Clinical trials: Tremor Essential
Parkinson's Disease, Essential Tremor
Deep Brain Stimulation (DBS) Data Base Study
The primary goal of this study is to evaluate and compare outcomes, trends, and effectiveness of both awake and asleep Deep Brain Stimulation (DBS) surgical treatments, target selection, targeting accuracy and outcomes in…
- Trial name
- NCT01909531
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Essential Tremor
Cyclic Deep Brain Stimulation in Essential Tremor
The aim of the study is to prove the efficacy and safety of cyclical deep brain stimulation (DBS) in patients with essential tremor, and demonstrate non-inferiority of cyclical DBS on tremor control when compared to continuous…
- Trial name
- NCT04260971
- Testing
- Abbott St Jude Medical Infinity 7 neurostimulator
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- King's College Hospital NHS Trust
Essential Tremor
Thalamic LFPs and VIM DBS in Essential Tremor: Correlation, Evolution, and Therapeutic Perspectives
The objective of this study is to characterize through spectral analysis intra-thalamic local field potentials (LFPs) recorded through implanted DBS leads during periods with and without tremor in patients suffering from severe…
- Trial name
- VIM-CLT (NCT02264925)
- Testing
- Deep Brain Stimulation with Medtronic Activa PC+S systems
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Bordeaux
Essential Tremor
A Clinical Study to Evaluate CAD-1883 in Essential Tremor
This is an open-label study designed to evaluate the safety, tolerability and efficacy of CAD-1883, a positive allosteric modulator of the SK channel, administered twice daily orally to adult patients with ET.
- Trial name
- NCT03688685
- Testing
- CAD-1883
- Where
- 7 sites in United States
- Volunteers
- 25 people
- Sponsor
- Cadent Therapeutics
Essential Tremor
Deep braIn Stimulation for Tremor TractographIC Versus Traditional
This is a monocentric, randomized, controlled, 2 arms, interventional, observer-blinded feasibility trial. Patients suffering from essential tremor (ET) will be treated with Deep Brain Stimulation (DBS).
- Trial name
- DISTINCT (NCT02491554)
- Testing
- Conventional AC-PC based implantation of ACTIVA INS DBS system, MR-tractography guided implantation of ACTIVA INS DBS system
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University Hospital Freiburg
Essential Tremor, Multiple System Atrophy
Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders (PD), Essential Tremor (ET), Cortical Basal Degeneration (CBD), Multiple Systems Atrophy (MSA), Magnetoencephalography.
Investigators hypothesize that there are specific characteristic of each cognitive and motor condition that can be defined using brains scans.
- Conditions
- Essential Tremor, Multiple System Atrophy, Corticobasal Degeneration, Supranuclear Palsy, Progressive
- Trial name
- PHENO (NCT02132052)
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Colorado, Denver
Parkinson's Disease, Tremor
Randomised Crossover Trial of DBS of Differential PSA Regions in Parkinson's Disease and Tremor
The posterior subthalamic area holds promise as a target region for deep brain stimulation in tremor and Parkinson's disease. Using the magnetic resonance-directed implantable guide tube surgical technique, subregions of the…
- Trial name
- NCT01945567
- Testing
- Up to 3 mA, 60 us, 130 Hz deep brain stimulation, Empirical unblinded deep brain stimulation programming
- Where
- Australia
- Volunteers
- 39 people
- Sponsor
- The University of Western Australia
Essential Voice Tremor, Deep Brain Stimulation
Deep Brain Stimulation for Voice Tremor: Left, Right, or Both Hemispheres?
Deep Brain Stimulation (DBS) is the gold standard treatment for Essential Tremor (ET). ET is a movement disorder which causes the arms, feet, fingers, head or voice to involuntarily shake.
- Conditions
- Essential Voice Tremor, Deep Brain Stimulation, Essential Tremor, Laryngeal Diseases
- Trial name
- EVT (NCT02960243)
- Testing
- Deep Brain Stimulation
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University of British Columbia
Essential Tremor
Pregabalin in the Treatment of Essential Tremor
Pregabalin is approved for the treatment of nerve pain as well as an additional therapy in the treatment of seizures. In December 2004, Pfizer gained Food and Drug Administration (FDA) approval for use of pregabalin in nerve pain…
- Trial name
- NCT00646451
- Testing
- pregabalin (Lyrica)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor College of Medicine
Essential Tremor-plus
National Survey of Essential Tremor Plus in China
National Survey of Essential Tremor Plus in China（NSETP-China）is a multicenter cross-sectional study designed to investigate the clinical features of ET-plus in mainland China.
- Trial name
- NCT04837079
- Testing
- Clinical observational study
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Xiangya Hospital of Central South University
Parkinson Disease, Essential Tremor
Brain Network Activation in Patients With Movement Disorders
The diagnosis and management of movement disorders, such as Parkinson's disease (PD), parkinson-plus syndromes (PPS), dystonia, essential tremor (ET), normal pressure hydrocephalus (NPH) and others is challenging given the lack…
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia, Normal Pressure Hydrocephalus
- Trial name
- BNA-MDi (NCT03269201)
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Sheba Medical Center
Essential Tremor
Functional Neuroimaging Feedback for Focused Ultrasound Thalamotomy
Focused ultrasound for Essential Tremor is an FDA approved treatment performed by neurosurgeons at the Ohio State Center for Neuromodulation that utilizes ultrasound technology to create a lesion in the thalamus of Essential…
- Trial name
- NCT03560622
- Testing
- multi-modality neuroimaging
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vibhor Krishna
Essential Tremor of the Upper Limbs
Botulinum Toxin A to Treat Arm Tremor
The objective of this study is to assess the efficacy and safety of a single, kinematic-analysis-based intramuscular injection of NT 201, compared with placebo, in moderate to marked essential tremor of the upper limb.
- Trial name
- NCT02207946
- Testing
- IncobotulinumtoxinA
- Where
- 6 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Merz Pharmaceuticals GmbH
Parkinson's Disease, Movement Disorders
Imaging Blood Brain Imaging Dysfunction in Parkinson's Disease
The purpose of this study is to evaluate the blood brain barrier in the striatum of patients that have other types of movement disorders compared to patients with Parkinson's Disease that are receiving similar treatment, to…
- Trial name
- NCT02605161
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- Ottawa Hospital Research Institute
Essential Tremor, Tremor
Functional Imaging of Tremor Circuits and Mechanisms of Treatment Response
Essential Tremor (ET) is the most common tremor disorder, currently affecting an estimated 2.9 million Americans and leading to disability and decreased quality of life in 75% of cases.
- Trial name
- NCT02495883
- Testing
- Ethanol, Propranolol
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Parkinson Disease
Masotherapy With Neural Tension in Patients With Parkinson's Disease
The objective of this study is to assess if the masotherapy with neural tension is more effective than non-neural tension to improve and reduce tremor in patients with Parkinson's disease.
- Trial name
- NCT04303338
- Testing
- Masotherapy with neural tension and masotherapy with non-neural tension
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- University of Jaén
Essential Tremor, Deep Brain Stimulation
Ataxia in Essential Tremor: Describing the Differences Between Disease Process and Treatment Effect
The proposed study aims to characterize ataxia occurring in essential tremor and essential tremor with DBS.
- Conditions
- Essential Tremor, Deep Brain Stimulation, Ataxia, Cerebellar Diseases
- Trial name
- ATAX (NCT03769961)
- Testing
- No intervention
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Oregon Health and Science University
Essential Tremor
Alternating Current Stimulation for Essential Tremor
Movement disorders are common neurological disorders, characterized by either excess or paucity of movements. Essential tremor (ET) is one of the most common of these disorders, defined as chronic, rhythmic involuntary movements…
- Trial name
- NCT04509349
- Testing
- transcranial Altering Current Stimulation
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Essential Tremor
Kinematic-based BoNT-A Injections for Bilateral ET
The primary objective is to study the efficacy of botulinum toxin type A (Xeomin®) injected utilizing kinematically-based injection parameters for the treatment of upper extremity essential tremor (ET).
- Trial name
- NCT02551848
- Testing
- Botulinum toxin type A
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Western University, Canada
Parkinson Disease, Essential Tremor
GADGET-PD Genetic and Digital Diagnosis of Essential Tremor and Parkinson's Disease Trial
The proposed study will capitalize on the early predictive information stored in an individual's genetic risk for Parkinson Disease (PD) in combination with the subtle features of tremors that can be extracted from movement data…
- Trial name
- GADGET-PD (NCT02668835)
- Testing
- Non intervention-Monitoring device, Non intervention-Genetic testing
- Volunteers
- 67 people
- Sponsor
- Scripps Translational Science Institute