Clinical trials: Tremor Essential
Essential Tremor
Cerebellar Research in Ultrasound Stimulation
Experiment 1: Modulation of Physiological Tremor in Healthy Volunteers Thirty healthy volunteers will undergo TUS targeting the dentate nucleus in a randomized, double-blinded crossover design.
- Trial name
- CERBERUS (NCT07508696)
- Testing
- Transcranial focused ultrasound delivered to the dentate nucleus using the NeuroFUS Pro by Brainbox, Transcranial focused ultrasound delivered to the ventricles (control) using the NeuroFUS Pro by Brainbox
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Parkinson Disease, Essential Tremor
Cortical-Basal Ganglia Speech Networks
In this research study the researchers want to learn more about brain activity related to speech perception and production.
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia
- Trial name
- NCT04286308
- Testing
- electrophysiological data collection
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Physiological Tremor, Exercise-Induced Neuromuscular Fatigue
Effect of Trigger Point Cryostimulation on Exercise-Induced Tremor in Adolescent Swimmers
This study examines whether local cryostimulation of myofascial trigger points can reduce physiological tremor that occurs after intense physical exercise.
- Trial name
- NCT07480200
- Testing
- Cryostimulation of Myofascial Trigger Points
- Where
- Poland
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Józef Piłsudski University of Physical Education
Essential Tremor
Staged Bilateral Exablate Treatment of Medication Refractory Essential Tremor
The objective of this prospective, multi-site, single-arm, open-label study is to capture the safety and efficacy (outcome) of bilateral staged Exablate treatment in subjects with bilateral medication-refractory essential tremor…
- Trial name
- NCT03465761
- Testing
- ExAblate
- Where
- 2 sites in Spain, United Kingdom
- Volunteers
- 7 people
- Sponsor
- InSightec
Essential Tremor (ET)
Motor and Non-Motor Effects of Low-Intensity Focused Ultrasound (LIFU) as a Neuromodulation Tool in Essential Tremor
This study investigates the motor and non-motor effects of Low-Intensity Focused Ultrasound (LIFU) as a non-invasive neuromodulation technique in patients with essential tremor (ET) and refractory tremor.
- Trial name
- LIFU-ET (NCT07484152)
- Testing
- Low-Intensity Focused Ultrasound (LIFU) - NeuroFUS PRO
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo General Hospital
Essential Tremor, Parkinson Disease
RAD 1601: EDGE Radiosurgery for Intractable Essential Tremor and Tremor-Dominant Parkinson's Disease
To determine the efficacy of frameless Virtual Cone Radiosurgical Thalamotomy for medically refractory tremor resulting from either Essential Tremor or Tremor-Dominant Parkinson's Disease with the Fahn-Tolosa-Marin Tremor Rating…
- Trial name
- NCT03305588
- Testing
- Unframed Virtual Cone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Parkinson's Disease (PD), Essential Tremor
Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients
This study will examine how two important brain circuits - one involving the subthalamic nucleus (STN) and one involving the ventral intermediate nucleus of the thalamus (VIM) - contribute to learning and producing speech…
- Trial name
- NCT07455760
- Testing
- Phoneme sequence learning, Cessation and re-enabling of stimulation of the STN, Cessation and re-enabling of stimulation of the VIM thalamic nucleus
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Boston University Charles River Campus
Essential Tremor, Neuromodulation
Ultrasound Neuromodulation in Essential Tremor
This study is being done to test whether low-intensity focused ultrasound (LIFU) (low energy sound waves) cause temporary changes in brain activity and behavior when directed at particular parts of the brain.
- Trial name
- UNMET (NCT06610877)
- Testing
- Focused ultrasound neuromodulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Action Tremor, Stigma, Social
ET Stigma Response to Tremor Suppression
Essential Tremor (ET) is prevalent, affecting approximately 3% of the adult population. Involuntary shaking of the hands during action is a prominent feature, interfering with feeding and writing and other manual tasks.
- Trial name
- NCT07430761
- Testing
- stereotactic thalamotomy with focused ultrasound
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- University of Texas Southwestern Medical Center
Essential Tremor
Dual Lead Thalamic Deep Brain Recording (DBR)-DBS Interface for Closed Loop Control of Severe Essential Tremor
This is a feasibility study based on physician-initiated Investigational Device Exemption (IDE) including intraoperative experiments and chronic testing of implanted dual thalamic DBS lead systems.
- Trial name
- NCT04212780
- Testing
- Medtronic Summit Rechargable (RC)+S, ipsilateral thalamic (VIM+VO) DBS, standard ET DBS
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Florida
Essential Tremor
Long-Term Transcutaneous Stimulation and Essential Tremor: A PET Study
Essential tremor (ET) is the most common movement disorder in the United States and affects up to 5% of the population. ET patients experience involuntary shaking of the hands, head and/or voice that can range from mildly…
- Trial name
- NCT03778060
- Testing
- Cala TWO stimulator
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Essential Tremor
Algorithms for Programming DBS Systems for ET
Deep brain stimulation (DBS) targeting the Vim thalamus (ventralis intermedius nucleus) is an FDA-approved neuromodulation therapy for treating postural and action tremor in individuals with essential tremor (ET).
- Trial name
- NCT03984643
- Testing
- Vim-Deep Brain Stimulation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Minnesota
Essential Tremor
Dual-Site Transcranial Magnetic Stimulation of the Supplementary Motor Area and Cerebellum for the Treatment of Essential Tremor.
Essential tremor is a common movement disorder that causes involuntary shaking, mainly during voluntary actions such as writing or holding objects.
- Trial name
- NCT07344194
- Testing
- Dual-site repetitive transcranial magnetic stimulation (rTMS) of the supplementary motor area and cerebellum
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- São Paulo State University
Upper Limb Essential Tremor (UL ET)
Study of BOTOX Injections to Assess Change in Disease Symptoms in Adult Participants With Upper Limb Essential Tremor
Upper limb essential tremor (UL ET) is a movement disorder characterized by postural and/or kinetic tremor. It can cause difficulty with everyday tasks such as writing, pouring, and eating, and patients also experience associated…
- Trial name
- NCT05216250
- Testing
- BOTOX
- Where
- 40 sites in United States, Canada
- Volunteers
- 174 people
- Sponsor
- AbbVie
Essential Tremor, Parkinson's Disease
The Motor Network in Essential Tremor: Mechanisms of Therapy
Essential tremor (ET) is among the most common movement disorders, and is the most prevalent tremor disorder. It is a progressive, degenerative brain disorder that results in increasingly debilitating tremor, and afflicts an…
- Trial name
- NCT02712515
- Testing
- Deep brain stimulation implantation surgery, Ad-Tech Medical Instrumentation Corp. electrodes/subdural strips, FHC Guideline 4000+ system and/or Medtronic RC+S
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Florida
Essential Tremor
Responsive Deep Brain Stimulator for Essential Tremor
Essential tremor is an incurable, degenerative brain disorder that results in increasingly debilitating tremor, and afflicts an estimated 7 million people in the US.
- Trial name
- NCT02649166
- Testing
- Deep brain stimulation, Closed-loop deep brain stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
Movement Disorders, Parkinson Disease
Abbott DBS Post-Market Study of Outcomes for Indications Over Time
The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling…
- Conditions
- Movement Disorders, Parkinson Disease, Essential Tremor, Tremor
- Trial name
- ADROIT (NCT04071847)
- Testing
- Deep Brain Stimulation (DBS)
- Where
- 48 sites in United States, Australia and 7 more
- Volunteers
- 1,000 people
- Sponsor
- Abbott Medical Devices
Essential Tremor
Neuromodulation Strategies for Treatment-Resistant Essential Tremor Using Chronos™ DBS
The goal of this observational study is to learn whether a new way of programming Deep Brain Stimulation (DBS) can improve and maintain tremor control in adults with essential tremor (ET) who stopped responding to standard DBS…
- Trial name
- NCT07302867
- Testing
- Continuous, Continuous + High Frequency Cycling, High Frequency
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University of British Columbia
Essential Tremor
Proof of Concept Study on BP1.4979 Effect on Essential Tremor
The goal of this clinical trial is to learn if drug BP1.4979 works to treat essential tremors in adults. It will also learn about the safety of drug BP1.4979.
- Trial name
- NCT07074002
- Testing
- BP1.4979
- Where
- 14 sites in France
- Volunteers
- 50 people
- Sponsor
- Bioprojet
Dystonia, Drug Induced Dystonia
Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia
This research involves retrospective and prospective studies for clinical validation of a DystoniaNet deep learning platform for the diagnosis of isolated dystonia.
- Conditions
- Dystonia, Drug Induced Dystonia, Parkinson Disease, Essential Tremor
- Trial name
- NCT05317390
- Testing
- DystoniaNet-based diagnosis of isolated dystonia
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary