Clinical trials: Twin Diseases
Prenatal Disorder, Premature Birth
Develop a Multi-disciplinary Approach for a Personalized Prenatal Diagnostics and Care for Twin Pregnancies
Different screening modalities evaluation to develop algorithms to predict pregnancy complications in twin pregnancies, and evaluation of serologic response to BNT162b2 Pfeizer/BioNTech vaccination.
- Conditions
- Prenatal Disorder, Premature Birth, Twin Pregnancy With Antenatal Problem, Twin; Pregnancy, Affecting Fetus or Newborn
- Trial name
- PRETWINSCREN (NCT04595214)
- Testing
- TTTS cases are treated by intra-uterine laser for separation.
- Where
- 7 sites in Belgium, Canada and 4 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Fetal Conditions, Maternal; Procedure
A Prospective Study on the Role of Karl Storz Curved and Straight Fetoscopes (11508AAK and 11506AAK) for Fetoscopic Intrauterine Procedures
In this research study, the investigators want to learn more about the role of new innovative surgical devices, the Karl Storz Curved and Straight Fetoscopes for in-utero surgery.
- Conditions
- Fetal Conditions, Maternal; Procedure, Pregnancy Related, Twin to Twin Transfusion Syndrome
- Trial name
- NCT06056635
- Testing
- Karl Storz Curved Scope, Karl Storz Straight Scope
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Type 2 Diabetes
Study of Metformin Pharmacogenetics in Twins
The trough concentration of metformin will be examined in monozygotic and dizygotic twins. Current twin study will determine the total weight of genetics on the trough concentration of metformin.
- Trial name
- NCT01869621
- Testing
- Metformin
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Liver Disease
Heritability of Fatty Liver as Measured by MRI: a Cross Sectional Study of Twins and Family Members
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the United States. The cause of NAFLD is poorly defined but is thought to involve complex interactions of genetic and environmental factors.
- Trial name
- NCT01643512
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Twin Dichorionic Diamniotic Placenta, Twin Monochorionic Monoamniotic Placenta
Austrian Registry on the Outcome of Monochorionic Pregnancies
About one third of twin pregnancies are resulting from a single fertilized oocyte. Two third of these monozygotic twins share a common placenta and are therefore called monochorionic.
- Conditions
- Twin Dichorionic Diamniotic Placenta, Twin Monochorionic Monoamniotic Placenta, Twin-To-Twin Transfusion Syndrome, Twin Pregnancy With Antenatal Problem
- Trial name
- MonoReg (NCT03171909)
- Where
- 13 sites in Austria
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Preterm Birth
The Contribution of Internal Maternal Resources to Creation of Motherhood. Comparison Among Mothers to Twins and Singleton
Delivery of twins or preterm infant is a very stressful episode to mothers. The purpose of this study is to characterize maternal psychological resources in dealing with this situation and compare it to mothers giving birth to…
- Trial name
- NCT00353236
- Where
- Israel
- Sponsor
- Sheba Medical Center
Preeclampsia/Toxemia
The Prediction of Preeclampsia/Toxemia in Twin Pregnancy
The purpose of this study is to finout whetere uterinae artery flow , PP13 and endogolin levels in the serum and kongo red in the urine can predict preeclamsia toxemia in twin pregnancies.
- Trial name
- NCT01255202
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Preterm
Cerclage Plus Progesterone vs Progesterone Alone in Twin Short Cervix
This study aims to compare the effectiveness of cervical cerclage combined with progesterone versus progesterone alone in preventing preterm birth among women with twin pregnancies and a short cervix (cervical length ≤ 30 mm).
- Trial name
- VNTWINC (NCT07372495)
- Testing
- Cervical cerclage, Progesterone
- Where
- 6 sites in Vietnam
- Volunteers
- 260 people
- Sponsor
- National Hospital of Obstetrics and Gynecology
Cardiovascular Diseases, Heart Diseases
Genetics and Cardiovascular Reactivity in Young Twins
To evaluate the effects of genetic variants in all of the nine adrenergic receptor subtype genes, alone or in combination, on cardiovascular reactivity and other quantitative cardiovascular traits in a population of 1048 healthy…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00083850
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Skeletal Class II Malocclusion, Mandibular Retrognathia
Fixed Versus Conventional Twin Block Appliances for Skeletal Class II Malocclusion
This study compares two types of dental appliances a fixed Twin Block appliance and a conventional (removable) Twin Block appliance used to treat a bite problem called skeletal Class II malocclusion in growing children and…
- Trial name
- NCT07687927
- Testing
- Conventional Twin Block Appliance
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Malocclusion, Angle Class II
Effects of Modified Fixed Twin Block Versus Removable Twin Block on Skeletal Class 2 Growing Patients With Mandibular Deficiency
Effects of modified fixed twin block versus removable twin block on skeletal class 2 growing patients with mandibular deficiency: A Randomized Clinical Trial
- Conditions
- Malocclusion, Angle Class II, Mandible Small
- Trial name
- NCT05993156
- Testing
- modified Fixed twinblock, removable twin block
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Twin Pregnancy With Antenatal Problem, Twin Diseases
Twin Pregnancy: a Challenge for Patients, Families and Health Professionals
Twin pregnancies represent 3-4% of all births and in the last two decades the rate of twin pregnancies has steadily increased, essentially due to the spread of assisted fertilization techniques, the use of drugs that stimulate…
- Conditions
- Twin Pregnancy With Antenatal Problem, Twin Diseases, Twin Placenta
- Trial name
- NCT05761769
- Testing
- no intervention
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Down Syndrome
Genetic and Epigenetic Variations in Heterokaryotypic Monozygotic Twins Discordant for Down Syndrome
Heterokaryotypic monozygotic twins discordant for Down syndrome (DS) are very rare, with an incidence estimated to be less than 1 over 7,000,000 pregnancy in the general population.
- Trial name
- Colibri (NCT05767216)
- Testing
- Biological sampling
- Where
- France
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Institut Jerome Lejeune
Lipid Metabolism, Glucose Intolerance
Twins Nutrition Study (TwiNS): Vegan vs. Omnivore
This study is designed to investigate the health impact of a vegan diet compared to a usual, omnivorous diet. The investigators plan to study these diets in twins, where one twin follows a vegan diet and the other twin follows an…
- Conditions
- Lipid Metabolism, Glucose Intolerance, Weight Change, Body, Microbiome
- Trial name
- TwiNS (NCT05297825)
- Testing
- Vegan diet, Omnivore diet
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Stanford University
Polycystic Ovary Syndrome
PCOS Twin Study - Environmental Factors in the Development of Polycystic Ovary Syndrome, Phase 2
Polycystic Ovary Syndrome, or PCOS, is the most common endocrine disorder in women. Depending on the strictness of the diagnostic criteria used, it is thought to occur in about 6-10% of all women, many of whom do not know they…
- Trial name
- NCT00444288
- Where
- United States
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Preterm Birth, Twin Dichorionic Diamniotic Placenta
Vaginal Progesterone in Twin With Short Cervix
Aim of the work The aim of this study is to assess the efficacy of the use of vaginal progesterone as a method of prevention of preterm labour in twin gestations with short cervix .
- Trial name
- NCT02697331
- Testing
- Progesterone
- Where
- Egypt
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Preterm Birth, Twin Pregnancy With Antenatal Problem
Emergency Cerclage in Twin Pregnancies at Imminent Risk of Preterm Birth: an Open-Label Randomised Controlled Trial
Twin pregnancies are at an increased risk of early delivery. One of the reasons for this may be due to a weakened neck of the womb (cervix). There are 2 main ways to manage a weakened cervix in pregnancy.
- Conditions
- Preterm Birth, Twin Pregnancy With Antenatal Problem, Twin to Twin Transfusion Syndrome
- Trial name
- ENCIRCLE (NCT03818867)
- Testing
- Insertion of cervical cerclage
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- St George's, University of London
Inflammatory Bowel Disease, Crohn's Disease
SSAT 054: Non Genetic Factors in the Pathogenesis of IBD in Twins
This study aims to investigate the role of non-genetic factors in the pathogenesis of inflammatory bowel disease.An exploratory study to investigate differences between the epigenome, microbiota and functional immunology in twins…
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT02383953
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- St Stephens Aids Trust
nCPAP, BiPAP
Bi-level Positive Airway Pressure for Respiratory Distress Syndrome in Twins Infants
The investigators compared advantages and disadvantages of two forms of noninvasive respiratory support -bi-level positive airway pressure(BiPAP) or nasal continuous positive airway pressure (nCPAP) -as a primary mode of…
- Conditions
- nCPAP, BiPAP, Respiratory Distress Syndrome
- Trial name
- NCT03235661
- Testing
- BiPAP, nCPAP
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Musculoskeletal Diseases or Conditions
Popliteal SNB:Evaluation of Block Dynamics After Subparaneural Injection Below CPN & TN
This study aims to assess the effect of twin subparaneural injection into individual paraneural sheaths of Common Peroneal Nerve (CPN) and Tibial Nerve (TN) below their point of divergence from the sciatic nerve on the sensory…
- Trial name
- NCT04506879
- Testing
- Popliteal Sciatic nerve block
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong