Clinical trials: Tumor Necrosis Factor-alpha
Ankylosing Spondylitis
Anti-Tumor Necrosis Factor Therapy In Patients With Ankylosing Spondylitis
Assessed using (1) Adalimumab(Humira) and NSAIDs (2) Use only Adalimumab(Humira) treatment of ankylosing spondylitis patient safety and efficacy.
- Trial name
- NCT02456363
- Testing
- TNF alpha, NSAIDs and sulfasalazine
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Chung Shan Medical University
Crohn's Disease, Ulcerative Colitis
Study to Determine Risk Factors for Post-operative Infection in Inflammatory Bowel Disease
Understanding of how best to treat inflammatory bowel disease (IBD) has evolved over the last ten years. Evidence now suggests that the most effective therapy early in the course of Crohn's disease (CD) and ulcerative colitis…
- Trial name
- PUCCINI (NCT02054533)
- Where
- 24 sites in United States
- Volunteers
- 974 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Rheumatoid Arthritis, Tuberculosis
Comparison of the Tuberculin Skin Test (TST) and QuantiFERON ®-TB Gold Test (QFT-G) In Patients With Rheumatoid Arthritis Being Considered for Anti-TNF-Alpha Therapy
This research will help doctors interested in the usefulness of a new test to discover hidden tuberculosis infections in patients diagnosed with rheumatoid arthritis (RA). This new test is called Quantiferon-Gold (QFT-G).
- Trial name
- NCT00925249
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Crohn Disease
Impact of Anti-Tumor Necrosis Factor (TNF) Antibodies on the T-lymphocyte and Macrophage Cooperation in Crohn Disease
The aim of this research is to study Crohn disease patients before and after anti-TNF, the cooperation between lamina propria T-lymphocytes and macrophages, through the expression of co-signalisation molecules and their ligands…
- Trial name
- NCT00561548
- Testing
- rectosigmoïdal biopsies
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Body Composition, Zinc Status
Dietary Patterns, Inflammation, Zinc Status, and Body Composition in Multi-Ethnic Women of Reproductive Age in Jakarta
This study aims to determine the relationship between dietary patterns and hair zinc levels with body composition, tumor necrosis factor alpha (TNF-α), and blood pressure in women of reproductive age from different ethnic…
- Conditions
- Body Composition, Zinc Status, Dietary Analysis, TNF Alpha
- Trial name
- DIVERSE (NCT07170904)
- Testing
- Not applicable- observational study
- Where
- Indonesia
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
FSGS, MCD
Tumor Necrosis Factor Inhibition in Focal Segmental Glomerulosclerosis and Treatment Resistant Minimal Change Disease
Adalimumab, a treatment which blocks tumor necrosis factor (TNF), was tested to see if it changed levels of urine biomarker levels, tissue inhibitor of metalloprotease-1 (TIMP1), and monocyte chemoattractant protein-1 (MCP1).
- Conditions
- FSGS, MCD, Focal Segmental Glomerulosclerosis, Minimal Change Disease
- Trial name
- NCT04009668
- Testing
- adalimumab
- Where
- 4 sites in United States
- Volunteers
- 7 people
- Sponsor
- University of Michigan
Periodontitis
GCF PLAP-1, Sclerostin and TNF-α Levels in Periodontitis
Periodontal ligament-associated protein-1 (PLAP-1) and sclerostin play an important role in the suppression of bone formation. Tumor necrosis factor-alpha (TNF-α) is an important proinflammatory cytokine involved in periodontal…
- Trial name
- NCT05656989
- Testing
- Periodontal clinical measurements and GCF sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Trauma
Apoptosis in Polymorphonuclear Cells and Inflammatory Cytokines of Trauma Patients
This study tries to find how hypoxia and hyperoxia, among types of the respiratory failure induced cell damage that can arise in the course of traumatic damage and treatment, influences apoptosis of PMN cells and IL-6 and tumor…
- Trial name
- NCT03319017
- Testing
- Multiple-trauma patients
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Korea University Guro Hospital
Dermatomyositis
A Pilot Study of Etanercept in Dermatomyositis
The purpose of the study is to obtain preliminary data regarding the safety and tolerability of etanercept in DM. In addition, we will use the study to assess the variability, reliability, and responsiveness of the core set of…
- Trial name
- NCT00112385
- Testing
- Etanercept
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Brigham and Women's Hospital
Crohn's Disease, Rheumatoid Arthritis
OTIS Cimzia Pregnancy Registry
The purpose of the OTIS Autoimmune Diseases in Pregnancy Study is to monitor planned and unplanned pregnancies exposed to certain medications, to evaluate the possible teratogenic effect of these medications and to follow live…
- Conditions
- Crohn's Disease, Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT01797224
- Where
- United States
- Volunteers
- 925 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Arthritis, Rheumatoid, Arthritis, Psoriatic
Study of Intra-articular Delivery of tgAAC94 in Inflammatory Arthritis Subjects
The 13G01 clinical trial is a Phase I/II dose escalation study designed to be conducted in adults with inflammatory arthritis who have persistent moderate or severe swelling in one or more joints, without a disease severe enough…
- Conditions
- Arthritis, Rheumatoid, Arthritis, Psoriatic, Ankylosing Spondylitis
- Trial name
- NCT00126724
- Testing
- tgAAC94 gene therapy vector
- Where
- 22 sites in United States
- Volunteers
- 120 people
- Sponsor
- Targeted Genetics Corporation
AS
Efficacy and Safety of IBI303 in Adult Patients With Active Ankylosing Spondylitis
Study of the efficacy and safety of IBI303 compared with adalimumab in adult patients with ankylosing spondylitis (AS) who have had an inadequate response to or who are intolerant to one or more nonsteroidal anti-inflammatory…
- Trial name
- NCT02893254
- Testing
- IBI303, Adalimumab
- Volunteers
- 438 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Metabolic Syndrome, Overweight
Systematic Review and Meta-analysis of the Differential Effects of DHA and EPA on Inflammation
According to the World Health Organization, cardiovascular diseases (CVDs) are the number 1 cause of death globally. Systemic and local tissue inflammation is now recognized as a key etiological process leading to CVD.
- Conditions
- Metabolic Syndrome, Overweight, Obesity, Chronic Inflammation
- Trial name
- NCT03520556
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Laval University
Moderate to Severe Rheumatoid Arthritis
A Comparison Study of Persistence of UPadacitinib vs. TNF-inhibitoRs In a German Real-world SettING
This study will compare the retention rates for UPA vs. TNFi treatment in adult participants with moderate to severe active RA per local label and according to local standard of care This is a mono-country, prospective…
- Trial name
- UP-RISING (NCT06712628)
- Where
- 75 sites in Germany
- Volunteers
- 678 people
- Sponsor
- AbbVie
Moderate to Severe Ulcerative Colitis
Fecal Calprotectin Levels, Quality of Life, and Workability in Patients Suffering From Ulcerative Colitis Under Adalimumab Therapy - AdaProQuo
The objectives of this study are to explore the fecal calprotectin (fC) levels of UC patients under adalimumab therapy and the correlation with their general wellbeing (Quality of Life [QoL]), workability, and disease activity.
- Trial name
- AdaProQuo (NCT02092389)
- Volunteers
- 10 people
- Sponsor
- AbbVie
Psoriasis
TYK2 Inhibition in Paradoxical Psoriasis
Paradoxical psoriasis is a side effect of a biological treatment (anti-tumor necrosis factor agent, short called anti-TNF) that is used to treat diseases of the skin, the intestine or the joints.
- Trial name
- TYPP (NCT06281106)
- Testing
- Deucravacitinib
- Where
- Switzerland
- Volunteers
- 2 people
- Sponsor
- Prof Curdin Conrad
Crohn's Disease
Long-term Study of Semapimod (CNI-1493) for Treatment of Crohn's Disease
CNI-1493-CD05 is an open-label extension study of CNI-1493-CD04. In the CD05 study, patients are eligible for up to 5 courses of semapimod 60 mg IV x 3 days every 6 - 8 weeks.
- Trial name
- CD05 (NCT00740103)
- Testing
- Semapimod
- Where
- 26 sites in United States, Belgium and 3 more
- Volunteers
- 119 people
- Sponsor
- Ferring Pharmaceuticals
Rheumatoid Arthritis
Evaluation of Tumour Necrosis Factor Alpha (TNFα) Blockers in Early Rheumatoid Arthritis in France
Aim: To describe 1) The use of TNF blockers in early arthritis in daily clinical practice in France 2) To evaluate symptomatic, structural efficacy, and retention rate over 5 years 3) To evaluate predictive factors for TNF…
- Trial name
- NCT02927509
- Testing
- TNF alpha blockers
- Volunteers
- 813 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Asthma
Study of TNFR:Fc (Enbrel) in the Treatment of Asthma
The proposed study is a phase II clinical trial of TNFR:Fc therapy in a segmental allergen bronchoprovocation model of atopic asthma.
- Trial name
- NCT00001893
- Testing
- TNFR:Fc
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Ankylosing Spondylitis
Human Anti-tumor Necrosis Factor (TNF) Monoclonal Antibody Adalimumab in Subjects With Active Ankylosing Spondylitis
The objective of this study was to evaluate the safety and efficacy of adalimumab 40 mg given every other week (eow) in subjects with active ankylosing spondylitis (AS) who have had an inadequate response to, or who are…
- Trial name
- ATLAS (NCT00085644)
- Testing
- adalimumab (D2E7)
- Where
- 22 sites in United States
- Volunteers
- 315 people
- Sponsor
- Abbott