Clinical trials: Trimethylamine N-oxide
Cardiovascular Risk Factor
Short Term Choline and Cardiovascular Health
Trimethylamine-N-oxide (TMAO), a metabolite produced by gut microbial metabolism of dietary choline, has recently been causally linked to atherosclerosis in animal models and has been shown to be predictive of cardiovascular…
- Trial name
- NCT03327805
- Testing
- Choline
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Healthy
Trimethylamine-N-oxide Production and Metabolism
The purpose of this study was to understand the production of trimethylamine-N-oxide (TMAO) and its metabolites from dietary precursors found in fish, eggs and beef.
- Trial name
- NCT02558673
- Testing
- TMAO dietary precursors, Control (or active comparator)
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cornell University
Microbiota, Nutrition, Healthy
Effect of the Sustainable Diet on Gut Microbiota and the Metabolome: a Randomised Crossover Study
Unhealthy diets are closely linked to non-communicable diseases and constitute higher risk of morbidity and mortality than unsafe sex, alcohol, tobacco and drugs use combined.
- Trial name
- SUSUGUT (NCT05231317)
- Testing
- Plant-based diet, Western diet
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Trimethylamine-N-oxide, Gut Microbiota
Red Wine Effects Upon Gut Flora and Plasma Levels of Trimethylamine-N-oxide (TMAO) - WineFlora Study
Recent evidence indicates that Trimethylamine-N-oxide (TMAO) is a pro-atherosclerotic, phosphatidylcholine-dependent metabolite of diet and intestinal flora.
- Conditions
- Trimethylamine-N-oxide, Gut Microbiota, Effects of Red Wine, Atherosclerosis
- Trial name
- NCT03232099
- Testing
- Red Wine consumption, Period without alcohol consumption
- Volunteers
- 42 people
- Sponsor
- University of Sao Paulo General Hospital
Healthy
Trimethylamine N-oxide Effects of a Pomegranate Supplement Simultaneously With Carnitine (TESSA)
Trimethylamine N-oxide (TMAO) is produced in some individuals whose diets include meat, fish, and dairy.These foods are rich in L-carnitine. L-carnitine is metabolised by the liver and gut microorganisms (bacteria) into TMAO.
- Trial name
- TESSA (NCT06518343)
- Testing
- L-carnitine + Pomegranate extract, L-carnitine + Microcrystalline cellulose
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
Dietary Exposure
Investigation on the Effect of Carnitine Supplement on Gut Microbiota and TMAO Production Capacity
In this project, the investigators aim to explore the impact of dietary L-carnitine supplementation on the TMAO production capacity of gut microbiota.
- Trial name
- NCT02838732
- Testing
- L-carnitine supplementation (500 mg per tablet per day, purchased from GNC company)
- Where
- Taiwan
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Aortic Stenosis, Heart Failure
TMAO in Patients With Severe Aortic Stenosis
Trimethylamine N-oxide (TMAO) has recently gained increasing scientific interest in the field of cardiovascular disease, including its role in cell protection against osmotic and hydrostatic stress.
- Trial name
- TASTE (NCT04406805)
- Testing
- Measurement of plasma and urine trimethylamine-N-oxide concentration
- Where
- Poland
- Volunteers
- 70 people
- Sponsor
- Medical University of Warsaw
Liver Transplant
Targeting Trimethylamine N-Oxide for Cardiovascular Health In Liver Transplant Recipients
Despite medical and surgical advances, long-term survival in liver transplant (LT) recipients is compromised by an increased risk of cardiovascular disease (CVD) after transplant, the mechanisms of which are still not fully…
- Trial name
- NCT06043531
- Testing
- Experimental: EVOO
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Virginia Commonwealth University
Dietary Modification, Cardiovascular Diseases
Oral Carnitine Challenge Test Guides Personalized Nutrition for CV Patients
The investigators plan to use the recently developed oral carnitine challenge test (OCCT) as a tool to exam individual's trimethylamine N-oxide (TMAO) production capacity from their gut microbiota.
- Trial name
- NCT03781011
- Testing
- Vegetarian diet intervention
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
STEMI - ST Elevation Myocardial Infarction, Microvascular Coronary Artery Disease
Impact of TMAO Serum Levels on Hyperemic IMR in STEMI Patients
Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite of dietary choline, L-carnitine, and phosphatidylcholine-rich foods.
- Trial name
- TAMIR (NCT05406297)
- Testing
- pressure-temperature sensor guidewire-based measurement
- Where
- Lithuania
- Volunteers
- 400 people
- Sponsor
- Lithuanian University of Health Sciences
Coronary Ectasia, Microbial Disease
The Relationship Between Microbiota and Coronary Ectasia
Introduction: It is now known that the microbiota is far beyond the microbial communities living in certain parts of our body and functions like a metabolic organ.
- Trial name
- NCT06384703
- Testing
- Taking blood for kit study
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Konya Beyhekim Training and Research Hospital
Cardiometabolic Risk Factors
Facilitated Vegan Diet on Cardiometabolic Endpoints and Trimethylamine N-oxide
Vegan meal kit delivery offers consumer convenience and has shown benefit in cardiometabolic parameters such as low-density lipoprotein cholesterol (LDL-c) and weight.
- Trial name
- NCT05071196
- Testing
- Facilitated Vegan Diet, Omnivorous Diet
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- David Grant U.S. Air Force Medical Center
Amyotrophic Lateral Sclerosis
Correlation Between Intestinal Microflora Metabolites and Amyotrophic Lateral Sclerosis
To verify the correlation between TMAO level and the pathogenesis and progression of ALS
- Trial name
- NCT04948346
- Testing
- diagnosed with ALS
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University Third Hospital
Vascular Diseases, Leukoaraiosis
Concentration of Trimethylamine Oxide (TMAO) in Blood Plasma as a Risk Factor for Vascular Cerebral Damage
The primary aim of the current research project is to answer the question, whether plasma trimethylamine N-oxide (TMAO) level may be used as a marker of ischemic changes in the brain.
- Conditions
- Vascular Diseases, Leukoaraiosis, Ischemia, Cerebral
- Trial name
- NCT03903601
- Testing
- Magnetic Resonance Imaging (MRI), Blood samples collection, Neuropsychological tests
- Where
- Poland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Diabetes Mellitus, Type 2, Heart Diseases
The Effects of an 8-week Vegan Diet on TMAO Levels and Post-challenge Glucose Levels in Individuals With Dysglycaemia
The amount of people with diabetes mellitus has now reached over 4 million in the United Kingdom. Type 2 diabetes accounts for the majority of all cases of diabetes and increases the risk of many other diseases such as heart…
- Trial name
- PYH (NCT03315988)
- Testing
- Adoption of a vegan diet
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- University of Leicester
Gestational Diabetes
Association Between Trimethylamine-N-oxide and Gestational Diabetes Mellitus
Background: The microbiota-dependent metabolite trimethylamine-N-oxide (TMAO) has been reported as a novel and independent risk factor for the development of cardiovascular and metabolic diseases, but the association with…
- Trial name
- NCT03415295
- Testing
- Plasma TMAO concentration
- Volunteers
- 1,694 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Carotid Artery Plaque
TMAO and Atherosclerosis in HIV
In the present study, the investigators sought to prospectively examine the associations of plasma levels of TMAO (trimethylamine oxide), choline, betaine, dimethylglycine, and sarcosine with risk of incident carotid artery…
- Trial name
- NCT03416257
- Testing
- No intervention
- Volunteers
- 737 people
- Sponsor
- Albert Einstein College of Medicine
CKD Stage 3b, CKD Stage 4
The Effect of Sevelamer Carbonate on Serum Trimethylamine-n-Oxide (TMAO) Level in Patients With Chronic Kidney Disease (CKD) Stage 3b-4
The aim of this study is to investigate effects of sevelamer carbonate on reducing TMAO in stage 3b-4 CKD (pre-dialysis) patients.
- Trial name
- NCT03596749
- Testing
- Sevelamer Carbonate
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Fan Fan Hou
Coronary Artery Disease
Impact of Time Restricted Eating on Patients With Coronary Artery Disease (CAD) Undergoing Cardiac Rehabilitation
The purpose of this study is to see if reducing the number of hours during which one eats each day will help reduce levels of LDL cholesterol and improve other markers of metabolic and cardiovascular health (i.e.
- Trial name
- TRE x ICR (NCT05014880)
- Testing
- ICR (Intensive Cardiac Rehabilitation), ICR x TRE (Intensive Cardiac Rehabilitation x Time-Restricted Eating)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, San Diego
Body Weight, Oxidative Stress
The Effect of a Meatless,Keto Restrictive Diet on Body Composition,Strength Capacity,Oxidative Stress,Immune Response
The subject of doctoral dissertation: Assessment of the effects of a meatless, ketogenic restrictive diet on body composition, strength capacity, oxidative stress and immune response During planning of research and topic of the…
- Conditions
- Body Weight, Oxidative Stress, Trimethylamine N-oxide, Immunologic Factors
- Trial name
- NCT05558488
- Testing
- Meatless, restrictive ketogenic diet
- Where
- Poland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Katarzyna Siedzik