Clinical trials: Tremor Essential
Parkinson Disease, Parkinson's Disease and Parkinsonism
Complex Eye Movements in Parkinson's Disease and Related Movement Disorders
Diagnosing Parkinson's disease (PD) depends on the clinical history of the patient and the patient's response to specific treatments such as levodopa.
- Conditions
- Parkinson Disease, Parkinson's Disease and Parkinsonism, Progressive Supranuclear Palsy, Corticobasal Degeneration
- Trial name
- NCT04925622
- Testing
- Complex eye movement exam
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Saccadous, Inc.
Essential Tremor
Deep braIn Stimulation for Tremor TractographIC Versus Traditional
This is a monocentric, randomized, controlled, 2 arms, interventional, observer-blinded feasibility trial. Patients suffering from essential tremor (ET) will be treated with Deep Brain Stimulation (DBS).
- Trial name
- DISTINCT (NCT02491554)
- Testing
- Conventional AC-PC based implantation of ACTIVA INS DBS system, MR-tractography guided implantation of ACTIVA INS DBS system
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University Hospital Freiburg
Tremor, Essential Tremor
Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor
This objective of this study is to document the safety and feasibility of electrical stimulation of the deep cerebellar nuclei for refractory tremor using the Medtronic Percept RC Deep Brain Stimulation System.
- Trial name
- rT DBS (NCT07049003)
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The Cleveland Clinic
Tremor, Limb
Deep Brain Frameless Radiosurgery for Drug Resistant Invalidating Tremor. Dose Escalation Pilot Study
The gamma knife radiosurgical thalamotomy to treat many movement disorders is recently becoming a new and well defined treatment paradigm.
- Trial name
- PRDBRS2 (NCT02585583)
- Testing
- Thalamotomy
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Essential Tremor
Functional Outcomes of Awake vs. Asleep Deep Brain Stimulation (DBS) for Essential Tremor
Recently, there has been increasing interest in performing DBS under general anesthesia, where the stimulated targets are located anatomically (i.e.
- Trial name
- NCT02418858
- Testing
- Deep Brain Stimulation surgery
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Parkinson Disease, Essential Tremor
Effects of Stimulation Patterns of Deep Brain Stimulation
The purpose of this study is to measure the effects of non-regular temporal patterns of deep brain stimulation (DBS) on motor symptoms and neural activity in persons with Parkinson's disease (PD), essential tremor (ET), dystonia…
- Conditions
- Parkinson Disease, Essential Tremor, Multiple Sclerosis, Dystonia
- Trial name
- NCT02553525
- Testing
- Therapeutic Stimulation Patterns, Symptogenic Stimulation Patterns
- Where
- 3 sites in United States
- Volunteers
- 180 people
- Sponsor
- Duke University
Essential Tremor, Movement Disorders, Essential Tremor
Analysis of Cutaneous Phosphorylated Alpha-Synuclein to Identify Patients at Risk of Progressing From Essential Tremor to Parkinson's Disease
Background and Rationale Essential tremor (ET) affects over 6 million Americans and approximately 5% of adults over age 60. Patients with ET have a 10-20 times higher risk of developing Parkinson's disease (PD) compared to…
- Conditions
- Essential Tremor, Movement Disorders, Essential Tremor, Essential Tremor-plus
- Trial name
- Syn-T (NCT07428447)
- Where
- 8 sites in United States
- Volunteers
- 300 people
- Sponsor
- CND Life Sciences
Essential Tremor
Transcranial Temporal Interference Stimulation (tTIS) To Modulate Essential Tremor
The goal of this proof-of-concept study is to examine the effects of a relatively new, non-invasive electrical current-based technique, transcranial temporal interference stimulation (tTIS), in patients with Essential Tremor…
- Trial name
- TremorTIS (NCT07531238)
- Testing
- Transcranial temporal interference stimulation, Tremor monitoring through Inertial Measurement Units (IMUs)
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- University Hospital, Geneva
Parkinson Disease
Masotherapy With Neural Tension in Patients With Parkinson's Disease
The objective of this study is to assess if the masotherapy with neural tension is more effective than non-neural tension to improve and reduce tremor in patients with Parkinson's disease.
- Trial name
- NCT04303338
- Testing
- Masotherapy with neural tension and masotherapy with non-neural tension
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- University of Jaén
Essential Tremor
A Clinical Study to Evaluate CAD-1883 in Essential Tremor
This is an open-label study designed to evaluate the safety, tolerability and efficacy of CAD-1883, a positive allosteric modulator of the SK channel, administered twice daily orally to adult patients with ET.
- Trial name
- NCT03688685
- Testing
- CAD-1883
- Where
- 7 sites in United States
- Volunteers
- 25 people
- Sponsor
- Cadent Therapeutics
Essential Tremor
Directional Bilateral Thalamic Patterned Stimulation (Chronos)
Population Size and Eligible Patients: The investigators aim to recruit 5 to 10 patients with tremors who have previously undergone Ventral Intermedius Deep Brain Stimulation (VIM-DBS) treatment but have experienced early or late…
- Trial name
- NCT06325852
- Testing
- DBS programing
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Alfonso Fasano
Essential Voice Tremor, Deep Brain Stimulation
Deep Brain Stimulation for Voice Tremor: Left, Right, or Both Hemispheres?
Deep Brain Stimulation (DBS) is the gold standard treatment for Essential Tremor (ET). ET is a movement disorder which causes the arms, feet, fingers, head or voice to involuntarily shake.
- Conditions
- Essential Voice Tremor, Deep Brain Stimulation, Essential Tremor, Laryngeal Diseases
- Trial name
- EVT (NCT02960243)
- Testing
- Deep Brain Stimulation
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University of British Columbia
Essential Tremor, Parkinson Disease
Symptomatic Relief of Action Tremor With Cala Trio Using Trio+ Bands
Demonstrate safety and effectiveness of symptomatic action tremor relief in the treated hand following stimulation with the Cala Trio System using the Trio+ bands as compared to the Trio bands in adults with Essential Tremor (ET)…
- Trial name
- NCT05480215
- Testing
- Cala Device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cala Health, Inc.
Parkinson's Disease, Essential Tremor
Deep Brain Stimulation Surgery for Movement Disorders
Background: Deep brain stimulation (DBS) is an approved surgery for certain movement disorders, like Parkinson's disease, that do not respond well to other treatments.
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- NCT01581580
- Testing
- Medtronic Activa Tremor Control System, Deep Brain Stimulation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dystonia, Parkinson Disease
Impact of a Standardized Music Therapy Protocol on the Quality of Life of Patients With Abnormal Movements Treated With Continuous Electrical Neuromodulation
The study of the impact of music on emotional, motor and cognitive aspects remains recent. Music therapy has experienced a major boom over the last half century thanks to neuroradiological techniques for investigating the brain…
- Conditions
- Dystonia, Parkinson Disease, Essential Tremor
- Trial name
- Music-QOL (NCT05214313)
- Testing
- Music Therapy
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Montpellier
Essential Tremor
Novel Therapies for Essential Tremor
This clinical research program is designed to evaluate medications as new treatments for essential tremor. Essential tremor is a common condition with few available therapies.
- Trial name
- NCT00018564
- Testing
- treatments for essential tremor
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Essential Tremor
Cyclic Deep Brain Stimulation in Essential Tremor
The aim of the study is to prove the efficacy and safety of cyclical deep brain stimulation (DBS) in patients with essential tremor, and demonstrate non-inferiority of cyclical DBS on tremor control when compared to continuous…
- Trial name
- NCT04260971
- Testing
- Abbott St Jude Medical Infinity 7 neurostimulator
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- King's College Hospital NHS Trust
Essential Tremor
A Pilot Clinical Trial Of Memantine for Essential Tremor
The purpose of this study is to obtain information on whether or not the medication Memantine reduces tremor in persons with essential tremor and is well-tolerated.
- Trial name
- NCT00439699
- Testing
- Memantine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- VA Greater Los Angeles Healthcare System
Parkinson's Disease
Deep Brain Stimulation Therapy in Movement Disorders
Background: In deep brain stimulation (DBS), a device called a neurostimulator is placed in the chest. It is attached to wires in parts of the brain that affect movement.
- Trial name
- NCT02119611
- Testing
- Deep Brain Stimulation management
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Essential Tremor
Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract
The purpose of this study is to elucidate the structural connectivity of the dentato-rubro-thalamic tract (DRTt) and to detect functional network changes due to DRTt stimulation
- Trial name
- NCT04758624
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Northwell Health