSA Among Children
Adeno-tonsillar hypertrophy causing OSA are treated surgically however, over the last years it has been shown that montelukast or nasal steroidal spray can significantly improve symptoms, adenoid size, and polysomnographic…
- Trial name
- NCT05651750
- Testing
- Montelukast, Fluticasone Furoate
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Disorder in Complete Remission in Response to Treatment
Short-course Radiotherapy Combined With Neoadjuvant Chemotherapy and PD-1 Inhibitor in the Treatment of Locally Advanced Gastric Adenocarcinoma
This is a Prospective, Single-center, Single-arm, phase II clinical trial to explore the efficacy and safety of sintilimab (PD1 inhibitor) combined with XELOX chemotherapy, evaluate the pathological complete response rate of…
- Trial name
- NCT05563012
- Testing
- Sintilimal Injection
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Renmin Hospital of Wuhan University
Head and Neck Cancer, Multiparametric MRI
Use of Multiparametric MRI in the Management of Head and Neck Cancer: a Prospective Analysis
The investigators aim to validate specific MRI parameters that could improve diagnostic accuracy of metastatic cervical lymph nodes in patients with a squamous cell carcinoma in the head and neck region.
- Conditions
- Head and Neck Cancer, Multiparametric MRI, Cervical Lymph Node, Bone Invasion
- Trial name
- NCT03993665
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- AZ Sint-Jan AV
Iron Deficiency Anemia, Vaccine Preventable Disease
Iron and Vaccine Response
Vaccines often underperform in Africa compared to high-income countries. Why vaccines do not work as well in Africa remains uncertain. Malnutrition likely plays a role.
- Conditions
- Iron Deficiency Anemia, Vaccine Preventable Disease, Vaccine Response Impaired, Iron Deficiency Anemia Treatment
- Trial name
- NCT04912661
- Testing
- Ferinject
- Where
- Kenya
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Anaemia Response to the Treatment, Peripheral Iron Indices
Ascorbic Acid Administration in the Treatment of Anemia in Chronic Hemodialysed Patients
The administration of ascorbic acid seemed to increase the iron available for erythropoiesis, thus improving the anemia response to the treatment.
- Conditions
- Anaemia Response to the Treatment, Peripheral Iron Indices, Oxalemia
- Trial name
- FeVitC (NCT02225886)
- Testing
- Ascorbic Acid
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Anemia Working Group Romania
Patients With CLL Relapsing After an Initial Response (CR, PR ≥ 6 Months) Following no More Than Two Prior Treatment Lines; or, Patients With CLL Refractory (SD, PD or CR/PR < 6 Months) Following no More Than Two Prior Treatment Lines
GIMEMA CLL0809 Study (BendOfa)
In the last ten years there have been significant developments in CLL treatment. The advent of fludarabine, rituximab and the association of chemo-immunotherapy have substantially increased overall response rate, CR rate, time to…
- Trial name
- BendOfa (NCT01244451)
- Testing
- Ofatumumab, Bendamustine
- Where
- 32 sites in Italy
- Volunteers
- 49 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Osteosarcoma, Feasibility
Feasibility Study of Interval Compressed Regimen Using Four-drugs for Osteosarcoma
The aim of the study is to test the feasibility of four-drug, interval-compressed regimen in osteosarcoma. Primary objective is to explore the toxicity and mortality related to treatment.
- Conditions
- Osteosarcoma, Feasibility, Treatment Response, Biomarker
- Trial name
- NCT03390946
- Testing
- Poor responder group adjuvant chemotherapy, Good responder group adjuvant chemotherapy
- Where
- South Korea
- Volunteers
- 23 people
- Sponsor
- Byung-Kiu Park
Opioid Analgesic Treatment Response, Chronic Pain
Predictive Markers of the Effects of Opioid Therapy
The overall goal of the ABILITY study is to help improve pain diagnostics and treatment by developing an implementable clinical computerised decision support system based on individual patient characteristics.
- Trial name
- ABILITY (NCT02308306)
- Where
- 5 sites in Belgium, Denmark and 1 more
- Volunteers
- 62 people
- Sponsor
- University of Aarhus
Treatment Response, Adverse Events
Photodynamic Therapy in Locally Advanced Hilar Cholangiocarcinoma
To determine the safety and efficacy of photodynamic therapy with a novel photosensitizer and a flexible laser probe in locally advanced hilar cholangiocarcinoma.
- Conditions
- Treatment Response, Adverse Events, Feasibility
- Trial name
- PDT (NCT02725073)
- Testing
- Photodynamic therapy
- Where
- 2 sites in South Korea
- Volunteers
- 32 people
- Sponsor
- Asan Medical Center
T Cell Response to Asthma in HIV-infected Patients Before and After Starting Treatment
Children With HIV and Asthma (CHIVAS)
To explore allergen-specific effector and regulatory T cell response in HIV-infected children before and after HAART initiation
- Trial name
- NCT01644370
- Testing
- HAART
- Where
- 2 sites in Thailand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The HIV Netherlands Australia Thailand Research Collaboration
Breast Cancer, HER-2 Positive Breast Cancer
An Open-Label Multicenter Phase 2 Window of Opportunity Study Evaluating Ganetespib in Women With Breast Cancer
The purpose of this study is to determine if ganetespib (STA-9090) is effective in the treatment of patients with HER2+ or triple negative breast cancer who have not received prior systemic treatment in the metastatic setting.
- Conditions
- Breast Cancer, HER-2 Positive Breast Cancer, Triple Negative Breast Cancer, ER/Progressive Response (PR) + Refractory to Prior Hormonal Treatment
- Trial name
- Enchant (NCT01677455)
- Testing
- ganetespib
- Where
- 25 sites in United States, Argentina and 6 more
- Volunteers
- 51 people
- Sponsor
- Synta Pharmaceuticals Corp.
Prior Treatment With PD-0325901 With Ongoing Clinical Response
A Single Patient IND for PD-0325901
The purpose of this study is to provide access for a single patient to PD-0325901 who was previously enrolled in a phase I clinical trial.
- Trial name
- NCT02297802
- Testing
- PD-0325901
- Where
- United States
- Sponsor
- Sharp HealthCare
Chronic Hepatitis B, Inadequate Response
Efficacy Optimizing Extension Study of Chronic Hepatitis B Patients With Inadequate Response to NUC Therapy
The purpose of this study is to compare the long-term efficacy and safety of entecavir 1.0 mg/d + adefovir 10 mg/d with entecavir 0.5 mg/d + adefovir 10 mg/d for chronic hepatitis B patients with inadequate response to NUC therapy
- Conditions
- Chronic Hepatitis B, Inadequate Response, Nucleos(t)Ide Analogues Treatment
- Trial name
- Dragon-Ex (NCT01829685)
- Testing
- Entecavir, Adefovir
- Where
- 16 sites in China
- Volunteers
- 360 people
- Sponsor
- Nanfang Hospital, Southern Medical University
To Correlate RPM Respiratory-gating Methods Analyses, Treatment Response, and Normal Tissue Metabolic Effect., Application in Clinical Outcomes and Prediction of Prognosis.
PET With Respiratory Gating Technique in Evaluation of Response and Normal Tissue Effect in Thoracic Cancer
Technologic advances in the field of radiation oncology have made in possible to deliver a highly conformal and accurate radiation dose to a target tissue.
- Trial name
- NCT02063633
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Far Eastern Memorial Hospital
Visceral Leishmaniasis, Immune Response
Immune Response of Visceral Leishmaniasis PatientsTreated With Antimonial Plus N-Acetylcysteine
This study is designed to evaluate the immune and therapeutic responses of visceral leishmaniasis patients using N-acetylcysteine (NAC) as an adjuvant therapy to pentavalent antimony.
- Conditions
- Visceral Leishmaniasis, Immune Response, Treatment
- Trial name
- VLNAC (NCT01138956)
- Testing
- N-acetylcysteine, Pentavalent antimonial
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Hospital Universitário Professor Edgard Santos
Major Depressive Disorder, Antidepressant Treatment Response
Citalopram Versus Citalopram Plus Pindolol in Major Depressive Disorder
The purpose of this study is to examine whether the speed of the clinical antidepressant action of citalopram can be accelerated by administering double doses of pindolol (15 mg/day, tid) which presumably should lead to increased…
- Trial name
- CIT-PIN (NCT00931775)
- Testing
- Pindolol
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau