Clinical trials: Treatment of Periodontitis
Apical Periodontitis
Therapeutic Irrigation Procedures to Treat Apical Periodontitis
Apical periodontitis is a dental infection which develops around the root of a tooth and affects ~4-6% of the UK population. Current treatment strategies focus solely on removing bacteria from within the root canal space during…
- Trial name
- TIPTAP (NCT03987659)
- Testing
- Irrigation protocols that promote release of dECMs, Conventional Irrigation protocols
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Intrabony Periodontal Defects
Minimally Invasive Non-Surgical Therapy Versus Single Flap Approach in Management of Periodontal Intrabony Defects
This study aims to evaluate the clinical and 3D radiographic effects of minimally invasive non-surgical periodontal therapy (MINST) compared to single flap approach (SFA) in management of intrabony defects in stage III or IV…
- Trial name
- NCT07822659
- Testing
- minimally invasive non-surgical therapy, minimally invasive periodontal surgery
- Volunteers
- 40 people
- Sponsor
- Cairo University
Chronic Periodontitis, Diabetes Mellitus, Type 2
Effectiveness of Non-surgical Periodontal Treatment on HbA1c Levels in a Patient With Type 2 Diabetes Mellitus
This study evaluates the effectiveness of an intervention, non-surgical periodontal treatment (SPR), in patients with poorly controlled type 2 diabetes mellitus and moderate-severe periodontal disease aimed at reducing HbA1c…
- Trial name
- NCT04051866
- Testing
- Non-surgical periodontal treatment: Scaling and root planing (SRP), Oral hygiene instructions
- Where
- Spain
- Sponsor
- Gerencia de Atención Primaria, Madrid
Periodontitis
The Effect of I-PRF As An Adjunct to Non-Surgical Periodontal Therapy on Clinical Parameters in Smokers With Periodontitis
The aim of this clinical trial is to evaluate the effect of subgingival injectable platelet-rich fibrin (i-PRF) application on clinical periodontal parameters as an adjunct to non-surgical periodontal treatment (NSPT) in smokers…
- Trial name
- NCT06605547
- Testing
- Non-surgical periodontal treatment, Subgingival application of saline, Subgingival application of i-PRF
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Abant Izzet Baysal University
Chronic Periodontitis
1.2% Atorvastatin and 1.2% Simvastatin in Treatment of Chronic Periodontitis
Background: Statins are the recently evolved agents that aid in periodontal regeneration and ultimately attaining periodontal health.
- Trial name
- NCT02060032
- Testing
- 1.2% Atorvastatin local drug delivery, 1.2% simvastatin local drug delivery
- Volunteers
- 96 people
- Sponsor
- Government Dental College and Research Institute, Bangalore
Apical Periodontitis, Endodontically Treated Teeth
Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurgery
The purpose of this study is to evaluate the effect of Photobiomodulation (PBM) in postoperative pain after endodontic microsurgery (EMS) in patients from the University of Texas Health Science Center at Houston, School of…
- Conditions
- Apical Periodontitis, Endodontically Treated Teeth, Endodontic Disease, Apical Cyst
- Trial name
- NCT06574152
- Testing
- PBM treatment, EMS
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- The University of Texas Health Science Center, Houston
Apical Periodontitis
"Effect of Apical Patency on Post-endodontic Pain"
This study is designed to find out the effect of maintaining apical patency versus non maintaining apical patency on post-operative pain after single visit endodontic treatment in necrotic teeth with asymptomatic apical…
- Trial name
- NCT04551209
- Testing
- Maintaining apical patency
- Where
- Pakistan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National University of Medical Sciences, Pakistan
Periodontitis
Local Minocycline in Patients Under Supportive Periodontal Therapy
The aims of the present study are to assess the significance of the adjunctive effect of the subgingival application of a 2% minocycline hydrochloride controlled-delivery system (MHS) in comparison to subgingival instrumentation…
- Trial name
- NCT04036890
- Testing
- 2% minocycline hydrochloride controlled-delivery system (MHS)
- Volunteers
- 68 people
- Sponsor
- National Dental Centre, Singapore
Periodontitis, Gingival Recession, Localized
Efficacy of a Gel Containing Polynucleotides and Hyaluronic Acid in Supraosseous Periodontal Defects Treated with the Single Flap Approach
Treatment of supraosseous defects (SD) may be challenging due to their limited regenerative potential. When located in aesthetic areas, treatment may result in a gingival recession increase with consequent patients' concerns in…
- Conditions
- Periodontitis, Gingival Recession, Localized, Aesthetic Perception, Aesthetic Outcomes
- Trial name
- SFA-SD (NCT06897085)
- Testing
- viscoelastic gel containing polynucleotides and hyaluronic acid, No intervention
- Volunteers
- 70 people
- Sponsor
- Azienda Unità Sanitaria Locale (A.U.S.L.) Ferrara, Italy
Periodontal Diseases, Periodontitis
An Evaluation of the Effect of the Erchonia FX-405 Laser as an Adjunctive Treatment of Periodontitis
The purpose of this clinical study is to determine the effectiveness of the Erchonia® FX-405 (manufactured by Erchonia Corporation (the Company) in providing a noninvasive adjunctive treatment in combination with periodontal…
- Conditions
- Periodontal Diseases, Periodontitis, Gum Disease
- Trial name
- NCT06656325
- Testing
- Erchonia® FX405
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Erchonia Corporation
Periapical Abscess
Resolution of Pain and Swelling After the Use of Neem Leaf Extract Compared to Chlorhexidine Gluconate as an Intracanal Irrigant During Pulpectomy
The trial is to test the resolution of pain, swelling and other signs of periapical infection and the antimicrobial efficacy when using the neem leaf extract compared to chlorhexidine as root canal irrigant in Pulpectomy…
- Trial name
- NCT02943759
- Testing
- Neem leaf extract, Chlorhexidine gluconate
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Pocket
The Proposed Study Aims to Investigate the Efficacy of Quercetin as an Adjunctive to Mechanical Debridement in Treatment of Periodontitis
the proposed study aims to investigate the effect of Quercetin in treatment of periodontitis patients
- Trial name
- NCT06982248
- Testing
- NSP and chitosan nanoparticles gel loaded by quercetin, NSP and chitosan nanoparticles gel, scaling and root planning
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Chronic Periodontitis, Type 2 Diabetes
Diabetes and Periodontal Therapy Trial
The primary aim of the study is to determine if non-surgical periodontal therapy (scaling and root planing and supportive periodontal therapy) is efficacious compared to delayed therapy in reducing elevated glycosylated…
- Trial name
- DPTT (NCT00997178)
- Testing
- Non-surgical periodontal therapy, Delayed non-surgical periodontal therapy
- Where
- 8 sites in United States
- Volunteers
- 514 people
- Sponsor
- Stony Brook University
Adult Periodontitis
Periocline as an Adjunct to Scaling and Root Planing for Adult Periodontitis
Periodontal disease (commonly called gum disease) is generally treated by deep cleaning of the root surfaces of the teeth. This is also called scaling and root planing.
- Trial name
- NCT00529555
- Testing
- minocycline HCl 2.1%, Scaling and root planing
- Where
- 10 sites in United States
- Volunteers
- 602 people
- Sponsor
- Sunstar Americas
Furcation Defects, Periodontitis
Treatment of Advanced Grade III Periodontal Furcation Lesions
Periodontitis, a microbially-driven inflammatory disease has been shown to be the sixth most common disease of mankind. The 2009 UK Adult Dental Health Survey found that 54% of adults experience gum bleeding (gingivitis) with 45%…
- Conditions
- Furcation Defects, Periodontitis, Surgical Procedure, Unspecified, Periodontal Bone Loss
- Trial name
- NCT05237739
- Testing
- Non-Surgical Periodontal treatment (NSPT), Open Flap Debridement (OFD)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- King's College London
Periodontal Diseases
Clinical Relevance of Different Time of Periodontal Re-evaluation
Treatment of periodontitis follows an incremental step approach. The results after step 1 (Oral Hygiene Instruction and Professional Mechanical Plaque Removal) and 2 (subgingival instrumentation) are re-evaluated in order to…
- Trial name
- NCT06086821
- Testing
- Periodontal Re-Evaluation
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Florence
Periodontitis, Periodontal Diseases
Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis
The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis).
- Conditions
- Periodontitis, Periodontal Diseases, Periodontal Inflammation, Gingival Diseases
- Trial name
- NCT07536204
- Where
- Chile
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Chile
Regeneration
Evaluation of the Survival of Inflamed Mature Single Rooted Teeth
The majority of articles present in literature concerning the enrollment of tissue engineering in the field of root canal treatment is concerned with the treatment of affected teeth with immature apex, after proper systematic…
- Trial name
- NCT03725514
- Testing
- Conventional, PRF
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis, Bleeding Gum
Effect of a Hydrogen-Peroxide and Hyaluronic-Acid Mouthwash (BMG0703) in the Treatment of Periodontitis
Assessment of the efficacy of BMG0703 in the treatment of periodontitis and control of supragingival plaque, compared to Chlorhexidine and a placebo product
- Conditions
- Periodontitis, Bleeding Gum, Pocket, Periodontal
- Trial name
- NCT04446533
- Testing
- Hydrogen Peroxide and Hyaluronic acid filming formulation, Chlorhexidine 0.2%
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Milan
Diabetes Mellitus, Chronic Periodontitis
Effects of Omega-3 Plus Low-dose Aspirin as Adjunct to Periodontal Debridement for Chronic Periodontitis in Diabetics
Therefore, the aim of this study is to investigate the effectiveness of daily supplementation of omega-3 polyunsaturated fatty acids and low-dose aspirin as adjunct therapy to one-stage full-mouth periodontal ultrasonic…
- Trial name
- NCT02800252
- Testing
- 3g omega-3 plus 100mg aspirin daily for 60 days, omega-3 plus aspirin before periodontal therapy
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
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