Clinical trials: Treatment of Periodontitis
Periodontitis
"Effect of Ibuprofen on Acute Inflammatory Response After One-Stage Periodontal Therapy"
The goal of this ( Clinical Trial ) is to evaluate the efficacy of Ibuprofen in reducing acute inflammatory response (hs-CRP, ProCT, IL-6) after one hour and one week following one stage non surgical periodontal therapy.
- Trial name
- NCT07459049
- Testing
- Non surgical root surface debridement in one stage without receiving Ibuprofen, Non surgical root surface debridement in one stage with receiving Ibuprofen
- Where
- Iraq
- Volunteers
- 30 people
- Sponsor
- University of Baghdad
Periodontitis, Periodontal Diseases
Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis
The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis).
- Conditions
- Periodontitis, Periodontal Diseases, Periodontal Inflammation, Gingival Diseases
- Trial name
- NCT07536204
- Where
- Chile
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Chile
Periodontitis
the Clinical Effect of Nd: YAG Laser Assisted Periodontal Initial Therapy in Patients With Moderate to Severe Periodontitis
The goal of this clinical trial is to learn if Neodymium-Doped Yttrium Aluminum Garnet（Nd: YAG） Laser-assisted non-surgical periodontal treatment is effective in treating stage II/III periodontitis.
- Trial name
- NCT06587334
- Testing
- SRP, Nd: YAG Laser Assisted SRP
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Chronic Periodontitis
Platelet Rich Fibrin+1% Alendronate in Treatment of Chronic Periodontitis
The present study is designed to evaluate the combined efficacy of Platelet Rich Fibrin (PRF) and 1% Alendronate (ALN) with open flap debridement (OFD) in treatment of intrabony defects in chronic periodontitis patients.
- Trial name
- NCT02518152
- Testing
- Open flap debridement (OFD), OFD with Platelet rich fibrin (PRF), OFD with Platelet rich fibrin (PRF)+1% Alendronate
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Periodontitis
Osseous Resective Surgery Vs Conservative Surgery with or Without Papilla Preservation Technique
The primary aim of the study is to evaluate the efficacy of either fibre retention osseous resective surgery (FibReORS) or conservative surgery with or without PPT in the treatment of deep residual pockets ≥ 6 mm in stage III-IV…
- Trial name
- FibReORS vs AF (NCT06663202)
- Testing
- Fiber retention osseous resective surgery, Papilla preservation flap, Widman flap procedure
- Volunteers
- 120 people
- Sponsor
- University of Turin, Italy
Chronic Periodontitis
Effect of Nonsurgical Periodontal Therapy Verses Oral Hygiene Instructions on Patients With Chronic Periodontitis
Periodontitis, a bacterial dental biofilm based infectious disease, is a chronic inflammatory disease of the periodontium which results in irreversible destruction of supporting structures of the teeth such as periodontal…
- Trial name
- NCT02208739
- Testing
- Nonsurgical periodontal therapy, Oral hygiene instructions
- Where
- Malaysia
- Volunteers
- 56 people
- Sponsor
- University of Malaya
Periodontitis
Comparative Evaluation of the Effect of Different Adjunctive Air Polishing Powders in Nonsurgical Periodontal Therapy in Patients with Stage II and III Periodontitis
The aim of this clinical trial is to evaluate and compare the effect of a newly designed air-polishing device (APD) using Erythritol, Glycine, and Trehalose air-polishing powders in nonsurgical periodontal therapy with control…
- Trial name
- GBT (NCT06726902)
- Testing
- GBT and SI with erythritol powder, GBT and SI with glycine powder, GBT and SI with trehalose powder
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Diana Ibrahim
Periodontal Diseases, Wound Heal
Hyaluronic Acid and Polynucleotides for Supra-bony Defects
The goal of this pilot study is to describe the early wound healing molecular events and the vascularization pattern associated with the treatment of supra-bony defects with access flap alone or in association with a combined…
- Conditions
- Periodontal Diseases, Wound Heal, Periodontal Inflammation, Periodontal Pocket
- Trial name
- NCT06309719
- Testing
- Periodontal Access Flap (AF) + Combined Formulation of Hyaluronic acid and Polydeoxyribonucleotides (PNHA), Periodontal Access Flap (AF)
- Where
- 2 sites in United Kingdom
- Volunteers
- 24 people
- Sponsor
- Queen Mary University of London
Systemic Lupus Erythematosus, Periodontitis
Treatment of Periodontal Disease in Systemic Lupus Erythematosus
The primary objective of this study is to: Part 1 - Baseline Comparisons The primary objective of Part 1 is to: Investigate the association between SLE and a measures of vascular health (brachial artery flow-mediated dilatyation)…
- Trial name
- NCT04046172
- Testing
- supra/sub gingival root surface debridement, supra-gingival scaling and polishing
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University College, London
Symptomatic Irreversible Pulpitis (SIP), Symptomatic Apical Periodontitis
Comparison of Postoperative Pain After Root Canal Treatment Using Hand-Held vs Rotary ProTaper Files: A Randomized Controlled Trial
This randomized controlled trial aims to compare postoperative pain after root canal treatment using two different types of ProTaper file systems: manual (hand-held) and rotary (engine-driven).
- Conditions
- Symptomatic Irreversible Pulpitis (SIP), Symptomatic Apical Periodontitis, Postoperative Pain After Endodontic Treatment
- Trial name
- NCT07887087
- Testing
- ProTaper Manual Root Canal Instrumentation, ProTaper Rotary Root Canal Instrumentation
- Volunteers
- 200 people
- Sponsor
- College of Physicians and Surgeons Pakistan
Healing Wound, Periodontitis
Imaging Analysis Following Periodontal Surgery
This is a single centre, randomised, single-blind, parallel-group clinical trial that aims at evaluating the use of imaging (2D and 3D) in obtaining geometric and thermometric changes of postoperative healing patterns and…
- Trial name
- NCT03631693
- Testing
- Simplified papilla preservation flap, Resective periodontal flap with osseous recontouring
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Queen Mary University of London
Periodontitis
Impact of E-Cigarette Smoking on Healing Response to Non-Surgical Periodontal Therapy
the goal of this clinical trial is to compare the effect of vaping vs traditional smoking on non surgical periodontal therapy . the main question it aims to answer is what is the impact of traditional smoking and vaping on…
- Trial name
- NCT07668947
- Testing
- non surgical periodontal therapy
- Where
- Egypt
- Volunteers
- 117 people
- Sponsor
- Ain Shams University
Periodontitis
The Effect of Locally Delivered Ciclosporin as an Adjunct to Healing After Treatment of Periodontal Pockets
The main purpose of the trial is to investigate the effect of locally delivered ciclosporin as an adjunct to non-surgical mechanical debridement in the treatment of chronic periodontitis and to compare it to mechanical…
- Trial name
- NCT02366585
- Testing
- Ciclosporin
- Where
- Sweden
- Volunteers
- 23 people
- Sponsor
- PerioC Limited
Periodontitis
Curcumin Paste as an Adjunctive Therapy in Periodontitis
The turmeric (Curcuma longa) plant, a herb belonging to the ginger family. The most active component of turmeric is curcumin, which makes up 2 to 5% of the spice.
- Trial name
- NCT04032132
- Testing
- curcumin paste, curettage
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Chronic Periodontitis
Evaluation Efficacy of Melatonin Gel as Adjunctive Therapy in Chronic Periodontitis
This study was conducted to assess the benefit of locally delivered melatonin gel as adjunctive to scaling and root planning (SRP) in the treatment of chronic periodontitis.
- Trial name
- NCT05759416
- Testing
- Melatonin2%gel
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Teeth, Endodontically-Treated, Tooth, Nonvital
Comparison Between RCT in Single and Two Visits, With and Without Intracanal Dressing, in Apical Repair
This is a randomized, prospective, double-blind, controlled clinical trial designed to evaluate 3 distinct clinical approaches used during endodontic therapy: Group 1- Root canal treatment in single visit (RCT-SV); Group 2- Root…
- Conditions
- Teeth, Endodontically-Treated, Tooth, Nonvital, Periapical Periodontitis, Chronic Nonsuppurative, Periapical Granuloma
- Trial name
- NCT05256667
- Testing
- RCT-SV, RCT-TVWD, RCT-TVWOD
- Where
- Brazil
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- New York University
Apical Periodontitis
"Effect of Apical Patency on Post-endodontic Pain"
This study is designed to find out the effect of maintaining apical patency versus non maintaining apical patency on post-operative pain after single visit endodontic treatment in necrotic teeth with asymptomatic apical…
- Trial name
- NCT04551209
- Testing
- Maintaining apical patency
- Where
- Pakistan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National University of Medical Sciences, Pakistan
Periapical Periodontitis
Single Versus Multiple Visits Endodontic Treatment
Healing rate after single visit or multiple visit endodontic treatment using triple paste intracanal medicament will be assessed both clinically and radio-graphically for follow-up period up to one year
- Trial name
- NCT02947763
- Testing
- mixture of metronidazole, ciprofloxacin, and minocycline
- Volunteers
- 44 people
- Sponsor
- Cairo University
Periodontitis, Heart Valve Disease
Effect of Preoperative Periodontal Treatment on Postoperative Infection and Mortality After Aortic and Mitral Valve Surgery
This retrospective observational study aims to evaluate the effect of preoperative periodontal treatment on postoperative infection and mortality in patients undergoing aortic and mitral valve surgery.
- Conditions
- Periodontitis, Heart Valve Disease, Postoperative Infection, Cardiovascular Disease
- Trial name
- Perio-CVS (NCT07626801)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Istanbul University - Cerrahpasa
Peridontal Disease, Periodontal Inflammation
Analysis of the Impact of Contemporary Subgingival Debridement Techniques on Immunological Biomarkers in Gingival Crevicular Fluid
AIM: This prospective clinical study aimed to evaluate the efficacy of two distinct non-surgical periodontal therapy modalities in patients diagnosed with Stage 1 and Stage 2 periodontitis.
- Conditions
- Peridontal Disease, Periodontal Inflammation, Periodontitis, Adult
- Trial name
- NCT07243145
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Selcen Ozcan Bulut
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