Clinical trials: Tremors
Essential Tremor
A Pilot Efficacy and Safety Study of ST101 in Essential Tremor
This study will look at the ability of ST101 to treat symptoms in subjects with Essential Tremor. This study will also examine the safety and tolerability of the drug.
- Trial name
- NCT01332695
- Testing
- ST101
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Sonexa Therapeutics, Inc.
Essential Tremor
Magnetoencephalography (MEG) Pilot Study
The purpose of this research is to learn more about how the brain works in people with essential tremor, and how it changes after treatment with High-Intensity Focused Ultrasound (HiFU).
- Trial name
- MEG (NCT07446192)
- Testing
- MRI and fMRI scans, MEG, Sensor-based motor assessments
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Florida
Renal Failure, Tremors
Switching Study of Kidney Transplant Patients With Tremor to LCP-Tacro (STRATO)
This study will evaluate and measure symptomatic hand tremor in stable kidney transplant subjects on Prograf or generic tacrolimus maintenance therapy at baseline (pre-conversion) and following conversion to LCP-Tacro.
- Trial name
- STRATO (NCT01438710)
- Testing
- Prograf, LCP-Tacro
- Where
- 10 sites in United States
- Volunteers
- 44 people
- Sponsor
- Veloxis Pharmaceuticals
Parkinson Disease, Essential Tremor
Investigating LFP Correlates of TUS in Patients With Movement Disorders
Transcranial Ultrasound Stimulation (TUS) is an emerging non-invasive brain stimulation(NIBS) technique that can be used on both superficial and deep brain targets with a high spatial resolution as small as a few cubic…
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia
- Trial name
- TUS-LFP (NCT05965960)
- Testing
- TUS Active
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University Health Network, Toronto
Multiple Sclerosis, Tremor
The Efficacy of Botulinum Toxin in Disabling Multiple Sclerosis (MS) Tremor
The incidence of tremor in Multiple Sclerosis (MS) has been estimated to affect up to 2/3rds of patients. Over half of the tremors involve the upper limb and frequently lead to further disability.
- Trial name
- NCT01018485
- Testing
- Botulinum Toxin Type A
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Melbourne Health
Laryngeal Dystonia, Spasmodic Dysphonia
Characterization of Clinical Phenotypes of Laryngeal Dystonia and Voice Tremor
The researchers will systematically evaluate current and novel clinical voice assessment tools and measures to elucidate distinct clinical phenotypes of those with laryngeal dystonia and voice tremor.
- Conditions
- Laryngeal Dystonia, Spasmodic Dysphonia, Tremor
- Trial name
- NCT05150106
- Testing
- Clinical assessments of laryngeal function
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Essential Tremor, Deep Brain Stimulation
Multicentre RCT of Awake Versus Asleep Tractography Based DBS for ET
Rationale: Deep brain stimulation (DBS) of the thalamus is an effective surgical treatment for patients with disabling essential tremor, despite optimal pharmacological treatment.
- Conditions
- Essential Tremor, Deep Brain Stimulation, Diffusion Tensor Imaging, Magnetic Resonance
- Trial name
- TREMBLE (NCT05968976)
- Testing
- Awake DBS, Asleep DBS
- Where
- Netherlands
- Volunteers
- 110 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Essential Tremor
A Pilot Study of the Cala ONE Device for Essential Tremor
Prospective, multi-center, randomized, controlled study designed to evaluate safety and repeatable effectiveness. Subjects will be randomized 2:1:1 to transcutaneous afferent patterned stimulation (TAPS), sham, or 'no…
- Trial name
- EXCITE (NCT03152136)
- Testing
- Cala ONE device
- Where
- 4 sites in United States
- Volunteers
- 62 people
- Sponsor
- Cala Health, Inc.
Essential Tremor
A Clinical Trial of PRAX-944 in Participants With Essential Tremor
This is a 2-part clinical trial to evaluate the efficacy, safety, and tolerability of 40 and 120 mg oral PRAX-944 compared to placebo in the treatment of adults with essential tremor.
- Trial name
- NCT05021978
- Testing
- Part A: 20 and 40 mg PRAX-944, Part B: 120 mg PRAX-944
- Where
- 9 sites in United States, Australia and 1 more
- Volunteers
- 24 people
- Sponsor
- Praxis Precision Medicines
Dystonia, Tremor
Repetitive Transcranial Magnetic Stimulation (rTMS) for Dystonia and Tremor
The study will include subjects diagnosed with Dystonic Tremor (DT), Essential Tremor (ET), and healthy controls in the age range of 21-80 years. Electroencephalography (EEG) will be used as the primary outcome measure.
- Trial name
- NCT04299087
- Testing
- repetitive Transcranial Magnetic Stimulation (rTMS), Control group
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Florida
Debulking Surgery for Ovarian Cancer
Study of Nutritional Supplement Shakes in People About to Receive Their Debulking Surgery for Ovarian Cancer
The purpose of this study is to find out if it is possible to establish a nutritional support program for people who are scheduled to receive primary debulking surgery.
- Trial name
- NCT03956095
- Testing
- Ensure Surgery Immunonutrition Shake supplements, Daily Food Intake form
- Where
- 8 sites in United States
- Volunteers
- 23 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Essential Tremor
A Comparison of the Efficacy and Safety of Topiramate Versus Placebo in Treating Tremor of Unknown Cause.
The purpose of this study is to assess the safety and effectiveness of topiramate as compared to placebo in treating patients with tremor of unknown cause.
- Trial name
- NCT00236496
- Testing
- topiramate
- Volunteers
- 223 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Parkinson Disease, Essential Tremor
Comparison of the Electric Plasma Surgical Tool "PlasmaBlade" for Replacement of the Deep Brain Stimulation (DBS) Devices With Conventional Surgery
The deep brain stimulation is surgical technique used for the Parkinson's disease, essential tremor, dystonia, epilepsy, and psychiatric diseases.
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia, Epilepsy
- Trial name
- NCT05535556
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Essential Tremor, Neurology
Echo-Focusing in Patients With Treatment-Resistant Neurologic and Psychiatric Indications (EF001)
Evaluate the safety and effectiveness of Echo-Focusing using Exablate Neuro as a tool for treating patients with treatment-refractory neurologic and psychiatric disorders.
- Trial name
- NCT05089786
- Testing
- Exablate Neuro Type 1.0 System with Echo Focusing
- Sponsor
- InSightec
Parkinson Disease
Vibration Impact on Parkinson's Tremor
The primary purpose of this study is to test the safety, tolerability and efficacy of vibration (delivered by an experimental device called RMBand that is worn on the subject's arm) on parkinsonian tremor.
- Trial name
- NCT03799614
- Testing
- RMBand lower dose, RMBand higher dose
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Virginia Commonwealth University
Parkinson Disease (PD), Tremor
A Study Comparing Propranolol and Amantadine for Reducing Tremors in People With Parkinson's Disease
Parkinson's disease is a common brain disorder in older adults that causes tremors (shaking), stiffness, and problems with movement.
- Trial name
- NCT07113015
- Testing
- propranolol, Amantadine
- Where
- Pakistan
- Volunteers
- 220 people
- Sponsor
- Multan Medical And Dental College
Essential Tremor
Zonisamide in the Treatment of Essential Tremor
The purpose of this study is to determine if Zonisamide is effective in reducing tremors in patients with Essential Tremor.
- Trial name
- NCT00616343
- Testing
- Zonisamide
- Volunteers
- 9 people
- Sponsor
- Loma Linda University
Essential Tremor
Efficacy of Pramipexole Extended Release in the Treatment of Essential Tremor
Aim of the study is to perform a double-blind, crossover, placebo-controlled multicenter study evaluating the efficacy of pramipexole on essential tremor.
- Trial name
- NCT01441284
- Testing
- pramipexole
- Where
- 2 sites in Hungary
- Sponsor
- University of Pecs
Dystonia, Parkinson Disease
Impact of a Standardized Music Therapy Protocol on the Quality of Life of Patients With Abnormal Movements Treated With Continuous Electrical Neuromodulation
The study of the impact of music on emotional, motor and cognitive aspects remains recent. Music therapy has experienced a major boom over the last half century thanks to neuroradiological techniques for investigating the brain…
- Conditions
- Dystonia, Parkinson Disease, Essential Tremor
- Trial name
- Music-QOL (NCT05214313)
- Testing
- Music Therapy
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Montpellier
Essential Tremor, Parkinsons Disease (PD)
Effects of Microelectrode-based Brain Stimulation in Humans
The currently available treatments of Parkinson's disease (PD) and Essential Tremor (ET) are inadequate and accompanied by adverse side effects making the treatment much less effective.
- Trial name
- HDBS (NCT07820189)
- Testing
- High Definition Brain Stimulation (HDBS)
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Lund University