Clinical trials: Treatment-as-usual
Mild Cognitive Impairment (MCI)
Working Memory Training in Patients with Mild Cognitive Impairment
The purpose of this study is to test whether a special memory training program, called CogMed, can help people with early memory problems.
- Trial name
- NCT06734286
- Testing
- CogMed
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Depression
Study to Compare the Use of a Behavioral Health App Versus Care As Usual for 16-22 Year Olds with Depression
Randomized Controlled Trial comparing a coach-enhanced digital cognitive behavioral intervention (d-CBI) (RxWell) + treatment as usual (TAU) versus TAU alone for moderate depression as determined by Patient Health Questionnaire…
- Trial name
- NCT05159713
- Testing
- dCBI, Treatment as Usual
- Where
- 3 sites in United States
- Volunteers
- 185 people
- Sponsor
- University of Pittsburgh
Depression - Major Depressive Disorder, Depression Disorder
Virtual Reality-Based Mindfulness as an Adjunct to Treatment as Usual in Treatment-Resistant Depression
The primary aim of this study is to evaluate the efficacy and tolerability of a combined Virtual Reality (VR)-based mindfulness intervention and pharmacological treatment compared with pharmacological treatment alone in reducing…
- Conditions
- Depression - Major Depressive Disorder, Depression Disorder, Depression Chronic, Treatment-Resistant Major Depressive Disorder
- Trial name
- NCT07422519
- Testing
- Virtual-Reality-based mindfulness intervention, Esketamine Treatment as Usual (ESK)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma
Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy
The goal of this clinical trial is to compare the effectiveness of a navigation-based multilevel intervention (ENDURE) with treatment as usual (TAU) to improve the initiation of guideline-adherent postoperative radiation therapy…
- Conditions
- Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma, Oropharynx Cancer, Oral Cavity Cancer
- Trial name
- ENDURE (NCT05793151)
- Testing
- ENDURE
- Where
- 4 sites in United States
- Volunteers
- 532 people
- Sponsor
- Medical University of South Carolina
First Episode Psychosis
Role of Minocycline in First Episode Psychosis
The purpose of this study is to determine whether the addition of minocycline or placebo to treatment as usual (TAU): 1. prevents the accumulation of negative symptoms and intellectual decline following a first episode of…
- Trial name
- NCT00916461
- Testing
- Minocycline
- Where
- 4 sites in Brazil, Pakistan
- Volunteers
- 52 people
- Sponsor
- Stanley Medical Research Institute
Depressive Disorder
Effectiveness of a Brief Psychological Mindfulness Based Intervention for the Treatment of Depression in Primary Care
The aim of this study is to assess and compare a mindfulness low-intensity (4 weeks) psychological intervention for the treatment of depression in Primary Care between different groups: a mindfulness intervention applied face to…
- Trial name
- NCT03034343
- Testing
- Mindfulness
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Universitat Jaume I
Intimate Partner Violence
Evaluating Interventions for Intimate Partner Violence Use in Washington State
Intimate partner violence (IPV), specifically physical and psychological aggression toward an intimate partner, represents a public health crisis that affects millions of Americans each year.
- Trial name
- NCT06526247
- Testing
- Strength at Home (SAH), Treatment as usual for IPV
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Boston University
Bipolar Depression
The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
Bipolar disorders affect approximately 4.5 million people across the European Union (EU) and are associated with high annual healthcare and societal costs.
- Trial name
- INTENSIFY BD (NCT05973786)
- Testing
- Escitalopram, Sertraline, Venlafaxine
- Where
- 13 sites in Austria, Germany and 4 more
- Volunteers
- 418 people
- Sponsor
- Dr. Inge Winter
Intellectual Disabilities, Depression
Behavioural Activation and Severe Learning Disabilities
Research shows that people with severe learning disabilities get depressed at least as often as the wider population. Psychological therapies are recommended to treat depression, and some of these have been adapted for those…
- Trial name
- NCT06851741
- Testing
- Behavioural Activation for depression (BeatIt2)
- Volunteers
- 50 people
- Sponsor
- NHS Greater Glasgow and Clyde
Migraine
A Pragmatic Trial of Machine Prescription for Migraine
The purpose of this study is to estimate the ability of ML models to predict the effect of migraine preventives. This will be achieved by first identifying sociodemographic, headache and comorbidity features of migraine patients.
- Trial name
- MigPred (NCT06893874)
- Testing
- Preventive migraine treatment
- Where
- Norway
- Volunteers
- 169 people
- Sponsor
- Norwegian University of Science and Technology
Depressive Disorder
Study to Evaluate the Safety and Efficacy of PEER Interactive Versus Treatment as Usual in Subjects With a Primary Diagnosis of Depression
This is a prospective, multicenter, randomized, double-blind, controlled study to evaluate the effectiveness of PEER Interactive to inform treatment in subjects with a primary diagnosis of depression with comorbidity of…
- Trial name
- NCT01794559
- Testing
- PEER Interactive Report
- Where
- 2 sites in United States
- Volunteers
- 1,922 people
- Sponsor
- MYnd Analytics
Mother-infant Relational Disturbances
Mother-Infant Psychoanalysis Project of Stockholm
Mother-infant relationship disturbances broadly comprise three areas; maternal distress, infant functional problems, and relationship difficulties.
- Trial name
- MIPPS (NCT00923559)
- Testing
- Treatment as Usual at Child Health Centre, Mother-Infant Psychoanalytic treatment (MIP)
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Hyperlipidemia
A 16 Week Comparative Study of Fenofibrate Versus Ezetimibe as Add-on Therapy to Atorvastatin
The objective of this study is to evaluate the effects of adding Tricor 145 mg to once daily atorvastatin 20 mg on CHD lipid laboratory parameters.
- Trial name
- NCT00195793
- Testing
- fenofibrate, ezetimibe, atorvastatin
- Volunteers
- 174 people
- Sponsor
- Abbott
Low Back Pain, Chronic Pain
Chronic Low Back Pain Rehabilitation in Primary Care: an RCT
The aim of this study is to evaluate the effectiveness and cost-effectiveness of a new primary care intervention "Back on Track" as compared to usual primary care in patients with non-specific chronic low back pain in which…
- Conditions
- Low Back Pain, Chronic Pain, Musculoskeletal Pain
- Trial name
- NCT02220543
- Testing
- Back on Track intervention, Primary care as usual
- Where
- 8 sites in Netherlands
- Volunteers
- 25 people
- Sponsor
- Maastricht University Medical Center
Opioid-use Disorder, Opioid Misuse
Comparing a Patient Self-Assessment Software to Treatment as Usual in Opioid Prescriber and Patient Opioid Outcomes
The Care Continuity Program (CCP), a product of Sure Med Compliance, is a novel, online patient self-assessment used by prescribers of opioids to better identify patient risk factors and therapy benefit.
- Conditions
- Opioid-use Disorder, Opioid Misuse, Opioid Use, Chronic Pain
- Trial name
- NCT04945525
- Testing
- Care Continuity Program
- Where
- United States
- Volunteers
- 1,840 people
- Sponsor
- Sure Med Compliance
Psychological Distress, Cancer Recurrence
COMpassion FOcused Therapy and Breathing Pattern REtraining After Cancer Recurrence
The purpose of this study is to investigate how effective a particular psychological intervention is at reducing psychological distress for people who were diagnosed with cancer 'recurrence' since the beginning of the COVID…
- Trial name
- COMFORT (NCT05518591)
- Testing
- Compassion Focused Therapy (CFT) combined with Breathing Pattern Retraining (BPR)
- Where
- Ireland
- Volunteers
- 160 people
- Sponsor
- University College Dublin
Age-related Macular Degeneration, Low Vision
Automatic Self Transcending Meditation (ASTM) for Patients With Severe Age Related Macular Degeneration (AMD)
Age-related macular degeneration (AMD) is a condition affecting 20 to 25 million people worldwide. Symptoms of AMD includes difficulty in reading, recognizing faces and completing house work which may result in increased…
- Trial name
- NCT03104608
- Testing
- Automatic Self Transcending Meditation, Treatment as Usual
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Bipolar I Disorder
Lurasidone and Cognition in Bipolar I Disorder
This is a 6 week, randomized, open-label, parallel group study in patients with Bipolar-I disorder (manic depression), who are in remission from an episode.
- Trial name
- NCT02147379
- Testing
- Lurasidone
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- University of British Columbia
Advanced Cancer, Various, NOS
Existential Distress in Advanced Cancer: Comparing a Short-term Psychodynamic Psychotherapy (ORPHYS) to Treatment as Usual (TAU)
The psychological challenges faced by patients with incurable cancer and their caregivers include an uncertain future, fear of dying and uncontrollable suffering, grief, and loneliness.
- Trial name
- NCT07312760
- Testing
- ORPHYS (ShORt-term psychodynamic psychotherapy in serious PHYSical illness), TAU (Treatment As Usual: Standard psycho-oncological care)
- Where
- 3 sites in Germany
- Volunteers
- 160 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Partner Assisted Interpersonal Psychotherapy, Treatment as Usual
Partner-Assisted Interpersonal Psychotherapy or Antidepressant Medication for Antenatal Depression
Purpose: To compare a novel psychotherapy, Partner-Assisted Interpersonal Psychotherapy (PA-IPT), with treatment as usual (TAU) in a sample of pregnant women seeking treatment for Major Depressive Disorder (MDD) at the University…
- Trial name
- NCT01732055
- Testing
- Partner-Assisted Interpersonal Psychotherapy, Treatment as Usual
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill