Clinical trials: Trigeminal Autonomic Cephalalgias
Cluster Headache
PACAP-38 Infusion in Patients With Cluster Headache
A randomized, double-blinded, two-way crossover study investigating the headache inducing capabilities of PACAP-38 in patients with cluster headache.
- Trial name
- NCT03814226
- Testing
- Evaluation of headache inducing capabilities of PACAP38
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Danish Headache Center
Cluster Headache - Episodic and Chronic, Migraine Headache
Yogabased Movements for Primary Headaches (Migraine and/or Cluster Headache) - YOURHEAD
Brief Summary: Migraine and/or Cluster Headache: Study Overview Background: Migraine and cluster headache are two primary headache disorders that significantly impact quality of life and functionality in those affected.
- Conditions
- Cluster Headache - Episodic and Chronic, Migraine Headache, Migraine Headache, With or Without Aura, Migraine in Adults
- Trial name
- NCT07348783
- Testing
- Intervention yoga based exercises
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Cluster Headache
Circadian Rhythm and Attack-timing in Episodic Cluster Headache Patients in- and Outside of Bout: an Actigraphic Study
The aim is to investigate circadian rhythm in episodic cluster headache using actigraphy.
- Trial name
- NCT02853487
- Testing
- Actigraphy, Diary
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Resistant Migraine, Chronic Migraine Headache
A Pivotal Clinical Study to Evaluate the MySalvia System for the Treatment of Resistant Migraine
The purpose of this pivotal clinical study is to evaluate the safety and effectiveness of the MySalvia System, a minimally invasive implantable neuromodulation therapy, for the preventive treatment of adults with resistant…
- Conditions
- Resistant Migraine, Chronic Migraine Headache, Headache (Migraine), Headache, Cluster
- Trial name
- RECLAIM-II (NCT07719608)
- Testing
- Neurostimulator
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Salvia BioElectronics
Cluster Headache, Episodic
Exploration of Cluster Headache in a PET-MRI Study
Observational study in PET-MRI using the 5-HT1A agonist PET radiotracer [18F]F13640.
- Trial name
- F13640-AVF (NCT05084469)
- Testing
- PET-MRI in pain-free remission period
- Volunteers
- 12 people
- Sponsor
- Hospices Civils de Lyon
Chronic Cluster Headache
Pathway CH-1 Long-Term Follow-Up
The objective of the study is to demonstrate the long-term safety and performance of the ATI Neurostimulation System when used for stimulation of the sphenopalatine ganglion (SPG) in cluster headache subjects.
- Trial name
- NCT01616511
- Where
- 3 sites in Belgium, Denmark and 1 more
- Volunteers
- 33 people
- Sponsor
- Autonomic Technologies, Inc.
Cluster Headache
Cluster Headache, Addictions and Vascular Function
Cluster headache (CH) is one of the most painful primitive headaches. Developments in neuroimaging have demonstrated activation of the ipsilateral hypothalamic and orexinergic system, which is similar in patients with addictions.
- Trial name
- CHAD (NCT02640105)
- Testing
- Neurological clinical examination, Psychological clinical examination, Questionnaires
- Where
- France
- Volunteers
- 95 people
- Sponsor
- University Hospital, Bordeaux
Migraine, Cluster Headache
Saccadometry in Primary Headache Syndromes
Migraine is one of the commonest neurological disorders, affecting up to 12% of the general population, but remains relatively under-diagnosed and under-treated.
- Conditions
- Migraine, Cluster Headache, Control, Menstrual Migraine
- Trial name
- NCT01395264
- Where
- 2 sites in United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Tim Young
Migraine, Chronic Tension-Type Headache
Nurse Intervention Trial
This randomized open-label prospective study focus on headache patients initiating preventive treatment, where the treating physician identifies a need for follow-up visits in specialized healthcare.
- Conditions
- Migraine, Chronic Tension-Type Headache, Cluster Headache, Hemicrania Continua
- Trial name
- NCT06200480
- Testing
- Telephone by nurse
- Where
- Norway
- Volunteers
- 147 people
- Sponsor
- Norwegian University of Science and Technology
Cluster Headache
Prophylactic Effects of Psilocybin on Chronic Cluster Headache
The purpose of this study is to investigate the prophylactic effects of psilocybin in chronic cluster headache. Subjects will receive a low dose of psilocybin during 3 sessions spaced by one week.
- Trial name
- EPOCH (NCT04280055)
- Testing
- Psilocybin
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Gitte Moos Knudsen
Headache Disorders, Primary, Migraine
China HeadAche DIsorders RegiStry
It is planned to include 10000 patients. In the China HeadAche DIsorders RegiStry CHAIRS）, patients aged over 12 years with primary headache and medication-overuse headache(MOH) were collected.
- Conditions
- Headache Disorders, Primary, Migraine, New Daily Persistent Headache, Medication Overuse Headache
- Trial name
- CHAIRS (NCT05334927)
- Testing
- Medicine Overuse Headache/New Daily Persistent Headache, Episodic Migraine and Chronic Migraine, Patients with other types of primary headache
- Where
- 61 sites in China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Tiantan Hospital
Migraine Disorders, Facial Pain Disorder, Cluster Headache, Trigeminal Neuralgia, Trigeminal Autonomic Cephalalgias
Sphenopalatine Ganglion Pulsed Radiofrequency Treatment Outcomes
Purpose of the Study: This study aims to evaluate the clinical effectiveness and long-term outcomes of "Sphenopalatine Ganglion (SPG) Pulsed Radiofrequency (PRF)" treatment in patients with chronic headaches and facial pain.
- Trial name
- SPG-PRF (NCT07370142)
- Testing
- Pulsed Radiofrequency of the Sphenopalatine Ganglion
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Ankara City Hospital Bilkent
Chronic Cluster Headache
Anodal Transcranial Direct Stimulation (tDCS) for the Treatment of Chronic Cluster Headache
Cluster headache is a primary headache that chiefly affects young men, and is less common than migraine. This disease can have devastating consequences due to the pain intensity (it is also called "suicide headache"), to the side…
- Trial name
- ANODECCH (NCT02462395)
- Testing
- tDCS
- Where
- Belgium
- Volunteers
- 32 people
- Sponsor
- University of Liege
Cluster Headache - Episodic and Chronic
Safety and Efficacy Study of SOM230 s.c. in Cluster Headache
The purpose of this study was to determine if SOM230 is safe and effective for the treament of cluster headache.
- Trial name
- NCT02619617
- Testing
- SOM230
- Where
- 4 sites in United States, Germany and 1 more
- Volunteers
- 28 people
- Sponsor
- Novartis Pharmaceuticals
Refractory Chronic Cluster Headache
Ketamine + Magnesium for Chronic Cluster Headache (KETALGIA)
Chronic cluster headache (CCH) is a rare primary headache disorder, defined by episodic attacks that occur for more than one year with no remission period or with remission periods lasting < 3 months (ICHD-3 criteria).
- Trial name
- KETALGIA (NCT04814381)
- Testing
- Ketamine + Magnesium sulfate (drug combination)
- Where
- 14 sites in France
- Volunteers
- 93 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cluster Headache
Study of Hypothalamic Metabolism in Spontaneous Cluster Headache Attacks
Cluster headache is characterized by unilateral excruciating head pain and autonomic dysfunction. Hypothalamic overactivity was observed in nitrate-induced cluster-headache and in only one case of spontaneous cluster headache…
- Trial name
- NCT00458770
- Testing
- position emission transaxial tomography
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Episodic Cluster Headache
A Phase III Study of Civamide Nasal Solution (Zucapsaicin) for the Treatment of Episodic Cluster Headache
This is a 49-day study to evaluate the effectiveness of Intranasal Civamide (Zucapsaicin) in the treatment of an episodic cluster headache period compared to placebo (medically inactive substance which does not contain any active…
- Trial name
- NCT00033839
- Testing
- Civamide (Zucapsaicin)
- Where
- 26 sites in United States
- Volunteers
- 60 people
- Sponsor
- Winston Laboratories
Cluster Headache
Evaluation of Efficacity and Safety of Deep Brain Stimulation (DBS) in Chronic and Treatment-Resistant Cluster Headache(CH)
The aim of this study is to evaluate the efficacy and safety of deep brain stimulation (DBS) in chronic and treatment-resistant CH.
- Trial name
- NCT00662935
- Testing
- setting-up of an electrode in deep brain
- Volunteers
- 12 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Cluster Headache
The Effects of Levcromakalim in Patients With Cluster Headache
Cluster headache is a primary headache disorder characterized by attacks of unilateral headache of short duration and severe pain intensity.
- Trial name
- NCT05093582
- Testing
- Levcromakalim, Saline
- Where
- Denmark
- Volunteers
- 41 people
- Sponsor
- Danish Headache Center
Episodic Cluster Headache
A Study to Evaluate the Efficacy and Safety of TEV-48125 (Fremanezumab) for the Prevention of Episodic Cluster Headache (ECH)
This is a 13-week, multicenter, randomized, double-blind, double-dummy, placebo-controlled, parallel-group study to compare the efficacy and safety of 2 dose regimens of TEV-48125 (Fremanezumab) versus placebo in adult…
- Trial name
- NCT02945046
- Testing
- Fremanezumab
- Where
- 82 sites in United States, Australia and 10 more
- Volunteers
- 169 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.