Clinical trials: Tumor Necrosis
Avascular Necrosis, Acute Lymphoblastic Leukemia
AVN of Weight-Bearing Joints In Patients With Hematologic Malignancies Treated With Dexamethasone Or Prednisone
The primary purpose of this study is to compare the incidence of AVN in children with hematologic malignancies treated with prednisone versus dexamethasone during continuation.
- Trial name
- NCT00719147
- Testing
- MRI, Functional Status and Symptom Questionnaire
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- St. Jude Children's Research Hospital
Rheumatoid Arthritis
An Observational Study of MabThera/Rituxan (Rituximab) in Patients With Rheumatoid Arthritis and an Inadequate Response or Intolerance to One Anti-Tumor Necrosis Factor (Anti-TNF) Agent
This observational, prospective, multicenter study will evaluate the efficacy and safety of MabThera/Rituxan in participants with active rheumatoid arthritis and an inadequate response or intolerance to one anti-TNF therapy.
- Trial name
- NCT01641952
- Testing
- Rituximab
- Where
- Romania
- Volunteers
- 505 people
- Sponsor
- Hoffmann-La Roche
Cerebral Necrosis, Nashopharyngeal Cancer
Treatment of Cerebral Radiation Necrosis (CRN) With Nerve Growth Factor (NGF)
Cerebral radiation necrosis (CRN) is a well-documented late complication of radiation therapy for cancers, and may have a devastating effect on the patient's quality of life (QOL).
- Conditions
- Cerebral Necrosis, Nashopharyngeal Cancer, Nerve Growth Factor
- Trial name
- NCT02032147
- Testing
- NGF group
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fudan University
Brain Metastasis
Methionine and PBR28-PET (Peripheral Benzodiazepine Receptors) in Brain Metastases Following Radiosurgery
The goal of this protocol is to evaluate the potential of PET imaging of amino acid transport and microglial activation to improve the differentiation of tumor recurrence and radiation necrosis in patients with brain metastases…
- Trial name
- NCT02433171
- Testing
- Standard of Care FDG-PET Imaging
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Yale University
Burn Injury, Soft Tissue Injury
Phase I Study for Autologous Dermal Substitutes and Dermo-epidermal Skin Substitutes for Treatment of Skin Defects
The purpose of this study is the evaluation of the safety of autologous tissue-engineered dermal substitutes "denovoDerm" (first arm) and dermo-epidermal skin substitutes "denovoSkin" (second arm) transplanted onto the wound bed…
- Conditions
- Burn Injury, Soft Tissue Injury, Skin Necrosis, Scars
- Trial name
- NCT02145130
- Testing
- denovoDerm, denovoSkin
- Where
- 2 sites in Switzerland
- Volunteers
- 12 people
- Sponsor
- University of Zurich
Brain Tumor, Recurrent, Adult
18F-Fluciclovine PET and Multiparametric MR Imaging
The purpose of the study is to investigate the use of the investigational agent Axumin (fluciclovine-F18) with PET/CT imaging in combination with standard MR imaging to detect remaining or recurrent brain tumor.
- Trial name
- NCT03925675
- Testing
- PET/CT with F-Fluciclovine (Axumin)
- Where
- United States
- Sponsor
- Loma Linda University
Crohn's Disease, Rheumatoid Arthritis
OTIS Humira Pregnancy Registry
The purpose of the OTIS Autoimmune disease in pregnancy study is to monitor planned and unplanned pregnancies exposed to certain medications, to evaluate the possible teratogenic effect of these medications and to follow live…
- Trial name
- NCT01086059
- Where
- United States
- Volunteers
- 944 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Aneurysm, Stroke
Infliximab Therapy for Dolichoectactic Vertebrobasilar Aneurysms
Patients harboring dolichoectactic vertebrobasilar (DVB) aneurysms are at risk of suffering SAH, ischemic stroke, and/or brainstem compression and many patients are not offered invasive treatment due to the futility of existing…
- Conditions
- Aneurysm, Stroke, Vasculitis, Tumor Necrosis Factor-alpha
- Trial name
- NCT02638701
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of California, San Francisco
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Breast Cancer
The Role of C1q Tumor Necrosis Factor-related Protein 6 in Breast Cancer
Globally, breast cancer is one of the most prevalent cancers in women and is the second leading cause of cancer death , representing 15% of worldwide deaths per year .
- Trial name
- NCT04611308
- Testing
- C1q tumor necrosis factor-related protein 6 levels
- Volunteers
- 102 people
- Sponsor
- Assiut University
Psoriasis (PsO), Periodontal Disease
Evaluation of TNF-α, IL-17A, and YKL-40 in GCF and Serum of Psoriasis Patients and Healthy Controls
Background: Psoriasis is a chronic inflammatory skin disease that affects 2-3% of the global population and is linked to immune dysregulation and systemic inflammation.
- Trial name
- NCT06897722
- Testing
- TNF-α analysis in GCF, IL-17A analysis in GCF, YKL-40 analysis in GCF
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zhala Vatankha Sain
Anatomic Stage IV Breast Cancer AJCC v8, Hormone Receptor Positive Breast Adenocarcinoma
Immunotherapy (NHS-IL12 & Bintrafusp Alfa) and Radiation Therapy for the Treatment of Hormone Receptor Positive, HER2 Negative Metastatic Breast Cancer, the REINA Trial
This phase I trial is to find out the best dose, possible benefits and/or side effects of NHS-IL12 given together with bintrafusp alfa and radiation therapy in treating patients with hormone receptor positive, HER2 negative…
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Hormone Receptor Positive Breast Adenocarcinoma, Metastatic Breast Carcinoma, Metastatic HER2 Negative Breast Adenocarcinoma
- Trial name
- NCT04756505
- Testing
- Bintrafusp Alfa, Immunocytokine NHS-IL12, Radiation Therapy
- Sponsor
- M.D. Anderson Cancer Center
Crohn's Disease
Anti-Tumor Necrosis Factor (TNF) Treatments, Work Productivity and Quality of Life in Crohn's Disease
This multicenter, prospective, post marketing observational study (PMOS) was designed to demonstrate long-term effects of anti-Tumor Necrosis Factor therapies on Work Productivity and Impairment scales in participants with…
- Trial name
- IDEA (NCT01860846)
- Volunteers
- 106 people
- Sponsor
- AbbVie
Cancer, Myocardial Infarction
NORVIT and WENBIT - Long-term Follow-up
Two large homocysteine-lowering B-vitamin intervention trials have been performed in Norway during the period 1998 to 2005, NORVIT and WENBIT.
- Conditions
- Cancer, Myocardial Infarction, Cerebrovascular Stroke
- Trial name
- NORVITWENBIT (NCT00671346)
- Where
- 2 sites in Norway
- Volunteers
- 6,839 people
- Sponsor
- Haukeland University Hospital
Radiation Necrosis
The Role of Bevacizumab in the Treatment of Radiation Necrosis in Children With Central Nervous System Tumors
This study is being done to learn about the safety of the study drug bevacizumab(Avastin®), when used to treat radiation necrosis.
- Trial name
- NCT01201850
- Testing
- Bevacizumab (Avastin®)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Colorado, Denver
Stem Cell Transplantation
Investigating Cytokine Genes of Stem Cell Donors
This study seeks to investigate the factors that may account for the differences in the way a stem cell recipient s immune system works after a transplant.
- Trial name
- NCT00353821
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Oral Lichen Planus
Efficacy of Topical Glucosamine Versus Corticosteroid in Oral Lichen Planus
Glucosamine (GlcN) is an N-deacetyl amino sugar derived from the complete hydrolysis of chitosan. It is classified as a nutraceutical and it is used mainly orally for the therapy of osteoarthritis since GlcN has immunoregulatory…
- Trial name
- NCT07114016
- Testing
- Glucosamine Hydrochloride, Triamcinolone Acetonide
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Future University in Egypt
Breast Cancer
Tumour Necrosis Factor Release in Locally Advanced Breast Cancer Patients Receiving Neoadjuvant Docetaxel
The purpose of this study is to assess the fine needle aspiration methodology in collecting sufficient tumour cells to measure tissue TNFa levels serially in human breast cancer sample receiving Taxane treatment
- Trial name
- TNFactor (NCT01539876)
- Testing
- Fine needle aspiration assessing tumour TNFa levels
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Psoriasis
Concomitant Longitudinal Evaluation of Adalimumab With Methotrexate in the Real World: the CLEAR Study
The purpose of this study is to determine the safety and efficacy of the use of the combination therapy adalimumab (ADA) every other week (EOW) with methotrexate (MTX) in suboptimal responders to ADA monotherapy.
- Trial name
- CLEAR (NCT02196701)
- Testing
- Adalimumab, Methotrexate
- Volunteers
- 46 people
- Sponsor
- AbbVie
Systemic Inflammatory Response Syndrome, Coronary Arteriosclerosis
Cleansing of Suction Blood in Cardiac Surgery for Reduced Inflammatory Response
Cardiac surgery using heart and lung machine produces an inflammatory reaction in the body. This leads in few percent of cases to heart, lung, and kidney disturbances that potentially causes death.
- Trial name
- NCT00159926
- Testing
- Cell saver, No cell saver
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet