Clinical trials: Troponin T
Acute Coronary Syndrome, Chest Pain
High-Sensitivity Cardiac Troponin T to OPtimize Chest Pain Risk Stratification
This is a prospective observational cohort study of ED patients with acute chest pain or other symptoms suggestive of ACS. Blood samples will be collected from study participants for High-Sensitivity Cardiac Troponin T (hs-cTnT)…
- Trial name
- STOP CP (NCT02984436)
- Testing
- Blood Sample, HEART Score
- Where
- 6 sites in United States
- Volunteers
- 1,572 people
- Sponsor
- University of Florida
Atrial Fibrillation, Atrial Flutter
High Sensitivity Troponin T Levels Following DC Cardioversion for Atrial Fibrillation / Atrial Flutter
The purpose of this study is to determine if there is a rise in serum high sensitivity troponin T (a marker for heart muscle injury) following a direct current cardioversion (shock therapy) used for patients with atrial…
- Trial name
- NCT02268799
- Where
- Ireland
- Volunteers
- 101 people
- Sponsor
- University of Limerick
COPD, Myocardial Diseases
Troponin T in Chronic Obstructive Pulmonary Disease (COPD) Patients After Physical Exercise
The primary purpose of the study is to investigate if physical exercise is associated with myocardial damage, expressed by elevated troponin T, in patients with COPD.
- Trial name
- NCT02721693
- Testing
- Treadmill exercise test
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- LHL Helse
Interstitial Lung Disease, Pulmonary Hypertension
Biomarkers in Pulmonary Hypertension Associated to Interstitial Lung Disease
The presence of an abnormally increased pulmonary blood pressure worsens the prognosis of patients with interstitial pulmonary disease.
- Conditions
- Interstitial Lung Disease, Pulmonary Hypertension, Biomarkers
- Trial name
- NCT00820729
- Where
- 2 sites in Denmark
- Volunteers
- 212 people
- Sponsor
- University of Aarhus
Acute Myocardial Infarction, Acute Coronary Syndrome
COmparisoN of High-sensitivity Cardiac TRoponin I and T ASsays Trial
Compare the analytical and clinical performance of hs-cTnI and hs-cTnT assays for the diagnosis of acute myocardial injury and myocardial infarction in patients presenting to the emergency department in whom serial cTnI…
- Trial name
- CONTRAST (NCT03214029)
- Testing
- Cardiac troponin testing
- Where
- United States
- Volunteers
- 2,286 people
- Sponsor
- Fred Apple
Sepsis
The Study of NT-proBNP Combined With HS-cTnT in Evaluating the Prognosis of Sepsis
To study the clinical value of combined detection of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hs-cTnT) in assessing the prognosis of patients with sepsis.
- Trial name
- NCT04963699
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Myocardial Infarction, Disorder; Heart, Functional, Postoperative, Cardiac Surgery
High-sensitivity Troponin T in Acute Myocardial Infarction After Cardiac Valvular Surgery
A measurable degree of heart muscle tissue injury is expected in patients undergoing heart valvular surgery. The level of this injury can be measured by cardiac biomarkers in blood samples.
- Conditions
- Acute Myocardial Infarction, Disorder; Heart, Functional, Postoperative, Cardiac Surgery, Myocardial Infarction, Heart Valve Diseases
- Trial name
- NCT02518282
- Testing
- Serum levels of high-sensitivity troponin T, Twelve-lead ECGs, Transthoracic echocardiography (TTE)
- Where
- Spain
- Volunteers
- 800 people
- Sponsor
- University of Valladolid
Congenital Heart Disease
Cardiac Troponin T After Transcatheter Closure of the Interatrial Septum
To examine retrospectively whether transcatheter closure of the interatrial septum leads to myocardial injury and to determine the mechanism.
- Trial name
- NCT03099967
- Testing
- Transcatheter closure of an atrial septal defect or patent foramen ovale.
- Volunteers
- 51 people
- Sponsor
- Skane University Hospital
Acute Kidney Injury, Postoperative Complications
Evaluation of Postoperative Organ Injury, Risk Factors, and Short-Term Clinical Outcomes in Patients Admitted to Intensive Care After Noncardiac Surgery
This retrospective observational study examines whether troponin levels measured before surgery are associated with acute kidney injury during the first 48 hours after surgery in patients admitted to intensive care after…
- Trial name
- TROP-AKI (NCT07907887)
- Where
- Turkey (Türkiye)
- Volunteers
- 224 people
- Sponsor
- Ankara Training and Research Hospital
Acute Coronary Syndrome
5th Generation cTnT in ED ACS
This study intends to investigate the usefulness of the new "5th generation" cardiac troponin enzyme in determining which patients presenting with possible acute coronary syndrome can be quickly and safely discharged or admitted…
- Trial name
- NCT03590535
- Testing
- 4th Gen cTnT, 5th Gen cTnT
- Where
- United States
- Volunteers
- 1,949 people
- Sponsor
- Columbia University
Silent Myocardial Ischemia, Acute Myocardial Infarction
Silent Myocardial Ischemia in Patients Undergoing Non-oncological Abdominal Surgeries
Perioperative mortality in non-cardiac surgical procedures is 1-2 % with half of these cases attributed to cardiovascular events.
- Trial name
- NCT06536686
- Testing
- Silent myocardial ischemia, STEMI
- Where
- Slovenia
- Volunteers
- 200 people
- Sponsor
- University Medical Centre Ljubljana
Renal Insufficiency, Chronic
Is Hemodialysis Associated With Cardiac Markers Change?
Hemodialysis (HD) triggers recurrent and cumulative ischemic insults to the brain and the heart. Cooled dialysate may have a protective effect on major organs and improve hemodynamic tolerability of dialysis.
- Trial name
- NCT04929366
- Testing
- Hypothermic dialysis followed with routine dialysis, Routine dialysis followed with hypothermic dialysis
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- Ziv Hospital
Acute Coronary Syndrome
TnThs Predicting Evolving Non-STEMI
BACKGROUND: We sought to determine the diagnostic value of the new TnThs assay for early detection of evolving non-STEMI in patients with acute coronary syndrome and a negative 4th generation cTnT result on admission.
- Trial name
- NCT00953251
- Where
- Germany
- Volunteers
- 115 people
- Sponsor
- Heidelberg University
Type 2 Diabetes Mellitus
Nitrate and Exercise-induced Cardiac Troponin T in Type 2 Diabetes
Blood cardiac troponin T (cTnT) concentration is a widely used marker of acute cardiac injury. Previous research has shown that type 2 diabetic patients may experience large increments in cTnT levels over the subsequent hours…
- Trial name
- NO troponin (NCT01714674)
- Testing
- Dietary nitrate beverage, NaCl beverage
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Maastricht University Medical Center
Coronary Artery Bypass Graft Triple Vessel, Apoptotic DNA Damage
Remote Ischemic Preconditioning of Human Myocardium
The investigators aim to definitively show if human myocardium can be remotely preconditioned. In the writings there are no experiments that would prove that the remote preconditioning protocol effects on the higher protection of…
- Trial name
- NCT01994707
- Testing
- Remote ischemic preconditioning
- Where
- Poland
- Volunteers
- 134 people
- Sponsor
- Medical University of Silesia
NSTEMI - Non-ST Segment Elevation MI, ACS - Acute Coronary Syndrome
Early Cardiac Magnetic Resonance Imaging in Suspected Non-ST-Elevation Myocardial Infarction
Background and rationale: Evaluating patients with acute chest pain, elevated high-sensitive cardiac troponin (hs-cTn) levels and non-diagnostic electrocardiogram (ECG), i.e.
- Trial name
- CMR-OBSERVE (NCT04140019)
- Testing
- CMR
- Where
- Netherlands
- Volunteers
- 87 people
- Sponsor
- Maastricht University Medical Center
Heart Failure
RISK Stratification Using a Combination of Cardiac Troponin T and Brain Natriuretic Peptide in Patients Receiving CRT-D
The purpose of the study is to identify if the combined use of cardiac troponin enzyme (cTnT) and brain natriuretic peptide (BNP) can predict Heart Failure (HF)improvement and all-cause mortality in patients implanted with…
- Trial name
- RISK (NCT00453622)
- Testing
- Cardiac Resynchronization Therapy-Defibrillator
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- Abbott Medical Devices
Heart Failure With Preserved Ejection Fraction
A Study of Mavacamten in Participants With HFpEF and Elevation of NT-proBNP With or Without Elevation of cTnT
This is a Phase 2a proof-of-concept study to assess safety, tolerability, and preliminary efficacy of mavacamten treatment on biomarker levels in participants with heart failure with preserved ejection fraction (HFpEF) and…
- Trial name
- EMBARK-HFpEF (NCT04766892)
- Testing
- mavacamten
- Where
- 21 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Bristol-Myers Squibb
Troponin T, Hemolysis
Effect of in Vitro Haemolysis on Serum High Sensitivity Troponin T Measurements From Patients in Accident & Emergency
This study will be investigating how a common blood test for identifying heart damage (Troponin T) is affected by red blood cell damage in the blood sample (Haemolysis).
- Trial name
- NCT03439605
- Where
- United Kingdom
- Volunteers
- 61 people
- Sponsor
- Poole Hospital NHS Foundation Trust
Myocardial Infarction (MI), Perioperative Myocardial Injury
High-Sensitivity Troponin T Kinetics and 30-Day Outcomes After Major Abdominal Surgery (TROP-MAS)
Major abdominal surgery (MAS) carries a high risk of 30-day mortality (>5%). Perioperative myocardial injury (PMI) and myocardial injury after noncardiac surgery (MINS) frequently develop asymptomatically due to surgical…
- Conditions
- Myocardial Infarction (MI), Perioperative Myocardial Injury, Sepsis, Digestive System Surgical Procedures
- Trial name
- TROP-MAS (NCT07850492)
- Testing
- High-sensitivity cardiac troponin T (hs-cTnT) surveillance
- Where
- Vietnam
- Volunteers
- 650 people
- Sponsor
- Bach Mai Hospital