Clinical trials: Trigeminal Neuropathy
Trigeminal Neuralgia, Idiopathic
Recurrence of Trigeminal Neuralgia in Patient's Undergoing Radiofrequency Ablation
This study aims to find recurrence rate of the trigeminal neuralgia after patients undergo stereotactic rhizotomy by radiofrequency ablation at 80 degrees Celsius for 90 seconds under fluoroscopic guidance, a protocol that was…
- Trial name
- NCT05101577
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Shifa Clinical Research Center
Trigeminal Neuralgia
Pathophysiological Mechanisms of Trigeminal Neuralgia - Neurophysiological Assessment of the Blink-reflex
This study aims to increase the understanding of the pathophysiology of trigeminal neuralgia by investigating the potential association between blink reflex abnormalities and phenotypical traits e.g.
- Trial name
- TNBR (NCT05328661)
- Testing
- Blink reflex
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Danish Headache Center
Trigeminal Neuralgia
RP-008 in Combination With Daily Oral Varenicline for the Treatment of Trigeminal Neuralgia
The goal of this study is to evaluate if KRIYA-748 (RP-008) is safe, tolerable, and preliminary effective in treating trigeminal neuralgia (TN) when used in combination with varenicline tartrate.
- Trial name
- RELIEF (NCT07596485)
- Testing
- RP-008, Varenicline tartrate
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Kriya Therapeutics, Inc.
Inferior Alveolar Nerve Injuries
Risk of Nerve Damage After Administration of Local Anesthesia
This research aims to evaluate of the risk of nerve damage following the administration of articaine 4% and lidocaine 2% for Inferior Alveolar nerve Block (IANB).
- Trial name
- NCT06564987
- Testing
- 4% Articaine with 1:200,000 epinephrine, 2% lidocaine with 1:100,000 epinephrine
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cleveland Dental Institute
Trigeminal Neuralgia, Glossopharyngeal Neuralgia
Anti-CGRP for Inflammation and Pain Modulation in Small Fiber Neuropathy/Fibromyalgia
The investigators will treat patients (targeting enrollment of n=20) who suffer from trigeminal or glossopharyngeal nerve pain in the context of painful small fiber neuropathy.
- Trial name
- NCT04158752
- Testing
- Galcanezumab
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Duke University
Trigeminal Neuralgia
The Efficacy and Safety of Pulsed Radiofrequency Combined With Continuous Radiofrequency for the Trigeminal Neuralgia
Trigeminal neuralgia is a very painful condition, and radiofrequency therapy is reserved for patients who are resistant or intolerant to pharmacological therapy.
- Trial name
- PRFCRF (NCT04174443)
- Testing
- High-voltage pulsed radiofrequency, Low-temperature continuous radiofrequency
- Where
- China
- Volunteers
- 146 people
- Sponsor
- Beijing Tiantan Hospital
Idiopathic Trigeminal Neuralgia
High-voltage Pulsed Radiofrequency on Gasserian Ganglion to Treat Patients With Primary Trigeminal Neuralgia
The study is designed to compare the effectiveness and safety of high-voltage Pulsed radiofrequency and nerve block for the treatment of primary Trigeminal Neuralgia patients with ineffective conservative treatment and explore…
- Trial name
- NCT03131466
- Testing
- High-voltage pulsed radiofrequency, Nerve block
- Where
- 3 sites in China
- Volunteers
- 134 people
- Sponsor
- Beijing Tiantan Hospital
Trigeminal Neuralgia
Management of Arachnoid Nerve Tethering in Trigeminal Neuralagia
This study aims to evaluate the clinical significance of arachnoid-trigeminal nerve conflict in patients with medically refractory trigeminal neuralgia without demonstrable neurovascular conflict on preoperative magnetic…
- Trial name
- NCT07811973
- Testing
- Arachnoid nerve detethering
- Volunteers
- 23 people
- Sponsor
- Assiut University
Trigeminal Neuralgia
Effect of Non-invasive Photobiomodulation Therapies in Patients With Trigeminal Neuralgia
The aim of this study was to compare the effectiveness of two different photobiomodulation (PBM) therapies as an alternative to medical treatment to reduce pain and improve quality of life in patients with trigeminal neuralgia…
- Trial name
- NCT06440356
- Testing
- laser therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Trigeminal Neuralgia
5% Lidocaine-medicated Plaster for the Treatment of Trigeminal Neuralgia
Trigeminal neuralgia (TN) is characterized by sudden, severe, usually unilateral, transient, stinging, recurrent electrocute-like shock in one or more divisions of the trigeminal nerve, lasting from a few seconds to less than 2…
- Trial name
- NCT04570293
- Testing
- 5% lidocaine medicated plaster, vehicle plaster
- Where
- 5 sites in China
- Volunteers
- 226 people
- Sponsor
- Beijing Tiantan Hospital
Neuropathic Pain, Orofacial Pain
Bilateral TMS vs. Unilateral TMS
Rationale: In 2016, Henssen et al. discuss that orofacial pain may be conducted in a bilateral fashion, inducing activation of both thalami [1].
- Conditions
- Neuropathic Pain, Orofacial Pain, Trigeminal Neuropathy
- Trial name
- biTMSvsuniTMS (NCT03710967)
- Testing
- Transcranial magnetic stimulation
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Radboud University Medical Center
Trigeminal Neuralgia
The Alternative Effects of Electroacupuncture in the Treatment of Trigeminal Neuralgia
Trigeminal neuralgia (TN), characterized by its refractory nature and recurrence, frequently leads to anxiety, depression, and insomnia, thereby significantly diminishing patients' quality of life and potentially inducing…
- Trial name
- NCT06977932
- Testing
- Carbarmazepine, Electroacupuncture
- Volunteers
- 126 people
- Sponsor
- Yuanyuan Wu
Trigeminal Neuralgia
A Study to Validate a Pain Diary for Patient With Trigeminal Neuralgia
The aim of the study is to establish the validity of a patient reported diary in TN . The following objectives have been identified: 1.
- Trial name
- NCT06019338
- Testing
- Pain Diary use
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Noema Pharma AG
Malignant Tumor, Benign Neoplasm
Twenty-five Years of Advanced RadioTherapy at San Raffaele Hospital
This retrospective observational study aims to evaluate the efficacy and toxicity of advanced radiotherapy (ART) techniques- intensity-modulated radiotherapy (IMRT), image-guided radiotherapy (IGRT), and stereotactic radiotherapy…
- Conditions
- Malignant Tumor, Benign Neoplasm, Parkinson Disease, Trigeminal Neuralgia
- Trial name
- 25-ART-HSR (NCT07894900)
- Testing
- Advanced radiotherapy techniques
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- IRCCS San Raffaele
Trigeminal Neuralgia
The Effect of Intravenous Lidocaine on Trigeminal Neuralgia
The aim of this randomized double blind, placebo controlled, crossover study is to investigate in a prospective way the effect of lidocaine in patients with trigeminal neuralgia.
- Trial name
- NCT01955967
- Testing
- Lidocaine
- Volunteers
- 20 people
- Sponsor
- Pain Relief & Palliative Care Center, Athens, Greece
Trigeminal Neuralgia, Trigeminal Neuralgia, Idiopathic
CT-guided vs Fluoroscopy-guided Trigeminal Ganglion Radiofrequency Thermocoagulation for Idiopathic Trigeminal Neuralgia
The goal of this clinical trial is to compare the effectiveness and safety of CT-guided versus fluoroscopy-guided trigeminal ganglion radiofrequency thermocoagulation (TG-RFT) in treating idiopathic trigeminal neuralgia (TN) in…
- Trial name
- NCT06620172
- Testing
- CT-guided Radiofrequency Thermocoagulation (RFT), Fluoroscopy-guided Radiofrequency Thermocoagulation (RFT)
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Zagazig University
Trigeminal Neuralgia
Efficacy and Complications of Microvascular Decompression
The study is a non-interventional prospective observational study in patients with trigeminal neuralgia that undergoes micovascular decompression.
- Trial name
- NCT04445766
- Volunteers
- 115 people
- Sponsor
- Danish Headache Center
Trigeminal Neuralgia
A Study of Amifostine for Prevention of Facial Numbness in Radiosurgery Treatment of Trigeminal Neuralgia
Trigeminal neuralgia or tic douloureux is severe, often debilitating, facial pain that significantly impairs the patient's quality of life and health.
- Trial name
- NCT01364259
- Testing
- Amifostine, CyberKnife stereotactic radiosurgery
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Stanford University
Trigeminal Neuralgia
Electroacupuncture Therapy for Change of Pain in Classical Trigeminal Neuralgia
The classical trigeminal neuralgia (CTN) is a common neuropathic pain in clinic by recurrent attacks of chronic sharp pain in the distribution of neuropathy branches of trigeminal neuralgia.
- Trial name
- NCT03580317
- Testing
- EA+ Carbamazepine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Zhejiang Chinese Medical University
Trigeminal Neuralgia, Facial Pain
Incidence of Intravascular (IV) Injection During Trigeminal Nerve Blocks
The purpose of this study is to investigate the incidence of intravascular injection during trigeminal nerve blocks.
- Conditions
- Trigeminal Neuralgia, Facial Pain, Postherpetic Neuralgia, Cluster Headache
- Trial name
- NCT04467398
- Testing
- trigeminal nerve block
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University